INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(382, 'November 16, 2016 at 2.30 pm in B-333 (DBS Seminar R00m)', 'Title :\nSupramolecular Chemistry: A Tale of a Container &amp;  Novel Proposed Materials for Biome', '<h3>Title</h3>\n<h3>Supramolecular Chemistry: A Tale of a Container <span style=\"font-size: 12.16px;\">&amp; </span><span style=\"font-size: 12.16px;\"> Novel Proposed Materials for Biomedical and Material Applications</span></h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Supramolecular chemistry has evolved from the molecular chemistry over the years as the science of “chemistry beyond the molecule”. Molecules are held-together by intermolecular non-covalent interactions in a supramolecular assembly. In this seminar, I will talk about a new water-soluble synthetic supramolecular host named as \"octa acid\" (OA) as a reaction cavity for manipulating photochemical and photophysical properties of organic molecules. Most of the guest molecules are enclosed within a capsule made of two OA molecules. The interior of OA capsule is benzene-like nonpolar despite the complex being present in water. Additionally, the confined guests are not isolated but can communicate with molecules present in solution. This part will be discussed with photoinduced electron transfer from the donor incarcerated within OA-capsule to the acceptor free in solution as well as to TiO<sub>2</sub> semiconductor. </p>\n<p style=\"text-align: justify;\">In the second part, I will propose a novel “support-free iterative” strategy to build a new class of functionally-controlled architecturally diverse macromolecules. With this strategy, I will discuss how we, as chemists, can create functional materials in a rapid, scalable and economic way for diverse biomedical and material applications. In addition, design of a unique supramolecule-based functional devise will be proposed for advanced applications.  </p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2598, 'NULL', '2016-10-27 04:23:59', '2030-12-01 18:30:00'),
(383, 'November 4, 2016 at 2.30 pm in AG-66', 'Title :\nProteins as Polymers', '<h3>Title</h3>\n<h3>Proteins as Polymers</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2867, 'NULL', '2016-11-01 23:42:16', '2030-12-01 18:30:00'),
(384, 'November 7, 2016 at 4.00 pm in AG-69', 'Title :\nForm, Function, and Phase Behavior of Intrinsically Disordered Proteins', '<h3>Title</h3>\n<h3>Form, Function, and Phase Behavior of Intrinsically Disordered Proteins</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2596, 'NULL', '2016-11-01 23:43:44', '2030-12-01 18:30:00'),
(385, 'November 21, 2016 at 4.00 pm in AG-69', 'Title :\nProbing Photoinduced Charge Generation in Organic-inorganic Hybrid Perovskites Using Ultrafa', '<h3>Title</h3>\n<h3>Probing Photoinduced Charge Generation in Organic-inorganic Hybrid Perovskites Using Ultrafast Spectroscopy</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2502, 'NULL', '2016-11-15 23:37:19', '2030-12-01 18:30:00'),
(386, 'November 28, 2016 at 2.30 pm in B-333 (DBS Seminar R00m)', 'Title :\nProbing the Fate of Excitons in Organic Semiconductors', '<h3>Title</h3>\n<h3>Probing the Fate of Excitons in Organic Semiconductors</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2852, 'NULL', '2016-11-22 01:48:48', '2030-12-01 18:30:00'),
(387, 'December 5, 2016 at 4.00 pm in AG-69', 'Title :\nWhat XAFS can answer for nano-structure? \nAbstract :\nX-ray Absorption Fine Structure (XAFS)', '<h3>Title</h3>\n<h3>What XAFS can answer for nano-structure? </h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>X-ray Absorption Fine Structure (XAFS) is unique local structural tool - particularly useful for disordered systems where long-range-order is absent and diffraction/ HRTEM fail to extract details beyond a certain limit. The talk will present characterization and quantification of structural configurations/ defects / oxidation states for wide-ranged nano-systems (bimetallic and semiconductor-metal composite catalysts, semiconductor biosensors, drugs, spintronics, multiferroics, molecular magnetic switches, metallic glass) and their correlation with respective properties of scientific interest. Technical, analytical and sample considerations for the suitability of XAFS for a certain scientific problem and the scope of XAFS at INDUS-2 synchrotron facility (RRCAT) will be addressed. </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 3336, 'NULL', '2016-12-01 05:08:59', '2030-12-01 18:30:00'),
(388, 'December 13, 2016 at 2.30 pm in AG-69', 'Title :\nMononuclear copper(II) complexes with the residues in the metal ion binding peptide loop of ', '<h3>Title</h3>\n<h3>Mononuclear copper(II) complexes with the residues in the metal ion binding peptide loop of the CuA center of cytochrome oxidase</h3>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2862, 'NULL', '2016-12-01 05:12:02', '2016-12-07 23:23:15'),
(389, 'January 3, 2017 at 2.30 pm in AG-69', 'Title :\nElectron Transport in Molecular Circuits\nAbstract :\nThe idea of building electronic devices ', '<h3>Title</h3>\n<h3>Electron Transport in Molecular Circuits</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>The idea of building electronic devices using single molecule as active component was first proposed by Aviram and Ratner in the early seventies. Indeed, molecules are of great interest for application in electronic devices because of their small size, their recognition properties, their ability of self-organization and their possibility of chemical modification and customisation. Thus, the ability to measure and control charge transport across metal/molecule/metal junction is of considerable fundamental interest and represents a key step towards the development of molecular electronic devices.</p>\n<p> </p>\n<p>In the first part of my presentation, I will introduce working principle our measurement techniques (i.e STM break junctions (STM-BJ), mechanically controllable break junction (MCBJ) and Conducting probe AFM (CP-AFM) technique).<sup>1,2</sup> Using the results from several case studies, I will try to demonstrate a frame work for building a molecular circuit theory based on metal/molecule/metal junctions at single molecular level.<sup>2,3,4,5</sup> In the later part of my presentation, I will discuss the results mainly focusing on bottom up fabrication of smart surfaces and exploiting the functionality of these smart surfaces for different applications ranging from molecular electronics to catalysis and energy storage/conversion.<sup>5,6</sup> </p>\n<p><span style=\"font-size: 12.16px;\"> </span></p>\n<p><span style=\"font-size: 12.16px;\">References: </span></p>\n<p>1. Hong, W.J et al., Beilstein J. Nanotechnol. 2011. 2, 699-713. </p>\n<p>2. Kaliginedi et al., Journal of American chemical society. 2012, 134 (11), 5262–5275. </p>\n<p>3. Seth, C., Kaliginedi et al., Chemical Science. 2016, Accepted (DOI: 10.1039/C6SC03204D). </p>\n<p>4. Moreno-Garcia et al., Journal of American chemical society. 2013, 135(33), 12228−12240. </p>\n<p>5. Kaliginedi et al., Nanoscale. 2015, 7 (42), 17685-17692. </p>\n<p>6. Kaliginedi et al., Science Advances. 2016, under revision.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2255, 'NULL', '2016-12-27 23:17:21', '2016-12-28 01:24:25'),
(390, 'January 5, 2017 at 2.30 pm in AG-80', 'Title :\nDesign and Application of Sensors for Bioimaging\nAbstract :\nOver the last two decades, the d', '<h3>Title</h3>\n<h3>Design and Application of Sensors for Bioimaging</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Over the last two decades, the development and applications of optical chemical sensors and bio-imaging agents have been pursued with great interest by many researchers. There is a tremendous potential for employing such methods in diverse areas, such as the determination of pollutants in the environment or that of bioactive small molecules in living systems. This talk attempts to address three key problems. Firstly, to detect the real time distribution of toxic heavy metals i.e. Hg<sup>2+</sup>; secondly, to design and synthesise carbon dot-based probes for toxic quinone derivatives; and finally to visualize and quantify monoamine neurotransmitter (MNT) like serotonin (5-HT) and dopamine (DA) in live cells and in living organisms  (e.g. zebrafish). I will talk about how tools of organic synthesis, fluorescence correlation spectroscopy (in solution) and optical imaging methods help us tease out the critical roles of the respective analytes in these model systems. </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 3721, 'NULL', '2016-12-28 01:23:50', '2016-12-28 02:39:34'),
(391, 'January 16, 2017 at 4.00 pm in AG-69', 'Title :\nRNA Editing by Adenosine Deaminases\nAbstract :\nADARs (adenosine deaminases acting on RNA) ar', '<h3>Title</h3>\n<h3>RNA Editing by Adenosine Deaminases</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">ADARs (adenosine deaminases acting on RNA) are editing enzymes that convert adenosine (A) to inosine (I) in duplex RNA, a modification that has wide-ranging consequences on RNA function including altering miRNA recognition sites, redirecting RNA splicing and changing the meaning of specific codons in mRNA. Recent work has demonstrated a causal link between altered RNA editing and human disease. However, our understanding of the ADAR reaction mechanism, origin of editing site selectivity and the effect of disease-causing mutations was limited by the lack of high-resolution structural data for complexes of ADARs bound to RNA. This presentation will describe the combined chemical biology/structural biology approach used to solve this problem wherein we used RNA bearing a nucleoside analog to trap the reaction intermediate allowing for crystallization of the complexes. Solving the structures of the complexes uncovered ADARs’ use of a unique base-flipping mechanism well-suited for modifying duplex RNA, revealed an ADAR-specific RNA-binding loop near the enzyme active site and explained flanking sequence preferences. In addition, our results provide a structural framework for understanding the effects of ADAR mutations associated with human disease.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2197, 'NULL', '2017-01-15 20:27:29', '2030-12-01 18:30:00'),
(392, 'January 19, 2017 at 2.30 pm in AG-69', 'Title :\nVariation of the Cooperativity and the Role of Ligand-field States in Spincrossover Compound', '<h3>Title</h3>\n<h3>Variation of the Cooperativity and the Role of Ligand-field States in Spincrossover Compounds</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">The spin-crossover process involves the rearrangement of electrons within metal dorbitals from the high-spin (HS) to the low-spin (LS) configuration corresponding to the distribution that yields maximum and minimum number of unpaired electrons respectively. The relative population of the spin states is a function of various external perturbations such as temperature, magnetic fields, external pressure, and light irradiation. Therefore, these materials are of current interest in chemistry and materials science not only because of their intrinsic fundamental properties but also because of their potential applications as functional materials for the construction of sensors, as well as memory and display devices. In the present talk, the thermal and photo-induced spin switching dynamics and the variation of the cooperative effects in the spin-crossover coordination networks will be discussed. The aim is to understand the physics of cooperative effects and establish the limits of cooperativity. In addition, the role of ligand-field states in the ultrafast photophysics of the prototypical spin-crossover compound will be discussed. The involvement of ligand-field states in transition-metal photophysics is nevertheless crucial, and that they are by no means innocent is borne out by the discovery of photo-induced processes in spin-crossover compounds, which has no low-energy Metal-to-Ligand-Charge-Transfer (MLCT) states.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2329, 'NULL', '2017-01-15 22:59:27', '2030-12-01 18:30:00'),
(393, 'January 20, 2017 at 2.30 pm in AG-69', 'Title :\nStrategy to Tune Equilibrium Dopant Composition in Semiconductor Nanocrystals\nAbstract :\nInt', '<h3>Title</h3>\n<h3>Strategy to Tune Equilibrium Dopant Composition in Semiconductor Nanocrystals</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Intentional incorporation of dopants into the semiconductor nanocrystals can dramatically alter the electronic, optical, magnetic, and electrical properties. Understanding the fundamental chemical boundaries of nanocrystal composition control for new and challenging dopant/host combinations could yield unprecedented doped semiconductor nanomaterials for applications from spectral conversion in lighting and luminescent solar concentrators (LSCs), to optical nano-thermometry, bioimaging, plasmonics, or spinbased electronic/photonic information processing. Enormous efforts and many attempts have been made to dope semiconductor nanocrystals with transition metal ions by means of colloidal chemical synthesis. Despite these efforts, successful dopant incorporation into host nanocrystals remains a long-standing challenge. The primary challenges are associated with unfavorable impurity/host competition kinetics during nanocrystal growth. To overcome these challenges, a qualitatively new method of nanocrystal diffusion doping under thermodynamic control has recently been developed where dopants are introduced into preformed nanocrystals via stoichiometric addition of cations and anions, followed by diffusion of these impurities into the nanocrystal\'s internal volume while maintaining the nanocrystal size, shape, and structural uniformity. This talk focuses on broadening the scope of this powerful chemistry, in conjunction with cation exchange chemistries, to allow dopants to be incorporated into the host nanocrystal lattice, thereby providing a general methodology for controlling dopant composition under thermodynamic equilibrium. In addition, mechanistic understanding of the dopant ion diffusion in these nanocrystals will be discussed, which contributes to our fundamental understanding of this rich area of nanoscience and improves our ability to tailor the compositions of nanostructures for future advanced technological applications.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2414, 'NULL', '2017-01-15 23:01:03', '2030-12-01 18:30:00'),
(394, 'January 23, 2017 at 4.00 pm in AG-69', 'Title :\nEncoding Formation Mechanism of KCC-1', '<h3>Title</h3>\n<h3>Encoding Formation Mechanism of KCC-1</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2621, 'NULL', '2017-01-19 22:08:12', '2030-12-01 18:30:00'),
(395, 'January 25, 2017 at 11.00 a.m. in AG-80', 'Title :\nAllostery in Chaperonins: How and Why?\nAbstract :\nChaperonins are large protein assemblies t', '<h3>Title</h3>\n<h3>Allostery in Chaperonins: How and Why?</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Chaperonins are large protein assemblies that assist protein folding in an atp-dependent fashion. I will discuss their allosteric mechanisms and how they impact their folding function.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2466, 'NULL', '2017-01-20 02:50:42', '2030-12-01 18:30:00'),
(396, 'January 24, 2017 at 2.30 pm in AG-80', 'Title :\nCarbonaceous- and Layered-material based Hybrids for Drug Delivery and Catalysis\nAbstract :\n', '<h3>Title</h3>\n<h3>Carbonaceous- and Layered-material based Hybrids for Drug Delivery and Catalysis</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>In this presentation, I will talk about synthesis and characterization of various hybrid materials and their applications in drug delivery and catalysis. Carbonaceous nanospheres derived from glucose show preferential accumulation into the mice brain. We have modified the surface of these spheres with magnetic (Prussian blue and its analogues) nanoparticles and luminescent (lanthanide) probes to make brain theranostic agents. These multifunctional hybrid spheres showed enhanced magnetic and luminescent behaviour. They were biocompatible, entered brain, and showed no toxicity to the mice. The method of fabrication was versatile and could be used to create a number of theranostic systems for brain. Hybrid nanoparticles were synthesized from glucose derived carbon and iron oxide in the form of different morphology. Depending on their shape, these nanoparticles could compartmentalize inside the brain cells in the in vivo conditions. Biconcave shape of nanoparticles showed preferential nuclear entry, whereas nanotube morphology was restricted to the cytoplasm. Also, shape dependent compartmentalized delivery of an activator of an epigenetic enzyme was demonstrated. Smart hybrid nanospheres were prepared using layered clay and polyelectrolytes in a layer-by-layer fashion. These hybrid spheres showed reversible size change (about 60%) in response to pH, in the range of physiologically relevant pH values. Hybrids were also demonstrated for their pH dependent drug release ability. Catalytic behaviour of layered boron nitride and boron nitride supported metals towards oxidative dehydrogenation of propane was studied. Boron nitride (a generally accepted inert material) catalysed the propane oxidative dehydrogenation reaction. The catalytic activity was found to improve with increasing surface area of the catalyst. The catalytic activity was stable for nearly 5 hours and could be regenerated easily by heating in dilute ammonia. Oxidation of surface B-N bonds in oxygen leads to the diminishing catalytic activity, which on heating in ammonia reduced back to their native form regaining the indigenous catalytic activity. Remarkably, the high propene selectivity and yields obtained for these metal free catalysts were comparable to the reported catalysts and could be further increased by using higher surface area boron nitride samples.</p>\n<p>References:</p>\n<p>1. P Chaturbedy et. al. Journal of Nanobiotechnology (2012), 10, 35.</p>\n<p>2. P Chaturbedy et. al. J. Mater. Chem. B (2013), 1, 939-945.</p>\n<p>3. P Chaturbedy et. al. Journal of Controlled Release (2015), 217, 151-159.</p>\n<p>4. P Chaturbedy et. al. ACS Nano (2010), 4, 5921-5929.</p>\n<p>5. P Chaturbedy et. al. Manuscript under preparation (2017).</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2462, 'NULL', '2017-01-20 04:01:58', '2030-12-01 18:30:00'),
(397, 'January 30, 2017 at 4.00 pm in AG-69', 'Title :\nTowards a Novel Theoretical Approach to Characterize Biomolecular Flexibility', '<h3>Title</h3>\n<h3>Towards a Novel Theoretical Approach to Characterize Biomolecular Flexibility</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2610, 'NULL', '2017-01-26 22:46:03', '2030-12-01 18:30:00'),
(398, 'February 2, 2017 at 2.30 pm in AG-80', 'Title :\nRevealing the Nanoscale Order of Dynamic Molecules Within Microscale Assemblies (Part-I) \nA', '<h3>Title</h3>\n<h3>Revealing the Nanoscale Order of Dynamic Molecules Within Microscale Assemblies (Part-I) </h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Living systems differ from inanimate ones by their ability to create and sustain ordered assemblies of molecules at the expense of chemical energy. The ‘parts list’ of biomolecular assemblies is being discovered at a rapid pace, but how these parts come together to form functional cellular mechanisms remains an outstanding question in many fields of biology. For example, the principal components of the cellular contractile machinery that shapes, divides, and moves cells have been known for a long time, viz., actomyosin network, plasma membrane, and adhesion complexes. But the dynamic architecture of this machinery remains challenging to measure, especially in three-dimensional (3D) (patho)physiological environments.</p>\n<p style=\"text-align: justify;\">Our recent work has led to fluorescence-based computational microscopy assays that reveal nanoscale architecture of molecules within the context of microscale assemblies. We exploit intrinsic polarization of fluorescence to measure sub-resolution orientation and alignment of molecules. We have developed an instantaneous fluorescence polarization microscope (instantaneous fluorescence PolScope) to analyze the dynamic changes in concentration, position, and orientation of molecules (Mehta et al., PNAS 2016). Instantaneous fluorescence PolScope acquires four polarization-resolved images of dynamic molecules with single molecule sensitivity. The image data is then computationally translated into orientation, concentration, and kinetics of the cytoskeletal networks. This computational microscopy approach revealed nanoscale orientation of actin filaments relative to the retrograde flow of the network at the leading edge of cells migrating on 2D surfaces. Analysis of actin filament orientation at the leading edge has been possible only in fixed cells with electron microscopy. Further, in a multi-institutional collaboration (Swaminathan et al., bioRxiv 2016 and Nordenfelt et al., bioRxiv 2016), synergistic use of fluorescence polarization microscopy and computational analysis revealed that integrin transmembrane receptors are ‘actively aligned’ by their engagement with retrograde flow and extracellular ligand. The active alignment of integrin receptors may be a general mechanism used by cells to sense directional cues within extracellular matrix and is uniquely accessible with fluorescence polarization microscopy in live cells. </p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2294, 'NULL', '2017-01-26 23:05:35', '2030-12-01 18:30:00'),
(399, 'February 3, 2017 at 2.30 pm in AG-69', 'Title :\nRevealing the Nanoscale Order of Dynamic Molecules Within Microscale Assemblies (Part-II)\nAb', '<h3>Title</h3>\n<h3>Revealing the Nanoscale Order of Dynamic Molecules Within Microscale Assemblies (Part-II)</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Living systems differ from inanimate ones by their ability to create and sustain ordered assemblies of molecules at the expense of chemical energy. The ‘parts list’ of biomolecular assemblies is being discovered at a rapid pace, but how these parts come together to form functional cellular mechanisms remains an outstanding question in many fields of biology. For example, the principal components of the cellular contractile machinery that shapes, divides, and moves cells have been known for a long time, viz., actomyosin network, plasma membrane, and adhesion complexes. But the dynamic architecture of this machinery remains challenging to measure, especially in three-dimensional (3D) (patho)physiological environments.</p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">The architecture of the molecular assemblies within cells that adhere to 2D unphysiological substrates often does not provide predictive insights into the assemblies’ function in the 3D physiological environments. We have devised a confocal LC-PolScope, which employs liquid crystal (LC)-based tuning of polarization, to measure nanoscale alignment and orientation of filamentous assemblies in 3D environments. Our data provides new insights into the molecular architecture of the contractile machinery that drives cytokinesis and migration of cells in 3D environments. </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Building upon above advances, the future studies will reveal the molecular architectural basis of the directional forces generated by single cells and a collective of cells within 3D (patho)physiological environments.</span></p>\n<p style=\"text-align: justify;\"> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2308, 'NULL', '2017-01-26 23:07:26', '2030-12-01 18:30:00'),
(400, 'February 6, 2017 at 4.00 pm in AG-69', 'Title :\nFibrous Nanosilica: Tunable Synthesis, Its Applications in Catalysis, CO2 Capture and Novel ', '<h3>Title</h3>\n<h3>Fibrous Nanosilica: Tunable Synthesis, Its Applications in Catalysis, CO<sub>2</sub> Capture and Novel Materials Design</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2191, 'NULL', '2017-02-01 02:22:22', '2030-12-01 18:30:00'),
(401, 'February 7, 2017 at 2.30 pm in AG-69', 'Title :\nModulation of the Electronic Structure and Phonon Transport of SnTe for High Thermoelectric ', '<h3>Title</h3>\n<h3>Modulation of the Electronic Structure and Phonon Transport of SnTe for High Thermoelectric Performance</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Lead chalcogenides are the best performers for thermoelectric power generation at mid-high temperatures; however, environmental concern about Pb limits its use in large-scale thermoelectric applications. SnTe, a IV-VI narrow band gap semiconductor, can be an alternative of PbTe due to its similar crystal structure and valence band characteristics.1 The journey of SnTe, as a potential thermoelectric material begins with In doped SnTe where In creates resonance level. This has been further optimized via lattice thermal conductivity reduction in SnTe1-xSex.2 Another constraint of SnTe is the large energy separation between the light and heavy hole valence bands which restricts the contribution of heavy hole mass to the Seebeck coefficient. Doping of Mg and Ag in SnTe significantly tunes the electronic structure of SnTe, which decreases energy difference between the light hole and heavy hole valence bands, leading to enhanced Seebeck coefficient and thermoelectric efficiency.3,4 Co-doping of the In and Ag in SnTe yields synergistic enhancement in Seebeck coefficient and power factor over a broad temperature range because of the introduction of resonance state and convergence of valence bands.1 Moreover, pristine SnTe exhibits κlat of ~2.88 Wm-1K-1 at room temperature, while theoretical limit for minimum lattice thermal conductivity (κmin) is ~0.5 Wm-1K-1. We have successfully reduced lattice thermal conductivity of SnTe near to its theoretical minimum limit, κmin, via Sb alloying which spontaneous form nanodomains of Sb-rich layered intergrowth SnmSb2nTe3n+m compounds.5</p>\n<p>1. Banik, A.; Shenoy, U. S.; Waghmare, U. V.; Biswas, K. J. Am. Chem. Soc. 2016, 138, 13068.</p>\n<p>2. Banik, A.; Biswas, K. J. Mater. Chem. A 2014, 2, 9620-9625.</p>\n<p>3. Banik, A.; Shenoy, U. S.; Anand, S.; Waghmare, U. V.; Biswas, K. Chem. Mater. 2015, 27, 581.</p>\n<p>4. Banik, A.; Biswas, K. J. Solid State Chem. 2016, 242, 43.</p>\n<p>5. Banik, A.; Vishal, B.; Perumal, S.; Datta, R.; Biswas, K. Energy Environ. Sci. 2016, 9, 2011-2019.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2220, 'NULL', '2017-02-01 02:27:32', '2030-12-01 18:30:00'),
(402, 'February 15, 2017 at 2.30 pm in AG-80', 'Title :\nDNA Based Emerging Technologies for Biological and Bioengineering Applications\nAbstract :\nSt', '<h3>Title</h3>\n<h3>DNA Based Emerging Technologies for Biological and Bioengineering Applications</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Structural DNA nanotechnology explores various nanoscale structural and functional properties of DNA to manipulate matter at nanoscale for diverse applications1. Three dimensional architectures based on DNA polyhedra have raised particular interest in biomedical applications2. DNA polyhedra possess an internal void bounded by a welldefined three-dimensionally structured surface3,4. I will present the first successful delivery of quantum dots (QDs) as the internal payload of DNA icosahedra that are monofunctionalized with specific, endocytic ligands like folic acid, Galectin-3 (Gal35), Shiga toxin B-subunit (STxB6) and transferrin. Single particle tracking of Gal3/STxB-bearing, QDloaded icosahedra reveal new observations of compartment dynamics along the endocytic pathways7. QD-loaded DNA polyhedra bearing ligands of unique stoichiometry represent a new class of high-precision molecular imaging tools for quantitative approaches to complex biological phenomena arising from receptor clustering. Similarly, DNA caged magnetic particles were produced to purify galectin-3 enriched endocytic vesicles. Quantitative mass-spectrometry revealed new and pathway specific cargo molecules and trafficking machinery on the pre-early endosomal structures arising from Gal3 induced carriers. Using inhibitors and siRNA based screens I have validated the key cargo and cytosolic candidates involved in CLIC biogenesis and its endocytic trafficking. Our multidisciplinary and innovative approach using DNA nanotechnology and lattice light sheet microscopy has contributed immensely to fundamental understanding of formation of distinct endocytic pits via clathrin- independent carriers and the molecular anatomy of these carriers. Further, our results highlight the emerging potential of DNA devices in cell biology and biomedical applications that could enable probing and programming various biological systems as well as developing next generation tools probe and program the living systems for advanced bioengineering and biomedical applications.</p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">References</span></p>\n<p>1. Modi, S., Bhatia, D., Simmel, F. C. &amp; Krishnan, Y. J. Phys. Chem. Lett. 1, 1994–2005.</p>\n<p>2. Bhatia, D., Surana, S., Chakraborty, S., Koushika, S. P. &amp; Krishnan, Y.. Nat.Commun. 2, 339 (2011).</p>\n<p>3. Bhatia, D., Sharma, S. &amp; Krishnan, Y. 22, 475–484 (2011).</p>\n<p>4. Bhatia, D., Chakraborty, S. &amp; Krishnan, Y. Nat Nanotechnol 7, 344–346 (2012).</p>\n<p>5. Lakshminarayan, R., Wunder, C. &amp; Becken, U..Nat. Cell Biol. 16, 595–606 (2014).</p>\n<p>6. Johannes, L. &amp; Römer, W. Nat. Rev. Microbiol. 8, 105–16 (2010).</p>\n<p>7. Bhatia. D., et al., Nat Nananotehnol 11, 1112-1119 (2016).</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2673, 'NULL', '2017-02-01 03:09:29', '2030-12-01 18:30:00'),
(403, 'February 13, 2017 at 4.00 pm in AG-69', 'Title :\nEUV Laser Photoelectron Spectroscopy of Mass Selected Neutral Clusters and Molecules\nAbstrac', '<h3>Title</h3>\n<h3>EUV Laser Photoelectron Spectroscopy of Mass Selected Neutral Clusters and Molecules</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<h2 class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"font-size: 12.0pt;\" lang=\"EN-US\">Over the past 15 years our research interests have focused on four main and related areas: 1. properties, chemistry, catalytic, and photo-catalytic behavior of neutral, inorganic, isolated clusters, M<sub>m</sub>M’<sub>n</sub>X<sub>p</sub>H<sub>q</sub> (M,M’ = metals, X = O, S, C); 2. initial release of stored chemical energy from isolated energetic molecules (e.g., RDX, HMX, CL -20, high N- content species, …); 3. small molecule, neutral clusters (e.g., (NH<sub>3</sub>)<sub>n</sub>, (H<sub>2</sub>O)<sub>n</sub>, (NH<sub>3</sub>BH<sub>3</sub>)<sub>n</sub>, (SO<sub>2</sub>)<sub>n</sub>, …) and their ion chemistry; and 4. structure, energetics, ion fragmentation reactions of “simple” bio-related molecules (e.g., amino acids, saccharides, neurotransmitters, and DNA bases). These studies have evolved from characterization of energy levels and intermolecular interactions, to ultrafast kinetics and dynamics of molecular cluster reactions, to the study of inhomogeneous catalytic and photo-catalytic cluster reactions. Clusters and molecules are identified through mass spectrometry, UV/Vis electronic spectroscopy, and most recently photo-electron spectroscopy (PES) employing visible, UV, VUV, extreme ultraviolet (EUV, soft x-ray) lasers. Decomposition reactions for the initial release of molecular stored chemical energy have been time resolved at less than 100 fs. In order to acquire, analyze, and interpret the experimental data obtained on these systems, we have had to develop an essential theoretical/calculational component for our program. This seminar reviews our initial synthesis and reaction studies through mass spectrometry of neutral catalytic and photo-catalytic inorganic clusters, small molecule cluster ion reactions, and generation of new cluster species. These results serve as motivation for constructing a new PES apparatus employing visible, UV, VUV, and EUV photons for photo-detachment of anionic and neutral species in order to acquire spectroscopic data on the systems of interest. We will discuss these new results for Fe<sub>x</sub>S<sub>y</sub>H<sub>z</sub> clusters, energetic materials, and bio-related saccharides and DNA bases. The importance of the new spectroscopic (PES) data for these systems is that they enable the evaluation of theoretical techniques in order that proper algorithms and approaches may be employed to generate results that are not presently experimentally accessible, such as cluster and molecular structure, reaction mechanisms, and general electronic state specific potential energy surfaces. </span></h2>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2032, 'NULL', '2017-02-06 23:25:12', '2030-12-01 18:30:00'),
(404, 'February 14, 2017 at 2.30 pm in AG-69', 'Title :\nInhibition of formation of alpha-synuclein amyloid fibrils by Triphala, a herbal preparation', '<h3>Title</h3>\n<h3>Inhibition of formation of alpha-synuclein amyloid fibrils by Triphala, a herbal preparation</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1959, 'NULL', '2017-02-07 03:27:43', '2030-12-01 18:30:00'),
(405, 'February 16, 2017 at 2.30 pm in AG-80', 'Title :\nThe cryo- electron microscopy (cryo-EM) structure of the group II intron at 3.8 Å resolutio', '<h3>Title</h3>\n<h3>The cryo- electron microscopy (cryo-EM) structure of the group II intron at 3.8 Å resolution</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Single-particle cryo-electron microscopy (cryo-EM) is an emerging technique in the field of structural biology. With the recent advancement in electron detection technology and improved image processing algorithms, now it is possible to achieve atomic resolution structure of macromolecular complexes.  We have been applying cryo-EM to illustrate the architecture of ribonucleoprotein complexes, such as bacterial group II introns and ribosomes. Bacterial group II introns are large catalytic RNAs related to nuclear spliceosomal introns and eukaryotic retrotransposons. They self-splice, yielding mature RNA, and integrate into DNA as retroelements. A fully active group II intron forms a ribonucleoprotein complex comprising the intron ribozyme and an intron-encoded protein that performs multiple activities including reverse transcription, in which intron RNA is copied into the DNA target. Recently, the first cryo-EM structure of Lactococcus lactis group IIA intron, in complex with an intron-encoded protein, was resolved at 3.8 Å resolution and its protein-depleted form at 4.5-Å resolution. Molecular analysis of the cryo-EM structure of the group II intron reveals functional coordination of the intron RNA with the protein. Interestingly, the protein structure revealed a close relationship between the reverse transcriptase catalytic domain and telomerase, whereas the active splicing center resembles the spliceosomal Prp8 protein. These extraordinary similarities hint at intricate ancestral relationships and provide new insights into splicing and retromobility. I will highlight the recent development in the cryo- EM field and summaries our findings on group II introns.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2299, 'NULL', '2017-02-14 23:36:28', '2030-12-01 18:30:00'),
(406, 'February 17, 2017 at 2.30 pm in AG-69', 'Title :\nCryo-electron microscopy (cryo-EM) studies of mammalian mitochondrial and Mycobacterium smeg', '<h3>Title</h3>\n<h3>Cryo-electron microscopy (cryo-EM) studies of mammalian mitochondrial and Mycobacterium smegmatis ribosomes</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Ribosomes the protein synthesis machinery are large macromolecular complexes. The mammalian mitochondrial ribosomes (mitoribosomes) are responsible for synthesizing 13 membrane proteins that form essential components of the complexes involved in oxidative phosphorylation (or ATP generation) for the eukaryotic cell. The mitoribosome contains significantly smaller rRNAs and a large mass of mitochondrial ribosomal proteins (MRPs), including large mito-specific amino acid extensions and insertions in MRPs that are homologous to bacterial ribosomal proteins and an additional 35 mito-specific MRPs. The cryo-EM structures of the mitoribosome have yielded the architecture of small subunit of the mitoribosome and existence of the previously eluded E-site within the mitoribosome. The mitoribosomes are susceptible to the antibiotics that targets the bacterial ribosomes because the mitoribosomes are believed be of prokaryotic origin. A docking study of antibiotics in to bacterial and mitochondrial ribosomes have provided rational to the differential affinity of these antibiotic. </p>\n<p style=\"text-align: justify;\"> </p>\n<p style=\"text-align: justify;\">Mycobacterium smegmatis is widely used as a model organism to study pathogenic mycobacteria, such as Mycobacterium tuberculosis. About one third of M. smegmatis mRNAs are leaderless, lacking a 5’UTR and therefore also lacking a Shine-Dalgarno sequence. How ribosomes initiate protein synthesis from leaderless mRNAs is unknown. We have obtained a 5 Å resolution cryo- EM map of the M. smegmatis 70S ribosome, with some core regions resolved to 4 Å. Our map reveals two unique features of the mycobacterial ribosome: (i) an altered conformation of the previously identified steeple feature on the large (50S) ribosomal subunit (ii) a novel protein density mass is found below the origin of the rim of the small (30S) ribosomal subunit platform that appears to correspond to an α-helical structure of up to ~33 amino acid residues. While we continue to improve the resolution of our cryo-EM map, we are also using mass spectroscopy to identify the α-helical density. I will summarize the results of these studies that I have been involved in, and will outline my future research plan on the protein synthesis in Plasmodium falciparum ribosome that I would like to pursue as an independent investigator.</p>\n<p style=\"text-align: justify;\"> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2504, 'NULL', '2017-02-14 23:38:15', '2030-12-01 18:30:00'),
(407, 'February 20, 2017 at 4.00 pm in AG-69', 'Title :\nBi-ion : A new electroactive species for batteries', '<h3>Title</h3>\n<h3>Bi-ion : A new electroactive species for batteries</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2472, 'NULL', '2017-02-14 23:39:49', '2030-12-01 18:30:00'),
(408, 'February 21, 2017 at 2.30 pm in AG-69', 'Title :\nDirected Evolution of Thermally Stable Cytochrome P450: An Approach for Alkane Hydroxylation', '<h3>Title</h3>\n<h3>Directed Evolution of Thermally Stable Cytochrome P450: An Approach for Alkane Hydroxylation</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2378, 'NULL', '2017-02-14 23:41:02', '2030-12-01 18:30:00'),
(409, 'February 27, 2017 at 4.00 pm in AG-69', 'Title :\nStructural Insights into the Mechanical Properties of Ubiquitin Family Proteins (using Steer', '<h3>Title</h3>\n<h3>Structural Insights into the Mechanical Properties of Ubiquitin Family Proteins (using Steered Molecular Dynamics Simulations)</h3>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2239, 'NULL', '2017-02-21 23:49:45', '2030-12-01 18:30:00'),
(410, 'March 2, 2017 at 2.30 pm in AG-80', 'Title :\nOrganometallic Complexes: Application Spanning from Cataysis to Material Chemistry\nAbstract ', '<h3>Title</h3>\n<h3>Organometallic Complexes: Application Spanning from Cataysis to Material Chemistry</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Catalysis of organic reactions is one of the most important applications of organometallic chemistry and has been a significant factor in the rapid development of the field as a whole. Organometallic complexes now have numerous applications in the pharmaceuticals, fine chemical, and in material chemistry and are beginning to contribute to the rising topic of energy and green chemistry. The first part of my talk consist of synthesis of unconventional organometallic systems for the hydroamination reaction (addition of amine across C-C multiple bond). The main focus will be on the development of novel bimetallic complexes and their application. The second part of my talk consist of development of metal complexes using phenalenyl (PLY) based ligand systems. PLY is a well-known building block for constructing organic radical based materials for its ability to exist in three redox active states such as cation, neutral radical and anion by accepting sequential electron into its nonbonding molecular orbital (NBMO). The discussion will be utilizing the cationic state of the PLY unit to develop metal complexes for application in catalysis and spintronics.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2280, 'NULL', '2017-02-21 23:55:04', '2030-12-01 18:30:00'),
(411, 'March 3, 2017 at 2.30 pm in AG-69', 'Title :\nDevelopment of Cost Effective Organometallic Catalysts for Ccompounds of Industrial Interest', '<h3>Title</h3>\n<h3>Development of Cost Effective Organometallic Catalysts for Ccompounds of Industrial Interest</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Catalysis is one of the most important branches of chemistry because it enables the production of new molecules and materials that have impact on numerous final applications. Some 75% of all commercially-produced chemical products involve catalysts at some stage in their manufacture, and catalytic processes generate ca. £700Bn in products worldwide annually. Hence, an inexpensive and environmentally benign transition-metal surrogate based catalytic systems, replacing scarce, toxic, and expensive transition metals, is a pressing need. In first part of my talk, I will discuss about the development of earth abundant metal based complexes using pincer ligand scaffold for the (de)hydrogenation reaction(s) of small molecules of industrial importance. This involves synthesis of novel catalytic systems and understanding of the catalytic reactions with a focus on the mechanistic aspect. The second part of my talk consist of development of novel ligand framework based on the cationic phosphine unit, starting from elemental white phosphorous and application in carbon dioxide sequestration chemistry. Additionally, synthesis of metal complexes based on the phosphate back bone relevant for material application will be discussed</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2169, 'NULL', '2017-02-21 23:56:55', '2030-12-01 18:30:00'),
(412, 'February 23, 2017 at 2.30 pm in AG-80', 'Title :\nA Theoretical Model to explain the DNP Induced NMR Signals Using TEMPOL at 3.4 T\nAbstract :\n', '<h3>Title</h3>\n<h3>A Theoretical Model to explain the DNP Induced NMR Signals Using TEMPOL at 3.4 T</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p class=\"Default\" style=\"text-align: justify;\"><span lang=\"EN-US\">Dynamic nuclear polarization (DNP) is one of the most efficient methods to increase the sensitivity of NMR and MRI by transferring polarization from electron spins to nuclear spins.  For radicals in solid solutions the nuclear signal enhancements during microwave irradiation are interpreted either using the thermal mixing (TM) mechanism or a combination of the solid-effect (SE) and cross-effect (CE) mechanisms.  Although the SE and CE based analysis of the lineshape of the enhancement as a function of the MW frequency has been possible, it was only realized recently that these lineshapes are correlated to the electron polarization distribution in the sample. To quantify this correlation a theoretical model was introduced based that describes the electron spectral-diffusion (<em>eSD</em>) mechanism and its contribution to DNP through the new indirect-CE (<em>iCE</em>) mechanism. </span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2379, 'NULL', '2017-02-22 01:57:54', '2030-12-01 18:30:00'),
(413, 'February 28, 2017 at 2.30 pm in AG-69', 'Title :\nFibrous Nanosilica/TiO2 Hybrids for Photocatalytic H2 Production', '<h3>Title</h3>\n<h3>Fibrous Nanosilica/TiO<sub>2</sub> Hybrids for Photocatalytic H<sub>2</sub> Production</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2398, 'NULL', '2017-02-23 23:07:28', '2030-12-01 18:30:00'),
(414, 'March 6, 2017 at 4.00 pm in AG-69', 'Title :\nKCC-1 Supported Metal Nanoparticles as Highly Active and Selective Nanocatalysts', '<h3>Title</h3>\n<h3>KCC-1 Supported Metal Nanoparticles as Highly Active and <span style=\"font-size: 12.16px;\">Selective Nanocatalysts</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2326, 'NULL', '2017-03-01 01:56:17', '2030-12-01 18:30:00'),
(415, 'March 9, 2017 at 4.00 pm in AG80', 'Title :\nUnderstanding Amyloid Aggregation in Terms of its Distal Folding Contacts', '<h3>Title</h3>\n<h3>Understanding Amyloid Aggregation in Terms of its Distal Folding Contacts</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2132, 'NULL', '2017-03-06 23:46:52', '2030-12-01 18:30:00'),
(416, 'March 14, 2017 at 2.30 pm in AG-69', 'Title :\nSoft-oxometalates, Polyoxometalates, Light and Chemistry\nAbstract :\nMany metal centres, many', '<h3>Title</h3>\n<h3>Soft-oxometalates, Polyoxometalates, Light and Chemistry</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Many metal centres, many oxygen atoms and usually charged species can be formally defined as polyoxometalates. They are crystalline and exist in solid state and also as molecular ions in solutions. In our group we explore the formation of unusually large polyoxometalates like that of [Mo132] and it will be discussed. Using light their photocatalytic activities in various organic reactions have also been explored by us and has led to the synthesis of polymeric materials and speciality organic compounds. All such aspects will be discussed and presented. However there exists a liquid like colloidal paradigm based on oxometalates which has been proposed by us to be called soft-oxometalates. Being colloidal they provide a unique opportunity for patterning of polyoxometalates on a microscopic chip using thermo-optic laser tweezers. Such soft states of oxometalates in conjugation with polymeric organic frameworks have been patterned to catalyse simple oxidation reactions and will also be discussed. Finally the use of soft-oxometalates in achieving CO2 reduction coupled with water oxidation will be demonstrated which opens up new possibilities of using these materials for photochemical reduction reactions coupled with oxidation reactions and the reverse.   </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 3100, 'NULL', '2017-03-09 02:00:25', '2030-12-01 18:30:00');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(417, 'March 16, 2017 at 2.30 pm in AG-80', 'Title :\nBiological Fingerprints in Molecular Electronics\nAbstract :\nElectron transfer in and across ', '<h3>Title</h3>\n<h3>Biological Fingerprints in Molecular Electronics</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Electron transfer in and across proteins plays a key role in many biological processes of organisms. Fundamental understanding electron flow within protein structures is not only important for biology, but may also help in the design of bio-electronic devices that directly couple to biological systems. Electrochemistry of redox-active proteins and enzymes is widely used to study electron transfer processes in those systems, while the impact of external voltage-driven electronic transport across bio-molecular junctions has been limited because of limited information that could be obtained from resulting current-voltage characteristics. However, as I will show, protein-based molecular junctions can demonstrate distinct transport efficiencies, i.e. junction-currents, depending on protein orientation, conformation, mutation and especially, the presence of cofactors. Molecular junctions with photoactive membrane proteins and photochromic photoreceptor proteins, which alter their conformation upon light absorption, demonstrate modulation in junction-current with illumination.  Removing or modifying protein cofactors not only shows direct effects on junction currents, but also a transition from tunneling (temperature-independent) to temperature-dependent transport. The high conducting nature of the protein junctions raises questions about the fundamental nature of electron transport across proteins. Finally, I will demonstrate how these biomolecular signatures from molecular electronic transport can be used to map electron transport paths within the protein. Detailed knowledge of nanoscale conduction pathways would enable developing synthetic proteins with higher conductance and different functionalities, which will directly impact the field of bioelectronics.</p>\n<p> </p>\n<p>References:</p>\n<p>[1] Christopher, B.; Mukhopadhyay, S; Cahen, D; Lederman, D., Towards Bioelectronics with Immobilized Proteins: a review of what we (do not) know. Rep. Prog. Phys. (submitted, arXiv article - 1702.05028)</p>\n<p>[2] Mukhopadhyay, S.; Cohen, S. R.; Marchak, D.; Friedman, N.; Pecht, I.; Sheves, M.; Cahen, D. Nanoscale Electron Transport and Photodynamics Enhancement in Lipid-Depleted Bacteriorhodopsin Monomers ACS Nano, 2015, 137, 11226.  </p>\n<p>[3] Mukhopadhyay, S.; Dutta, S.; Pecht, I.; Sheves, M.; Cahen, D. Conjugated Cofactor Enables Efficient Temperature-Independent Electronic Transport Across ∼ 6 nm Long Halorhodopsin. J. Am. Chem. Soc. 2014, 8, 7714.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2145, 'NULL', '2017-03-09 02:04:46', '2030-12-01 18:30:00'),
(418, 'March 23, 2017 at 4.00 pm in AG-80', 'Title :\nConstruct, Deconstruct, Rebuild: Mimicking Nature to Engineer Functional Modules for Bottom-', '<h3>Title</h3>\n<h3>Construct, Deconstruct, Rebuild: Mimicking Nature to Engineer Functional Modules for Bottom-up Synthetic Biology</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>An ambitious goal posed by synthetic biology is the bottom-up construction of a functional cell. Recently, a droplet-based bilayer platform termed ‘droplet interface bilayer’ was developed. Nanoliter-sized lipid-encased water droplets can be arranged in networks of desired patterns, forming electrical connections between them via membrane pores. The droplets can also be encapsulated in a hydrogel matrix opening new directions for bottom-up protocell / prototissue construction. </p>\n<p><span style=\"font-size: 12.16px;\">The key to designing functional protocells is understanding the engineering principles of molecular construction at all biological scales (nanometer, nm – millimeter, mm). To this end, I am studying the structural mechanics of protein assemblies, specifically the nuclear lamina, using atomic force microscopy, cryo-electron tomography and in silico approaches. Besides paving the way to rationally design synthetic systems for bio-nanotechnology, the combined approach provides understanding of the structure-function of the macromolecular assembly involved in diseases from a materials science perspective, the underlying goal of ‘materiomics’.</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 4277, 'NULL', '2017-03-14 04:03:53', '2030-12-01 18:30:00'),
(419, 'March 20, 2017 at 4.00 pm in AG-69', 'Title :\nMembrane-Protein Interaction at the Single Molecule Level\nAbstract :\nUnderstanding the inter', '<h3>Title</h3>\n<h3>Membrane-Protein Interaction at the Single Molecule Level</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Understanding the interaction between membranes and amyloid protein oligomers  is a key unsolved challenge in the field of antimicrobial peptides and amyloid diseases such as Alzheimer’s and Type II diabetes. While the structure of the membrane-bound monomeric subunit is slowly emerging from bulk studies, we need to know how many monomers make up the oligomer, whether this species subsequently grows to specific sizes, whether specific membrane architectures determine binding, and whether interaction with other membrane proteins substantially alter their statistics. Here we approach this problem by the interaction of amylin and amyloid beta with artificial lipid bilayers. We perform single molecule photobleaching experiment with Total Internal Reflection Fluorescence Microscope to probe the stoichiometry. We also employ an atomic force microscope to probe changes in membrane rheology. Our answers may be significant consequences for the underlying toxic mechanism. </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 3393, 'NULL', '2017-03-14 22:07:16', '2030-12-01 18:30:00'),
(420, 'March 27, 2017 at 4.00 pm in AG-69', 'Title :\nMechanistic Origin of Protein Flexibility of Ubiquitin Family Proteins\nAbstract :\nHere we in', '<h3>Title</h3>\n<h3>Mechanistic Origin of Protein Flexibility of Ubiquitin Family Proteins</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Here we investigate the mechanistic origins of protein malleability. We develop a methodology using Single-Molecule Force spectroscopy (SMFS), fluorescence spectroscopy and circular dichroism to probe the native and transition states of Ubiquitin and small ubiquitin-related modifier (SUMO2), to get insights into the protein dynamics and mechanical resistance. Both SUMO2 and Ubiquitin have mechanical clamp which serve as a major resistor to force in SMFS experiments. But we show that the core of the protein actually couples to the clamp and determines its overall malleability. And to top it off we look at the interactions which determine the core flexibility in both the proteins.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2299, 'NULL', '2017-03-21 02:25:44', '2030-12-01 18:30:00'),
(421, 'April 6, 2017 at 11.30 1m in AG-80', 'Title : \nImproving Properties of Platinum Anticancer Drugs\nAbstract :\nThe three FDA approved platin', '<p><strong><span style=\"text-decoration: underline;\">Title</span> : </strong></p>\n<h3>Improving Properties of Platinum Anticancer Drugs</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">The three FDA approved platinum anticancer drugs, cisplatin, carboplatin and oxaliplatin, are widely used in the clinic to treat various forms cancer including testicular, ovarian, cervical, head and neck, non-small-cell lung, and colorectal cancer.[1] Despite their phenomenal clinical success, however, the severe undesired side effects such as nephrotoxicity, myelosuppression, peripheral neuropathy, ototoxicity, and nausea are main drawbacks of platinum-based chemotherapy.[1] The side effectes could be mitigated by introducing tumor-targeting properties into platinum anticancer compounds, thereby reducing the nonspecific platinum accumulation in the healthy tissues. Glucose transporter GLUT1 is known to widely overexpress in many human cancers and its expression levels in tumor biopsy samples correlate well with poor prognosis.[1] We designed various D-glucose-platinum(II) conjugates (Glc-Pts) for targeted delivery of platinum anticancer drugs to cancer cells.[2] To investigate the effect of D-glucose substitution position on the biological activity of Glc-Pts, we synthesized all possible positional isomers (C1α, C1β, C2, C3, C4, and C6) of a Glc-Pt.[3] The biological activities of the compounds were evaluated both in vitro and in vivo. We discovered that varying the position of substitution of D-glucose alters not only the cellular uptake and cytotoxicity profile but also the GLUT1 specificity of resulting glycoconjugates. Results from this study revealed that the C2-substituted Glc-Pt 2 has the highest GLUT1-specific internalization, which also reflects the best cancer-targeting ability. In a syngeneic breast cancer mouse model overexpressing GLUT1, 2 showed excellent antitumor efficacy and selective uptake in tumors with no observable toxicity. [3] The design, synthesis, anticancer activity and in-depth characterization of the cellular uptake mechanism of Glc-Pts will be presented in the research seminar. </p>\n<p style=\"text-align: justify;\">Additionally, some of our recent findings on the modulation of cell death mechanism of platinum complexes by incorporating a second metal fragment, namely a ferrocenyl moiety, will also be discussed briefly. In general, the rationale behind this approach was to merge the fascinating biological properties of ferrocene with the anticancer properties of platinum within one molecule to acquire multi-modal targeting properties. The hybrid heterometallic derivative was found to have a completely different mode of action compare to classical platinum drugs.  </p>\n<p>  </p>\n<p>References.</p>\n<p>1.L. Kelland, Nat. Rev. Cancer, 2007, 7, 573; L. Szablewski, Biophys. Acta. 2013, 1835, 164.</p>\n<p>2.M. Patra, T. C. Johnstone, K. Suntharalingam, S. J. Lippard, Angew. Chem. Int. Ed. 2016, 55, 2550.</p>\n<p>3.M. Patra, S. G. Awuah, S. J. Lippard, J. Am. Chem. Soc., 2016, 138, 12541.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2007, 'NULL', '2017-03-30 02:52:50', '2017-03-31 06:00:16'),
(422, 'April 7, 2017 at 2.30 pm in AG-80', 'Title :\nDiscovery and Development of a New Class of Metal-Based Antibacterial Compound\nAbstract :\nTh', '<h3>Title</h3>\n<h3>Discovery and Development of a New Class of Metal-Based Antibacterial Compound</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">The worrying appearance of microbial resistance to antibiotics is a worldwide problem which needs to be tackled urgently. Microbial resistance to the common classes of antibiotics involving purely organic compounds unfortunately develops very rapidly and in most cases, resistance was detected soon after or even before release of the antibiotic to the market. Therefore, novel concepts for antibiotics must be investigated, and metal-containing compounds hold particular promise in that area. We discovered a tri-hetero-metallic complex that has potent activity against various pathogenic bacterial strains including methicillin-resistant Staphylococcus aureus (MRSA).[1] A systematic structure–activity relationship (SAR) study was carried out in order to improve the properties of the lead compound. The most potent mono-metallic complex derived from this SAR has an antibacterial activity comparable to the well-established organic drugs amoxicillin and norfloxacin and importantly, only moderate cytotoxicity against mammalian cells.[2] Microbiological studies on membrane potential, membrane permeabilization, and cell wall integrity revealed that the compound targets the bacterial membrane and disturbs cell wall integrity. The design, synthesis and biological evaluation of these novel class of metal-based antibacterial drug candidates will be presented in the first half of the research seminar.</p>\n<p style=\"text-align: justify;\">In the second half, I will briefly discuss my future research plans.  </p>\n<p>  </p>\n<p>References.</p>\n<p>1.M. Wenzel§, M. Patra§, C. H. R. Senges, J. J. Stepanek, A. Pinto, P. Prochnow, I. Ott, N. Metzler-Nolte*, J. E. Bandow*, ACS Chem. Biol. 2013, 8, 1442-1450</p>\n<p>        (§ = co-first authors).</p>\n<p>2.M. Patra, M. Wenzel, P. Prochnow, V. Pierroz, G. Gasser, J. E. Bandow* and N. Metzler-Nolte*. Chem. Sci., 2015, 6, 214-224.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2143, 'NULL', '2017-03-30 02:55:35', '2030-12-01 18:30:00'),
(423, 'April 11, 2017 at 2.30 pm in AG-69', 'Title :\nCurvature remodelling of cell membranes: from the biochemistry to the biophysics\nAbstract :', '<h3>Title</h3>\n<h3>Curvature remodelling of cell membranes: from the biochemistry to the <span style=\"font-size: 12.16px;\">biophysics</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\">A biological cell is a complex soft matter system in which many of physical and chemical <span style=\"font-size: 12.16px;\">processes span multiple spatial and temporal scales. The various theoretical and </span><span style=\"font-size: 12.16px;\">computational tools developed in the context of soft matter physics can be utilized to build </span><span style=\"font-size: 12.16px;\">highly quantitative models to investigate these processes, and gain new insights </span><span style=\"font-size: 12.16px;\">specifically in the mesoscale (order of 100 nm). In this talk, I will show how computational </span><span style=\"font-size: 12.16px;\">models at various spatiotemporal scales along with multiscale bridging techniques may </span><span style=\"font-size: 12.16px;\">be used to develop biophysical models that closely relate to the underlying biochemical </span><span style=\"font-size: 12.16px;\">information. I will demonstrate these aspects using two specific problems: (i) estimating </span><span style=\"font-size: 12.16px;\">the excess area in a cell membrane through the extraction of tethers, and (ii) atomistic to </span><span style=\"font-size: 12.16px;\">thermodynamic descriptions of the spontaneous membrane remodeling activity of ENTH </span><span style=\"font-size: 12.16px;\">and Exo70 domain containing proteins.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2078, 'NULL', '2017-03-30 03:08:17', '2030-12-01 18:30:00'),
(424, 'April 12, 2017 at 2.30 pm in B-333 (DBS Seminar Room)', 'Title :\nBiophysics of the specific adhesion of nano-sized particles to cell membranes\nAbstract :\nNa', '<h3>Title</h3>\n<h3>Biophysics of the specific adhesion of nano-sized particles to cell <span style=\"font-size: 12.16px;\">membranes</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\">Nano-sized particles such as a virus or an affinity ligand coated nanocarrier gain entry into a cell <span style=\"font-size: 12.16px;\">by first strongly adhering to the target cell membrane. The adhesion proceeds through </span><span style=\"font-size: 12.16px;\">multivalent interactions of ligands on the particle surface with their corresponding cell surface </span><span style=\"font-size: 12.16px;\">receptors. Such binding processes are ubiquitous in cell biology and their study may help in </span><span style=\"font-size: 12.16px;\">furthering our understanding of cellular adhesion. In this talk, I will present a multiscale </span><span style=\"font-size: 12.16px;\">computational framework that accounts for a variety of chemical and physical phenomena that </span><span style=\"font-size: 12.16px;\">govern the binding efficacy of the particles. I will demonstrate how the enthalpy of binding </span><span style=\"font-size: 12.16px;\">together with the loss in the configurational entropies sets an upper limit on the number of </span><span style=\"font-size: 12.16px;\">simultaneous receptor-ligand bonds. I will also show that the surface topography of the cell </span><span style=\"font-size: 12.16px;\">membrane alters this upper limit, and show comparisons of our model predictions with i<em>n vivo </em></span><span style=\"font-size: 12.16px;\">experimental results for five different organs in mouse.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2171, 'NULL', '2017-03-30 03:11:29', '2030-12-01 18:30:00'),
(425, 'April 3, 2017 at 4.00 pm in AG-69', 'Title :\nOptical Sensors for Metal ion Detection', '<h3>Title</h3>\n<h3>Optical Sensors for Metal ion Detection</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2408, 'NULL', '2017-03-31 02:35:38', '2030-12-01 18:30:00'),
(426, 'April 10, 2017 at 4.00 pm in AG-69', 'Title :\nHybrid Perovskites for Photovoltaic Applications', '<h3>Title</h3>\n<h3>Hybrid Perovskites for Photovoltaic Applications</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2129, 'NULL', '2017-04-05 02:10:13', '2030-12-01 18:30:00'),
(427, 'April 20, 2017 at 2.30 pm in AG-80', 'Title :\nEfficacious strategies for cysteine-mediated protein bioconjugation\nAbstract :\nThe developme', '<h3>Title</h3>\n<h3>Efficacious strategies for cysteine-mediated protein bioconjugation</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">The development of chemoselective organic reactions that proceed rapidly under physiological conditions to form stable covalent linkages have revolutionized modern biological and clinical research. One such reaction, Michael addition between the thiol functional groups of cysteine residues of proteins and maleimides to form thio-maleimide linkages, is extensively used for labeling proteins with fluorophores, affinity tags, polyethylene glycol moieties and drug molecules for a diverse range of applications. In particular, the tremendous success of antibody-drug conjugates (ADCs) generated by appending drug molecules to antibodies by employing this chemistry has had a transformative impact on cancer therapy. Consequently, recent reports on the susceptibility of these linkages to undergo thiol exchange-mediated breakdown in the physiological milieu1, 2 are extremely alarming. In my talk, I shall describe two approaches that my research group has developed3, 4 to overcome this problem. One of these approaches is based on our discovery that unlike conventional maleimides, exocyclic olefinic maleimides form thiol exchange-resistant conjugates and hence are preferable for thiol bioconjugation.3 In another approach, we have rationally designed a photoactivable maleimide derivative that after bioconjugation can be irradiated with UV light to trigger rapid thio-maleimide ring hydrolysis to form stable conjugates.4 I shall also discuss how we plan to use these new scaffolds for generating stable ADCs.</p>\n<p>1) B. Q. Shen et al., Nat. Biotechnol. 2012, 30, 184–189.</p>\n<p>2) R. P. Lyon et al., Nat. Biotechnol. 2014, 32, 1059–1062.</p>\n<p>3) D. Kalia* et al., Angew. Chem. Int. Ed. 2016, 55, 1432–1435.</p>\n<p>4) D. Kalia* et al., Angew. Chem. Int. Ed. 2017, 56, 1885–1889.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2388, 'NULL', '2017-04-11 05:35:21', '2030-12-01 18:30:00'),
(428, 'April 21, 2017 at 2.30 pm in AG-80', 'Title :\nLeveraging organic chemistry for solving biological problems: Bioconjugation and bacterial s', '<p>Title :</p>\n<p>Leveraging organic chemistry for solving biological problems: Bioconjugation and bacterial signaling as case studies</p>\n<p>Abstract :</p>\n<p style=\"text-align: justify;\">The underlying philosophy of my research program is to utilize organic chemistry to address questions in both applied and fundamental biological sciences. In this talk, I shall discuss how I propose to employ organic chemistry for: a) developing technologies for protein bioconjugation, and b) studying c-di-GMP signaling in bacteria. In the first half of my talk which will focus on bioconjugation, I shall describe my proposed approach for bridging disulfide bonds of proteins and using this chemistry for fabricating antibody-drug conjugates, for peptide stapling and as disulfide mimics. Additionally, I shall discuss my proposed strategies for performing cysteine-independent protein bioconjugation that we are currently pursuing in my research group. The second half of my talk will focus on the bacterial second messenger, c-di-GMP, a cyclic dinucleotide that plays a major role in biofilm formation.1 Intriguingly, bacteria contain numerous c-di-GMP synthase enzymes (diguanylate cyclases or DGCs) which when individually deleted, engender distinct phenotypes suggesting they have distinct roles despite each being responsible for generating the same product. To elucidate the roles of individual DGCs and to understand why bacteria express so many DGCs, I propose to develop a chemical genetics-based platform that I shall describe in my talk. Additionally, I shall describe a chemoproteomic approach that I seek to develop for discovering the c-di-GMP interacting proteome of bacterial cells. I believe that the insights on c-di-GMP signaling obtained from these studies will significantly contribute towards developing novel antibacterial therapy directed at targeting this fascinating signaling mechanism.</p>\n<p>1) D. Kalia et al., Chem. Soc. Rev., 2013, 42, 305–341.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2428, 'NULL', '2017-04-11 05:36:55', '2030-12-01 18:30:00'),
(429, 'April 17, 2017 at 4.00 pm in AG-69', 'Title : \nThe N-H...N Hydrogen Bond - Structure and Strength', '<p><strong><span style=\"text-decoration: underline;\">Title</span> : </strong></p>\n<h3>The N-H...N Hydrogen Bond - Structure and Strength</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2413, 'NULL', '2017-04-12 02:15:11', '2030-12-01 18:30:00'),
(430, 'April 24, 2017 at 4.00 pm in AG-69', 'Title :\nCharge Transfer Transitions Associated with Charged Aminoacids: A Classical Electronic Dono', '<h3>Title</h3>\n<h3>Charge Transfer Transitions Associated with Charged Aminoacids: A Classical Electronic <span style=\"font-size: 12.16px;\">Donor-Bridge-Acceptor Paradigm</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2403, 'NULL', '2017-04-19 22:18:08', '2030-12-01 18:30:00'),
(431, 'April 27, 2017 at 2.30 pm in AG-80', 'Title :\nNanostructured Materials for Photo-catalysis', '<h3>Title</h3>\n<h3>Nanostructured Materials for Photo-catalysis</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2318, 'NULL', '2017-04-24 22:57:02', '2030-12-01 18:30:00'),
(432, 'May 1, 2017 at 4.00 pm in AG-69', 'Title :\nAmylin and Amyloid beta: Structure, Membrane Interaction and Cellular Entry Mechanisms\nAbstr', '<h3>Title</h3>\n<h3>Amylin and Amyloid beta: Structure, Membrane Interaction and Cellular Entry Mechanisms</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Amyloid beta (Aβ) oligomer is thought to be the major toxic species for the Alzheimer’s disease. But it is still unknown whether different regions play specific roles in the multi-step toxicity pathway. Here, we have decoupled the functionality of the core region (residues 18-35) vs the N- terminal (1-9) in terms of affinity towards membrane, entry and spatial distribution within neuronal cells. Using temperature dependence of cell entry, we probe the underlying mechanism of cell entry is active or passive. We also probe the role of membrane potential in mediating membrane affinity, by artificially creating a transmembrane potential in small unilammelar vesicles.</p>\n<p style=\"text-align: justify;\">Amylin is another amyloidogenic peptide, which is responsible for type-II diabetes. For amylin too, the smaller oligomeric species is the major toxic species. Here, to understand the relation between structure and function, we have probed the secondary structural changes between the oligomers and fibrils of amylin using Raman and IR spectroscopy. We also perturb the lone di-sulphide linkage in this peptide to understand its role in membrane binding and toxicity. </p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2092, 'NULL', '2017-04-26 04:10:08', '2030-12-01 18:30:00'),
(433, 'May 8, 2017 at 4.00 pm in AG-69', 'Title :\nPhotocatalytic sp3 C-H Activation inside Water-soluble Nanocages', '<h3>Title</h3>\n<h3>Photocatalytic sp3 C-H Activation inside Water-soluble Nanocages</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2215, 'NULL', '2017-05-01 05:12:44', '2030-12-01 18:30:00'),
(434, 'May 9, 2017 at 2.00 pm in AG-69', 'Title :\nNanomaterials for Energy Application', '<h3>Title</h3>\n<h3>Nanomaterials for Energy Application</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2193, 'NULL', '2017-05-03 05:22:35', '2030-12-01 18:30:00'),
(435, 'May 9, 2017 at 3.00 pm in AG-69', 'Title :\nSurface Modified ZnO Nanostructures: Synthesis, Optical Studies and  Applications in Photoc', '<h3>Title</h3>\n<h3>Surface Modified ZnO Nanostructures: Synthesis, Optical Studies and  Applications in Photocatalysis</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2272, 'NULL', '2017-05-03 05:23:42', '2030-12-01 18:30:00'),
(436, 'May 15, 2017 at 4.00 pm in AG-69', 'Title :\nDesigning Ligands for Chelating Redox Active Metal Ions', '<h3>Title</h3>\n<h3>Designing Ligands for Chelating Redox Active Metal Ions</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2144, 'NULL', '2017-05-10 23:32:54', '2030-12-01 18:30:00'),
(437, 'May 22, 2017 at 4.00 pm in AG-69', 'Title :\nDendritic Fibrous Nano-Silica (DFNS) Based Hybrid Materials for Light Harvesting and Energy ', '<h3>Title</h3>\n<h3>Dendritic Fibrous Nano-Silica (DFNS) Based Hybrid Materials for Light Harvesting and Energy Storage</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2093, 'NULL', '2017-05-17 03:50:08', '2030-12-01 18:30:00'),
(438, 'May 29, 2017 at 4.00 pm in AG-69', 'Title :\nElucidating Energy Landscape of β-rich Globular Proteins', '<h3>Title</h3>\n<h3>Elucidating Energy Landscape of β-rich Globular Proteins</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1955, 'NULL', '2017-05-23 02:14:36', '2030-12-01 18:30:00'),
(439, 'May 30, 2017 at 2.30 pm in AG-69', 'Title :\nDesigning Carbon-Metal Oxide Nanostructures for Energy Applications\nAbstract :\nThe ever incr', '<h3>Title</h3>\n<h3>Designing Carbon-Metal Oxide Nanostructures for Energy Applications</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">The ever increasing world energy needs, the severity of environmental pollution issues, limited fossil fuel resources, have triggered extensive research in pursuit of efficient renewable energy sources and sustainable storage technologies. Electrochemical capacitors (ECs) often called supercapacitors (SCs) are promising clean energy storage solutions for high power management and grid applications. In general, the ultimate performance characteristics of SCs primarily depend on the way constituent electrode materials are engineered and how the electrodes are fabricated. The presentation is aimed at exploring three important aspects of the SC, such as i) simple, continuous and energy-efficient method to synthesize high-quality carbon nanomaterials such as hydrophilic carbon nano-onions (CNOs), ii) enhancing performance of such nanocarbon by various nanocomposites and efficient heteroatoms doping techniques, iii) working on different SC configurations (symmetric &amp; asymmetric) to enhance the specific energy and power density of the device and iv) to evaluate the device performance by using industrially recommended best practices and methods to get reliable performance data using fabricated devices which actually mimic the real supercapacitor in market. The carried out PhD research work essentially establishes an inherent relationship among synthesis-structure-property-application of as-synthesized CNOs, its nanocomposites and doped CNOs at the nanoscale.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2600, 'NULL', '2017-05-23 02:17:04', '2030-12-01 18:30:00'),
(440, 'July 3, 2017 at 4.00 pm in AG-69', 'Title :\nTessellation Models for Microstructure Evolution\nAbstract :\nAccurate morphological represent', '<h3>Title</h3>\n<h3>Tessellation Models for Microstructure Evolution</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Accurate morphological representation of polycrystalline microstructures is the key to structure-property linkage. Spatial tessellations exhibit great resemblance with the real microstructure evolution, which are driven by nucleation and growth. Voronoi, Avarami and Laguerre tessellations are the most popular models among the spatial tessellation models, but are only a small subset of the wide spectrum of the real microstructure evolution. Specifically, none of these models capture the anisotropy of grain shapes. The current research work proposes generalized ellipsoidal growth, in which grains grow as ellipsoids with specified 3D orientation and with velocities as a function of their size and initiate at different times from random nucleation sites represented by a spatial point process. This can be represented by a marked point process random field model. The mathematical representation of the grain cells, thus formed, is developed. This could be extended to the non-trivial inverse problem of locating a grain nucleation site from the grain centroid and volume data. This is demonstrated on data generated using diffraction Contrast Tomography (DCT).</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1860, 'NULL', '2017-06-30 00:31:17', '2030-12-01 18:30:00'),
(441, 'July 17, 2017 at 4.00 pm in AG-69', 'Title :\nModulation of emission signaling pathway through allosteric control on the conformational ri', '<h3>Title</h3>\n<h3>Modulation of emission signaling pathway through allosteric control on the conformational rigidity of coumarin-imidazole conjugate</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span>:</strong></p>\n<p style=\"text-align: justify;\">The allosteric regulation in the biological system is controlled at the molecular level by recognition events that are triggered by subtle conformational changes of the proteins.1 Although it is very challenging to mimic such complex communication pathways, one can still be inspired by these systems and design prototype that can give into fundamentals of molecular recognition2 in physiological environments. There seems to be a significant lag in the area of chemically controlled conformational switches that modulate new fluorescence signaling pathway through allostery; bridging this gap may lead to novel molecular systems. The design of such molecular systems represents a promising avenue for finding and manipulating allosteric networks3 in the biology. </p>\n<p style=\"text-align: justify;\"> </p>\n<p style=\"text-align: justify;\">In this presentation, I will discuss about a prototype based on coumarin-imidazole conjugate which undergo conformational changes through distal intramolecular H-bonding interactions.4 The key factor behind this<em> conformational switching is a cooperative effect that involves coumarin side arm, solvents, and leads to a conformational or dynamic changes in the distal coumarin sidearm through intramolecular H-bonds, <strong>affecting its emission output function.</strong></em> So we <strong>hypothesized</strong> that the <em><strong>combination of distal intramolecular H-bond interactions and allostery results in the observed effects on the fluorescence output signaling pathway.</strong> </em>The concept of new emission signaling pathways caused by conformational switching between two states offers a new paradigm to introduce functional allostery in macromolecular backbones. </p>\n<p style=\"text-align: justify;\"> </p>\n<p>References</p>\n<p>1. (a) Monod, J.; Changeux, J.; Jacob, F. J. Mol. Biol. 1963, 6, 306-329. (b) Changeux, J. P. Ann. Rev.</p>\n<p>    Biophys. 2012, 41, 103-133.</p>\n<p>2. (a) Mechanisms of cooperativity and allosteric regulation in proteins; University Press: Cambridge, </p>\n<p>    UK, 1990. (b) Laskowski, R. A.; Luscombe, N. M.; Swindells, M. B.; Thornton, J. M. </p>\n<p>    Protein Sci. 1996, 5, 2438-2452. (c) Faulkner, A.; Leeuwen, T. V.; Feringa, B. L.; Wezenberg, S. J. J.</p>\n<p>   Am. Chem. Soc. 2016, 138, 13597-13603.</p>\n<p>3. Dokholyan, N. V. Chem. Rev. 2016, 116, 6463-6487.</p>\n<p>4. Bhattacharjee, I.; Ghosh, N.; Raina, A.; Dasgupta, J.; Ray, D.- Manuscript under communication</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1678, 'NULL', '2017-07-12 02:55:01', '2017-07-12 02:55:17'),
(442, 'July 31, 2017 at 4.00 pm in AG-69', 'Title :\nIntegrity During Crisis in Colloidal Droplets\nAbstract :\nColloids are ubiquitous and it form', '<h3>Title</h3>\n<h3>Integrity During Crisis in Colloidal Droplets</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Colloids are ubiquitous and it forms an interesting branch of soft matter science owing to the nature of interactions among the constituent phases. Such interactions are amalgamation of various effects, namely, electro-static, van der Waal, excluded volume, etc. As soon as the continuous medium of a colloidal dispersion i.e., the solvent, starts disappearing, as by evaporation, the interaction among the particles gets altered. The extent of modification depends on the competitive dominance of the aforementioned factors. In fact, the phenomenon of evaporation of suspension droplets is widely used in various industries including food and pharmaceutical industries and this process is known as spray drying. Fast evaporating droplets exhibit spectacular behavior due to sudden transition from liquid to powder state associated with assembly of the nanostructures as drive by evaporation. Since last decade, the above mentioned spray drying process has re-embellished itself in nano-science and nano-technology. Using such evaporative technique, we have synthesized various hierarchically structured micro/meso/macro-porous granules. We have demonstrated sphere to doughnut like shape transformation during spray drying and quantified the role of various physicochemical factors responsible for effecting such transformation through buckling. Potential application of such spray dried micro-granules in filtration and bioremediation has also been indicated. Understanding the mesoscopic structure and correlation among the constituent nanostructures in a granule is crucial. In this regard, small-angle neutron scattering (SANS), X-ray scattering (SAXS) and scanning electron microscopy (SEM) have been found effective tools in probing such nano-structured granules. In this presentation, we will discuss some of our recent results on such spray dried micro-granules and will touch upon a few potential applications of such porous granules. </p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1774, 'NULL', '2017-07-19 05:33:01', '2030-12-01 18:30:00'),
(443, 'August 10, 2017 at 4.00 pm in AG-80', 'Title :\nPhysico-chemical Aspects of Synthesis, Characterization of Nanostructured Materials and its ', '<h3>Title</h3>\n<h3>Physico-chemical Aspects of Synthesis, Characterization of Nanostructured Materials and its Biological Applications</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Nanoparticles are promising candidate in interdisciplinary research in the field of physics, chemistry and biology. This talk includes synthesis of different type of nanomaterials (core and core shell quantum dots, silver nanoparticle, graphene, nanowire) and nano-bio conjugate with some interesting features and also thermodynamics involved in the formation of nanohybrids. Synthesis in aqueous route is preferred in order to allow the nanoparticles well-suited for biological applications. However, organic synthesis leads to better quality nanoparticles. Surface functionalization of organic nanoparticles with different organic ligands and biomolecules is another way to make them water soluble as well as biocompatible. Next, interaction of some important biological molecules, e.g. enzyme, peptide, vitamin etc. with the as synthesized quantum dot nanoparticles will be described, and a simple strategy for sensing those biomolecules have been proposed based on the fluorescence based interaction between quantum dot nanoparticles and biomolecules. Further designing quantum dot nanoparticle based multichannel biosensor will be discussed for sensing human serum proteins. Next, enhancing enzyme activity through incorporating nanoparticles into enzyme, i.e. designing nanozyme will be discussed.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 3484, 'NULL', '2017-07-19 22:59:24', '2030-12-01 18:30:00'),
(444, 'July 24, 2017 at 4.00 pm in AG-69', 'Title :\nDesigning Azurin Mutants Polygene to get Deeper Insights into Mechanical Properties of Azuri', '<h3>Title</h3>\n<h3>Designing Azurin Mutants Polygene to get Deeper Insights into Mechanical Properties of Azurin</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1725, 'NULL', '2017-07-20 01:33:33', '2017-07-20 01:33:55'),
(445, 'August 2, 2017 at 11.30 a.m.in AG-80', 'Title : \nConformational selection in a protein-protein interaction\nAbstract :\nMolecular recognition', '<p><strong><span style=\"text-decoration: underline;\">Title</span> :</strong> </p>\n<h3>Conformational selection in a protein-protein interaction</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Molecular recognition plays a central role in biology and protein dynamics has been acknowledged to be important in this process. However, it has been intensely debated for the last 50 years whether conformational changes happen before ligand binding to produce a binding-competent state (conformational selection) or are caused in response to ligand binding (induced fit) [1]. Proposals for both mechanisms in protein-protein interaction have been primarily based on structural arguments. However, the distinction between them is a question of the probabilities of going via these two opposing pathways. In this seminar I will discuss a direct demonstration of exclusive conformational selection in protein-protein recognition by measuring the flux for rhodopsin kinase binding to its regulator recoverin, an important molecular recognition in the vision system [2]. The combined use of nuclear magnetic resonance (NMR) spectroscopy, stopped-flow kinetics and isothermal calorimetry establishes that protein dynamics in free recoverin limits the overall rate of binding.  </p>\n<p> </p>\n<p>Reference:</p>\n<p> </p>\n<p>1. Changeux &amp; Edelstein (2011) F1000 Biol. Rep. 3 19.</p>\n<p>2. Chakrabarti et al. (2016) Cell Rep. 14 32-42.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2211, 'NULL', '2017-07-20 05:54:33', '2030-12-01 18:30:00'),
(446, 'August 3, 2017 at 4.00 pm in AG-80', 'Title :\nThe role of conformational dynamics in molecular recognition\nAbstract :\nConformational dynam', '<h3>Title</h3>\n<h3>The role of conformational dynamics in molecular recognition</h3>\n<p><strong>Abstract :</strong></p>\n<p>Conformational dynamics plays a fundamental role in molecular recognition and activity in proteins. Ubiquitin and ubiquitin-like proteins are involved in nearly all aspects of cellular function. Nuclear magnetic resonance (NMR) spectroscopy and Molecular dynamics simulations were used to show that conformational selection underlies the allosteric interaction between ubiquitin conjugating enzyme (E2) and ubiquitin ligase (E3) [1]. The E2, Ube2g2 functions with the canonical E3, gp78 to assemble poly-ubiquitin chains on target substrates. Two domains of the gp78, RING and G2BR, bind to two distinct regions of Ube2g2, and activate it for ubiquitin (Ub) transfer. The conformational dynamics in Ube2g2 reveals a clear correlation of binding G2BR and RING with sequential progression towards Ub transfer. The interrelationship of the existence and exchange between ground and excited states leads to a dynamic energy landscape model, in which the redistribution of populations contributes to allostery and activation [1]. Briefly, our current results about conformational selection of Ubiquitin will be discussed. Subsequently, I will discuss systems where the functional implications of conformational selection mechanism will be explored. The divergent evolution of proteins has been hypothesized to rely on the conformational selection mechanism [2]. The Small Ubiquitin-like Modifier (SUMO) protein can be investigated as a model system to test the hypothesis that conformational selection is a relic of evolution in ubiquitin-like protein family [2]. The conformational selection in a transporter protein partitioning between aqueous and lipid phases remains unexplored. I will discuss the selection of different conformations of the Synaptotagmin-like mitochondrial-lipid binding proteins (SMP) domain of the transporter protein Extended synaptotagmin (Esyt) [3] based on the physico-chemical properties (e.g., hydrophobicity) by different phases (aqueous, lipid) existing within the neuron, which is involved in transfer of lipid molecules from endoplasmic reticulum to plasma membrane in the axons [4]. The mechanism of Esyt has importance in understanding the axon degeneration in genetic diseases hereditary spastic paraplegia (HSP) [5] and amyotrophic lateral sclerosis (ALS) [6].</p>\n<p> </p>\n<p>Reference:</p>\n<p> </p>\n<p>1.Chakrabarti et al. (2017) Structure 25 794-805.</p>\n<p>2.Khersonsky &amp; Tawfik (2010) Annu Rev Biochem. 79 471-505.</p>\n<p>3.Schauder et al. (2014) Nature 510 552-555.</p>\n<p>4.Min et al. (2007) PNAS (USA) 104 3823-3828.</p>\n<p>5.Blackstone (2012) Annu Rev Neurosci. 35 25-47.</p>\n<p>6.Teuling et al. (2007) J. Neurosci. 27 9801-9815.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1857, 'NULL', '2017-07-20 05:56:18', '2030-12-01 18:30:00'),
(447, 'August 28, 2017 at 4.00 pm in AG-69', 'Title :\nDipole Organization and Membrane Biophysics: A Tale of Two Studies\nAbstract :\nBiological me', '<h3>Title</h3>\n<h3>Dipole Organization and Membrane Biophysics: <span style=\"font-size: 12.16px;\">A Tale of Two Studies</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p>Biological membranes are complex assemblies of lipids and proteins that allow cellular compartmentalization and act as an interface, through which cells communicate with each other and with the external milieu.  In physical terms, membranes can be treated as a complex oriented fluid which is a weakly coupled, non-covalent, and anisotropic assembly of molecules in two-dimensions, and can therefore be treated as soft matter.  </p>\n<p><span style=\"font-size: 12.16px;\">In this lecture, I will focus on the application of red edge excitation shift (REES) and membrane dipole potential to explore organization and dynamics of membrane lipids and proteins. Both these phenomena are dependent on organization of membrane dipoles.</span></p>\n<p><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">References</span>:</span></p>\n<p><span style=\"font-size: 12.16px;\">1.</span><span style=\"font-size: 12.16px;\">Haldar, S., Chaudhuri, A., and Chattopadhyay, A. (2011) J. Phys. Chem. B 115: 5693-5706 (Feature Article).</span></p>\n<p>2.Chattopadhyay, A., and Haldar, S. (2014) “Dynamic Insight into Protein Structure utilizing Red Edge Excitation Shift” Acc. Chem. Res. 47: 12-19.</p>\n<p>3.   Haldar, S., Kanaparthi, R.K., Samanta, A., and Chattopadhyay, A. (2012) Biophys. J. 102: 1561-1569. </p>\n<p>4.Lajevardipour, A., Chon, J.W.M., Chattopadhyay, A., and Clayton, A.H.A. (2016) Sci. Rep. 6: 37038. </p>\n<p> </p>\n<p>5.Sarkar, P., Chakraborty, H., and Chattopadhyay, A. (2017) Sci. Rep. 7: 4484.   </p>\n<p> </p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1766, 'NULL', '2017-08-02 05:42:07', '2030-12-01 18:30:00'),
(448, 'September 11, 2017 at 4.00 pm in AG-69', 'Title :\nBio-nanoconjugation of Mutant Cytochrome P450cam (CYP101) for electro-biocatalysis', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.0pt; font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-bidi-font-weight: bold;\" lang=\"EN-US\">Bio-nanoconjugation of Mutant Cytochrom<strong>e </strong>P450cam (CYP101) for electro<strong>-</strong>biocatalysis</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1888, 'NULL', '2017-09-06 23:47:50', '2030-12-01 18:30:00'),
(449, 'September 14, 2017 at 2.30 pm in AG-80', 'Title :\nApplication of Iminoboronate in Chemistry and Biology\nAbstract :\nIn past decades, dynamic co', '<h3>Title</h3>\n<h3>Application of Iminoboronate in Chemistry and Biology</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>In past decades, dynamic covalent chemistry has shown its great potential in the area of combinatorial chemistry and molecular recognition. Nonetheless, in this area, a few reactions have been explored that can allow selective recognition of endogenous nucleophile in reversible manner at physiological pH. Iminoboronate chemistry is one of them, which allow to capture amine at neutral pH. Here, I will present, how the fundamental understanding of iminoboronate complex formation was leveraged for numerous biological applications. Iminoboronate chemistry was known, however, it was poorly understood. For the first time, my work has revealed the dynamic nature of iminoboronate formation at physiological conditions.</p>\n<p> </p>\n<p>In this talk, I will focus first on the dynamic covalent recognition of biologically important molecules via iminoboronate chemistry. Using this unique chemistry, I developed strategies for the specific recognition of gram-positive bacteria in blood serum [1]. Importantly, this approach has the potential to transform the way bacterial infection diagnostics are performed in clinical setting. Harnessing the power of this iminoboronate formation, I also developed a new and efficient synthetic access for modular cyclic peptides [2] along with an unprecedented bioorthogonal reaction [3]. For instance, the impact of these findings were illustrated by a new bioorthogonal labeling technology to detect gramnegative bacteria selectively. To take the kinetic advantage of iminoboronate formation, a strategy of fast and selective conjugation of N-terminal cysteine containing protein will be demonstrated [4].</p>\n<p> </p>\n<p>1.Targeting Bacteria via Iminoboronate Chemistry of Amine-Presenting Lipids. Bandyopadhyay, A., MaCarthy, K., Kelly, M., Gao, J. Nat. Commun., 2015, 6:6561.</p>\n<p>2.Iminoboronate-based peptide cyclization that responds to pH, oxidation, and small molecule modulators. Bandyopadhyay, A., Gao, J.; J. Am. Chem. Soc., 2016, 138, 2098.</p>\n<p>3.Fast Diazaborine Formation of Semicarbazide Enables Facile Labeling of Bacterial Pathogens. Bandyopadhyay, A., Cambray, S., Gao, J.; J. Am. Chem. Soc., 2017, 139, 871.</p>\n<p>4.Fast and selective labeling of N-terminal cysteines at neutral pH via thiazolidino boronate formation. Bandyopadhyay, A., Cambray, S., Gao, J. Chem. Sci., 2016, 7, 4589.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2057, 'NULL', '2017-09-06 23:52:26', '2030-12-01 18:30:00');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(450, 'September 15, 2017 at 2.30 pm in AG-80', 'Title :\nNonribosomal Polyamides Binder Discovery of Ebola Glycoprotein\nand\nDevelopment of a Platform', '<h3>Title</h3>\n<h3>Nonribosomal Polyamides Binder Discovery of Ebola Glycoprotein</h3>\n<h3 style=\"text-align: justify;\">and</h3>\n<h3>Development of a Platform for Peptidomimetic Covalent Binder Discovery</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Specific recognition of biomolecules in the complex biological milieu inspires principally every aspect of biology and has been a long-standing goal of biological and medicinal chemists. On that front, nonribosomal amino acids and peptidomimetics have revealed great potential through the discovery of potent inhibitors. Designing novel molecular scaffolds that allow specific biomolecule recognition requires broad expertise and understanding in the area of organic synthesis, chemical biology, molecular design, and high-throughput screening technology. Since 2008, I have focused my efforts on discovering novel chemical entities containing amino acids that enable the recognition of biomolecules of interest. Here, I present strategies of molecular recognition via noncovalent and covalent interactions.</p>\n<p> </p>\n<p>In the second day presentation, I will describe noncovalent recognition in finding a binder of Ebola glycoprotein utilizing high-throughput screening of large peptide libraries. I prepared large <span style=\"font-size: 12.16px;\">combinatorial libraries comprising millions of peptides featuring nonribosomal amino acids and discovered the first peptide based binder of Ebola glycoprotein.</span></p>\n<p> </p>\n<p>In the future, I aim at developing an innovative approach for the discovery of peptidomimetic therapeutics and diagnostics for the treatment of neglected tropical diseases. My long term vision is to develop dengue inhibitors by specifically targeting dengue envelope protein. I believe, the discovery of such chemical entities will have a tremendous beneficial impact on Indian society and tropical countries in general.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1777, 'NULL', '2017-09-06 23:54:58', '2017-09-06 23:56:04'),
(451, 'September 18, 2017 at 4.00 pm in AG-69', 'Title :\nCoordination Chemistry of Cyclic Peptides: Possible Biological Functions of the Patellamides', '<h3>Title</h3>\n<h3>Coordination Chemistry of Cyclic Peptides: Possible Biological Functions of the Patellamides </h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Cyclic pseudo-peptides, derived from marine metabolites of the genus <em>Lissoclinum bistratum</em> and <em>Lissoclinum patella</em> have attracted scientific interest in the last two decades. Their structural properties and solution dynamics were analyzed in detail, elaborate synthetic procedures for the natural products and synthetic derivatives were developed, the biosynthetic pathways were studied and it now is possible to produce them biosynthetically. A major focus in the last decade was on their Cu<sup>II</sup> – more recently also on the Zn<sup>II</sup> – coordination chemistry, as a number of studies have indicated that di-nuclear Cu<sup>II</sup> and Zn<sup>II</sup> complexes of cyclic peptides may be involved in the ascidians’ metabolism. Recent in vitro studies indicate that the dicopper(II) complexes have phosphatase, carbonic anhydrase, lactamase and glycosidase activity. Intererstingly, first <em>in vivo</em> studies with a patellamide derivative with an appended fluorescence molecule indicate that Cu<sup>II</sup> is coordinated to the patellamides in the prochloron cells.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2023, 'NULL', '2017-09-13 04:47:02', '2030-12-01 18:30:00'),
(452, 'September 25, 2017 at 4.00 pm in AG-69', 'Title :\nA tale of two proteins: What folding dynamics can tell us about the function of structurally', '<h3>Title</h3>\n<h3>A tale of two proteins: What folding dynamics can tell us about the function of structurally similar proteins </h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Protein sequences have been optimized by evolution to facilitate fast folding (folding on a biologically relevant timescale). This implies that residues selected for folding are less likely to participate in non-native stabilizing interactions. Such interactions need to be broken before native interactions are formed and this breaking and forming slows folding. Functional residues, on the other hand, have been selected for function, may not be optimal for folding, may facilitate the formation of non-native traps and slow folding. My group has been working on understanding the effect of such non-optimal functional residues on folding energy landscapes using computational models.</p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In this talk, I will present results on the folding of two structurally similar but functionally distinct proteins: monellin (a sweet protein) and stefin-B (a cysteine protease inhibitor). Despite having similar structures, we find that their sequences and in turn, the energetics of the two proteins are tuned to facilitate their differing functions and these energetic differences lead to entirely different folding characteristics. Understanding these differences computationally has led to diverse predictions which could drive the design of intrinsically disordered proteins that fold upon binding as well as protein assembly. I will also outline some experiments that support these results.</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1688, 'NULL', '2017-09-19 02:11:17', '2030-12-01 18:30:00'),
(453, 'September 26, 2017 at 2.30 pm in AG-66', 'Title :\nMolecular Simulation of Long Time Structural Evolution in Nanomaterials\nAbstract :\nMaterials', '<h3>Title</h3>\n<h3>Molecular Simulation of Long Time Structural Evolution in Nanomaterials</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Materials used in energy applications, often undergo structural transformation that are crucial to the operation of the device. We have looked at three different materials to understand various aspects of their structural evolution at long time scale. These materials include i) Si used as an anode in lithium ion battery, ii) nanoporous metal alloys used as catalysts and iii) metal nanoparticles which is again used in catalysis. During lithiation/delithiation process, an amorphous lithiated phase is formed which is separated from the pure Si phase with a sharp phase boundary. The entire lithiation/delithiation process majorly depends on the migration of this phase boundary. When any lithiation occurs, due to presence of Li atoms in the system, we observe certain amount strain evolved. We have studied the effect of strain on the lithium diffusion barrier in bulk Si using nudged-elastic band (NEB) method applying modified embedded atom method (MEAM)  as interatomic potential. Nanoporous material is usually obtained by dealloying method where electrochemically active species undergoes dissolution process whereas electrochemically noble material agglomerates and forms new cluster of islands resulting in formation of several ligaments and nodes. To understand the structural morphology of these nanoporous materials, we need a characterization tool which can quantify them correctly. So we have developed a characterization technique to calculate the size (length/diameter/area) distribution of nanoporous ligaments and facets using of connectivity lists for sites. Understanding the behavior of different response surface like extent of dissolution, surface area of various facet planes with perturbation of different operating conditions like temperature, binding energy, composition or dissolution pre-factor is also important because this will help to provide an insight about the morphological evolution of different nanoporous structure and importance of parameters in dealloying process. A response surface model analysis for different dealloying times varying with different important controllable parameters is performed to understand the insight how different responses change with a small perturbation in any of the controllable parameters. Both of these systems are very complicated. Understanding the detailed kinetics of these systems is not straight forward. Novel simulation techniques are required which can systematically determine the relevant pathways required to understand the kinetic mechanism of the complete system. We have developed a MD based KMC simulation technique to determine the relevant pathways systematically. We have applied our framework on an Ag cluster system to understand the detail mechanism of relevant pathways.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1972, 'NULL', '2017-09-19 04:12:29', '2030-12-01 18:30:00'),
(454, 'October 12, 2017 at 2.30 pm in AG-80', 'Title :\nDevelopment of Heterojunction Based Photocatalysts for Hydrogen Evolution Reaction and Dye D', '<h3>Title</h3>\n<h3>Development of Heterojunction Based Photocatalysts for Hydrogen Evolution Reaction and Dye Degradation Applications</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Due to the increasing industrialization and population growth, energy crises and environmental pollution have become major challenging problems to the human society in the 21<sup>st</sup> century. Photocatalysis gain immense interest in the field of green energy as a photoconversion technology of converting solar fuel to chemical fuel. The rapid recombination of photogenerated charge carriers, poor light absorption and lack of satisfactory visible light active materials are the major hurdles for single component system to achieve descent photocatalytic activity under solar light. </p>\n<p style=\"text-align: justify;\"> </p>\n<p style=\"text-align: justify;\">This presentation will address our investigations of how the heterojunction based photocatalysts (metal/semiconductor-semiconductor) has constructive effect on the photocatalytic activity and overcomes drawbacks of single component photocatalysts. The main part of the work is to enhance the separation and transfer efficiency of photogenarated charge carriers and improve visible light absorption. In order to do this we have synthesized different heterojunction based photocatalysts Pd-SrIn<sub>2</sub>O<sub>4</sub>-TiO<sub>2</sub>, Pd-CdS@CdO-TiO<sub>2</sub>, In<sub>2</sub>S<sub>3</sub>-gC<sub>3</sub>N<sub>4</sub> and ZnCo<sub>2</sub>O<sub>4</sub> marigold flowers and investigated their photocatalytic activity for hydrogen evolution reaction and dye degradation applications. We found that heterojunction based photocatalysts exhibit the enhanced photocatalytic activity as compared to its individual parts. This enhancement may be due  to  the  combined  effect  of  increased visible light absorption, separation and transfer efficiency of photogenerated charge carriers, effective surface area and  co-catalytic  effect  of  Pd  NPs  through  the  formation  of   Schottky  junction. The structural, morphological and optical properties were studied using XRD, RAMAN, XPS, SEM, TEM and UV-Vis spectroscopy. Time resolved PL spectroscopy, photocurrent and electrochemical measurements were used to study the photoinduced charge-transfer in the composite samples. The band potentials were calculated from Mott-Schottky plot and UV-Vis spectroscopy. Based on the band potentials, probable charge transfer schemes in binary and ternary heterojunction photocatalysts were also proposed. The photocatalytic activity of these heterojunction photocatalysts were also investigated for dye degradation application. To investigate the degradation reaction mechanism in depth, the active species formed during the reaction process and pH dependence were studied.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1835, 'NULL', '2017-10-06 00:17:08', '2017-10-06 00:17:17'),
(455, 'October 16, 2017 at 4.00 pm in AG-69', 'Title :\nStructural Aspects of Ferritin Protein Cage for Designing Inorganic Biomaterials\nAbstract :', '<h3>Title</h3>\n<h3>Structural Aspects of Ferritin Protein Cage for Designing <span style=\"font-size: 12.16px;\">Inorganic Biomaterials</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p>Ferritin is a self-assembled 24-mer spherical cage shaped iron storage protein which has an internal cavity of diameter 8 nm. The internal cage is connected with several symmetric pores and interestingly, small metal complexes and organic molecules can easily pass through these pores. The cage is very stable up to 80ºC but disassembles beyond the pH range of 2-11 which can reassemble again at neutral pH. This interesting feature is useful for incorporating larger molecules into the cage. Although the disassembly-reassembly mechanism of ferritin cage has been studied using various spectroscopic and analytical methods, it remains challenging to have a direct structural insight into this mechanism. We used high-speed AFM to observe the phenomena at single molecule level in real-time scale. Due to unique structural features, the ferritin cage is widely utilized for preparing uniform metal nanoparticles which have important catalytic and biomedical applications. For example, magnetic iron oxide nanoparticles grown inside ferritin cage can promote catalytic reactions in the cell and can target and visualize cancer cells. Despite many promising applications, it remains challenging to explore the basic structural features of protein-nanoparticle interactions. In this context, we promoted the chemical reduction of gold ions within a crystalline ferritin cage and analyzed the X-ray crystal structures at various steps. This gives a direct visualization on the formation of gold nanocluster in protein environment and is considered to be an intermediate stage of nanoparticle growth. In another aspect, multiple metal complexes were incorporated simultaneously into the ferritin cage to construct protein-based microcompartment similar to bacterial microcompartment where several enzymes work together for metabolic functions. We studied the X-ray crystal structures and performed the catalytic cascade reactions in confined ferritin environment as a proof of concept. </p>\n<p> </p>\n<p>This presentation includes various structural aspects of metal immobilized ferritin protein cage with X-ray crystal structure analysis and their applications in catalysis as well as understanding the growth of metal nanoparticles in protein environment.   </p>\n<p>  </p>\n<p>References: </p>\n<p> </p>\n<p>(1) G. Jutz, P. van Rijn, B. S. Miranda, A. Böker. Chem. Rev., 2015, 115, 1653-1701. (2) E. C. Theil, T. Tosha, R. K. Behera, Acc. Chem. Res., 2016, 49, 784-791. (3) B. Maity, K. Fujita, T. Ueno. Curr. Opin. Chem. Biol. 2015, 25, 88-97. (4) B. Maity, K. Fukumori, S. Abe, T. Ueno. Chem. Commun. 2016, 52, 5463-5466. (5) B. Maity, S. Abe, T. Ueno.  Nat. Commun, 2017, 8, 14820. (6) S. Abe, B. Maity, T. Ueno. Chem. Commun. 2016, 52, 6496-6512. </p>\n<p> </p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2201, 'NULL', '2017-10-09 00:37:07', '2030-12-01 18:30:00'),
(456, 'October 27, 2017 at 10.00 am in AG-66', 'Title :\nControl of Actin Assembly by Polyphosphoinositides\nAbstract :\nPolyphosphoinositides (PPIs) s', '<h3>Title</h3>\n<h3>Control of Actin Assembly by Polyphosphoinositides</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-family: \'Times New Roman\', serif;\"><span style=\"font-size: 16px;\">Polyphosphoinositides (PPIs) such as phosphatidylinositol (4,5) bisphosphate (PIP2), are phospholipids that control many cellular events and bind to dozens of intracellular proteins, including many regulators of the actin-based cytoskeleton.  How phosphoinositides affect their ligands is much less understood than are the mutations that produce abnormal PPI production, but defining how these lipids exert their biological control at the membrane-cytoskeletal interface could lead to new approaches to limiting or reversing the abnormal function of these lipids in disease. The large number of proteins characterized as ligands for PPIs, usually PI(4,5)P<sub>2</sub>, suggests that specificity within the cell might be attained by changing the physical state of the lipid within the membrane, in addition to its local or global concentration. Recent experiments show that cholesterol-induced redistribution of PIP2 in the lipid bilayer strongly alters its ability to inhibit the actin severing protein gelsolin at constant total PIP2 concentrations and that nucleation of actin polymerization in brain extracts occurs preferentially from liquid disordered membrane domains and from 80 nm PIP2 clusters that form in the presence of µM Ca<sup>2+</sup>. These results suggest that PPI lateral distribution within cell membranes is structured by cholesterol and divalent or multivalent counterions and affects PPI interactions with the myriad of proteins they appear to regulate in vivo.  Therefore reagents that bind PIP2 and alter its distribution the cell can have important effects on cell function and potentially practical applications.</span></span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1911, 'NULL', '2017-10-20 00:36:15', '2030-12-01 18:30:00'),
(457, 'October 30, 2017 at 4.00 pm in AG-69', 'Title :\nInsights into the mechanical properties of polymers by probing their functional group, and s', '<h3>Title</h3>\n<h3>Insights into the mechanical properties of polymers by probing their functional group, and segmental motions using solid-state NMR</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Predicting mechanical properties like ductility of polymers is, in general, a very difficult problem. However, it is well known that ductility of a single component amorphous glassy polymer is related to the inter- and intra-molecular cooperative segmental motions that occur in the glassy state. These, in turn, are related to the motions of functional groups in the repeat unit of the polymer. In the case of semi-crystalline polymers, the morphology, in addition is also very crucial to the mechanical property of the polymer.</p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In this talk the results from a study of functional group, and segmental motions in amorphous and semi crystalline polymers using solid-state nuclear magnetic resonance (SSNMR) will be presented. The separated local field NMR has been used to probe the functional group motion. The Center Band only Detection of Exchange (CODEX) experiments have been used to probe the slow segmental motions. We have carried out studies on polycarbonates and polysulfones which are  purely amorphous. Results from the studies carried out on polyoxymethyline, a semi-crystalline polymer will be presented. In this study we have shown that the mechanical property is closely linked to the morphology of this polymer.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1771, 'NULL', '2017-10-22 23:39:22', '2030-12-01 18:30:00'),
(458, 'November 16, 2017 at 2.30 pm in AG-80', 'Title :\nFunctional Supramolecular Polymers of Extended π-Systems\nAbstract :\nSupramolecular polymer', '<h3>Title</h3>\n<h3>Functional Supramolecular Polymers of Extended <span style=\"font-size: 12.16px;\">π-Systems</span></h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Supramolecular polymers derived from novel π-conjugated molecules are promising candidates for modern electronic and photonic devices owing to their high internal order and strong exciton coupling<sup>1</sup>. Moreover, they are easy to process, dynamic, reversible and recyclable which are not observed in many of the covalent polymers. However, most of the supramolecular polymers are reported to have low mobility of charge carriers and often depolymerize into monomers at high temperatures<sup>2</sup>. In my talk, I will discuss about some of our strategies to improve the charge carrier mobility and thermal stability of supramolecular polymers of various extended π-systems<sup>3–5</sup>.</p>\n<p><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">References</span>:</span></p>\n<p><span style=\"font-size: 12.16px;\">1. Aida et al. Science 2012, 335, 813.</span></p>\n<p>2. Meijer et al. Chem. Rev. 2009, 109, 5687.</p>\n<p>3. K. V. Rao et al. Angew. Chem. Int. Ed. 2010, 49, 4218.</p>\n<p>4. A. Sagade et al. Adv. Mater. 2013, 25, 559.</p>\n<p>5. K. V. Rao et al. Nature Chem. 2017, in press (DOI: 10.1038/NCHEM.2812).</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2846, 'NULL', '2017-10-29 21:05:33', '2017-10-29 21:08:15'),
(459, 'November 17, 2017 at 2.30 pm in AG-66', 'Title :\nFunctional Supramolecular and Polymeric Materials of Extended π-Systems\nAbstract :\nHierarch', '<h3>Title</h3>\n<h3>Functional Supramolecular and Polymeric Materials of Extended π-Systems</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Hierarchical organization of supramolecular assemblies of π-conjugated molecules plays an important role to device the synthetic systems for efficient lightharvesting<sup>1,2</sup>. Though supramolecular assemblies of various π-systems are elegantly designed to fine-tune their optical properties, there are several limitations2. Hence, the development of new class of materials is not only important to overcome the existing limitations but also to provide opportunities to uncover their novel properties. In this talk I will discuss about the design, synthesis, optical properties and other novel attributes of two kinds of materials we have developed, namely, organicinorganic soft-hybrids and dynamic conjugated microporous polymers<sup>3–6</sup>.</p>\n<p> </p>\n<p>References:</p>\n<p><span style=\"font-size: 12.16px;\">1. Schenning et al. Chem. Rev. 2005, 105, 1491.</span></p>\n<p>2. Ajayaghosh et al. Chem. Soc. Rev. 2008, 37, 109.</p>\n<p>3. K. V. Rao et al. Angew. Chem. Int. Ed. 2011, 50, 1179.</p>\n<p>4. K. V. Rao et al. Adv. Mater. 2013, 25, 1713.</p>\n<p>5. K. V. Rao et al. Chem. Eur. J. 2012, 18, 4505.</p>\n<p>6. K. V. Rao et al. Phys. Chem. Chem. Phys. 2016, 18, 156.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1800, 'NULL', '2017-10-29 21:07:44', '2017-11-16 00:07:40'),
(460, 'November 8, 2017 at 2.30 pm in AG-80', 'Title :\nChemical Detoxification of Neurotoxic Methylmercury by Smart Molecules\nAbstract :\nMethylmerc', '<h3>Title</h3>\n<h3>Chemical Detoxification of Neurotoxic Methylmercury by Smart Molecules</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Methylmercury (MeHg<sup>+</sup>) is considered to be the most toxic form of mercury due to its ability to accumulate in fat tissues leading to its bio-magnification within the food chain. The toxicological implications associated with the ingestion of MeHg<sup>+</sup> may also differ according to its chemical form.<sup>1</sup> All seafood, mainly fish, contains mercury, primarily in the form of methylmercury. Consumption of mercury contaminated fish on a regular basis therefore could cause adverse neurodevelopmental, cardiovascular, and immunological health effects. High levels of mercury in fish stocks have been found in mining (Singrauli region in MP and Sonbhadra district in UP), and coastal areas, particularly Ulhas River Estuary and Thane Creek areas, Mumbai (mercury levels in fish from these contaminated areas: 0.89-1.78 mg total Hg/kg dry weight (dw); crabs had 1.42-4.94 mg total Hg/kg dw mercury compared to the permissible limit of 0.5 mg/kg).<sup>2 </sup></p>\n<p> </p>\n<p>In nature, however, several microorganisms have been reported as being MeHg<sup>+</sup> tolerant due to their ability to convert highly toxic MeHg<sup>+</sup> to either less toxic volatile elemental mercury, Hg<sup>0</sup> or biologically inert insoluble HgS (metacinnabar). For instance, bacterial organomercurial lyase (MerB) catalyzes the protolytic cleavage of the otherwise inert Hg-C bond of MeHg<sup>+</sup> and produces methane (CH<sub>4</sub>) gas and ionic mercury Hg<sup>2+</sup>, while a second enzyme mercuric ion reductase (MerA) reduces the product Hg<sup>2+</sup> to volatile Hg<sup>0</sup>. On the other hand, several sulfate reducing bacteria (SRB) convert highly toxic MeHg<sup>+</sup> to less toxic insoluble HgS(s) by producing H2S during metabolism.<sup>3</sup> In addition, insoluble mercury selenide (HgSe) particles have also been found in a wide range of tissues of marine mammals (whales and dolphins) and also detected in various organs (kidney, liver, muscle, and brain) of humans exposed to MeHg<sup>+</sup>. HgSe is considered to be much less toxic than mobile, soluble MeHg<sup>+</sup> species including MeHgCys and MeHgSG. In this talk I will mainly focus on how small organic molecules can be used intelligently to detoxify highly neurotoxic methylmercury by two distinct pathways, similar to those observed in nature.<sup>4-8</sup></p>\n<p> </p>\n<p>References:</p>\n<p> </p>\n<ol>\n<li><span style=\"font-size: 12.16px;\">Harris, H. H. et al. Science 2003, 301, 1203; Stern, A. H. et al. Science 2004, 303, 763–766; Korbas, M. et al. ACS Chem. Biol. 2012, 7, 411–420.</span></li>\n<li><span style=\"font-size: 12.16px;\">Menon, J. S. Indian J. Mar. Sci. 2013, 42, 812; Report of Centre for Science and Environment (CSE), 2012; Deshpande. A et al. Environ Monit assess 2009, 159, 493.</span></li>\n<li><span style=\"font-size: 12.16px;\">Baldi, F et al. Appl. Environ. Microbiol. 1993, 59, 2479; Clarkson, T. W. et al. Crit. Rev. Toxicol. 2006, 36, 609; Benison, G. C. et al. Biochemistry 2004, 43, 8333; Hong, B. et al. Biochemistry 2010, 49, 8187; Omichinski, J. G. et al. J. Biol. Chem. 2009, 284, 938;</span></li>\n<li><span style=\"font-size: 12.16px;\">Roy, G. et al. Angew. Chem., 2015, 127, 9455; Angew. Chem. Int. Ed., 2015, 54, 9323. This work is highlighted in Cover Page; Angew. Chem., 2015, 127, 9551; Angew. Chem. Int. Ed., 2015, 54, 9419.</span></li>\n<li><span style=\"font-size: 12.16px;\">Roy, G. et al. Chem. Eur. J, 2017, 23 (24), 5696. This article is highlighted in \"Frontispiece\" and considered as \"Hot Paper\"</span></li>\n<li><span style=\"font-size: 12.16px;\">International Patent filed (PCT): WO2017168451. </span></li>\n<li><span style=\"font-size: 12.16px;\">Roy, G. et al. Inorg. Chem. 2017, xx, xxxx (DOI: 10.1021/acs.inorgchem.7b01301). </span></li>\n<li><span style=\"font-size: 12.16px;\">Roy, G. et al. Inorg. Chem. 2017, xx, xxxx (DOI: 10.1021/acs.inorgchem.7b01048).</span></li>\n</ol>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1815, 'NULL', '2017-10-31 02:28:54', '2017-10-31 02:30:09'),
(461, 'November 13, 2017 at 4.00 pm in AG-69', 'Title :\nMechanistic Insights into the Protein-metal and Protein-protein Interactions of β-rich Glo', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Mechanistic Insights into the Protein-metal and Protein-protein Interactions of </span><span style=\"font-size: 12.16px;\">β-rich Globular Proteins</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1551, 'NULL', '2017-11-12 22:00:15', '2030-12-01 18:30:00'),
(462, 'November 20, 2017 at 4.00 pm in AG-69', 'Title :\nSynthesis and Comparative Evaluation of Carbon Dots from Glucose Based Saccharides', '<h3>Title</h3>\n<h3>Synthesis and Comparative Evaluation of Carbon Dots from Glucose Based Saccharides</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1771, 'NULL', '2017-11-14 00:31:55', '2030-12-01 18:30:00'),
(463, 'November 27, 2017 at 4.00 pm in AG-69', 'Title :\nFemtosecond Stimulated Raman Spectroscopy as a New Tool to Identify Twisted Intramolecular C', '<h3>Title</h3>\n<h3>Femtosecond Stimulated Raman Spectroscopy as a New Tool to Identify Twisted Intramolecular Charge Transfer States</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1663, 'NULL', '2017-11-14 00:33:06', '2030-12-01 18:30:00'),
(464, 'December 1, 2017 at 2.30 pm in AG-66', 'Title :\nExploring the Diverse Conformations and Biological Functions of IDPs\nAbstract :\nIntrinsicall', '<h3>Title</h3>\n<h3>Exploring the Diverse Conformations and Biological Functions of IDPs</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Intrinsically disordered proteins and regions (IDPs/IDRs) constitute about one third of protein sequence space in humans and enable complex conformational and functional behaviors that underlie diverse biological processes.  IDPs can function in the context of discrete multi-component assemblies but recently have been shown to undergo phase separation for form mesoscale cellular structures such as membraneless organelles and transcriptionally silent regions of chromatin.  Due to their heterogeneous and transient conformations, IDPs/IDRs are challenging to characterize at atomic resolution, making it difficult to establish detailed “disorder-function relationships”. We will discuss our multidisciplinary strategies toward understanding the roles of protein disorder in regulation of apoptosis and cell division, nucleolar structure and function, and interactions with small molecules.  A key goal is to illustrate the diversity and uniqueness of disorder-function relationships</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1745, 'NULL', '2017-11-16 00:06:53', '2030-12-01 18:30:00'),
(465, 'November 23, 2017 at 2.30 pm in AG-80', 'Title :\nStudies on Transition Metal Complexes of Flexible Polydentate Schiff Base Ligands \nAbstract', '<h3>Title</h3>\n<h3>Studies on Transition Metal Complexes of Flexible Polydentate Schiff Base Ligands </h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">The primary objective of this research work was to explore the structure-activity relationship between several kinds of biological, chemical as well as material properties and various complex structures tuned by flexible Schiff base ligands. In this regards several Ni(II) and Cu(II) Schiff base complexes have been synthesized by exploiting the flexibility of the piperazinyl moiety. The specific effectiveness towards DNA/Protein binding and catecholase like properties was observed due to flexibility and nuclearity in case of nickel and copper complexes respectively. Furthermore an interesting counter anion directed flexibility was observed in metal complexes after little modification in Schiff base ligands. Apart from protease, nuclease and catecholase like activities, these complexes have shown effective cytotoxicity towards HeLa cells.</p>\n<p style=\"text-align: justify;\">Pseudo-halide promoted and nuclearity driven enhanced corrosion inhibition activity of Zn(II) and Cd(II) Schiff base complexes was also observed to investigate the material applications of Schiff base complexes.</p>\n<p style=\"text-align: justify;\">Thus, it could be the stepping stone for further tuning of ligand using flexibility and to develop high nuclearity coordination compounds for more effectiveness in terms of biological and material applications. </p>\n<p style=\"text-align: justify;\"> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1725, 'NULL', '2017-11-22 00:00:04', '2030-12-01 18:30:00'),
(466, 'December 7, 2017 at 2.30 pm in B-333', 'Title :\nEnergy Relevant Processes Catalyzed by Corrole Metal Complexes\nAbstract:\nWe have recently in', '<h3>Title</h3>\n<h3>Energy Relevant Processes Catalyzed by Corrole Metal Complexes</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span>:</strong></p>\n<p>We have recently introduced corrole metal complexes (metallocorroles) as catalysts for various energy-relevant reactions. This includes those that are of prime importance for the electrochemical splitting of water into its elements, as well as the hydrogen and oxygen evolution reactions. Tuning of the redox potentials, M(I)/M(II) for proton reduction, M(II)/M(III) for oxygen reduction, and M(III)/M(IV)/M(V) for water oxidation (M= Fe, Co, or Mn), is achieved via variations of substituents on the corrole ligand. Practical catalysis is achieved via immobilization onto carbon electrodes, while mechanism-of-action insight is obtained by performing homogenous catalysis and characterization of reaction intermediates. The thus achieved conclusions are used for hypothesis-driven changes in the catalyst’s structures as to achieve the desired properties required for optimal catalytic efficacy and selectivity. This will be demonstrated by the introduction of newly developed catalysts with trifluoromethyl substituents.</p>\n<p> </p>\n<p>REFERENCES:</p>\n<p> </p>\n<p>•\"Metallocorroles as photocatalysts for driving endergonic reactions, exemplified by bromide to bromine conversion\", Angew. Chem. 2015, 54, 12370 –12373.</p>\n<p>•\"Metallocorroles as Non-Precious Metal Catalysts for Oxygen Reduction\", Angew. Chem. 2015, 54, 14080 –14084.</p>\n<p>•“Metallocorroles as Non-Precious Metal Electrocatalysts for Highly Efficient Oxygen Reduction in Alkaline Media\" ChemCatChem 2016, 8, 2832-2837.</p>\n<p>•“Metallocorroles as Electrocatalysts for the Oxygen Reduction Reaction (ORR)\", Israel J. Chem. 2016, 56, 756– 762 (invited review).</p>\n<p>•“Dioxygen bound Cobalt Corroles”, Chem. Commun. 2017, 53, 877-880.</p>\n<p>•“Selective CF3 Substitution for Affecting the Physical and Chemical Properties of Gold Corroles” Angew. Chem. 2017, 56, 9837-9841.</p>\n<p>•“Corroles as Triplet Photosensitizers”, Coord. Chem. Rev. 2017, 0000.</p>\n<p>•“One-pot synthesis of contracted and expanded porphyrins with meso-CF3 groups, from affordable precursors” Angew. Chem. 2017, 56, 0000.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1750, 'NULL', '2017-12-06 05:25:23', '2030-12-01 18:30:00'),
(467, 'December 14, 2017 at 2.30 pm in B-333', 'Title :\nComputational Material Design of Two Dimensional Materials and Their Energy Applications\nAbs', '<h3>Title</h3>\n<h3>Computational Material Design of Two Dimensional Materials and Their Energy Applications</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Two-dimensional materials have attracted attention from both fundamental aspects and application. In this work, we will present some of our recent effort to using first-principles based computational tools to design two-dimensional materials for energy applications. We have explored new possible ionic two dimensional materials and discover some that have not been synthesized yet1. Furthermore, their potential applications to adsorption of Li (for battery and hydrogen storage)2 and hydrogen evolution reactions3 are also examined.</p>\n<p> </p>\n<p>References :</p>\n<p> </p>\n<p>1.Chung-Huai Chang, Xiaofeng Fan, Shi-Hsin Lin, J-L Kuo, Phys. Rev. B, 88, 195420 (2013)</p>\n<p>2.S-H Lin, and J-L Kuo, Phys. Chem. Chem. Phys., 16, 20763 (2014)</p>\n<p>3.Yun-Wen Chen, Yaojun Du, and J-L Kuo, J. Phys. Chem. C, 118, 20383 (2014)</p>\n<p>4.D. B. Putungan, S-H Lin, and J-L Kuo, Phys. Chem. Chem. Phys., 17, 11367 (2015)</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1711, 'NULL', '2017-12-06 05:27:27', '2030-12-01 18:30:00'),
(468, 'December 13, 2017 at 11.30 am in AG-66', 'Title : \nVibrational Anharmonicity and IR Spectra of Hydrogen Bonded Clusters\nAbstract :\nStructure', '<p><strong><span style=\"text-decoration: underline;\">Title</span> : </strong></p>\n<h3>Vibrational Anharmonicity and IR Spectra of <span style=\"font-size: 12.16px;\">Hydrogen Bonded Clusters</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p>Structure of hydrate proton is typically classified into Eigen (H<sub>3</sub>O<sup>+</sup>) and Zundel (H<sub>5</sub>O<sub>2</sub><sup>+</sup>) forms. While this is a textbook knowledge, it remains very challenging to keep track of their vibrational signatures owing to the strong vibrational coupling. We have developed several computational scheme to reveal the vibrational couplings (from strong to weak) with the hope to link vibrational spectra and the structure of these clusters. Gas-phase ionic spectra collected over the last two decades have provided plenty of experimental vibrational spectra that allow us to examine the vibrational motion of proton in H-bonded cations. In this talk, we will present our recent systematic theoretical studies both different types of Zundel<sup>1,2</sup> and H<sub>3</sub>O<sup>+</sup> under different solvation environments<sup>3,4</sup>. Our theoretical studies engage <em>ab initio</em> treatment on a selected set of quantum degrees of freedom and treat their vibrational anharmonicity/coupling explicitly. If time permits, we will also access the performance of a few approximate treatments on vibrational coupling/anharmonicity to treat larger hydrogen-bonded molecular clusters<sup>5</sup>. </p>\n<p> </p>\n<p>References </p>\n<p> </p>\n<p>1.J.A. Tan and J.-L. Kuo. J. Phys. Chem. A., 119, 11320 (2015)</p>\n<p>2.J.A. Tan and J.-L. Kuo. Phys. Chem. Chem. Phys., 18, 14531 (2016)</p>\n<p>3.J-W Li, M. Morita, T. Takahashi, and J-L Kuo, J. Phys. Chem. A, 119, 10887 (2015)</p>\n<p>4.J. Tan, J-W Li, C-c Chiu, H. Huynh, H-Y Liao, and J-L Kuo, Phys. Chem. Chem. Phys., 18, 30721 (2016)</p>\n<p> </p>\n<p>5.K-L Ho, L-Y Lee, M. Katada, A. Fujii, and J-L Kuo, Phys. Chem. Chem. Phys., 18, 30498 (2016)</p>\n<p> </p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1786, 'NULL', '2017-12-07 00:38:41', '2017-12-12 00:45:32'),
(469, 'December 18, 2017 at 4.00 pm in AG-69', 'Title : \nSynthesis of TEMPO linked Chromophore Molecules and Their Photophysical Quenching', '<p><strong><span style=\"text-decoration: underline;\">Title</span> :</strong> </p>\n<h3>Synthesis of TEMPO linked Chromophore Molecules and Their Photophysical Quenching</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1628, 'NULL', '2017-12-12 21:11:20', '2030-12-01 18:30:00'),
(470, 'December 21, 2017 at 2.30 pm in AG-80', 'Title :\nThe electron’s spin and molecular chirality - How are they related and how can they be uti', '<p>Title :</p>\n<p>The electron’s spin and molecular chirality - How are they related and how can they be utilized?</p>\n<p>Abstract :</p>\n<p>Spin based properties, applications, and devices are commonly related to magnetic effects and to magnetic materials. However, we found that chiral organic molecules act as spin filters for photoelectrons transmission,<sup>1</sup>  in electron transfer,<sup>2</sup> and in electron transport.<sup>3</sup></p>\n<p> </p>\n<p>The new effect, termed Chiral Induced Spin Selectivity (CISS),<sup>4,5</sup>  was found, among others, in bio-molecules and in bio-systems. It has interesting implications for the production of new types of spintronics devices,<sup>6,7</sup> and on electron transfer in biological systems.<sup>8</sup>  The basic effect will be explained and various applications and implications will be discussed.</p>\n<p> </p>\n<p><span style=\"text-decoration: underline;\">References </span></p>\n<p> </p>\n<p>1.Göhler, B.; Hamelbeck, V.; Markus, T.Z.; Kettner, M.; Hanne, G.F.; Vager, Z.; Naaman, R.; Zacharias,  H. Science 2011, 331, 894.</p>\n<p>2.Mishra, D.; Markus, T.Z.; Naaman, R.; Kettner, M.; Göhler, B.; Zacharias, H.; Friedman, N.; Sheves, M.; Fontanesi, C. PNAS,   2013, 110, 14872.</p>\n<p>3.Xie, Z.; Markus, T. Z.; Cohen, S. R.; Vager, Z.; Gutierrez, R.; Naaman, R. Nano Letters, 2011, 11, 4652.</p>\n<p>4.Naaman, R.; Waldeck, D.H. J. Phys. Chem. Lett. (feature) 2012, 3, 2178.</p>\n<p>5.R. Naaman, D. H. Waldeck, Spintronics and Chirality: Spin Selectivity in Electron Transport Through Chiral Molecules, Ann. Rev. Phys. Chem. 2015, 66, 263–81. </p>\n<p>6.O. Ben Dor,  S. Yochelis, A. Radko, K. Vankayala, E. Capua, A. Capua, S.-H. Yang, L. T. Baczewski, S. S. P. Parkin, R. Naaman, and Y. Paltiel, Nat. Comm. 8:14567 (2017).</p>\n<p>7.K. Michaeli, V.  Varade, R. Naaman, D. Waldeck, Journal of Physics: Condensed Matter, 29, 103002 (2017) </p>\n<p>8.I. Carmeli, K. S. Kumar, O. Hieflero, C. Carmeli, R. Naaman,  Angew. Chemie  2014, 53, 8953 –8958.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1778, 'NULL', '2017-12-18 00:30:09', '2030-12-01 18:30:00'),
(471, 'January 4, 2018 at 2.30 pm in AG-80', 'Title :\nStable Radical Anions in Photocatalysis\nAbstract :\nIn the recent past visible light photored', '<h3>Title</h3>\n<h3>Stable Radical Anions in Photocatalysis</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">In the recent past visible light photoredox catalysis has gained enormous attention as an energy-efficient and versatile method for chemical synthesis.(1, 2) In my presentations, I will mainly talk about our recent work on visible light photoredox catalysis using stable radical anions of commercially available inexpensive organic dyes.(3-7) The applications of bioinspired consecutive photoinduced electron transfer (conPET)(3, 4, 6, 7) and sensitization initiated electron transfer (SenI-ET)(5) processes will be discussed in the context of breaking and making of stable chemical bonds for useful synthetic transformations.</p>\n<p> </p>\n<p><span style=\"text-decoration: underline;\">References:</span> </p>\n<p> </p>\n<p>1.  B. Konig, Eur. J. Org. Chem., 1979-1981 (2017).</p>\n<p>2.  I. Ghosh, L. Marzo, A. Das, R. Shaikh, B. Konig, Acc. Chem. Res. 49, 1566-1577 (2016).</p>\n<p>3.  I. Ghosh, T. Ghosh, J. I. Bardagi, B. Konig, Science 346, 725-728 (2014).</p>\n<p>4.  I. Ghosh, B. Konig, Angew. Chem. Int. Ed. 55, 7676-7679 (2016).</p>\n<p>5.  I. Ghosh, R. S. Shaikh, B. Konig, Angew. Chem. Int. Ed. 56, 8544-8549 (2017).</p>\n<p>6.  A. Das, I. Ghosh, B. Konig, Chem. Commun. 52, 8695-8698 (2016).</p>\n<p>7.  L. Marzo, I. Ghosh, F. Esteban, B. Konig, ACS Catal. 6, 6780-6784 (2016).</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1785, 'NULL', '2018-01-02 06:33:38', '2030-12-01 18:30:00'),
(472, 'January 5, 2018 at 2.30 pm in AG-69', 'Title :\nMaking and Breaking of Chemical Bonds with Visible Light\nAbstract :\nIn the recent past visib', '<h3>Title</h3>\n<h3>Making and Breaking of Chemical Bonds with Visible Light</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>In the recent past visible light photoredox catalysis has gained enormous attention as an energy-efficient and versatile method for chemical synthesis.(1, 2) In my presentations, I will mainly talk about our recent work on visible light photoredox catalysis using stable radical anions of commercially available inexpensive organic dyes.(3-7) The applications of bioinspired consecutive photoinduced electron transfer (conPET)(3, 4, 6, 7) and sensitization initiated electron transfer (SenI-ET)(5) processes will be discussed in the context of breaking and making of stable chemical bonds for useful synthetic transformations.</p>\n<p> </p>\n<p><span style=\"text-decoration: underline;\">References:</span> </p>\n<p> </p>\n<p>1.  B. Konig, Eur. J. Org. Chem., 1979-1981 (2017).</p>\n<p>2.  I. Ghosh, L. Marzo, A. Das, R. Shaikh, B. Konig, Acc. Chem. Res. 49, 1566-1577 (2016).</p>\n<p>3.  I. Ghosh, T. Ghosh, J. I. Bardagi, B. Konig, Science 346, 725-728 (2014).</p>\n<p>4.  I. Ghosh, B. Konig, Angew. Chem. Int. Ed. 55, 7676-7679 (2016).</p>\n<p>5.  I. Ghosh, R. S. Shaikh, B. Konig, Angew. Chem. Int. Ed. 56, 8544-8549 (2017).</p>\n<p>6.  A. Das, I. Ghosh, B. Konig, Chem. Commun. 52, 8695-8698 (2016).</p>\n<p>7.  L. Marzo, I. Ghosh, F. Esteban, B. Konig, ACS Catal. 6, 6780-6784 (2016).</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1968, 'NULL', '2018-01-02 06:35:35', '2030-12-01 18:30:00'),
(473, 'January 8, 2018 at 4.00 pm in AG-69', 'Title :\nOrganic Photocatalysis inside Water-Soluble Supramolecular Cages', '<h3>Title</h3>\n<h3>Organic Photocatalysis inside Water-Soluble Supramolecular Cages</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1737, 'NULL', '2018-01-02 06:39:37', '2030-12-01 18:30:00'),
(474, 'January 23, 2018 at 2.30 pm in AG-69', 'Title :\nMechanochemical strengthening of polymeric materials using piezoelectric nanoparticles\nAbstr', '<h3>Title</h3>\n<h3>Mechanochemical strengthening of polymeric materials using piezoelectric nanoparticles</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Mechanical actuation of synthetic polymers usually results in bond breakage leading to eventual failure. In contrast, biological systems use mechanical force for constructive purposes. For example, bones and muscles heal and become stronger under moderate levels of stress often encountered during exercise. In this talk, I will present my work towards developing synthetic polymeric materials that grow stronger under mechanical activation.</p>\n<p><span style=\"font-size: 12.16px;\">Mechanical force can be harnessed for performing constructive chemistry using the piezoelectric effect. Mechanical activation of piezoelectric nanoparticles generates several volts of electrochemical potential on the nanoscale. I present a method to harness this electro-mechanical reaction to enable polymerization reactions such as atom-transfer radical polymerization (ATRP) and copper-catalyzed azide-alkyne ‘click’ (CuAAC) using piezo reduction to generate a Cu(I) based catalysts. This research project is an entirely new area of polymer mechanochemistry and we were the first to demonstrate piezochemically-activated polymerization reactions. We are now starting to develop polymeric systems in which mechanical stress plays a constructive role. </span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2064, 'NULL', '2018-01-09 02:19:42', '2030-12-01 18:30:00'),
(475, 'January 24, 2018 at 2.30 pm in AG-69', 'Title :\nFrom destructive to constructive – Using energy to strengthen polymeric materials\nAbstract', '<h3>Title</h3>\n<h3>From destructive to constructive – Using energy to strengthen polymeric materials</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>In this talk, I will present my plans to design polymers with new capabilities – ones that improve their performance as a response to distinct energy inputs. I will discuss my proposals to develop: 1) polymers that can undergo autonomous strengthening when they experience mechanical force; and 2) polymerization methods that are self-catalyzed and require less energy to perform without sacrificing the material strength of resulting polymer. The former will be achieved by designing synthetic polymers containing mechanoresponsive functional groups that can rearrange to generate strong bases under mechanical actuations. The base in turn will trigger the formation of new polymer chains leading to strengthening of the overall polymeric material. The later project aims at designing new class of phthalonitrile based polymeric resins that undergo self-catalyzed crosslinking or curing. The first generation of these phthalonitrile monomers will contain masked phenolic curing promoters that can be unmasked under mild heating in the presence of suitable additives and then trigger a self-catalyzed polymer curing process.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1711, 'NULL', '2018-01-09 02:21:37', '2030-12-01 18:30:00');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(476, 'January 25, 2018 at 2.30 pm in AG-80', 'Title :\nChaperonin nano-machines: allostery and function\nAbstract :\nChaperonins are nano-machines th', '<h3>Title</h3>\n<h3>Chaperonin nano-machines: allostery and function</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Chaperonins are nano-machines that are built of two back-to-back stacked heptameric rings.  They assist protein folding by undergoing large conformational changes that are controlled by ATP binding and hydrolysis.  In the <em>E. coli</em> cell, only about 60 different proteins require GroEL for efficient folding.  In the first part of the talk, I will describe work that was aimed at determining the properties that distinguish GroEL clients from non-clients.  In the second part of the talk, I will describe new approaches for establishing allosteric mechanisms.  Using these approaches, it was possible to show that the chaperonin GroEL from <em>E. coli</em> undergoes concerted intra-ring conformational changes whereas its eukaryotic homologue CCT/TRiC undergoes sequential intra-ring conformational changes.  The impact of these different allosteric mechanisms on the folding functions of GroEL and CCT/TRiC will be discussed.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1791, 'NULL', '2018-01-09 02:38:24', '2030-12-01 18:30:00'),
(477, 'January 29, 2018 at 4.0 pm in AG-69', 'Title :\nElucidating the Reaction Coordinate for Charge Transfer Dynamics in Organic Donor-Acceptor F', '<h3>Title</h3>\n<h3>Elucidating the Reaction Coordinate for Charge Transfer Dynamics in Organic Donor-Acceptor Frameworks</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1768, 'NULL', '2018-01-25 03:42:36', '2018-01-25 04:24:46'),
(478, 'February 5, 2018 at 4.00 pm in AG-69', 'Title :\nExploring the mechanical properties of Ubiquitin-CUE2 complex', '<h3>Title</h3>\n<h3>Exploring the mechanical properties of Ubiquitin-CUE2 complex</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1646, 'NULL', '2018-01-31 22:14:06', '2030-12-01 18:30:00'),
(479, 'February 12, 2018 at 4.00 pm in AG-69', 'Title :\nTracking Phospholipid Induced Coil-Helix Transitions in Phosphoinositide-binding Motifs of A', '<h3>Title</h3>\n<h3>Tracking Phospholipid Induced Coil-Helix Transitions in Phosphoinositide-binding Motifs of Actin Binding Proteins</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1657, 'NULL', '2018-02-09 02:04:13', '2030-12-01 18:30:00'),
(480, 'February 13, 2018 at 2.30 pm in AG-66', 'Title :\nNonadiabatic Reaction Dynamics at Conical Intersection\nAbstract :\nExcited-state reactions ta', '<h3>Title</h3>\n<h3>Nonadiabatic Reaction Dynamics at Conical Intersection</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Excited-state reactions take place via couplings among near-lying electronic states. These electronic state couplings are mediated by nuclear momenta associated with vibrational motions and become most efficient at conical intersections where two or more electronic states are degenerate at the same nuclear configuration. Thereafter, nonadiabatic reaction pathways are open so that chemical reactions are driven into particular reaction outcomes. Even though conceptual description for nonadiabatic reactions as above is nicely conceived, actual experimental evidences are quite rare. Here, we present experimental cases where conical intersections are spectroscopically characterized and associated nonadiabatic dynamic pathways are identified in energy and time domains. Specifically, predissociation dynamics of thioanisoles in the supersonic jet are thoroughly investigated to unravel detailed mechanism involved in nonadiabatic transitions taking place in the vicinity of the conical intersection encountered along the reaction coordinate.</p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">References</span> :</span></p>\n<p>K.C. Woo, D. H. Kang, and S. K. Kim, J. Am. Chem. Soc. 139, 17152 (2017).</p>\n<p>H. S. You et. al., Int. Rev. Phys. Chem. 34, 429 (2015).</p>\n<p>H. S. You, S. Han, J. S. Lim, S. K. Kim, J. Phys. Chem. Lett. 6, 3202 (2015).</p>\n<p>J. S. Lim, S. K. Kim, Nat. Chem. 2, 627 (2010).</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1514, 'NULL', '2018-02-11 20:20:07', '2018-02-12 03:46:32'),
(481, 'February 19, 2018 at 4.00 pm in AG-69', 'Title :\nBreaking the RET barrier using metamaterials\nAbstract :\nResonance Energy Transfer (RET) is a', '<h3>Title</h3>\n<h3>Breaking the RET barrier using metamaterials</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Resonance Energy Transfer (RET) is a form of direct energy transfer between two dipoles. It has a very precise distance dependence that has allowed the technique to be widely used in particular for determining complex molecular structures. However, it is only effective over ˜ 15 nm separations. I will discuss our proof-of-principle experiments which extend the RET range of effectiveness by an order-of-magnitude and show RET between a donor-acceptor pair separated by 160 nm. This increase is facilitated by using metamaterials a class of custom-made nanophotonic structures that are designed to have unique optical properties, specifically, a topological transition from a closed to an open form which can be tuned for individual RET pairs. We will go over the design of the metamaterial for our experiment and also discuss the experimental demonstration of long distance RET using time resolved and steady state spectroscopy.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1603, 'NULL', '2018-02-14 22:27:30', '2030-12-01 18:30:00'),
(482, 'February 27, 2018 at 2.30 pm in AG-80', 'Title :\nDiscovery and Characterization of Microproteins\nAbstract :\nThe human genome project was supp', '<h3>Title</h3>\n<h3>Discovery and Characterization of Microproteins</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">The human genome project was supposed to have identified all protein-coding genes in the human genome, but recent work has revealed that gene finding algorithms had a blind spot; they failed to recognize protein-coding small open reading frames (smORFs). By definition, smORFs contain less than 150 codons and encode peptides or small proteins, collectively referred to as microproteins. Recent advances in the Mass Spectrometry and the Ribosome Profiling technology has led to the discovery of hundreds to thousands of these microproteins. The functional characterization of the microproteins is essential to understand their biological and cellular importance. The biological functions of a few microproteins have been elucidated, and these microproteins have fundamental roles in biology ranging from limb development to muscle function, highlighting the value of characterizing these molecules. Bioactive microproteins operate through microprotein-protein interactions (MPIs) and I’ll talk about the application of an in situ proximity tagging method that relies on an engineered ascorbate peroxidase (APEX) to elucidate MPIs. The APEX tagging method has been shown to be superior to traditional immunoprecipitation methods for microproteins. Furthermore, the application of APEX-tagging to uncharacterized microproteins called C11orf98 and MIEF revealed their interaction with protein complexes in nucleus and mitochondria respectively, thus, demonstrating the ability of this approach to identify novel hypothesis-generating MPIs.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1578, 'NULL', '2018-02-14 23:38:01', '2030-12-01 18:30:00'),
(483, 'February 23, 2018 at 2.30 pm in AG-66', 'Title :\nComplete Enumeration of BN-doped Polycyclic Aromatic Hydrocarbon Libraries in the MolDis rep', '<h3>Title</h3>\n<h3>Complete Enumeration of BN-doped Polycyclic Aromatic Hydrocarbon Libraries in the MolDis repository</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">The MolDis repository under development at TIFR Centre for Interdisciplinary Sciences aims to provide an analytics platform for Big Data of computed molecular properties. Presently massively large datasets are being generated for a multitude of domains of application.  The level-1 phase of data generation involves combinatorial enumeration of all possible molecules satisfying a few design rules. Starting with all possible plane-filling polycyclic aromatic hydrocarbons (PAHs), we have enumerated all possible doped analogues by substituting pairs of C atoms with B and N atom pairs. I will discuss the mathematics of this approach based on Polya enumeration theorem and show how a single PAH with six benzene rings can be doped into 241,813,226,150 different molecules providing a continuous spectrum of band-gap and other properties. </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1725, 'NULL', '2018-02-19 02:23:40', '2030-12-01 18:30:00'),
(484, 'Febrauary 22, 2018 at 2.30 pm in AG-80', 'Title :\nDevelopment of mixed N, O donor ligands for in vivo metal ion chelation and sensing', '<h3>Title</h3>\n<h3>Development of mixed N, O donor ligands for in vivo metal ion chelation and sensing</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1615, 'NULL', '2018-02-22 01:56:16', '2030-12-01 18:30:00'),
(485, 'February 28, 2018 at 2.30 pm in AG-66', 'Title :\nScience Stories: Communicating Science as Career, Hobby, or Habit\nAbstract :\nWhether it’s ', '<h3>Title</h3>\n<h3>Science Stories: Communicating Science as Career, Hobby, or Habit</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Whether it’s a new, better battery material, a company with controversial new drug, or tracking the impacts of climate change, science is an important part of the news. Science journalists translate research from the lab for public audiences—and they rely on working scientists to be a part of that process. Jessica Marshall will speak about the ins and outs of producing chemistry news for C&amp;EN readers, and she’ll discuss her prior work as a freelance science writer. She’ll also talk about ways that working scientists can improve their communication—whether in speaking with other scientists or as sources for the news media. Science communication can be a rewarding career for science graduates—and those who remain at the bench can increase their work’s impact by clear communication. This session will discuss both roles: science communicator and communicating scientist. Come join the conversation.</p>\n<p><em><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">About the Speaker</span>:</span></em></p>\n<p style=\"text-align: justify;\"><em><span style=\"font-size: 12.16px;\">Jessica Marshall is an associate editor at Chemical &amp; Engineering News. Prior to joining C&amp;EN, she spent a decade as a freelance science and environment writer. Her work appeared in Nature, TheAtlantic.com, Discover, Proceedings of the National Academy of Sciences, New Scientist, and other outlets. She contributed to The Science Writers’ Handbook: Everything You Need to Know to Pitch, Publish and Prosper in the Digital Age. She attended the University of California, Santa Cruz Science Communication Program. Prior to that, she earned a Ph.D. in chemical engineering at the University of California, Berkeley, and a B.S.E. in chemical engineering at Princeton University.  She lives in Seattle with her husband and three children.</span></em></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1490, 'NULL', '2018-02-22 02:07:02', '2030-12-01 18:30:00'),
(486, 'February 26, 2018 at 4.00 pm in AG-69', 'Title :\nExtracting the features of complex multidimensional energy landscape of proteins : a reactio', '<h3>Title</h3>\n<h3>Extracting the features of complex multidimensional energy landscape of proteins : a reaction coordinate free approach</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1780, 'NULL', '2018-02-22 22:07:36', '2030-12-01 18:30:00'),
(487, 'March 20, 2018 at 2.30 pm in AG-80', 'Title :\nNonvalence Correlation-Bound Anionic States: A New Doorway to Electron Transfer \nAbstract :', '<h3>Title</h3>\n<h3>Nonvalence Correlation-Bound Anionic States: A New Doorway to Electron Transfer </h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>The mechanistic details and the dynamics of electron transfer to molecules continue to be poorly understood. The key to unraveling this fundamentally important chemical process hinges upon a sound understanding of electron binding states. Here I will discuss the discovery, theoretical characterization and role of nonvalence correlation-bound (NVCB) states as a new low-energy doorway for electron capture and transfer. In the NVCB states of anions, the excess electron occupies a very diffuse orbital while its binding to the molecule or cluster is dominated by long-range dispersion-type correlation forces. Ab initio methods and one-electron model Hamiltonians will be used to characterize the NVCB anionic states. The existence of NVCB states and its implications for gas-  and condensed-phase electron transfer will be illustrated using examples ranging from small molecules to large fullerene systems. </p>\n<p> </p>\n<p><span style=\"text-decoration: underline;\">References</span>:</p>\n<ol>\n<li>V. K. Voora, A. Kairalapova, T. Sommerfeld, and K. D. Jordan. “Theoretical approaches for treating non-valence correlation-bound anions”, J. Chem. Phys., 2017, 147, 214114.</li>\n<li>V. K. Voora, and K. D. Jordan. “Nonvalence correlation-bound anion states of spherical fullerenes”, Nano Lett., 2014, 14, 4602. </li>\n<li>V. K. Voora, L. S. Cederbaum, and K. D. Jordan. “Existence of a correlation bound s-type anion state of C60”, J. Phys. Chem. Lett., 2013, 4, 849. </li>\n<li>J. P. Rogers, C. S. Anstöter, and J. R. R. Verlet. “Ultrafast dynamics of low-energy electron attachment via a non-valence correlation-bound state”, Nat. Chem., 2018, http://dx.doi.org/10.1038/nchem.2912.  </li>\n</ol>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1828, 'NULL', '2018-02-27 02:27:08', '2030-12-01 18:30:00'),
(488, 'March 21, 2018 at 2.30 pm in AG-80', 'Title :\nVariational Random Phase Approximation Method for Accurate Ionization Potentials and Interac', '<h3>Title</h3>\n<h3>Variational Random Phase Approximation Method for Accurate Ionization Potentials and Interaction Energies</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">A critical and outstanding challenge of electronic structure method development is to deliver both accurate total energy differences and quasiparticle spectra. I will address this challenge using a generalized Kohn-Sham (GKS) approach that variationally minimizes the random phase approximation (RPA) ground-state energy as a functional of the one-particle density matrix. The GKS-RPA approach enables highly accurate predictions of all observables from derivatives of a single variationally stable energy functional, and leads to remarkable advancements. Intermolecular binding-energies and quasiparticle spectra from GKS-RPA improve significantly upon those from state-of-the-art post-Kohn-Sham RPA or G0W0 theory. Anions, which are often unstable and poorly described by semi-local density functional approximations, are well described within GKS-RPA. Core ionization energies, which are traditionally hard to compute, can be accurately estimated using GKS-RPA; pilot applications for modeling solvation effects in conjunction with X-ray photoelectron spectroscopy will be discussed. Overall, the GKS scheme alleviates some of the most serious problems with semi-local density functional approximations, and paves the way for a new generation of electronic structure methods.</p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">References:</span></p>\n<ol>\n<li>G. Chen, V. K. Voora, M. Agee, S. Balasubramani, and F. Furche. “Random phase approximation methods”, Annu. Rev. Phys. Chem., 2017, 68, 421. </li>\n<li>V. K. Voora, S. G. Balasubramani, and F. Furche. “Variational Generalized Kohn-Sham Approach Combining Random Phase Approximation and Green’s Function Methods”, https://escholarship.org/uc/item/7gf3h1h9. </li>\n</ol>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2016, 'NULL', '2018-02-27 02:30:16', '2030-12-01 18:30:00'),
(489, 'March 5, 2018 at 4.00 pm in AG-69', 'Title :\nXeno-nuclei enable protein-specific modulation of order-disorder transition\nAbstract :\nThe a', '<h3>Title</h3>\n<h3>Xeno-nuclei enable protein-specific modulation of order-disorder transition</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>The ability to modulate the order to disorder or vice versa transition of a specific protein in a milieu of many proteins can be an important tool for chemical biology and pharmacology. Kinetics and thermodynamics of protein folding are routinely modulated by changing solvent conditions, but such changes are not very protein specific. Specific ligands with the ability to alter the stability of a </p>\n<p>protein are rarely available. Here, we propose a general approach for designing such ligands by mimicking the folding nucleus of a protein. The key idea is to choose a part of the protein itself, which is suspected/known to be the nucleation site for the folding pathway, and then to put it in a pre-formed shape to modulate the folding/unfolding. This xeno-nucleus can in principle, be used to selectively modulate the folding of a particular protein from a mixture of different proteins. </p>\n<p><span style=\"font-size: 12.16px;\">We show that the ⓵ - ⓶ part (residues 1 to 17) of ubiquitin [1], which is known to fold into a β-hairpin shape and to nucleate the folding of the rest of the protein, can make folding faster when it is introduced as a separate peptide at excess concentrations. No such acceleration is observed when the xeno-nucleus is unfolded to start with. Interestingly, the protein also becomes less stable, as the unfolding rate becomes even faster. We show that this effect is protein-specific, as another protein with no such β-hairpin (e.g. bovine serum albumin) remains unaffected by the peptide. Our results suggest that the folding of almost any protein that possesses a well-defined folding nucleus can be modulated, if a nucleus-mimicking molecule with a stabilized structure can be constructed. </span></p>\n<p><span style=\"font-size: 12.16px;\">References: </span></p>\n<p><span style=\"font-size: 12.16px;\">1. Atomic-level description of ubiquitin folding. PNAS, 2013, 110 (15), 5915–5920.</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1422, 'NULL', '2018-03-01 01:29:33', '2030-12-01 18:30:00'),
(490, 'March 13, 2018 at 2.30 pm in AG-80', 'Title :\nHomogeneous and Interfacial Proton Coupled Electron Transfer Reactions\nAbstract :\nProton cou', '<p><strong>Title :</strong></p>\n<h3>Homogeneous and Interfacial Proton Coupled Electron Transfer Reactions</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Proton coupled electron transfer (PCET) reactions are integral part of several catalytic processes, e.g. reduction of dioxygen to water, oxidation of water to dioxygen, carbon dioxide reduction, reduction of dinitrogen to ammonia, that are crucial for energy storage, fuel cell research and several biological processes. In this presentation, I will discuss (i) computational investigations of role of PCET reaction in the mechanism of oxygen reduction reaction by a Co-salophen complex in the presence of p-hydroquinone as a co-catalyst, (ii) computational study of PCET reaction between ZnO nanocrystal and an organic radical. In the first part of the talk we will see that my calculations along with substantial experimental studies provide ample evidence for reduction of dioxygen to a coordinated hydrogen peroxide intermediate, which is subsequently reduced to water. The role of p-hydroquinone as electron proton transfer mediator is explored in details. In the second part of the presentation I will show how to estimate rate constant for PCET between photoreduced ZnO nanocrystal and TEMPO. We will further explore the role of proton diffusion inside the ZnO nanocrystal coupled to PCET reaction at the surface to explain the experimental studies of reaction dynamics of the PCET reaction mentioned above at longer timescales.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1753, 'NULL', '2018-03-04 21:04:24', '2018-03-04 21:07:09'),
(491, 'March 14, 2018 at 2.30 pm in AG-80', 'Title :\nProton Coupled Electron Transfer and Charge Transfer Reactions at Solid-Liquid Interfaces an', '<h3>Title</h3>\n<h3>Proton Coupled Electron Transfer and Charge Transfer Reactions at Solid-Liquid Interfaces and Homogeneous Environment</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Proton coupled electron transfer (PCET) reactions are integral part of several catalytic processes that are crucial for energy storage, fuel cell research and several biological processes. On the other hand, excited state charge transfer reactions are at the heart of many photoinduced processes. In this presentation, I will discuss (i) computational study of PCET reaction between ZnO nanocrystal and an organic radical (ii) new theoretical methods to calculate solvent reorganization energies for electron transfer and PCET reactions in electrochemical systems, and (iii) implementation of a novel method to incorporate nuclear quantum effects in charge transfer dynamics. In the first part of the presentation I will show how to estimate rate constant for PCET between photoreduced ZnO nanocrystal and TEMPO. For reactions that involve a substantial redistribution of charge density in a polar environment, it is important to estimate the energy penalty involved in rearranging the solvent dipoles in order to estimate rate constant for the charge transfer process. In the second part of this talk I will describe a new method for calculating this important parameter, solvent reorganization energy, in the context of electrochemical electron transfer and PCET reactions. In the final part of this talk I will introduce my ongoing research on incorporating nuclear quantum effects in charge transfer dynamics within the framework of ring polymer surface hopping algorithm.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1459, 'NULL', '2018-03-04 21:06:20', '2030-12-01 18:30:00'),
(492, 'March 12, 2018 at 4.00 pm in AG-69', 'Title :\nHigh Surface Area Aluminosilicates : Novel synthesis and unraveling the active sites by cata', '<h3>Title</h3>\n<h3>High Surface Area Aluminosilicates : Novel synthesis and unraveling the active sites by catalysis and Solid State NMR</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1497, 'NULL', '2018-03-06 02:43:31', '2030-12-01 18:30:00'),
(493, 'March 26, 2018 at 4.00 pm in AG-69', 'Title :\nSeminal Electrode Materials for Battery and Supercapacitor Applications', '<h3>Title</h3>\n<h3>Seminal Electrode Materials for Battery and Supercapacitor Applications</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1688, 'NULL', '2018-03-20 02:08:22', '2030-12-01 18:30:00'),
(494, 'April 25, 2018 at 2.30 pm in AG-80', 'Title :\nMetallic Conductivity in Proteins: A New Paradigm for Biological Electron Transfer and Bioe', '<h3>Title</h3>\n<h3>Metallic Conductivity in Proteins: <span style=\"font-size: 12.16px;\">A New Paradigm for Biological Electron Transfer and Bioelectronics</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">Electron transfer is central to all life processes. Every living cell must get rid of a large number of electrons left behind in metabolism when nutrients convert into energy. Aerobic organisms use oxygen to dump these electrons. Electron transfer in proteins occurs through either tunneling or hopping a few nanometers via inorganic cofactors. However, the common soil bacteria <em>Geobacter sulfurreducens</em> transfers electrons over hundreds of micrometers, to insoluble electron acceptors<sup>1</sup> or syntrophic partner species<sup>2</sup>. Electron transfer is using hair-like protein filaments called pili<sup>1,2</sup> that function as molecular nanowires and this allows bacteria to survive in environments that lack membrane-permeable electron acceptors such as oxygen. The conductivity of pili exhibits temperature dependence similar to that of disordered metallic polymers<sup>1,3</sup>. However, metallic conductivity is considered improbable in proteins due to the lack of periodicity in protein structure, thermal fluctuations, and low conductivity values.</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">I will present our recent electrical, optical and structural studies to identify the structural, molecular and physical mechanism of metallic conductivity in pili. To determine the molecular architecture responsible for conductivity, we are using a suite of complementary experimental and computational methods such as molecular dynamics, x-ray diffraction, circular dichroism, fluorescence microscopy and infrared spectroscopy. Our studies suggest that aromatic amino acids in pili are closely packed from each other        (&lt; 4 Å), forming pi stacking, that can cause in intermolecular electron delocalization, conferring metallic conductivity to pili. Notably, we observe large conformational changes that accelerate electron transfer in pili. Furthermore, we show that improved metallic nature in the pili correlates with the improved pi stacking. These studies defy the current biochemical assumption that all proteins are electronic insulators and need inorganic cofactors for electron transfer. Pili thus represent a new class of electronically functional proteins that can transport electrons at rates and distances unprecedented in biology. I will discuss the implications of these studies for biological electron transfer as well as for bioelectronics.</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">[1] Malvankar et al. <strong><em>Nature Nanotechnology</em></strong>, 6, 573-579 (2011)</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">[2] Summers et al. <strong><em>Science</em></strong>, 330, 1413-1415 (2010)</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">[3] Malvankar et al. <strong><em>Nature Nanotechnology</em></strong>, 9, 1012-1017 (2014)</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"> </span></p>\n<p> </p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"margin-right: -49.7pt; mso-add-space: auto; tab-stops: 36.0pt 72.0pt 108.0pt 144.0pt 180.0pt 216.0pt 252.0pt 288.0pt;\"><span lang=\"EN-US\">Research website: <span class=\"MsoHyperlink\"><em>https://malvankarlab.yale.edu</em></span></span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 2418, 'NULL', '2018-03-23 02:15:12', '2030-12-01 18:30:00'),
(495, 'April 2, 2018 at 4.00 pm in AG-69', 'Title :\nMn(II) Sensor Diaries: Stumbling upon a Hg(II) Sensor', '<h3>Title</h3>\n<h3>Mn(II) Sensor Diaries: Stumbling upon a Hg(II) Sensor</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1429, 'NULL', '2018-03-27 00:36:25', '2030-12-01 18:30:00'),
(496, 'April 9, 2018 at 4.00 pm in AG-69', 'Title :\nUnderstanding the Effect of Distant Mutation on the Charge Transfer Band of Azurin Using Ult', '<h3>Title</h3>\n<h3>Understanding the Effect of Distant Mutation on the Charge Transfer Band of Azurin Using Ultrafast Spectroscopy</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1501, 'NULL', '2018-04-04 02:13:18', '2030-12-01 18:30:00'),
(497, 'April 12, 2018 at 4.00 pm in AG-66', 'Title :\nMechanistic Insights into the Inhibition of Fibrillation of Alpha-Synuclein by Triphala and ', '<h3>Title</h3>\n<h3>Mechanistic Insights into the Inhibition of Fibrillation of Alpha-Synuclein by Triphala and Destabilization of Preformed Fibrils</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1615, 'NULL', '2018-04-10 00:38:54', '2030-12-01 18:30:00'),
(498, 'April 16, 2018 at 4.00 pm in AG-69', 'Title :\nNew approaches for studying the structure of protein oligomers in lipids and in solutions\nAb', '<h3>Title</h3>\n<h3>New approaches for studying the structure of protein oligomers in lipids and in solutions</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Understanding the interaction between membranes and amyloid protein oligomers is a key unsolved challenge in the field of biophysics. Here we describe new tools to address this challenge. We show that single molecule photobleaching with a home-built Total Internal Reflection Fluorescence Microscope can measure the relative membrane affinity of each type of oligomers. Also, an Atomic Force Microscope coupled to a home-built Confocal Fluorescence Microscope can probe the membrane phase dependant binding of these oligomers.  Separately, fiber-optic in-probe modulation of pH  during an NMR experiment can potentially probe the evolving oligomeric structure.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1343, 'NULL', '2018-04-12 00:17:51', '2030-12-01 18:30:00'),
(499, 'May 11, 2018 at 2.30 pm in AG-80', 'Title :\nMany body effects in biomolecular ionic interactions\nAbstract :\nMolecular insight into ion-d', '<h3>Title</h3>\n<h3>Many body effects in biomolecular ionic interactions</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Molecular insight into ion-driven processes requires a precise knowledge of how the energetics, structures, dynamics of ions differ between hydrated and biomolecule-bound states. While first principles quantum mechanical models can yield reliable estimates for relative binding energies, estimates for thermodynamics and ion-binding response are subject to limitations from conformational sampling and system size. In contrast, molecular mechanics models that do not describe many body effects explicitly can technically get past sampling/system-size issues, but suffer severely from accuracy. Polarizable models are being developed as a compromise between accuracy and efficiency, but are they sufficiently reliable to derive causalities? In general, where do we stand in terms of being able to use molecular simulations to understand selective ion binding to biomolecules, and the response of ion binding to biomolecular function? Here I’ll discuss these issues and potential solutions in the context of our work on potassium channels that excel at transporting K<sup>+</sup> ions across cell membranes, while at the same time discriminating K<sup>+</sup> from the slightly smaller Na<sup>+</sup> ions.</p>', 'draft', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 38, 'NULL', '2018-04-12 04:03:49', '2030-12-01 18:30:00'),
(500, 'April 20, 2018 at 2.30 pm in AG-66', 'Title :\nPeptide Ligand G Protein-Coupled Receptors are Dynamic Molecules in Lipid Membrane\nAbstract', '<h3>Title</h3>\n<h3>Peptide Ligand G Protein-Coupled Receptors <span style=\"font-size: 12.16px;\">are Dynamic Molecules in Lipid Membrane</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"font-size: 11.0pt;\" lang=\"EN-US\">G protein-coupled receptors (GPCRs) constitute a large group of membrane proteins, known to undergo a set of well-defined structural transitions upon activation and signaling. In our work, we address the molecular dynamics of peptide ligand GPCRs using solution and solid-state NMR. We work with human class A GPCRs that are activated by peptide hormones, such as neuropeptide Y (NPY) or ghrelin. The GPCRs are expressed in prokaryotic systems or by cell-free synthesis. In the talk, results on three research topics will be discussed. (<em>i</em>) Studies on the equilibrium dynamics of GPCRs using static <sup>15</sup>N CP NMR, <sup>15</sup>N NMR spectra acquired as a function of the CP contact time, and <sup>13</sup>C MAS NMR experiments confirm the high molecular dynamics of three peptide ligand GPCRs. Quantitative determination of <sup>1</sup>H-<sup>13</sup>C order parameters through measurement of the <sup>1</sup>H-<sup>13</sup>C dipolar couplings in separated local field NMR experiments revealed axially symmetric motions of the GPCRs and molecular fluctuations of large amplitude [1, 2]. (<em>ii</em>) </span><span style=\"font-size: 11.0pt; mso-ansi-language: EN-GB;\" lang=\"EN-GB\">Data will be reported that led to the development of structural models of NPY bound to the Y<sub>1</sub> and the </span><span style=\"font-size: 11.0pt;\" lang=\"EN-US\">Y<sub>2</sub> receptors</span><span style=\"font-size: 11.0pt; mso-ansi-language: EN-GB;\" lang=\"EN-GB\">. </span><span style=\"font-size: 11.0pt;\" lang=\"EN-US\">Isotope-labeled NPY was used to determine the secondary structure of the receptor bound ligand. Upon receptor binding, the C-terminal α‑helix of NPY, formed in membrane environment in the absence of receptor, is unwound starting at Thr<sup>32</sup> to make optimal contact of the C‑terminal residues within the binding pocket. The NMR signals of several hydrophobic residues in the α-helical region of NPY were broadened upon receptor binding. The ligands are tethered to the second extracellular loop by hydrophobic contacts, with the N-terminal part of its helix facing the solvent. The C‑terminal pentapeptide of NPY inserts deeply into the transmembrane bundle, making optimal contacts to the Y<sub>2</sub> receptor including a contact NPY’s amidated C‑terminus with Gln<sup>3.32</sup> in a polar cluster within helices 2 and 3 of the receptor [3, 4]. (<em>iii</em>) We will report data on the dynamics and ligand binding of the human GHS receptor, which plays a key role in the development of obesity [5]. </span></p>\n<p class=\"MsoNormal\"><span style=\"font-size: 11.0pt;\" lang=\"EN-US\"> </span></p>\n<p class=\"References\"><span style=\"font-size: 11.0pt; font-family: \'Times New Roman\',\'serif\'; mso-ansi-language: DE;\" lang=\"DE\">[1]</span><span style=\"font-size: 11.0pt; font-family: \'Times New Roman\',\'serif\'; mso-ansi-language: DE;\" lang=\"DE\">Schmidt et al. <em>Chemistry</em> <strong>2014</strong>, 20, 4986.</span></p>\n<p class=\"References\"><span style=\"font-size: 11.0pt; font-family: \'Times New Roman\',\'serif\'; mso-ansi-language: DE;\" lang=\"DE\">[2] Thomas et al. <em>J. Biomol. NMR</em> <strong>2015</strong>, 61, 347.</span></p>\n<p class=\"References\"><span style=\"font-size: 11.0pt; font-family: \'Times New Roman\',\'serif\'; mso-ansi-language: DE;\" lang=\"DE\">[3] Kaiser et al. <em>Angew. </em></span><em><span style=\"font-size: 11.0pt; font-family: \'Times New Roman\',\'serif\'; mso-ansi-language: EN-US;\" lang=\"EN-US\">Chem. Int. Ed.</span></em><span style=\"font-size: 11.0pt; font-family: \'Times New Roman\',\'serif\'; mso-ansi-language: EN-US;\" lang=\"EN-US\"> <strong>2015</strong>, 52, </span><span style=\"font-size: 11.0pt; font-family: \'Times New Roman\',\'serif\';\" lang=\"FR\">7446.</span></p>\n<p class=\"References\"><span style=\"font-size: 11.0pt; font-family: \'Times New Roman\',\'serif\';\" lang=\"FR\">[4] </span><span style=\"font-size: 11.0pt; font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Batang;\" lang=\"FR\">Yang et al. <em>Nature</em> <strong>2018</strong>, DOI: 10.1038/s41586-018-0046-x, <em>in press</em>.</span></p>\n<p> </p>\n<p class=\"References\"><span style=\"font-size: 11.0pt; font-family: \'Times New Roman\',\'serif\';\" lang=\"FR\">[5] Schrottke et al. </span><em><span style=\"font-size: 11.0pt; font-family: \'Times New Roman\',\'serif\'; mso-ansi-language: EN-US;\" lang=\"EN-US\">Sci. Rep.</span></em><span style=\"font-size: 11.0pt; font-family: \'Times New Roman\',\'serif\'; mso-ansi-language: EN-US;\" lang=\"EN-US\"> <strong>2017</strong>, 7, 46128.</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1536, 'NULL', '2018-04-17 22:22:39', '2018-04-18 00:23:33'),
(501, 'April 23, 2018 at 4.00 pm in AG-69', 'Title :\nOptical Charge Transfer Transitions Associated with Charged Amino Acids: Creating a Spectra', '<h3>Title</h3>\n<h3>Optical Charge Transfer Transitions Associated with Charged Amino Acids: Creating a <span style=\"font-size: 12.16px;\">Spectral Basis Set to Interpret ProCharTS</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1551, 'NULL', '2018-04-17 22:24:13', '2018-04-17 22:30:06'),
(502, 'April 26, 2018 at 2.30 pm in D-406', 'Title :\nMethane transformation to higher oxygenates over nanostructured catalysts\nAbstract :\nIncreas', '<h3>Title</h3>\n<h3>Methane transformation to higher oxygenates over nanostructured catalysts</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Increasing methane reserves in terms of natural gas, biogas, and shell gas explore its utilization as a solution to future energy security and environment safety. Therefore, methane value addition to higher chemicals get researchers interest in the present scenario.  The direct route is restricted due to low conversion as well low selectivity; hence, indirect route, i.e., via syngas is preferred by industries.</p>\n<p><span style=\"font-size: 12.16px;\">The focus of my talk will be on the effect of various parameters, like noble metal, surface acidity basicity, promotion with another transition metal in a bimetallic system to improve the activity and durability of methane reforming catalyst and the way to regulate ethanol selectivity in CO hydrogenation. </span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1414, 'NULL', '2018-04-20 05:16:55', '2030-12-01 18:30:00'),
(503, 'May1, 2018 at 2.30 pm in AG-80', 'Title :\nDendritic Fibrous Nanosilica Coated Titanium Dioxide for Morphology Controlled Photocatalysi', '<h3>Title</h3>\n<h3>Dendritic Fibrous Nanosilica Coated Titanium Dioxide for Morphology Controlled Photocatalysis</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1746, 'NULL', '2018-04-20 05:29:33', '2030-12-01 18:30:00'),
(504, 'April 30, 2018 at 4.00 pm in AG-69', 'Title :\nIdentifying key interactions that maintain flexibility of a protein', '<h3>Title</h3>\n<h3>Identifying key interactions that maintain flexibility of a protein</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1459, 'NULL', '2018-04-23 23:38:03', '2030-12-01 18:30:00'),
(505, 'May 2, 2018 at 2.30 pm in AG-69', 'Title :\nViscoelastic response of Liquid at Nanoconfinement\nAbstract :\n \nFlow properties of confined', '<h3>Title</h3>\n<h3>Viscoelastic response of Liquid at Nanoconfinement</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p> </p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify;\"><span style=\"font-family: \'Times New Roman\',\'serif\';\" lang=\"EN-US\">Flow properties of confined liquids play crucial roles in a wide range of areas from biology to nanofluidics. Liquids, when confined between two surfaces that are tens of nanometers apart, exhibit unique structural, dynamic, and mechanical properties, which are significantly different from those observed in bulk. In the past, viscosity measurement of confined liquids by different techniques has resulted in contradictory findings.<span style=\"background: white;\"> We have developed an experimental scheme, which has two key advantages over<span style=\"mso-spacerun: yes;\">  </span>previous techniques used to measure shear-viscosity for liquid films with thickness of few nanometers; (i) the spring measuring the viscous drag has very high stiffness (55000 N/m), and yet force sensitivity of few nN, thus reducing the thermal noise in our measurement. (ii) the force sensing spring stays out of the liquid, and hence has a high resonance frequency and quality factor, allowing us to perform off-resonance measurements with high shear frequency (5-20 kHz) and shear rates (</span>10<sup>4</sup>- 10<sup>6</sup> s<sup>-1</sup><span style=\"background: white;\">). </span>Using this novel shear rheometer, w<span style=\"background: white;\">e investigated the role of confinement and substrate wettability on flow properties of polar (water) and non-polar (organic) liquids on several surfaces. We observed reduction in dissipation coefficient under confinement; which is modeled with Carreau-Yasuda model of shear thinning including finite slippage. We found </span>that for purely wetting substrate the nonlinear rheological response solely originates due to nano-confinement, whereas both wettability and confinement play crucial role in case of non-wetting substrates. Finite Element Method (FEM) simulations were performed to understand the behavior of two prongs of our force sensor (tuning fork) at off resonance frequency in air and in liquid medium. Our study helps to separate out the effects of substrate wettability and confinement on shear resistance experienced by liquids at nano-confinement. The rheological response of nano-confined liquids is intriguing and we propose that it is result of criticality with respect to degree of confinement.<span style=\"mso-spacerun: yes;\">  </span><span style=\"mso-spacerun: yes;\">   </span></span></p>\n<p> </p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1512, 'NULL', '2018-04-25 04:06:19', '2030-12-01 18:30:00'),
(506, 'May 7, 2018 at 4.00 pm in AG-69', 'Title :\nBeyond the Conventional Hybrid Perovskites', '<h3>Title</h3>\n<h3>Beyond the Conventional Hybrid Perovskites</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1395, 'NULL', '2018-04-30 22:11:19', '2030-12-01 18:30:00'),
(507, 'May 21, 2018, at 4.00 pm in AG-69', 'Title :\nComparative study of Native and Hybrid-enzymes: Preparation, Characterization and Reactivity', '<h3>Title</h3>\n<h3>Comparative study of Native and Hybrid-enzymes: Preparation, Characterization and Reactivity</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1519, 'NULL', '2018-05-16 02:36:52', '2030-12-01 18:30:00'),
(508, 'May 24, 2018 at 2.30 pm in NMR Seminar Room', 'Title :\nRevisiting the BIM-Trimethylamine and BIM-Ammonia H-Bonded Complexes', '<h3>Title</h3>\n<h3>Revisiting the BIM-Trimethylamine and BIM-Ammonia H-Bonded Complexes</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1746, 'NULL', '2018-05-21 05:27:32', '2030-12-01 18:30:00'),
(509, 'May 28, 2018 at 4.00 pm in AG-69', 'Title :\nDisordered Proteins: Spontaneous Fluctuations, Membrane Interactions and Toxicity', '<h3>Title</h3>\n<h3>Disordered Proteins: Spontaneous Fluctuations, Membrane Interactions and Toxicity</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1736, 'NULL', '2018-05-21 22:21:04', '2030-12-01 18:30:00'),
(510, 'May 29, 2018 at 2.30 pm in AG-69', 'Title :\nHot Spot Engineering in Gold-DFNS  Plasmonic Nanostructures: Synthesis and Applications as ', '<h3>Title</h3>\n<h3>Hot Spot Engineering in Gold-DFNS  Plasmonic Nanostructures: Synthesis and Applications as Nano-Heaters</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1433, 'NULL', '2018-05-23 01:34:46', '2030-12-01 18:30:00'),
(511, 'June 5, 2018 at 2.30 pm in AG-80', 'Title :\nApplications of coherent Raman scattering microscopy in bioimaging\nAbstract :\nMuch progress ', '<h3>Title</h3>\n<h3>Applications of coherent Raman scattering microscopy in bioimaging</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Much progress in biology and allied sciences is driven by optical microscopy methods. Techniques involving extraneous labels (e.g. fluorescent molecules) with affinity to one or more sample components are widely used, with some implementations even breaching the diffraction limit. Other than the fact that the introduction of these labels changes sample chemistry, availability of suitable labels, issues of photobleaching, and phototoxicity can limit the applicability of these methods.</p>\n<p style=\"text-align: justify;\">Spectroscopy techniques, which rely on energy-level transitions of various molecular species in the sample are chemically specific, sensitive, and label-free. Coherent Raman scattering (CRS), namely coherent anti-Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS) have been applied in bioimaging, with short acquisition times and promising results.</p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In this talk, I will discuss my research at Cardiff University (PhD) and KU Leuven, where I used CARS and SRS microscopy to image biological samples. Using volumetric hyperspectral CARS microscopy [1-3], I studied mitosis in human osteosarcoma (U-2OS) cells, revealing the sub-cellular distribution of various biomolecules. As an outlook to pharmacodynamical studies, I imaged the effects of two anti-cancer drugs in single cells. In addition to these, I will also show some results from an exploratory application of CARS to 3D tissue cultures- organoids. Not only a proof of principle, this work has revealed interesting information previously unresolved with CRS. </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">As a classic example of how fluorescent molecules are not always the best choice for bioimaging, I will present results of SRS imaging of lipids in desert locust (Schistocerca gregaria) oocytes which do not stain efficiently using conventional methods.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">When applied to statistically significant sample sizes, the methods demonstrated in this research could establish CARS and SRS as novel and extremely useful tools in biomedical/biochemical research. </span></p>\n<p> </p>\n<p>References</p>\n<p>1.Pope I, Langbein W, Watson P, Borri P, Optics Express 21, 7096 (2013)</p>\n<p>2.Masia F, Glen A, Stephens P, Borri P, Langbein W, Anal. Chem. 85, 10820 (2013)</p>\n<p>3.Karuna A, Masia F, Borri P, Langbein W, Journ. Raman Spec. 47, 1167 (2016)</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1430, 'NULL', '2018-06-04 01:54:18', '2030-12-01 18:30:00'),
(512, 'June 11, 2018 at 4.00 pm in AG-69', 'Title :\nCarbon-Fixation by Plasmonic Catalysts\nAbstract :\nMimicking plant photosynthesis requires a ', '<p>Title :</p>\n<p>Carbon-Fixation by Plasmonic Catalysts</p>\n<p>Abstract :</p>\n<p style=\"text-align: justify;\">Mimicking plant photosynthesis requires a synthetic photocatalyst that absorbs sunlight and uses that energy efficiently to convert CO<sub>2</sub> into energy-dense hydrocarbons. My talk will make the case that noble metal nanostructures, which exhibit collective free electron resonances called plasmons, may be well-suited to this task. Not only do plasmonic nanoparticles of Au, Ag, and Cu offer a means to absorb visible light efficiently, their strong-light-matter interaction can be paired with their ability to activate small molecules, such as CO<sub>2</sub>. We have had preliminary success with plasmonic catalysts, which under visible-light-excitation, can drive kinetically challenging multi-electron multi-proton processes such as methane generation. Moreover, the product selectivity is controllable by the nature of the exciting light, which suggests that a novel phenomenon is at work. In order to understand the light-driven pathway for CO<sub>2</sub> reduction, we have probed with single-site spatial resolution the dynamics of a plasmonic photocatalyst under operando conditions. From captured intermediates and density functional theory simulations, we are beginning to understand the mechanism which plasmonic excitation activates physisorbed CO<sub>2</sub>. It is clear that a close interplay between photoexcited states and surfaces is involved in this scheme of artificial photosynthesis. </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1433, 'NULL', '2018-06-08 05:10:53', '2030-12-01 18:30:00');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(513, 'June 22, 2018 at 2.30 pm in AG-69', 'Title :\nSwitching On and Off of Interfacial Water Ordering at Air/Water Interface\nAbstract :\nCarbon ', '<h3>Title</h3>\n<h3>Switching On and Off of Interfacial Water Ordering at Air/Water Interface</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Carbon quantum dots (CQDs) are recently famed and well developed class of fluorescent probe and have shown tremendous potential in numerous fields such as biosensing, bioimaging, drug delivery, and optoelectronics. After its accidental discovery, it has created huge excitement due to their unique features like chemical inertness, high water solubility, excellent biocompatibility, resistance to photo bleaching. Mostly it has been extensively studied to exploit its fluorescence properties through displacement assay for various applications by using conventional fluorescence spectroscopy. Fluorescence spectroscopy does not provide any information directly related to the structural changes of the system or its impact on the surrounding aqueous medium during displacement assay process. In my talk, I will provide a thorough discussion about our recent work on interfacial activities of carbon quantum dots and its impact on perturbing the pristine hydrogen bonding network of interfacial water structure at air/water interface. We have used surface specific and chemically sensitive sum frequency generation (SFG) vibrational spectroscopy to probe the air/water interface with the presence of QCDs and various metal ions. SFG is a nonlinear optical spectroscopic tool based on second order nonlinear optical process. It is quite fascinating to observe the role of various intermolecular interactions in terms of hydrogen bonding, electrostatic interaction during the process of interaction of the QCDs with various metal ions at the air/aqueous interface. I will also extend my discussion about the physics of surface protein unfolding and its kinetics through diffusion and intermolecular interactions at a neutral air/water interface.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1405, 'NULL', '2018-06-10 20:20:46', '2018-06-19 00:34:37'),
(514, 'June 18, 2018 at 4.00 pm in AG-69', 'Title :\nDesigning Optical Probes for Sensing Signaling Lipids', '<h3>Title</h3>\n<h3>Designing Optical Probes for Sensing Signaling Lipids</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1423, 'NULL', '2018-06-17 22:26:15', '2030-12-01 18:30:00'),
(515, 'June 25, 2018 at 4.00 pm in AG-69', 'Title :\nDevelopment of metal oxide based photocatalysts for the CO2 reduction to fuel\nAbstract :\n \n', '<h3>Title</h3>\n<h3>Development of metal oxide based photocatalysts for the CO<sub>2</sub> reduction to fuel</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p> </p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\">Continuous depletion of fossil fuel resources and growing environmental concerns due to the huge CO<sub>2</sub> emissions, have focused the need to develop renewable and clean energy resources. CO<sub>2</sub> is a major greenhouse gas and cause of global warming. CO<sub>2</sub> capture, storage and utilization particularly, catalytic conversions of CO<sub>2</sub> to fuels and chemicals have attracted much attention in recent years.  Activation of CO<sub>2</sub> requires high amount of energy due to its stability. Harvesting the photon energy and its storage in the form of fuels hold promise to address the current and future demand of energy supply. The photocatalytic conversion of CO<sub>2</sub> over heterogeneous photocatalysts is a potential approach to mitigate CO<sub>2</sub>.</p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"> </p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\">Designing of material with suitable band gap and product selectivity remained key challenges. Problems associated are: (i) massive recombination of generated charge carriers and (ii) low yield and less selectivity for product formation and (iii) development of stable visible light active catalyst. Metal oxides with suitable properties can convert solar energy to chemical energy using artificial photosynthesis and it will be a good technique to develop sustainable environment.</p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"> </p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\">The talk will cover my work on designing and synthesis of metal oxide catalysts for the photocatalytic reduction of CO<sub>2</sub> to fuel. </p>\n<p style=\"text-align: justify;\"> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1445, 'NULL', '2018-06-19 00:25:07', '2030-12-01 18:30:00'),
(516, 'June 25, 2018 at 4.45 pm in AG-69', 'Title :\nInvestigations on photocatalytic H2 generation using modified TiO2 and g-C3N4 semiconductors', '<h3>Title</h3>\n<h3>Investigations on photocatalytic H<sub>2</sub> generation using modified TiO<sub>2</sub> and g-C<sub>3</sub>N<sub>4</sub> semiconductors</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Generation of hydrogen from renewable sources like water and solar energy is considered to be an attractive and viable solution for replacing fossil fuels. Photocatalytic water splitting has attracted much attention as it involves conversion of solar energy into useful chemical energy. The major challenge involved in the process is the development of stable and visible light active photocatalyst with required solar to fuel energy conversion efficiency (SFE). In the present work, studies were undertaken to improvise the optical and photocatalytic properties of several photocatalysts; conventionally known UV active TiO<sub>2</sub> and novel organic semiconductor, graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>). Various strategies such as cationic doping by Cu in TiO<sub>2</sub>, composite formation with NiO and CuO inducing pn heterojunctions, carbon and TiO<sub>2</sub> heterojunction to improve electronic conductivity, surface modification of g-C<sub>3</sub>N<sub>4</sub> by dispersing carbon nanodots (CND) and noble metal (Pt, Pd, Cu, Ag and Au) were adopted to limit the e<sup>-</sup>/h<sup>+</sup> recombination reaction and to enhance the photoresponse under visible light illumination. All samples were thoroughly characterized by relevant techniques and their potential for H<sub>2</sub> generation was evaluated under sunlight and UV-visible light in presence of sacrificial reagent. Density functional theory calculations were performed and life time of e<sup>-</sup>/h<sup>+</sup> from PL decay curves was measured to support the activity trend. Parameters such as illumination area, catalyst concentration, form of catalyst (powder/films) and different sacrificial reagents were optimized for maximum H<sub>2</sub> yield. Performance of the screened photocatalysts was also tested in up-scaled photoreactors (volume = 0.5, 1 and 2 L). H<sub>2</sub> yield @ 16 ml/h/g with apparent quantum efficiency (AQE) of 7.5 % and SFE of 3.9 % over Cu<sub>0.02</sub>Ti<sub>0.98</sub>O<sub>2-δ</sub> (without cocatalyst) was observed under sunlight suggesting that 0.96 m<sup>2</sup> illumination area will yield H<sub>2</sub> @ 1 L/h photocatalytically. Among modified g-C<sub>3</sub>N<sub>4</sub> photocatalysts, maximum H<sub>2</sub> yield of 398 μmol/h over 80 mg of Pt/CND/ g-C<sub>3</sub>N<sub>4</sub> (0.48 wt %) under sunlight with AQE of 4.0 % and SFE of 2.0 % was achieved as compared to almost negligible yield over pristine carbon nitride. The present study is targeted to provide valuable inputs for actual large scale solar photocatalytic H<sub>2</sub> production.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1768, 'NULL', '2018-06-19 00:34:04', '2030-12-01 18:30:00'),
(517, 'July 9, 2018 at 4.00 pm in AG-69', 'Title :\nWhen Nano Break H2O\nAbstract :\nWhile H2O (water) is life to all living organisms on earth, i', '<h3>Title</h3>\n<h3>When Nano Break H<sub>2</sub>O</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">While H<sub>2</sub>O (water) is life to all living organisms on earth, it is also one of the key technological components of hydrogen economy. In an electrolysis cell, water can be decomposed into hydrogen and oxygen due to an electric current passing through it. Although hydrogen evolution reaction (HER) is the major reaction of interest, oxygen evolution reaction (OER) is the most energy intensive step. To overcome the activation barrier of splitting water, a catalyst is needed. The more active and stable the catalyst, more effective is the splitting. One of our major research interests is to develop nanoheterostructured electrocatalysts for OER and HER,<sup>1,2</sup> thereby leading to overall water splitting.<sup>3</sup> The best performances are obtained not only by designing a suitable catalyst but also by optimizing the substrate on which the catalyst nanoparticles are supported, among which flexible substrates are fascinating.<sup>4</sup> When the electrolyzer is integrated to solar cells, water photolysis with high solar-to-hydrogen efficiency also becomes possible.</p>\n<p> </p>\n<p>References :</p>\n<p> </p>\n<p>1.Datta, A.; Kapri, S.; Bhattacharyya, S. J. Mater. Chem. A 2016, 4, 14614-14624.</p>\n<p>2.Debnath, B.; Kumar, A.; Salunke, H. G.; Bhattacharyya, S. J. Phys. Chem. C 2017, 121, 25594-25602.</p>\n<p>3.Kumar, A.; Bhattacharyya, S. ACS Appl. Mater. Interfaces 2017, 9, 41906-41915.</p>\n<p> </p>\n<p>4.Sahasrabudhe, A.; Dixit, H.; Majee, R.; Bhattacharyya, S. Nat. Commun. 2018, 9, 2014.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1862, 'NULL', '2018-07-03 03:37:29', '2030-12-01 18:30:00'),
(518, 'July 10, 2018 at 2.30 pm in AG-69', 'Title :\nBioinorganic Chemistry Approach to Nanozymes for Cellular Redox Regulation\nAbstract :\nOrgani', '<p><strong>Title :</strong></p>\n<h3>Bioinorganic Chemistry Approach to Nanozymes for Cellular Redox Regulation</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">Organic/metal organic compounds that mimic the functional role of enzymes have been extensively investigated. Recently, few nanomaterials such as gold nanoparticles, ferromagnetic nanoparticles and graphene-based materials have been innovatively shown to exhibit unprecedented biochemical catalysis by mimicking certain enzymes (nanozymes). Owing to their simplicity of preparation and storage and stability, nanozymes have been investigated for their application in many fields such as biosensing, immunoassays, cancer diagnostic, therapeutic and pollutant removal, etc. Despite current interest on nanozymes, tackling with some of the difficulties associated with them such as selectivity, cooperativity with other enzymes, limited surface area due to functionalization, biocompatibility and activity in cells, etc. is a challenging task. </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">In this seminar, I will discuss about the novel antioxidant and phosophotriesterase nanozymes. We have recently reported the graphene-hemin hybrid material for its remarkable peroxynitrite reductase and isomerase antioxidant activities. Noncovalent interactions of hemin and reduced graphene oxide (RGO) resulted in synergistic activity to effectively scavenge peroxynitrite, which is a potent reactive nitrogen species (RNS) found <em>in vivo</em>.</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">In another related study, we found that vanadium pentoxide (V<sub>2</sub>O<sub>5</sub>), an oxidant, reveals an unexpected antioxidant role in its nano-form and exerts tremendous cytoprotective effects. The vanadia nanozyme exhibit excellent glutathione peroxidase (GPx)-like catalytic antioxidant activity and prevents oxidative damage to cells from reactive oxygen species (ROS) without affecting the expression level of other antioxidant enzymes. This work demonstrates the first experimental evidence that the biological property of a metal ion in its nano-form can be completely different from that of a bulk material. In a similar line, I will also briefly highlight about MnFe<sub>2</sub>O<sub>4</sub> nanooctahedrons as oxidase and vacancy-engineered nanoceria as phosphotriesterase nanozymes for antibody-free detection of major biomarkers of oxidative stress and detoxification of sarin gas-related nerve agents, respectively. </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><strong><span lang=\"EN-US\">References:</span></strong></p>\n<p class=\"MsoListParagraphCxSpFirst\" style=\"margin-top: 0cm; margin-right: 0cm; margin-bottom: .0001pt; margin-left: 18.0pt; mso-add-space: auto; text-align: justify; text-indent: -18.0pt; line-height: normal; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span style=\"font-size: 10.0pt; mso-bidi-font-family: Calibri;\" lang=\"EN-US\">1.<span style=\"font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: \'Times New Roman\';\">       </span></span><!--[endif]--><span style=\"font-size: 10.0pt;\" lang=\"EN-US\">A. A. Vernekar, G. Mugesh, <em>Chem. Eur. J.</em> <strong>2012</strong>, <em>18</em>, 15122-15132.</span></p>\n<p class=\"MsoListParagraphCxSpMiddle\" style=\"margin-top: 0cm; margin-right: 0cm; margin-bottom: .0001pt; margin-left: 18.0pt; mso-add-space: auto; text-align: justify; text-indent: -18.0pt; line-height: normal; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span style=\"font-size: 10.0pt; mso-bidi-font-family: Calibri;\" lang=\"EN-US\">2.<span style=\"font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: \'Times New Roman\';\">       </span></span><!--[endif]--><span style=\"font-size: 10.0pt;\" lang=\"EN-US\">A. A. Vernekar, G. Mugesh, <em>Chem. Eur. J.</em> <strong>2013</strong>, <em>19</em>, 16699-16706.</span></p>\n<p class=\"MsoListParagraphCxSpMiddle\" style=\"margin-top: 0cm; margin-right: 0cm; margin-bottom: .0001pt; margin-left: 18.0pt; mso-add-space: auto; text-align: justify; text-indent: -18.0pt; line-height: normal; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span style=\"font-size: 10.0pt; mso-bidi-font-family: Calibri;\" lang=\"EN-US\">3.<span style=\"font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: \'Times New Roman\';\">       </span></span><!--[endif]--><span style=\"font-size: 10.0pt;\" lang=\"EN-US\">A. A. Vernekar, D. Sinha, S. Srivastava, U. P. Prasath, P. D’Silva, G. Mugesh, <em>Nature Commun.</em> <strong>2014</strong>, <em>5</em>, 5301.</span></p>\n<p class=\"MsoListParagraphCxSpLast\" style=\"margin-top: 0cm; margin-right: 0cm; margin-bottom: .0001pt; margin-left: 18.0pt; mso-add-space: auto; text-align: justify; text-indent: -18.0pt; line-height: normal; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span style=\"font-size: 10.0pt; mso-bidi-font-family: Calibri;\" lang=\"EN-US\">4.<span style=\"font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: \'Times New Roman\';\">       </span></span><!--[endif]--><span style=\"font-size: 10.0pt;\" lang=\"EN-US\">A. A. Vernekar, T. Das, S. Ghosh, G. Mugesh, <em>Chem. Asian J.</em> <strong>2016</strong>, <em>11</em>, 72-76.</span></p>\n<p><span style=\"font-size: 12.16px;\">5.    A. A. Vernekar, T. Das, G. Mugesh, </span><em style=\"text-indent: -18pt; font-family: \'Times New Roman\', serif; font-size: 10pt;\">Angew. Chem. Int. Ed.</em><strong style=\"text-indent: -18pt; font-family: \'Times New Roman\', serif; font-size: 10pt;\">2016</strong><span style=\"text-indent: -18pt; font-family: \'Times New Roman\', serif; font-size: 10pt;\">, </span><em style=\"text-indent: -18pt; font-family: \'Times New Roman\', serif; font-size: 10pt;\">55</em><span style=\"text-indent: -18pt; font-family: \'Times New Roman\', serif; font-size: 10pt;\">, 1412-1416.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1393, 'NULL', '2018-07-03 03:47:40', '2030-12-01 18:30:00'),
(519, 'July 11, 2018 at 2.30 pm in AG-69', 'Title :\nPlant Viruses for the Delivery of Platinum Anticancer Therapeutics\nAbstract :\nPlatinum-based', '<h3>Title</h3>\n<h3>Plant Viruses for the Delivery of Platinum Anticancer Therapeutics</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Platinum-based anticancer drugs such as cisplatin, carboplatin, and oxaliplatin are used in the treatment of nearly half of the population of the cancer patients undergoing chemotherapy. These drugs, however, lack selectivity and have dose-limiting toxicities, low bio-availability, rapid clearance from the body, and may encounter drug resistance mechanisms, leading to the recurrence of the cancer. Therefore, efficient loading of drugs in novel delivery agents has the potential to substantially improve therapy by directly targeting the diseased tissue and avoiding unwanted side effects.  Given that the development of new drugs is expensive, reducing toxicity caused by existing drugs by packaging them into delivery vehicles is attractive and can be achieved by controlled and targeted methodologies. Although presently available nano-sized delivery agents impart safety, their limited efficacy and inability to penetrate tissue adequately are some of the limitations. Consequently, development of new drug delivery methods has been a subject of recent burgeoning interest.</p>\n<p> </p>\n<p>Viruses are very simple in structure and composition, and they can be considered as biology-derived nanocarriers, naturally evolved to carry and delivery cargos to target cells. Moreover, they can transfect host cells with a very high efficiency. However, their immunogenic nature hinders their development as drug carriers. In this regard, plant viruses form an emerging platform technology as they offer several advantages over mammalian vectors.</p>\n<p>In this talk, I will highlight the use of tobacco mosaic virus (TMV) for the delivery of platinum anticancer therapeutics. It has been shown previously by our research group that the highly potent analogues of cisplatin, phenanthriplatin (1) and its aqua-form (2), are differentially taken up in the TMV channel. Whereas ~1000 molecules of 1 are loaded in TMV, 2 is taken up in higher quantities (~2000 molecules per TMV particle). Studies on delineating the mechanism of their differential uptake and their stabilization in the TMV channel will be discussed in detail. Furthermore, I will also discuss on the heat-transition of TMV nanorods to nanospheres (SNPs) in the presence of 1, which leads to significant uptake of 1 in the bulk of SNPs, and their mechanism of formation. These SNPs are stable in the fetal bovine serum (FBS) medium and they do not release 1 at pH 7.4 and pH 5, which may further prevent the toxicity arising due to off-target release of drugs. To an added advantage, the release of 1 is only triggered by proteolytic enzyme like trypsin which is a constituent of endosome. SNP delivery system presents a comparable to better anticancer efficacy in the panel of cancer cell lines. These investigations inform the design of future drug analogues that can be efficiently encapsulated, stabilized in different morphologies of TMV, and delivered to the tumor site.</p>\n<p> </p>\n<p>References</p>\n<p>1.A. E. Czapar, Y. Zheng, I. A. Riddel, S. Shukla, S. G. Awuah, S. J. Lippard, N. F. Steinmetz, ACS Nano, 2016, 10, 4119-4126.</p>\n<p>2.A. A. Vernekar, G. Berger, A. E. Czapar, F. A. Veliz, D. Wang, N. F. Steinmetz, S. J. Lippard, J. Am. Chem. Soc., 2018, 140, 4279-4287.</p>\n<p>3.A. A. Vernekar, F. A. Veliz, N. F. Steinmetz, S. J. Lippard, (SNP work will be submitted soon).</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1467, 'NULL', '2018-07-03 04:09:39', '2030-12-01 18:30:00'),
(520, 'July 17, 2018 at 2.30 pm in AG-69', 'Title :\nCharge transport at Electrode|Molecule interface: From Molecular Electronics to Energy Resea', '<h3>Title</h3>\n<h3>Charge transport at Electrode|Molecule interface: From Molecular Electronics to Energy Research Applications</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">The idea of building electronic devices using single molecule as an active component was first proposed by Aviram and Ratner in the early seventies.<sup>1</sup> Indeed, molecules are of great interest for application in electronic devices because of their small size, recognition properties, ability of self-organization, possibility of chemical modification and customisation. Thus, the ability to measure and control charge transport across metal|molecule|metal junction is of considerable fundamental interest and represents a key step towards the development of molecular electronic and spintronics devices.<sup>2-6</sup></span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">In addition to the applications in molecular electronics and spintronics research, studying charge or electron transport properties at metal|molecule interfaces under the influence of external stimuli like light, temperature, electrochemical potential or magnetic field will have a variety of applications in other research fields like (i) energy research (for example, solar cells, where the charge or electron transfer at metal|molecule interfaces plays a crucial role in determining the efficiency of the solar cell); (ii) photocatalysis and electrocatalysis (activity of a catalyst depends on the effective charge transport at electrode|catalyst interface); (iii) Sensors (sensitivity and selectivity of a sensor may depend on the effective charge transport at electrode|sensor moiety interface) and etc.<sup>5,7</sup></span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">In the first part of my presentation, I will introduce working principle of measurement techniques (i.e STM break junctions (STM-BJ), mechanically controllable break junction (MCBJ) and conducting probe AFM (CP-AFM) techniques) and data analysis procedures used to extract conductance properties of molecular junctions.<sup>2</sup> Using the results from several case studies, I will try to demonstrate a frame work for building structure-property correlations of metal|molecule|metal junctions at single and multi-molecular level.<sup>2-6</sup> In the later part of my presentation, I will discuss the molecular conductance measurement results which will have direct consequences in electrocatalysis and energy researh.<sup>3,5,7</sup></span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"text-decoration: underline;\"><span lang=\"EN-US\">References</span></span><span lang=\"EN-US\">:</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">1. Aviram, A.,Ratner, M., Chem. Phys. Lett. 1974, 29, 277.</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">2. Kaliginedi et al., Journal of American chemical society. 2012, 134, 5262–5275.</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">3. Rudnev, A., Kaliginedi et al., Science Advances. 2017, 3, e1602297.</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">4. Seth, C., Kaliginedi et al., Chemical Science. 2017, 8, 1576-1591.</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">5. Atesci, H., Kaliginedi et al., Nature Nanotechnology. 2018, 13, 117.</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">6. Kaliginedi et al., PCCP. 2015, 16, 23529.</span></p>\n<p><span style=\"font-size: 10.0pt; font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\" lang=\"EN-US\">7. Kaliginedi et al., Nanoscale. 2015, 7, 17685.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1363, 'NULL', '2018-07-03 22:28:47', '2030-12-01 18:30:00'),
(521, 'July 18, 2018 at 2.30 pm in AG-69', 'Title :\nCharge Transport and Catalysis Reactions at the Electrified Interfaces\nAbstract :\nPossibilit', '<h3>Title</h3>\n<h3>Charge Transport and Catalysis Reactions at the Electrified Interfaces</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">Possibility of studying the properties of molecules or nanostructures at single enity level offers huge opportunities to tune structure property relationships at nanoscale. The problem with current state-of-the-art nanomaterials and energy research involving charge or electron transport at electrode|molecule interface as a key process is centered in the fact that no single experimental technique can independently provide complete information on nanoscale structure-property relationships. The development of fast, cost effective and structure sensitive characterization methods at single entity level is the target of much current nanotechnology research. </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">During this presentation, I will try to show the experimental framework (experimental technique and methodologies development) that I am planning to implement/develop in my future laboratory to address the key issue of nanoscale structure-property relationships under in-operando conditions.<sup>1-4</sup></span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"text-decoration: underline;\"><span lang=\"EN-US\">References</span></span><span lang=\"EN-US\">:</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">1. Kaliginedi et al., Nanoscale. 2015, 7 (42), 17685-17692.</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">2. Rudnev, A., Kaliginedi et al., Science Advances. 2017, 3, e1602297.</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">3. Seth, C., Kaliginedi et al., Chemical Science. 2017, 8, 1576-1591.</span></p>\n<p><span style=\"font-size: 10.0pt; font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\" lang=\"EN-US\">4. Atesci, H., Kaliginedi et al., Nature Nanotechnology. 2018, 13, 117.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1477, 'NULL', '2018-07-03 22:31:10', '2030-12-01 18:30:00'),
(522, 'July 16, 2018 at 4.00 pm in AG-69', 'Title :\nCircular permutations in azurin: Creating new termini for pulling along different directions', '<h3>Title</h3>\n<h3>Circular permutations in azurin: Creating new termini for pulling along different directions</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1347, 'NULL', '2018-07-11 23:40:15', '2030-12-01 18:30:00'),
(523, 'July 30, 2018 at 4.00 pm in AG-69', 'Title :\nDirect observation of the Mechanical Foldase Activity of Trigger Factor Chaperone by Magneti', '<h3>Title</h3>\n<h3>Direct observation of the Mechanical Foldase Activity of Trigger Factor Chaperone by Magnetic tweezers</h3>\n<p>Abstract :</p>\n<p style=\"text-align: justify;\">Proteins fold under mechanical forces in a number of biological processes, ranging from muscle contraction to co-translational folding at the mouth of the ribosome. As force hinders the folding reaction, chaperones must play a crucial role in this scenario. Nevertheless, to date, it has not been possible to monitor the direct influence of a chaperone on a protein folding under force. Here, we introduce single molecule magnetic tweezers to study the folding dynamics of protein L in presence of the prototypical molecular chaperone Trigger Factor (TF) over the range of physiological forces (4 to 10 pN). Our results show that TF modulates the folding of protein L by prominently increasing the probability of folding against the force and accelerating the refolding kinetics. Moreover, we find that the ability of TF to catalyze the folding reaction depends on the pulling force; as the force increases, higher concentrations of TF are needed for rescue folding, although no effect is observed above 12 pN even with saturating amounts of TF. Here, we propose for the first time that chaperones such as TF can work as foldases under force, playing a relevant role in many biological processes such as protein translation.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1508, 'NULL', '2018-07-16 06:09:09', '2030-12-01 18:30:00'),
(524, 'July 31, 2018 at 11.30 am in AG-69', 'Title :\nGroEL Chaperonin Assisted Protein Folding: studied by PETFCS and SmFRET \nAbstract :\nMany ne', '<h3>Title</h3>\n<h3>GroEL Chaperonin Assisted Protein Folding: studied by PETFCS and SmFRET </h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Many newly synthesized unfolded polypeptides require assistance by molecular chaperones in order to reach their active folded states. The GroEL/GroES chaperonin system is one of the most important bacterial chaperonin systems, which fulfills an essential function in assisting the folding of cytosolic proteins. GroEL is a homo-tetradecameric double-ring assembly of 60 kDa subunits with two opposing central cavities stacked back to back. Upon binding of ATP and the co chaperone GroES, GroEL transiently encapsulates newly synthesized or misfolded substrate proteins, which then can fold to the native state while being shielded from the crowded cytosolic environment. The mechanism of GroEL remains controversial whether GroEL acts as a passive cage, merely providing an aggregation preventing micro compartment, or whether GroEL actively accelerates the refolding of a subset of substrate proteins by modulation of the folding energy landscape. </p>\n<p style=\"text-align: justify;\">We resorted to a variety of single molecule fluorescence techniques to address this controversy. A novel and sensitive dual color fluorescence cross-correlation spectroscopy assay shows the absence of transient aggregates at single molecular concentration. Using a single molecule FRET (SmFRET) based assay, we show that the acceleration of substrate protein folding by GroEL is preserved under single molecule conditions, where aggregation is excluded. We apply photoinduced electron transfer fluorescence quenching correlation spectroscopy (PETFCS) to demonstrate that the acceleration of substrate protein folding is achieved by encapsulation of a dynamic folding intermediate inside the GroEL cavity. Furthermore, we provide evidence that modulation of the folding energy landscape is a result not only of steric confinement during encapsulation, but also of the net negative charge of the GroEL cage wall. Taken together, these results represent a substantial advance in our understanding of the mechanism of the prokaryotic chaperonin system and our findings suggest that GroEL, by an active chaperonin mechanism, promotes substrate protein folding by entropic destabilization of folding intermediates.</p>\n<p style=\"text-align: justify;\"> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1608, 'NULL', '2018-07-16 06:10:44', '2030-12-01 18:30:00'),
(525, 'July 23, 2018 at 4.00 pm in AG-69', 'Title :\nDesign of Catalysts and Nano-Heaters by Decorating Ultrasmall Nanoparticles and Pseudo-Singl', '<h3>Title</h3>\n<h3>Design of Catalysts and Nano-Heaters by Decorating Ultrasmall Nanoparticles and Pseudo-Single Atoms of Metal on DFNS: Tuning their Plasmonic Response by Hot Spot Engineering</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1446, 'NULL', '2018-07-18 22:05:47', '2030-12-01 18:30:00'),
(526, 'September 27, 2018 at 2.30 pm in AG-80', 'Title :\nComputational Studies on Mechanism and Stereoinduction in Asymmetric Catalysis \nAbstract :\n', '<p><strong>Title :</strong></p>\n<h3><span style=\"font-size: 12.16px;\">Computational Studies on Mechanism and Stereoinduction in Asymmetric Catalysis </span></h3>\n<p><strong><span style=\"font-size: 12.16px;\">Abstract :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">One of the leading goals in contemporary catalysis is to render improved efficiency to existing catalytic protocols.<sup>1</sup> While different forms of catalysis have witnessed tremendous success in the synthesis of complex molecules, there is minimal clarity at the mechanistic front. Further developments in the new form of catalysis/catalysts require a thorough knowledge of the reaction pathways. In asymmetric catalysis, the rationalization of selectivity is of prime importance as it paves the way for rational catalyst design. In the current talk, I will discuss the use of use of computational tools in providing a mechanistic understanding and insights into the factors controlling the stereoselectivity in a few landmark asymmetric reactions catalyzed by axially chiral catalysts/ligands. In particular, all calculations have been carried out with hybrid density functional theory (DFT) methods (B3LYP, M06, M06-2X and B3LYP-D3). The talk will focus on three forms of catalysis; 1) organocatalysis, 2) metal catalysis and, 3) cooperative catalysis. The first part encompasses the role of a newly developed class of chiral imidodiphosphoric acids in inducing selectivity in an asymmetric sulfoxidation reaction.<sup>2</sup> The second part will focus on the fine tuning of noncovalent interactions to design new phosphoramidite ligands for an asymmetric diamination reaction.<sup>3</sup> In the last part, the role of chiral Brønsted acids when used in conjunction with Pd metal and the importance of ligand exchange in the formation of spirocyclic ring formation will be elucidated.<sup>4</sup></span></p>\n<p><sup><span style=\"font-size: 12.16px;\"> </span></sup></p>\n<p><span style=\"text-decoration: underline;\"><strong><span style=\"font-size: 12.16px;\">References</span></strong></span></p>\n<p><span style=\"font-size: 12.16px;\">[1] Houk, K. N.; Cheong, P. H.-Y. Nature 2008, 455, 309.</span></p>\n<p><span style=\"font-size: 12.16px;\">[2] Jindal, G.; Sunoj, R. B. Angew. Chem. Int. Ed. 2014, 53, 4432.</span></p>\n<p><span style=\"font-size: 12.16px;\">[3] (a) Jindal, G.; Sunoj, R. B. Chem. Eur. J. 2012, 18, 7045. (b) Jindal, G.; Sunoj, R. B. Org. Biomol. Chem. 2014, 12, 2745.</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">[4] (a) Jindal, G.; Sunoj, R. B. J. Am. Chem. Soc. 2014, 136, 15998. (b) Jindal, G.; Sunoj, R. B. Org. Lett. 2015, 17, 2874.</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1244, 'NULL', '2018-09-09 23:28:09', '2030-12-01 18:30:00'),
(527, 'September 28, 2018 at 2.30 pm in AG-80', 'Title :\nExploring the Challenges in Computational Enzyme Design\nAbstract :\nEnzymes are nature’s mo', '<p><strong>Title :</strong></p>\n<h3><span style=\"font-size: 12.16px;\">Exploring the Challenges in Computational Enzyme Design</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\">Abstract :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Enzymes are nature’s most efficient catalysts and are also harnessed in synthetic chemistry for the sustainable production of several non-natural products. However, the design of new enzymes presents a major practical and fundamental challenge. Despite an interesting progress, the main advances are achieved through directed evolution and not by computational design.<sup>1</sup> Moreover, several designed systems adopt the less efficient route of ground state destabilization instead of transition state stabilization. In the talk, I will discuss the design of two enzymes; Kemp eliminases and haloalkane dehalogenase. Kemp eliminases are computationally designed enzymes that catalyze the conversion of 5-nitrobenzisoxazole to cyanophenol product. Haloalkane dehalogenase; DhlA is an important enzyme that helps in breaking down the toxic haloalkanes (1,2-dichloroethane) to alcohol via a series of steps. EVB (Empirical valence bond) approach is used to calculate the activation energies for the wild type and mutants. For Kemp eliminases, the origin of catalysis in different systems is rationalized on the basis of solvation free energies.<sup>2</sup> The different trends observed in the directed evolution of different systems is investigated to understand the effect of multiple mutations. For halolalkane dehalogenase, after successfully reproducing the activation barriers of known mutants, new mutations are proposed on the basis of structural data.<sup>3</sup> We mutated residues that are known to contribute to catalysis and then attempted to restore the activity by mutating residues in the first and second solvation shells. Various factors responsible for certain anomalies and the challenges encountered during computational enzyme design will be discussed.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\"> </span></p>\n<p><span style=\"font-size: 12.16px;\">References</span></p>\n<p><span style=\"font-size: 12.16px;\">[1] Frushicheva, M. P.; Cao, J.; Chu, Z. T.; Warshel, A. Proc. Natl. Acad. Sci. U. S. A. 2010, 107, 16869. </span></p>\n<p><span style=\"font-size: 12.16px;\">[2] (a) Jindal, G.; Ramachandran, B.; Bora, R. B.; Warshel, A. ACS Catal. 2017, 7, 3301. (b) Jindal, G.; Mondal, D.; Warshel, A. J. Phys. Chem. B 2017, 121, 6831.</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">[3] Jindal, G.; Slánská, K.; Kolev, V.; Damborsky, J.; Prokop, Z.; Warshel, A. Proc. Natl.  Acad. Sci. U. S. A. 2018 (Under Revision).</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1259, 'NULL', '2018-09-09 23:31:33', '2030-12-01 18:30:00'),
(528, 'September 24, 2018 at 4.00 pm in AG-69', 'Title :\nCarbonyl-carbonyl interactions in small molecules and proteins\nAbstract :\nThe carbonyl group', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Carbonyl-carbonyl interactions in small molecules and proteins</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">The carbonyl group is ubiquitous in both chemistry and biology. Apart from being involved in numerous chemical transformations, it can also participate in various distinct weak noncovalent interactions including hydrogen bonding (C=O•••H), carbonyl-chalcogen interactions (C=O•••X; X = S, Se, Te) and nucleophile-carbonyl interactions. In recent years, carbonyl-carbonyl (CO•••CO) interaction has emerged as an important noncovalent interaction that was observed in various small molecules, polyesters, peptoids, protein secondary structures and collagen-like peptides. It is believed that this interaction is n→π* in nature where the lone pair of oxygen of the donor carbonyl group is delocalized over the antibonding π orbital of C=O bond of another nearby acceptor carbonyl group. In this talk, I will discuss our current understanding of CO•••CO interactions with a focus on the “reciprocal” variant of n→π* interaction that we recently discovered. I will also discuss about the various structural motifs of CO•••CO interactions and put forward a hypothesis based on CO•••CO interactions that could explain the stabilization of polyproline II and collagen triple helices.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1238, 'NULL', '2018-09-20 22:53:19', '2030-12-01 18:30:00'),
(529, 'October 8, 2018 at 4.00 pm in AG-69', 'Title :\nNon-Linear Optical Organic Micro-Resonators\nAbstract:\nBottom-up molecular self-assembly tech', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Non-Linear Optical Organic Micro-Resonators</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span>:</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Bottom-up molecular self-assembly technique has emerged as one of the powerful methods to produce miniaturized organic photonic structures, such as optical waveguides, lasers, resonators, filters, circuits and modulators.  Optical waveguides and modulators are used to control the light propagation down to microscale and modulate the light propagation speed, respectively. In optical resonators their mirror-like geometry allows them to tightly trap the photons by repeated total internal reflection at the air-matter interface and act as optical gain media exhibiting high-quality factor (Q) with the low optical loss. We have been performing single-particle micro-PL spectroscopy studies to exploit the geometrical features of diverse self-assembled organic structures for photonic applications. In my talk, I will discuss some original results achieved in our group in linear and non-linear optical organic optical waveguide and microresonators useful for signal enhancement, sensing and lasing applications. I will also discuss our attempts towards creation and study of photonic molecules. </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\"> </span></p>\n<p><span style=\"font-size: 12.16px;\">REFERENCES</span></p>\n<p><span style=\"font-size: 12.16px;\">  [1]Adv. Mater. 2017, 29, 1605260.</span></p>\n<p><span style=\"font-size: 12.16px;\">  [2]Adv. Mater. 2013, 25, 2963.   </span></p>\n<p><span style=\"font-size: 12.16px;\">  [3]  Angew. Chem. Int. Ed. 2012, 51, 3556. </span></p>\n<p><span style=\"font-size: 12.16px;\">  [4]Adv. Funct. Mater. 2013, 23, 5875.</span></p>\n<p><span style=\"font-size: 12.16px;\">  [5]Adv. Funct. Mater. 2011, 21, 667.  </span></p>\n<p><span style=\"font-size: 12.16px;\">  [6]Adv. Opt. Mater. 2018, in the press [progress Report]. </span></p>\n<p><span style=\"font-size: 12.16px;\">  [7]Adv. Opt. Mater. 2017, 5, 1600613.</span></p>\n<p><span style=\"font-size: 12.16px;\">  [8]Adv. Opt. Mater. 2016, 4, 112-119.</span></p>\n<p><span style=\"font-size: 12.16px;\">  [9]Adv. Opt. Mater. 2015, 3, 1035.</span></p>\n<p><span style=\"font-size: 12.16px;\">[10]Adv. Opt. Mater. 2013, 1, 305.</span></p>\n<p><span style=\"font-size: 12.16px;\">[11]     ACS Appl. Mater. Interfaces, 2018, 10, 16723. </span></p>\n<p><span style=\"font-size: 12.16px;\">[12]     J. Mater. Chem. C 2018, DOI: 10.1039/C8TC02638F.</span></p>\n<p><span style=\"font-size: 12.16px;\">[13]     J. Mater. Chem. C 2017, 5, 7262.</span></p>\n<p><span style=\"font-size: 12.16px;\">[14]     J. Mater. Chem. C 2017, 2, 1404.</span></p>\n<p><span style=\"font-size: 12.16px;\">[15]     Chem.Nano.Mat. 2018, 4, 764.</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1639, 'NULL', '2018-10-05 03:15:03', '2030-12-01 18:30:00');

INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(547, 'February 5, 2019 at 2.30 pm in AG-69', 'Title :\nMaterials Simulation From First-Principles: Fundamental Challenges and Importance of Finite ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Materials Simulation From First-Principles: Fundamental Challenges and Importance of Finite Temperature Modeling</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">The discovery of the extraordinary activity in catalysis exhibited by small clusters has stimulated considerable research interest. However, in heterogeneous catalysis, materials property changes under operational environment (i.e. at a finite temperature (T) and pressure (p) in an atmosphere of reactive molecules). Therefore, a solid theoretical understanding at a realistic (T, p) is essential in order to address the underlying phenomena.</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">       This talk is, therefore, driven by the vision of computational design of materials at a finite (T, p). Here, I shall introduce a robust methodological approach that integrates various levels of theories combined into one multi-scale simulation to address the environmental effect to predict the  properties of materials at a finite T, p. Our approach employs density-functional theory (DFT) combined with ab initio atomistic thermodynamics<sup>[1]</sup>. In order to quantitatively account the contribution of anharmonic vibrational free energy to the configurational entropy, we have evaluated the excess free energy of selected clusters numerically by thermodynamic integration method with DFT inputs. We further establish the necessity of this finite temperature modeling as DFT (with appropriate exchange and correlation functionals) fails to predict the stable phases even at a moderately low temperature. We have successfully applied our finite temperature modeling approach in various inter-disciplinary fields viz. (i) catalysis<sup>[2-3]</sup>, (ii) defects in semi-conductor<sup>[4]</sup>, (iii) energy materials<sup>[5-6]</sup>, etc. I shall discuss in details one application<sup>[6]</sup> of this methodology in addressing (T, p) dependence on the composition, structure, thermodynamic stability of metal hydride clusters in a reactive atmosphere in the context of designing energy materials.</span></p>\n<p><span style=\"font-size: 12.16px;\">References:</span></p>\n<p><span style=\"font-size: 12.16px;\">1.S. Bhattacharya, S. Levchenko, L. Ghiringhelli, M. Scheffler Phys. Rev. Lett. 111, 135501 (2013).</span></p>\n<p><span style=\"font-size: 12.16px;\">2.S. Bhattacharya, D. Berger, K. Reuter, L. Ghiringhelli, S. Levchenko Phys. Rev. Materials (Rapid Commun.) 1, 071601(R) (2017).</span></p>\n<p><span style=\"font-size: 12.16px;\">3.S. Saini, D. Sarker, P. Basera, S. Levchenko, L. Ghiringhelli, S. Bhattacharya J. Phys. Chem. C 122, 16788 (2018).</span></p>\n<p><span style=\"font-size: 12.16px;\">4.A. Bhattacharya, S. Bhattacharya Phys. Rev. B 94, 094305 (2016).</span></p>\n<p><span style=\"font-size: 12.16px;\">5.E. Arora, S. Saini, P. Basera, M. Kumar, A. Singh, S. Bhattacharya J. Phys. Chem. C (article ASAP), DOI: 10.1021/acs.jpcc.8b08687.</span></p>\n<p><span style=\"font-size: 12.16px;\">6.A. Bhattacharya, S. Bhattacharya J. Phys. Chem. Lett. 6, 3726 (2015).</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1160, 'NULL', '2019-01-25 03:58:21', '2030-12-01 18:30:00'),
(548, 'February 1, 2019 at 2.30 pm in AG-69', 'Title :\nProbing Charge Transfer Reaction Coordinate in Supramolecular Donor-Acceptor Frameworks', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Probing Charge Transfer Reaction Coordinate in Supramolecular Donor-Acceptor Frameworks</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1208, 'NULL', '2019-01-25 04:05:58', '2030-12-01 18:30:00'),
(549, 'February 7, 2019 at 4.00 pm in AG-80', 'Title :\nStability and Copper-binding properties of Azurin and its variants probed using optical spec', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Stability and Copper-binding properties of Azurin and its variants probed using optical spectroscopy</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1031, 'NULL', '2019-02-01 03:46:36', '2030-12-01 18:30:00'),
(550, 'March 5, 2019 at 2.30 pm in AG-69', 'Title :\nTuning Photo-functionalization of sp2 Carbon-Hydrogen Bond Inside Water Soluble Supramolecul', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Tuning Photo-functionalization of sp<sup>2</sup> Carbon-Hydrogen Bond Inside Water Soluble Supramolecular Nanocage</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1111, 'NULL', '2019-02-01 04:05:42', '2030-12-01 18:30:00'),
(551, 'February 14, 2019 at 4.00 pm in AG-80', 'Title :\nDevelopment of Alkane hydroxylating Biocatalyst using Cytochrome P450 enzyme', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Development of Alkane hydroxylating Biocatalyst using Cytochrome P450 enzyme</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1066, 'NULL', '2019-02-11 21:59:32', '2019-02-12 23:28:32'),
(552, 'February 19, 2019 at 2.30 pm in AG-69', 'Title :\nPhotodissociation of Acetylacetone:  Photoionization and Threshold Photoelectron Spectrosco', '<p style=\"text-align: center;\"><strong><span style=\"text-decoration: underline;\">Title</span> :</strong></p>\n<h3><span style=\"font-size: 12.16px;\">Photodissociation of Acetylacetone:  Photoionization and Threshold Photoelectron Spectroscopy Reveal Much More Than OH Radicals</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">The absorption of light by an organic molecule, and the subsequent pathways for energy transformation and release, are fundamental process governing life on earth.  Two of the most important electronic chromophores in organic systems are C=O bonds (carbonyl molecules) and C=C bonds (alkenes and polyenes).  Carbonyl molecules, such as acetaldehyde (CH3CHO) also have enol tautomers (H2C=CHOH, vinyl alcohol).  This tautomerization converts the weakly absorbing C=O chromophore to a strongly absorbing C=C chromophore.  We have studied the photodissociation of acetylacetone (AcAc), which exists at 300 K in the gas phase mostly as the enolone tautomer, rather than the diketo tautomer (see figure).  The enolone tautomer is stabilized by both  conjugation and an internal hydrogen bond.  Previous studies have concluded that OH loss is the dominant (or only) channel when AcAc is excited in the ultraviolet at 266 or 248 nm.  However, truly universal detection techniques have not been used in these studies.  By combining multiplexed photoionization mass spectrometery (MPIMS), threshold photoelectron photoion coincidence spectroscopy (TPEPICO), and time-resolved infrared absorption spectroscopy of OH radicals, we have discovered that photodissociation of AcAc is much richer than previously presumed, and that OH production is not even energetically allowed following one-photon excitation at 266 or 248 nm.  This work demonstrates the power of multiplexed, universal detection of charged particles in photodissociation studies, and lifts the veil on the photodissociation of a molecule that is both an enol and a ketone.</span></p>\n<p style=\"text-align: center;\"><span style=\"font-size: 12.16px;\"><img src=\"images/osborn.jpg\" border=\"0\" alt=\"\" width=\"567\" height=\"167\" /></span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1075, 'NULL', '2019-02-12 23:34:29', '2019-02-12 23:35:52'),
(553, 'February 20, 2019 at 2.30 pm in AG-69', 'Title :\nProbing Ultrafast Chemical Dynamics Inspired by the Rhythms of Fireflies\nAbstract :\nCoherenc', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Probing Ultrafast Chemical Dynamics Inspired by the Rhythms of Fireflies</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Coherence phenomena arise from interference, or the addition, of wave-like amplitudes in phase [1]. While coherence has been shown to yield transformative new ways for improving function, advances have been limited to pristine matter, as quantum coherence is considered fragile. Here I will discuss how vibrational and vibronic wavepackets entrain ensembles of molecules, like the synchronized flashing of fireflies. I will discuss how this can be used to probe mechanisms of ultrafast dynamics and how in-step vibrational motion might be employed to control function on ultrafast timescales. I will give examples that include light-harvesting in photosynthesis, energy flow in organometallic molecules that is ‘wired’ by Fermi resonance, and ultrafast electron transfer in molecular systems. </span></p>\n<p>[1] Scholes, et al. “Optimal Coherence in Chemical and Biophysical Dynamics” Nature 543, 647–656 (2017).</p>\n<p style=\"text-align: center;\"><img src=\"images/Scholes.png\" border=\"0\" alt=\"\" width=\"618\" height=\"151\" /></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 975, 'NULL', '2019-02-14 23:54:26', '2019-02-14 23:57:54'),
(554, 'February 20, 2019 at 3.15 pm in AG-69', 'Title :\nRenewable Carbon Engineering Confluence of Modern Biological &amp; Chemical Sciences\nAbstrac', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Renewable Carbon Engineering Confluence of Modern Biological &amp; Chemical Sciences</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">World depends heavily on non-renewable fossil products for its energy, materials and chemical needs. Climate trends over past two decades necessitate an aggressive path towards reducing carbon emissions and increasing use of renewable carbon. The total of available renewable carbon is likely to be a combination of first generation (food derived), second generation (non-food derived), third generation (non-land use change) and fourth generation (CO<sub>2</sub>) carbon. Mankind generates substantial quantities of under-utilized surplus agricultural wastes as also other wastes such as municipal solid wastes, municipal liquid waste and industrial wastes. All these put together have the potential to fully substitute petroleum fuel and materials requirements of the world. Thus there is a need to be able to engineer the available renewable carbon to the products in use today. </span></p>\n<p style=\"text-align: justify;\">Renewable carbon however presents itself in varied and complex forms, and novel science and technology platforms are needed in order to derive desired products from these at reasonable costs. Sustainable and scalable technology platforms are being conceptualised, designed and scaled up at the DBT-ICT Centre for Energy Biosciences using combinations of chemical and biological processes that can convert carbonaceous wastes into products that are today derived from petroleum. The presentation shall broadly discuss these platforms that are likely to have impact on designing sustainable economies.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1093, 'NULL', '2019-02-14 23:57:31', '2030-12-01 18:30:00'),
(555, 'February 21, 2019 at 11:30 am in AG-69', 'Title :\nActivity-Based Sensing Approaches to Decipher Transition Metal Signaling\nAbstract :\nTraditio', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Activity-Based Sensing Approaches to Decipher Transition Metal Signaling</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Traditional strategies for development of chemoselective imaging reagents rely on molecular recognition and static lock-and-key binding to achieve high specificity. We are advancing an alternative approach to chemical probe design, termed activity-based sensing (ABS), in which we exploit inherent differences in chemical reactivity as a foundation for distinguishing between chemical analytes that are similar in shape and size within complex biological systems. This presentation will focus on ABS approaches to develop new fluorescent probes for transition metals and reactive oxygen, sulfur, and carbon species and their signal/stress contributions to living systems, along with activity-based proteomics to identify novel targets and pathways that these emerging classes of chemical signals regulate.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1036, 'NULL', '2019-02-15 00:00:31', '2030-12-01 18:30:00'),
(556, 'February 21, 2019 at 12.15 pm in AG-69', 'Title :\n[FeFe] Hydrogenase H-cluster Biosynthesis\nAbstract :\nRadical SAM enzymes (1) use a [4Fe-4S] ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">[FeFe] Hydrogenase H-cluster Biosynthesis</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Radical SAM enzymes (1) use a [4Fe-4S] cluster to cleave S-adenosylmethionine to generate the 5’-deoxyadenosyl radical, which in turn abstracts an H-atom from a given rSAM enzyme’s substrate to initiate catalysis. As an example, the RS enzyme HydG lyses tyrosine to generate the CO and CN ligands of the H-cluster of [FeFe] hydrogenase, building an organometallic Fe(CO)2CN(cysteine) moiety that incorporates an iron atom derived from a unique 5-Fe Fe-S cluster (2-7).  We have recently characterized the first organometallic intermediate of this catalytic cycle (8) (figure panel).  This presentation will focus on the use of EPR spectroscopy to interrogate the geometrical and electronic stuctures of such rSAM enzyme intermediates. Additionally, using HydG along with two other Fe-S maturase enzymes HydE and HydF, we can use cell free synthesis to precisely isotope-edit the H-cluster, which can then be fruitfully probed via EPR spectroscopy targeting its paramagnetic intermediates in the hydrogen oxidation or proton reduction catalytic cycle. New cell free synthesis experiments exploring the effects of deleting subsets of the maturases or adding synthetic analogs in the assembly process are giving new insights into the overall bioassembly of this important metallo-cofactor.</span></p>\n<p><span style=\"font-size: 12.16px;\"> </span></p>\n<p><span style=\"font-size: 12.16px;\">1.Horitani et al., Science (2016) 6287:822-825</span></p>\n<p><span style=\"font-size: 12.16px;\">2.Myers  et al., J. Am. Chem. Soc. (2014) 136:12237-12240.</span></p>\n<p><span style=\"font-size: 12.16px;\">3.Kuchenreuther et al., Science (2013) 342:472-475</span></p>\n<p><span style=\"font-size: 12.16px;\">4.Kuchenreuther et al., Science (2014)  343:424-427</span></p>\n<p><span style=\"font-size: 12.16px;\">5.Dinis et al., Proc. Natl. Acad. Sci. U.S.A.  (2015) 112:1362-1367.</span></p>\n<p><span style=\"font-size: 12.16px;\">6.Suess et al.,  Proc. Natl. Acad. Sci. U.S.A. (2015) 112:11455-11460. </span></p>\n<p><span style=\"font-size: 12.16px;\">7.Suess, et al., J. Am. Chem. Soc. (2016) 138:1146-1149. </span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">8.Rao et al., Nat. Chem. (2018) 10:555-560.</span></p>\n<p style=\"text-align: center;\"><img src=\"images/Britt.png\" border=\"0\" alt=\"\" width=\"536\" height=\"297\" /></p>\n<p style=\"text-align: center;\"><span style=\"font-size: 12.16px;\">Pulse EPR Characterization of the first organometallic intermediate in Fe-Fe hydrogenase bioassembly  formed by the radical SAM enzyme  HydG (ref 8)</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1310, 'NULL', '2019-02-15 00:04:39', '2030-12-01 18:30:00'),
(557, 'February 26, 2019 at 2.30 pm in AG-69', 'Title :\nSolvated Metal Atom Dispersion and Digestive Ripening – Duo par excellence for Diverse Nan', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Solvated Metal Atom Dispersion and Digestive Ripening – Duo par excellence for Diverse Nanostructured Materials</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">The properties of nanostructured materials strongly depend on their size, shape, interparticle distance, and the surrounding environment which could be tuned precisely by controlling the particle size of the material. Size dependent property of a polydisperse sample is an average effect due to the presence of different sized particles in the system. The property exhibited by a monodisperse sample however, could be ascribed as emerging from a single entity. Control over size and size distribution is indispensible for attaining a desired property. A lot of attention is focused on developing synthetic strategies leading to monodispersity and those that are simple to manipulate, easy to scale up and highly reproducible.</span></p>\n<p style=\"text-align: justify;\">We have been using the Solvated Metal Atom Dispersion (SMAD) method for the synthesis of colloids of metal nanoparticles. The as-prepared colloid from this method consists of polydisperse metal nanoparticles. In a process termed as digestive ripening, addition of a surfactant to the as-prepared sample renders it highly monodisperse. This combination, SMAD and digestive ripening has recently been extended to obtain nearly monodisperse semi-conductor nanostructured materials as well. In this talk, the power of the SMAD and the (co)digestive ripening processes will be demonstrated toward the synthesis of highly monodisperse metal, core-shell, alloy, intermetallic, and composite nanostructured materials. <strong><span style=\"text-decoration: underline;\">Additionally, applications of some of the materials synthesized using this methodology in the fields of hydrogen storage and generation, magnetism, catalysis, and surface enhanced Raman scattering will also be discussed</span></strong>.</p>\n<p style=\"text-align: justify;\"> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 978, 'NULL', '2019-02-24 23:20:31', '2030-12-01 18:30:00'),
(558, 'February 28, 2019 1t 4.00 pm in AG-80', 'Title :\nElectron Tunneling Barriers in Marcus Theory and Floppy Molecular Breadboard', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Electron Tunneling Barriers in Marcus Theory and Floppy Molecular Breadboard</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1001, 'NULL', '2019-02-26 22:40:05', '2030-12-01 18:30:00'),
(559, 'March 7, 2019 at 2.30 pm in AG-80', 'Title :\nFunctional Bridged Silsesquioxanes and applications\nAbstract :\nClick here', '<h3>Title</h3>\n<p><span style=\"font-size: 12.16px;\">Functional Bridged Silsesquioxanes and applications</span></p>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><strong><a href=\"images/Michel%20Wong%20Abstract.pdf\" target=\"_self\"><span style=\"font-size: 12.16px;\">Click here</span></a></strong></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1305, 'NULL', '2019-03-04 23:55:57', '2019-03-04 23:56:56'),
(560, 'March 28, 2019 at 2.30 pm in D-406', 'Title :\nDesign and Synthesis of Conjugated Molecules for Band Gap Engineering and Photostability of ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Design and Synthesis of Conjugated Molecules for Band Gap Engineering and Photostability of OPVs</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">             Organic photovoltaic (OPV) modules are flexible, light weight, transparent and thin compared to other emerging photovoltaic technologies, making them well-suited for applications ranging from solar windows to fabrics. A large number of polymer semiconducting materials of Donor-Acceptor–Donor (D-A-D) architecture have been synthesized and used in OPV devices in recent times reaching remarkable power conversion efficiencies up to 15%. However, the diversity of monomeric units and the numerous available reports in the structural complexity of D-A-D conjugated p-type polymers indicate that there is scope for new materials which can further improve the performance of OPV devices based on D-A-D polymers. In this seminar presentation, I will discuss briefly about my Ph.D. thesis work. The first part of work explores structural level architecturing of conjugated small molecules and polymers to modify the performance of the OPVs. Demonstrate the effect of molecular level modification on frontier molecular energy levels, planarity, absorption spectra and device performance. </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">             Additional to the development in power conversion efficiency of the OPVs, the cost of large area OPV device manufacture continues to decrease with improvements in roll-to-roll manufacturing processes. However, while these advances in efficiency and cost will ultimately the key to the success of the technology, the long term stability of OPV devices under illumination still remains an obstacle to their industrial viability. While the thermal and oxidative-stability of contacts and interfaces in an OPV device can contribute to a decrease in its performance with time, a leading contributor to device decay is photo-oxidation of the active layer itself. </span></p>\n<p style=\"text-align: justify;\"> </p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">             Hence in the second part of the work, a series of chalcogen based polymers have been synthesized and the photostability of the unencapsulated active layers and the device life time has been monitored over a period of time. The thesis work has further investigated the photostability of several combinations of fluorinated and non-fluorinated high-performance donor polymers with both traditional and fluorinated fullerenes. The miscibility of the active layer component is probed with time-resolved photoluminescence (TRPL). The miscibility of the polymers and the fluorinated fullerenes were improved by the strategic fluorination of the polymers, by new synthesis routes. These results ultimately suggest that appropriate fluorination strategies applied to both the donor and acceptor can be a viable route toward a new model of intrinsically photo- and phase-stable OPV active layers.</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1096, 'NULL', '2019-03-20 04:23:38', '2030-12-01 18:30:00'),
(561, 'March 25, 2019 at 4.00 pm in AG-69', 'Title :\nFluorescent Sensors for Imaging Signal Mediating Phospholipids', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Fluorescent Sensors for Imaging Signal Mediating Phospholipids</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 929, 'NULL', '2019-03-21 23:21:29', '2030-12-01 18:30:00'),
(562, 'April 1, 2019 at 4.00 pm in AG-69', 'Title :\nDesigning Protein-Specific Folding Catalysts', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Designing Protein-Specific Folding Catalysts</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 997, 'NULL', '2019-03-27 03:54:42', '2030-12-01 18:30:00'),
(563, 'April 2, 2019 at 2.30 pm in AG-80', 'Title : \nComputational Descriptions of Bis-terpyridine Based Molecular Breadboard Circuits and thei', '<p><strong>Title : </strong></p>\n<h3><span style=\"font-size: 12.16px;\">Computational Descriptions of Bis-terpyridine Based Molecular Breadboard Circuits and their Single-Molecule Break Junction Conductance</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1044, 'NULL', '2019-03-29 04:09:52', '2019-04-01 21:53:16'),
(564, 'April 4, 2019 at 4.00 pm in AG-80', 'Title :\nProbing Singlet Fission on all-trans Lycopene Aggregates', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Probing Singlet Fission on all-trans Lycopene Aggregates</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 936, 'NULL', '2019-03-29 04:11:21', '2030-12-01 18:30:00'),
(565, 'April 12, 2019 at 2.30 pm in AG-69', 'Title :\nA new GC Binder for Sequence-selective DNA Recognition\nAbstract :\nClick here\n ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">A new GC Binder for Sequence-selective </span>DNA Recognition</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p><strong><a href=\"images/Gadre%20Abstract.pdf\">Click here</a></strong></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 976, 'NULL', '2019-04-03 22:22:17', '2019-04-03 22:27:54'),
(566, 'April 8, 2019 at 4.00 pm in AG-69', 'Title :\nUnderstanding the mechanism of binding between proteins in CDK1/cyclin-B/CKS-2 complex', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Understanding the mechanism of binding </span>between proteins in CDK1/cyclin-B/CKS-2 complex</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 924, 'NULL', '2019-04-03 23:59:48', '2030-12-01 18:30:00'),
(567, 'April 11, 2019 at 4.00 pm in AG-80', 'Title :\nElucidating Folding-Unfolding Pathways of Ubiquitin Family Proteins', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Elucidating Folding-Unfolding Pathways of Ubiquitin Family Proteins</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 917, 'NULL', '2019-04-07 23:35:05', '2030-12-01 18:30:00'),
(568, 'April 9, 2019 at 2.30 pm in AG-69', 'Title :\nOnline Electrochemical Mass Spectrometry as A Tool to De-Convolute Catalysis, Instability an', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Online Electrochemical Mass Spectrometry as A Tool to De-Convolute Catalysis, Instability and Efficacy of Protection Strategies</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Limited stability of most electrode materials (EM) and electrolytes under stringent operating conditions is a matter of concern for the battery research community and industry. In past few years, it has been demonstrated that EMs degrade through their reactive interface with the electrolyte. Undesirable interfacial reactions result in formation of solid precipitates that impede the charge transfer and can serve as an active site for electrolyte consumption, anode corrosion and passivation, thereby, leading to inefficient lithium/sodium ion and metal-O2 batteries (LIB/SIB/LOB). Especially, the progress of high energy and high voltage batteries is mostly restricted by issues associated with the electrode/electrolyte interfacial instability and electro-chemomechanical degradation under the operation conditions. As a result, strategies that (1) stabilize the interface by designing a protection layer commonly known as “artificial solid electrolyte interface (ASEI)” and (2) that can electro/chemically catalyse the reactions and bring the potentials to lower values can significantly enhance battery performance by stabilizing the functional interface and addressing the deleterious reactions between electrode and electrolyte. Nevertheless, there is a dire need of in-operando and in-situ analytical tools to deconvolute the degradation paths to have targeted solutions based on the instability of the components. Online electrochemical mass spectrometry in synergy with solid state NMR can prove to be on such tool. </span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1133, 'NULL', '2019-04-08 00:36:46', '2030-12-01 18:30:00'),
(569, 'April 15, 2019 at 4.00 pm in AG-69', 'Title :\nTowards understanding the structure of amyloids in the lipid membrane', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Towards understanding the structure of amyloids in the lipid membrane</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 923, 'NULL', '2019-04-14 22:13:41', '2030-12-01 18:30:00'),
(570, 'May 1, 2019 at 2.30 pm in AG-69', 'Title :\nBuoyant Microcapsules: Simple motility to Complex Autonomous Behavior\nAbstract :\nNature has ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Buoyant Microcapsules: Simple motility to Complex Autonomous Behavior</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Nature has always been a great source of inspiration for the design of artificial materials with improved hierarchical organization, superior properties and smart functions. In this age of artificial intelligence and smart systems, chemists are increasingly looking to design active and adaptive materials taking inspiration from the various biological processes and their self-regulatory mechanisms which make ‘life’ possible. In this talk, I will illustrate with an example of a microcapsule with an entrapped gas bubble whose motility is governed by buoyancy forces, how we can design complex autonomous behavior into relatively simple systems. Our results show that microcapsules can be propelled by an active control of buoyancy forces and this buoyant motility can be used to trigger chemical reactions, simulate self-sorting behavior in microcapsule communities and achieve complex oscillatory motility.</span></p>\n<p>References:</p>\n<ol>\n<li><span style=\"font-size: 12.16px;\">B. A. Grzybowski &amp; W. T. S. Huck, The Nanotechnology of Life-inspired Systems, Nat. Nanotechnol. 2016, 11, 585.</span></li>\n<li><span style=\"font-size: 12.16px;\">B. V. V. S. P. Kumar, A. J. Patil &amp; S. Mann, Enzyme-powered motility in buoyant organoclay/DNA protocells, Nat. Chem. 2018, 10, 1154.</span></li>\n<li><span style=\"font-size: 12.16px;\">L. Rodriguez-Arco, B. V. V. S. P. Kumar, M. Li, A. J. Patil &amp; S. Mann, Modulation of Higher-order Behaviour in Model Protocell Communities by Artificial Phagocytosis, Angew. Chem. Int. Ed. 2019, DOI: 10.1002/ange.201901469.</span></li>\n</ol>\n<p> </p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1840, 'NULL', '2019-04-15 02:29:26', '2030-12-01 18:30:00'),
(571, 'April 30, 2019 at 2.30 pm in AG-69', 'Title :\nAdvancement of Nanomaterials: Nanotherapeutics and Antibacterial Performance\nAbstract :\n  ?', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Advancement of Nanomaterials: Nanotherapeutics and Antibacterial Performance</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">       Carbon nanomaterials are promising in nature due to their higher surface area, known chemistry and ease of structural functionalization. A higher surface area and modulation of functionalities is the key to success to extend their potential in various domains. Present chemistry of graphene oxide (GO) synthesis is dominated by Hummer’s method and its modified versions. The non-reproducibility, variation in sources and physical reaction parameters affect size, degree of oxidation, nature, and type of oxo-functionalities. Furthermore, problems associated with its mass production demands development of better and easier synthetic protocols. In our lab, we are exploring safer, easier, less-energy intensive protocols for synthesis of GO and their advancement in biomedical applications.</span></p>\n<p><span style=\"font-size: 12.16px;\">       Nanotherapeutics is most appealing and viable approach to enhance the potential of existing drugs rather than designing and synthesizing new drug molecules to counter diseases. More recently, gene-based antitumor therapy demands smart engineering of effective vectors.</span></p>\n<p><span style=\"font-size: 12.16px;\">In this respect, we have explored biocompatible polymers tethered GO nanoconjugates as efficient nonviral vectors for gene-based cancer therapeutics. A promisable transfection and gene-knock down efficiency is revealed and results were compared with commercial vector. A pH-triggered release of siRNA from the vector-siRNA complex was studied to provide a mechanistic insight toward unloading of siRNA from the vector.</span></p>\n<p><span style=\"font-size: 12.16px;\">       In another work, enhancement in efficacy of traditional medicine with non-toxic surface modified metal oxide nanoparticles is explored. The nanoparticles are specially designed to allow sustained release of bound species to facilitate prolonged activity of drug.</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">       Additionally, pristine GO coatings synthesized from different routes revealed remarkable antimicrobial activity due to its specific surface-interface interactions with the bacteria, which is again a valuable addition at biomedical frontiers.</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 963, 'NULL', '2019-04-15 02:41:40', '2030-12-01 18:30:00'),
(572, 'April 18, 2019 at 4.00 pm in AG-80', 'Title :\nAmorphous Zeolitic Nanosponges as Heterogeneous Solid Catalysts', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Amorphous Zeolitic Nanosponges as Heterogeneous Solid Catalysts</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 932, 'NULL', '2019-04-15 04:16:25', '2030-12-01 18:30:00'),
(573, 'April 25, 2019 at 4.00 pm in AG-80', 'Title :\nFluorescent Red Emitting Sensors for Imaging Signal Mediating Phospholipids', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Fluorescent Red Emitting Sensors for Imaging Signal Mediating Phospholipids</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 921, 'NULL', '2019-04-15 04:20:28', '2030-12-01 18:30:00'),
(574, 'April 22, 2019 at 4.00 pm in AG-69', 'Title :\nPredicting directional flexibility of protein from its crystal structure\nAbstract :\nMechanic', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Predicting directional flexibility of protein from its crystal structure</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">Mechanical flexibility is found to be anisotropic in protein molecules. In order to understand complex role of protein in mechano-biology or develop new allosteric protein based nano-materials, anisotropic response of protein to uniaxial mechanical stress is needed to be understood in detail. In this talk I will propose an analytical framework to compute directional flexibility in terms of directional spring constant of proteins from its native state crystal structure. Our formalism includes Cα atom based coarse-grained Elastic Network Model (ENM) where we employed statistical propagation of error to obtain variance of a distance between two atoms from standard deviation of coordinates of the constituent atoms using ENM normal modes. Directional flexibility of Ubiquitin predicted in this way is almost ~ 70% accurate in comparison to that obtained from all atom explicit solvent Molecular Dynamics simulation. I will also discuss about tuning ENM potential to get better agreement on directional flexibility prediction. </span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1020, 'NULL', '2019-04-16 00:35:53', '2030-12-01 18:30:00'),
(575, 'April 29, 2019 at 4.00 pm in AG-69', 'Title :\nThe interaction of neurotransmitters with lipid bilayer membranes\nAbstract :\nRecent studies ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">The interaction of neurotransmitters with lipid bilayer membranes</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Recent studies have shown that serotonin, a major neurotransmitter in the mammalian brain, can bind directly to lipid membranes with high affinity. It has been suggested that this can contribute to signal transduction in a receptor independent fashion. We also hypothesize that this may have a role in membrane-amyloid interactions. Here we probe these possibilities by studying the effect of serotonin on an artificial ternary lipid bilayer and also on the membranes of living cells, using AFM and confocal imaging, and force spectroscopy. Our results show that direct interaction of serotonin with lipid bilayer membranes can alter their properties, which can have a significant effect on the ability of a cell to bind disease-associated proteins, and on the activity of generic membrane proteins. We infer that serotonin can effect cellular properties through a receptor-independent membrane mediated pathway.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 961, 'NULL', '2019-04-25 22:21:01', '2030-12-01 18:30:00'),
(576, 'May 3, 2019 at 2.30 pm in AG-69', 'Title :\nSensors and Chelators for Essential Transition Metal Ions', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Sensors and Chelators for Essential Transition Metal Ions</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 839, 'NULL', '2019-04-29 23:07:13', '2030-12-01 18:30:00'),
(577, 'May 7, 2019 at 2.30 pm in AG-80', 'Title :\nAdvancing the Magnetic Resonance Frontiers for the Study of Complex Molecules and Active Mat', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Advancing the Magnetic Resonance Frontiers for the Study of Complex Molecules and Active Materials</span></h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\"><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">Nuclear Magnetic Resonance (NMR) is a spectroscopic method that provides atomically resolved structural and dynamical information of systems from a vast category including organic and inorganic chemistry, materials and biology. The technique offers unique capabilities to study complex molecules that are insoluble and non-crystalline such as amyloid fibrils, membrane proteins, amorphous polymers, catalytic compounds, and battery materials etc. A major challenge in the applications of solid-state NMR spectroscopy is the intrinsically low sensitivity of the technique that practically restricts its use to a limited number of NMR active isotopes such as </span><sup style=\"color: #222222; font-family: verdana, arial, serif; text-align: justify;\">1</sup><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">H, </span><sup style=\"color: #222222; font-family: verdana, arial, serif; text-align: justify;\">19</sup><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">F, </span><sup style=\"color: #222222; font-family: verdana, arial, serif; text-align: justify;\">31</sup><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">P, </span><sup style=\"color: #222222; font-family: verdana, arial, serif; text-align: justify;\">13</sup><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">C, and </span><sup style=\"color: #222222; font-family: verdana, arial, serif; text-align: justify;\">15</sup><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">N. Therefore, a number of practically relevant systems that in principle can be studied using solid-state NMR, remain out of its reach. </span><br style=\"font-size: 13px; color: #444444; font-family: verdana, arial, serif; text-align: justify;\" /><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\"> </span><br style=\"font-size: 13px; color: #444444; font-family: verdana, arial, serif; text-align: justify;\" /><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">I will present two approaches to address the problem of sensitivity in solid-state NMR. The first approach is development of new methods, i.e., radio frequency (RF) pulse sequences to probe NMR isotopes like </span><sup style=\"color: #222222; font-family: verdana, arial, serif; text-align: justify;\">2</sup><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">H, </span><sup style=\"color: #222222; font-family: verdana, arial, serif; text-align: justify;\">14</sup><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">N, </span><sup style=\"color: #222222; font-family: verdana, arial, serif; text-align: justify;\">7</sup><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">Li etc.  that are difficult due to their less sensitivity (low gyromagnetic ration and/or less natural abundance) and large anisotropic interaction like quadrupolar coupling and chemical shift anisotropy. A new RF pulse sequence and its applications to biological and material samples with various challenging NMR isotopes will be discussed, demonstrating the versatility of the new method and its impact.  </span><br style=\"font-size: 13px; color: #444444; font-family: verdana, arial, serif; text-align: justify;\" /><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\"> </span><br style=\"font-size: 13px; color: #444444; font-family: verdana, arial, serif; text-align: justify;\" /><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">In the second approach, I will discuss a rapidly emerging hyperpolarization technique known as dynamics nuclear polarization (DNP), which can enhance the sensitivity of NMR by orders of magnitude. DNP has already made a paradigm shift in solid-state NMR spectroscopy by enabling studies of systems like proteins in physiological conditions and materials with extremely insensitive NMR isotopes like </span><sup style=\"color: #222222; font-family: verdana, arial, serif; text-align: justify;\">17</sup><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">O. However, the state-of-the-art DNP methods rely on exogenously added source of paramagnetic centers (typically stable nitroxide or carbon-based radicals) for the polarization. The scope of DNP can be further expanded by performing endogenous DNP using paramagnetic metal centers as the source of polarization to enhance sensitivity of the surrounding nuclear spins. Such metal centers are intrinsically present in systems like metalloproteins, metalloenzymes, energy harvesting materials and battery compounds. More importantly, endogenous DNP is a critical step towards performing “hyperfine DNP spectroscopy” to extract the local structural information directly from the electron-nuclear hyperfine interaction while detecting sensitivity enhanced NMR signal. Recent results using V</span><sup style=\"color: #222222; font-family: verdana, arial, serif; text-align: justify;\">4+ </sup><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">centers for the first time to enhance polarization of protons in the sample will be shown to illustrate the concept of hyperfine DNP spectroscopy.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 869, 'NULL', '2019-04-29 23:38:44', '2030-12-01 18:30:00'),
(578, 'May 8, 2019 at 2.30 pm in AG-80', 'Title :\nUsing Microwave Pulses to Expand the Scope of DNP Enhanced Solid-State NMR Spectroscopy\nAbst', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Using Microwave Pulses to Expand the Scope of DNP Enhanced Solid-State NMR Spectroscopy</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p> </p>\n<div style=\"text-align: justify;\">Dynamic nuclear polarization has revolutionized the field of solid-state NMR by providing the sensitivity enhancement of orders of magnitude. Currently, most DNP experiments are performed using continuous-wave (CW) microwave irradiation near EPR frequency of the polarizing agents using dedicated gyrotrons. The CW-DNP mechanisms, i.e. solid-effect (SE), cross-effect (CE) and thermal mixing (TM) become less efficient at higher magnetic fields due to inefficient state mixing caused by large Zeeman splitting. Therefore, the signal enhancements achieved at high magnetic fields are well below the theoretical maximum of 658.<br style=\"font-size: 13px; color: #444444;\" /> <br style=\"font-size: 13px; color: #444444;\" />An alternative approach, which is recently gaining foothold, will be discussed. In this approach, microwave pulses with varying phase, length, amplitude and frequency are employed to obtain field independent electron-nuclear polarization transfer by fulfilling the required matching condition. Such methods require microwave irradiation with low duty cycle, which minimized the problem of sample heating that is prominent is CW-DNP experiments. Moreover, the paramagnetic effects, i.e. NMR line-broadening, signal quenching and relaxation enhancement, caused by the presence of a paramagnetic center can also be reversed using microwave pulses with frequency switching capabilities. I will show experimental evidences of reversal of paramagnetic effects at a magnetic field of 6.9 T and 4K temperature. <br style=\"font-size: 13px; color: #444444;\" /> <br style=\"font-size: 13px; color: #444444;\" />At the end, I will talk about my future research plans focusing at developments and applications of the magnetic resonance techniques (NMR and DNP) to study materials and biological samples.  </div>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 865, 'NULL', '2019-04-29 23:40:20', '2030-12-01 18:30:00'),
(579, 'May 2, 2019 at 4.00 pm in AG-80', 'Title :\nHow membrane characteristics influence membrane protein conformation\nAbstract :\nCell membran', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">How membrane characteristics influence membrane protein conformation</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Cell membranes not only maintain cell integrity, but possibly also influence the functioning of membrane proteins. Local membrane order and cholesterol content are two important factors, but they remain poorly understood.  Here, I have probed how the mode of interaction of Amylin (a disease causing peptide oligomer with high membrane affinity) is controlled by the nature of membrane. For this purpose, we have built a combined AFM-Confocal-FLIM-FCS set up and probed the accessibility of the terminals (N and C) and the extent of insertion in different membrane environments. We find that these parameters are highly dependent on the local lipid order. We also monitored the extent of depletion of cholesterol in presence and absence of amylin, and found that amylin resists the changes caused by cholesterol depletion and helps the membrane to retain its integrity. Thus, our study quantifies the strong reciprocal influence between membrane proteins and membranes, which has possible biological consequences.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 920, 'NULL', '2019-04-30 05:15:28', '2030-12-01 18:30:00'),
(580, 'May 9, 2019 at 4.00 pm in AG-80', 'Title :\nUnfolding of Proteins in Solution Under External Electric Field', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Unfolding of Proteins in Solution Under External Electric Field</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 914, 'NULL', '2019-05-07 00:00:33', '2030-12-01 18:30:00'),
(581, 'May 16, 2019 at 4.00 pm in AG-80', 'Title :\nRole of Salt Bridges in Thermodynamic Stability of Ubiquitin', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Role of Salt Bridges in Thermodynamic Stability </span>of Ubiquitin</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 972, 'NULL', '2019-05-07 00:02:00', '2030-12-01 18:30:00');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(582, 'May 14, 2019 at 2.30 pm in AG-69', 'Title :\nIn Search of New Materials for Electrical Energy Storage\n ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">In Search of New Materials for Electrical Energy </span>Storage</h3>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 988, 'NULL', '2019-05-07 00:11:37', '2030-12-01 18:30:00'),
(583, 'May 13, 2019 at 4.00 pm in AG-69', 'Title :\nEffect of Temperature and Circular Permutation on the Mechanical Stability of Proteins', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Effect of Temperature and Circular Permutation on the Mechanical Stability of Proteins</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 960, 'NULL', '2019-05-08 23:04:30', '2030-12-01 18:30:00'),
(584, 'June 3, 2019 at 4.00 pm in AG-69', 'Title :\nStability Aspects and Optoelectronic Properties of Hybrid Perovskites', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Stability Aspects and Optoelectronic Properties of Hybrid Perovskites</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 754, 'NULL', '2019-05-29 22:10:06', '2030-12-01 18:30:00'),
(585, 'June 10, 2019 at 4.00 pm in AG-69', 'Title :\nDefect Engineering in Dendritic Fibrous Nano Silica-based Material for CO2 Methanation', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Defect Engineering in Dendritic Fibrous Nano </span>Silica-based Material for CO<sub>2</sub> Methanation</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 897, 'NULL', '2019-06-04 04:14:20', '2030-12-01 18:30:00'),
(586, 'June 7, 2019 at 2.30 pm in AG-69', 'Title :\nMicrosecond conformational dynamics of biopolymers studied by two-dimensional fluorescence l', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Microsecond conformational dynamics of biopolymers studied by two-dimensional fluorescence lifetime correlation spectroscopy</span></h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p> </p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Many biological functions of biopolymers (protein/DNA/RNA) are realized with their spontaneous structural fluctuation. Therefore, the elucidation of the energy landscape of biopolymers and their structural dynamics is essential. Single molecule spectroscopy is a powerful tool to investigate this problem, and the single molecule Förster resonance energy transfer (smFRET) technique is widely utilized. However, conventional smFRET detects only millisecond and slower dynamics. In this presentation, I’ll introduce recently developed two-dimensional fluorescence lifetime correlation spectroscopy (2D FLCS)<sup>1,2</sup> that distinguishes the conformers by their fluorescence lifetime and detects their interconverstion dynamics with a microsecond time resolution. Next, I will introduce a new method that combines dynamic fluorescence quenching (DQ) and 2D FLCS. In comparison to FRET which detects relatively large structural change, DQ is more sensitive to the local solvent accessibility of the attached dye. A major advantage of this method is that it requires only single-dye labeling compared to FRET which requires double-labeling. By applying this DQ 2D FLCS to a singly-labeled DNA hairpin, we succesfully resolved the open and closed forms in the equilibrium and detected their microsecond interconversion dynamics. I’ll also show the application of 2D FLCS on preQ<sub>1</sub> riboswitch, an important antibiotic drug target, to resolve its heterogeneous folding dynamics and distinct ligand binding mechanisms.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\"> </span></p>\n<p style=\"text-align: justify;\">[1, 2] Ishii, K. &amp; Tahara, T. Journal of Physical Chemistry B, 2013 117, 11414 &amp; 11423.</p>\n<p style=\"text-align: justify;\"> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 825, 'NULL', '2019-06-06 22:22:47', '2030-12-01 18:30:00'),
(587, 'June 18, 2019 at 2.30 pm in AG-80', 'Title :\nOrganometallic Catalysis for Energy &amp; Environment: What we have achieved\nAbstract :\nCata', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Organometallic Catalysis for Energy &amp; Environment: What we have achieved</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"Default\" style=\"text-align: justify;\"><span style=\"font-family: \'Times New Roman\', serif;\"><span style=\"font-size: 14.6667px;\">Catalysis plays a major role in the production of food, pharmaceuticals and energy. We have been working in the area of green homogeneous catalysis using pincer complexes of transition-metals. We have developed several interesting methods that are environmentally-benign and sustainable for the production of industrially useful chemicals from the cheap and inexpensive starting materials using pincer complexes of earth-abundant metals such as manganese. These methods are based on hydrogenation or dehydrogenation reactions which makes the overall process highly atom-economic. Utilization of manganese in place of precious metals such as ruthenium makes the overall process cheaper and more sustainable. Some of these examples will be discussed in the lecture, such as: </span></span></p>\n<p class=\"Default\" style=\"text-align: justify;\"><span style=\"font-family: \'Times New Roman\', serif;\"><span style=\"font-size: 14.6667px;\"> </span></span></p>\n<p class=\"Default\" style=\"text-align: justify;\"><span style=\"font-family: \'Times New Roman\', serif;\"><span style=\"font-size: 14.6667px;\">1.We reported the first example of the direct synthesis of amides by the dehydrogenative coupling of amines with either alcohols or esters using an earth-abundant metal catalyst.</span></span></p>\n<p class=\"Default\" style=\"text-align: justify;\"><span style=\"font-size: 14.6667px; font-family: \'Times New Roman\', serif;\">2.</span><span style=\"font-size: 14.6667px; font-family: \'Times New Roman\', serif;\">We reported the first example of the direct hydrogenation of organic carbonates to methanol using an earth-abundant metal catalyst. As organic carbonates can be readily prepared from CO<sub>2</sub> and alcohols, this method can be utilized as an alternative route for the conversion of low-pressure CO<sub>2</sub> to methanol.</span></p>\n<p class=\"Default\" style=\"text-align: justify;\"><span style=\"font-size: 14.6667px; font-family: \'Times New Roman\', serif;\">3.</span><span style=\"font-size: 14.6667px; font-family: \'Times New Roman\', serif;\">We discovered a fundamentally new Liquid Organic Hydrogen Carrier (LOHC) based on coupling of diols and diamines for the development of a reversible hydrogen storage material.</span></p>\n<p class=\"Default\" style=\"text-align: justify;\"><span style=\"font-family: \'Times New Roman\', serif;\"><span style=\"font-size: 14.6667px;\"> </span></span></p>\n<p class=\"Default\" style=\"text-align: justify;\"><span style=\"font-size: 14.6667px; font-family: \'Times New Roman\', serif;\">1.</span><span style=\"font-size: 14.6667px; font-family: \'Times New Roman\', serif;\">(a) A. Kumar, N. A. E. Jalapa, G. Leitus, Y. Diskin Posner and D. Milstein, Angew. Chem. Int. Ed., 2017, 56, 14992. (b) N. A. E. Jalapa, A. Kumar, G. Leitus, Y. Diskin Posner and D. Milstein, J. Am. Chem. Soc., 2017,139, 11722. </span></p>\n<p class=\"Default\" style=\"text-align: justify;\"><span style=\"font-family: \'Times New Roman\', serif;\"><span style=\"font-size: 14.6667px;\">2.A. Kumar, T. Janes, N. A. E. Jalapa, D. Milstein, Angew. Chem. Int. Ed., 2018, 57, 12076. </span></span></p>\n<p class=\"Default\" style=\"text-align: justify;\"><span style=\"font-family: \'Times New Roman\', serif;\"><span style=\"font-size: 14.6667px;\">3.A. Kumar, T. Janes, N. A. E. Jalapa, D. Milstein, J. Am. Chem. Soc., 2018, 140, 7453.</span></span></p>\n<p style=\"text-align: justify;\"> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 879, 'NULL', '2019-06-09 22:32:19', '2019-06-09 22:35:29'),
(588, 'On June 19, 2019 at 2.30 pm in AG-80', 'Title :\nOrganometallic Catalysis for Energy &amp; Environment: What we can achieve\nAbstract :\nWe are', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Organometallic Catalysis for Energy &amp; Environment: What we can achieve</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">We are living in the age where we have witnessed critical rise in all types of pollution and the depletion of limited supply of fossil fuel. A lot of it is caused by the way our industries manufacture their products and our dependence on fossil fuel for the production of energy. In order to restore the balance of clean environment we need to develop production methods that are environmentally-benign, atom-economic and sustainable. This lecture will focus on some of the strategy in Green Catalysis that can be utilized for the production of industrially useful chemicals and energy storage materials from inexpensive and readily available starting materials. For example: (a) Based on our recent discovery,<sup>1</sup> utilization of alkali or alkaline earth-metal catalysts instead of transition-metal catalysts can make the overall process cheaper and sustainable. (b) Development of reversible chemical hydrogen storage materials such as those based on glycerols or amine-boranes<sup>2</sup>. (c) Chemical recycling of robust plastics such as nylons, polycarbonates and polyurethanes using ruthenium catalyzed hydrogenative depolymerization method. </span></p>\n<p><span style=\"font-size: 12.16px;\"> </span></p>\n<p><span style=\"font-size: 12.16px;\">1.A. Kumar, T. Janes, S. Chakraborty, P. Daw, N. von Wolff, R. Carmieli, Y. Diskin-Posner, D. Milstein, Angew. Chem. Int. Ed., 2019, 58, 3373. </span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">2.A. Kumar, N. Beatie, S. A. Macgregor, A. S. Weller, Angew. Chem. Int. Ed., 2016, 55, 6551.</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 789, 'NULL', '2019-06-09 22:34:46', '2030-12-01 18:30:00'),
(589, 'June 25, 2019 at 2.30 pm in AG-69', 'Title :\nCarbon dioxide capture: Insights from Raman spectroscopy\nAbstract :\nIncreasing carbon dioxid', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Carbon dioxide capture: Insights from Raman spectroscopy</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Increasing carbon dioxide levels stemming from various anthropogenic sources have led to adverse climatic conditions. CO<sub>2</sub> sequestration becomes vital to mitigate global warming. Metal organic frameworks (MOFs) have immense potential to sequester CO<sub>2</sub> owing to their porous and flexible architecture exhibiting high guest selectivity. While the as-synthesized structure can be predicted by X-ray diffraction, knowing in-situ structural dynamics during gas adsorption is a challenge. In the first part of the talk, I will discuss how adsorption or desorption of gases modulates the structure of MOFs. Investigating these dynamics frameworks are crucial for designing new materials with higher CO<sub>2</sub> uptake. </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\"> </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Furthermore, it is necessary to reduce captured CO<sub>2</sub> into fuels and one of the ways to achieve this is by using metal nanostructures. In addition to catalysing chemical reaction, plasmonic nanoparticles also amplify the signal of adsorbed molecules enabling their detection via surface enhanced Raman spectroscopy (SERS). In the second half of the talk, I will show different types of plasmonic nanostructures and further illustrate that silver nanoparticles exhibit high SERS enhancement and hence is a suitable catalyst for studying single molecule reaction. </span></p>\n<p style=\"text-align: justify;\">References. </p>\n<p>1.P. Kanoo, S. K. Reddy, G. Kumari, R. Haldar, C. Narayana, S. Balasubramanian, T. K. Maji. Chem. Commun. 2012, 48, 8487-8489. </p>\n<p><span style=\"font-size: 12.16px;\">2.G. Kumari, K. Jayaramulu, T. K. Maji, C. Narayana. J. Phys. Chem. A 2013, 117, 11006-11012. </span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">3.G. Kumari, C. Narayana. J. Phys. Chem. Lett 2012, 3, 1130-1135. </span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1032, 'NULL', '2019-06-12 00:50:38', '2030-12-01 18:30:00'),
(590, 'June 26, 2019 at 2.30 pm in AG-69', 'Title :\nVisible light driven carbon dioxide reduction on plasmonic catalyst\nAbstract :\nDirect conver', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Visible light driven carbon dioxide reduction on plasmonic catalyst</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Direct conversion of solar to chemical energy has gained renewed interest in the recent years. Plants uptake atmospheric CO<sub>2</sub> to produce sugar by the process of photosynthesis. Recreating this process requires materials which can absorb light and convert it into energy. Plasmonic nanoparticles of silver and gold are excellent candidates for photocatalysis due to their high absorption cross section. In my talk, I will show that under light irradiation, silver nanoparticles catalyze CO<sub>2</sub> reduction reaction. Spatially resolved single particle surface enhanced Raman spectroscopy shows formation of intermediate such as HOCO* as well products such as carbon monoxide and formic acid. Further, binding geometry of HOCO* plays decisive role in directing the reaction either towards carbon monoxide or formic acid. </span></p>\n<p style=\"text-align: justify;\">Although catalytic reaction on plasmonic nanostructures is fairly well studied, the fate of metal nanoparticles post photocatalysis is largely unknown. We found that plasmon-assisted CO<sub>2</sub> reduction reaction induces significant directional restructuring on catalyst surface. In the second part of the talk, I will show you how these structural changes in plasmonic catalysts also gives an insight into the mechanism of photocatalytic activation, the distribution of active sites on nanoparticle surface and the definite role of light. </p>\n<p>References. </p>\n<p>1.G. Kumari, X. Zhang, D. Devasia, J. Heo, P. K. Jain. ACS Nano 2018, 12, 8330−8340. </p>\n<p><span style=\"font-size: 12.16px;\">2.S. Yu, A. J. Wilson, G. Kumari, X. Zhang, P. K. Jain. ACS Energy Lett. 2017, 2, 2058-2070. </span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">3.X. Zhang, G. Kumari, J. Heo, P. K. Jain. Nat. Commun. 2018, 9, 3056 </span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1029, 'NULL', '2019-06-12 00:52:14', '2019-06-12 00:52:45'),
(591, 'June 28, 2019 at 2.30 pm in AG-69', 'Title :\nStability, Non-enzymatic hydrolysis, and Abiological activity of CYP175A1 and its analogues', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Stability, Non-enzymatic hydrolysis, and Abiological activity of CYP175A1 and its analogues</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 763, 'NULL', '2019-06-19 03:36:09', '2030-12-01 18:30:00'),
(592, 'July 9, 2019 at 2.30 pm in AG-80', 'Title :\nFrom Protein-Protein Interaction Modulators to Chemical Protein Synthesis: Exploring Unconv', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">From Protein-Protein Interaction Modulators to Chemical Protein Synthesis: Exploring </span>Unconventional Approaches</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Protein-protein interactions (PPIs) are associated with a wide range of crucial biological processes and targeting specific PPIs has been demonstrated to have tremendous therapeutic potential. However, PPIs – once termed as ‘undruggable’ targets, often involve large and flat binding sites along with conformational changes rendering traditional approaches ineffective. The kinetic target-guided synthesis (TGS) serves as an unconventional strategy, having the potential to streamline the development of protein-protein interaction modulators (PPIMs). In this fragment-based approach, the target is directly involved in the assembly of its own bidentate ligand from a library of reactive fragments. The first half of this seminar will focus on the application of kinetic TGS based on the sulfo-click reaction to identify PPIMs of the Bcl-2 family of proteins.</span></p>\n<p style=\"text-align: justify;\">Chemical synthesis of proteins serves as a powerful tool for accessing these valuable biomolecules with the ability to introduce chemical modifications site-selectively. Although native chemical ligation (NCL), reported by Kent and co-workers in 1994, has been the cornerstone of chemical protein synthesis, several mechanically distinct and thiol-independent ligation reactions have also emerged in the last decade. For example, the KAHA ligation, reported by the Bode group in 2006, features a chemoselective reaction between a peptide segment bearing a C-terminal a-ketoacid and another peptide with an N-terminal hydroxylamine. Successful application of the KAHA approach through convergent ligations to accomplish total synthesis of a 184-residue ferric heme-binding protein, nitrophorin 4 (NP4) will be discussed in the second half of this seminar.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 848, 'NULL', '2019-06-20 03:50:29', '2030-12-01 18:30:00'),
(593, 'July 10, 2019 at 2.30 pm in AG-80', 'Title :\nChemical Protein Synthesis via a Diselenide–Selenoester Ligation Approach\nAbstract :\nNativ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Chemical Protein Synthesis via a Diselenide–Selenoester Ligation Approach</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Native chemical ligation (NCL), reported by Kent and co-workers in 1994, has revolutionized the field of chemical protein synthesis, enabling access to numerous site-specifically modified proteins. While NCL is regarded as the most widely used method for the construction of proteins, some intrinsic limitations of this seminal technology have catalysed the search for an alternative approach. Recently, the Payne group developed a selenium-mediated ligation methodology – the diselenide–selenoester ligation (DSL). First disclosed in 2015, DSL offers number of unique and exciting features, greatly expanding the scope of NCL. Typically, these ligations are performed by simply mixing the two suitably functionalized peptide fragments (peptide bearing a C-terminal selenoester and another peptide with an N-terminal diselenide) dissolved in a denaturing buffer without any exogenous thiols or other additives and proceed to completion within 1-10 minutes, even at sterically hindered junctions. Moreover, due to the lower pKa of selenocysteine compared to cysteine, the ligations can be performed over a wide pH range (pH 3–7) and owing to their additive-free nature, allow one-pot deselenization after ligation. Chemical synthesis of therapeutic peptides and proteins bearing site-specific posttranslational modifications (PTMs) using this rapid and highly efficient ligation methodology will be showcased during this seminar.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 899, 'NULL', '2019-06-20 03:51:56', '2030-12-01 18:30:00'),
(594, 'July 8, 2019 at 4.00 pm in AG-69', 'Title :\nComputation of Resonance Magnetic Fields of CW‑EPR Spectra by Reversion of Power Series\nA', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Computation of Resonance Magnetic Fields of CW‑EPR </span>Spectra by Reversion of Power Series</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Electron paramagnetic resonance (EPR) spectra are generally recorded as a function of the magnetic field, while keeping the energy of transitions fixed.  Calculations of the EPR spectra, however, are almost always performed at a fixed magnetic field of a given spin-Hamiltonian to determine the energies of various transitions. These two methods, in general, do not produce equivalent spectra. In this pedagogical talk, I will first briefly highlight how various approaches have been used to handle this dichotomy by various workers. I will then describe our recent method to calculate the resonance magnetic fields at a fixed frequency.  With some help from the perturbation theory and the mathematics of reversion of polynominals, our method gives the resonance magnetic fields at a fixed frequency in a relatively simple and straightforward manner. </span></p>\n<p>Ref. Vinayak Rane and Ranjan Das, Applied Magnetic Resonance,  https://doi.org/10.1007/s00723-019-01128-6 </p>\n<p> </p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 863, 'NULL', '2019-06-21 03:24:37', '2030-12-01 18:30:00'),
(595, 'July 3, 2019 at 11.30 am in AG-80', 'Title :\nIs the early stage of aggregation important in understanding neurodegenerative diseases?\nAbs', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Is the early stage of aggregation important in understanding neurodegenerative diseases?</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Although majority of the neurodegenerative diseases do not have any cure available, protein aggregation and deposition has been found to be a common phenotype. The heterogeneity of aggregation process and the presence of large number of triggering mechanisms results in the difficulty to devise therapeutic strategies against these toxic inclusions formation. Our laboratory has been investigating these triggers, which contribute to the alteration of folding pathways leading to the early and unexplored stages of aggregation. The conformational heterogeneity of the early intermediates and their transient nature are some of the reasons why traditional techniques do not typically work for the early stage detection. We have been using sensitive biophysical methods to directly detect and characterize the early intermediates and oligomers in vitro and inside live cells using Parkinson’s diseases (PD) and ALS as our models. We are also using cryo-EM to investigate the structural insights into the early intermediates, which are believed to the primary inducer of cellular toxicity. Using a combination of biophysics, biochemistry and microscopy, we are developing protein early intermediates vs toxicity maps to determine the structural insights responsible for the neuronal toxicity.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 853, 'NULL', '2019-06-24 00:49:16', '2030-12-01 18:30:00'),
(596, 'July 18, 2019 at 2.30 pm in AG-80', 'Title :\nBiophysical characterization of DNA damage proteins from Rice Plant\nAbstract :\nDNA damage in', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Biophysical characterization of DNA damage proteins from Rice Plant</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">DNA damage in living cells is repaired by two main pathways, homologous recombination (HR) and non-homologous end joining (NHEJ). The proteins involved in HR pathway have been widely studied in eukaryotes. The MRX/N complex which consists of Mre11, Rad50 and Xrs2 in case of yeast and Nbs1 for vertebrates, are the first responders to double strand breaks. This complex scans the DNA double strand for a break, and binds to the broken DNA ends as soon as a break occurs. The Mre11 protein of the MRN complex is highly conserved in eukaryotes. Rad52 (Radiation sensitive 52) belongs to a different group of important genes, and is found to be highly conserved across different species. Until lately, it was believed that RAD52 is absent in plant systems. However, recent genetic studies have pointed out the presence of RAD52 homologues in plants, though these have not yet been characterized biochemically. </span></p>\n<p style=\"text-align: justify;\">In the current study, the biochemical properties of rice OsMre11 and OsRad52 protein were analysed. These proteins were over-expressed in Escherichia coli over expression host cells and the proteins purified. The identity of purified OsMre11 and OsRad52 protein was confirmed via peptide mass fingerprinting. DNA binding assays showed that the purified proteins were able to bind to different forms of DNA. Purified OsMre11 protein exhibited nuclease properties, which was promoted by presence of manganese as a co- factor. Gel filtration and native PAGE analysis indicated that the OsRad52 protein in its native state probably formed an undecameric structure. Purified OsRad52 mediated the renaturation of complementary single strands into duplex DNA via both agarose gel and FRET based assays. Hence concluding that both OsMre11 and OsRad52 proteins, binds to ssDNA/dsDNA for mediating important functions like nucleolytic cleavage and renaturation during homologous recombination. This study represents the first report on biochemical properties of OsMre11 and OsRad52 protein from important crop like rice, which shall help in dissecting the recombination and repair machinery in plant systems.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 956, 'NULL', '2019-07-09 03:44:20', '2030-12-01 18:30:00'),
(597, 'July 15, 2019 at 4.00 pm in AG-69', 'Title :\nThe response of blue copper protein to changes in beta sheet connectivity\n ', '<h3>Title</h3>\n<h3>The response of blue copper protein to changes in beta sheet connectivity</h3>\n<div> </div>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 854, 'NULL', '2019-07-10 03:57:25', '2030-12-01 18:30:00'),
(598, 'July 22, 2019 at 4.00 pm in AG-69', 'Title :\nCan EPR be used to probe solid-liquid phase transitions in confined systems?\nAbstract :\nStud', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Can EPR be used to probe solid-liquid phase transitions in confined systems?</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Study of systems such as water under confined conditions is actively pursued because of its relevance to real systems, such as cells, microorganisms, etc. In this regard, EPR spectroscopy offers a convenient route due to its excellent sensitivity to micro viscosity and penetrability power.  When used as a probe-based spectroscopy, however, the probe-system interactions need to be thoroughly examined beforehand. In this work, we consider a specific property: solid⇌liquid transition of water, and ask a fundamental question, “Can EPR detect the freezing of water at its conventional freezing point in bulk/confined conditions?”   Our work convincingly demonstrates that the spin probe can itself induce liquid domains in ice, which could be mistaken as a depression in the freezing point. We propose a theory to account for these solute induced perturbations. Finally, it will be discussed how the proposed theory can be applied to the extreme dilution case of a solution containing a single solute molecule.   </span></p>\n<p>References</p>\n<p>1.Thangswamy, M.; Maheshwari, P.; Dutta, D.; Rane, V.*; Pujari, P. K. J. Phys. Chem. A 2018, 122, 5177-5189.</p>\n<p>2.Thangswamy, M.; Maheshwari, P.; Dutta, D.; Rane, V.*; Pujari, P. K. J. Phys. Chem. C 2019, 123, 11244-11256.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 898, 'NULL', '2019-07-15 00:37:12', '2030-12-01 18:30:00'),
(599, 'July 29, 2019 at 4.00 pm in AG-69', 'Title :\nComputational investigation of the effect   of copper coordination and native disulfide bo', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Computational investigation of the effect   of copper coordination and native disulfide bond   on the mechanical unfolding   pathways of Azurin</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 835, 'NULL', '2019-07-23 05:13:34', '2030-12-01 18:30:00'),
(600, 'July 30, 2019 at 2.30 pm in AG-69', 'Title :\nSmall Molecule Activation at Transition Metal Centers: Structure-Function Correlations\nAbstr', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Small Molecule Activation at Transition Metal Centers: Structure-Function Correlations</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Small molecule activation constitutes one of the main frontiers of inorganic and organometallic chemistry, with much effort directed towards the development of new processes for the selective and sustainable transformation of abundant small molecules such as dioxygen (O<sub>2</sub>), water (H<sub>2</sub>O), hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) or protons (H<sup>+</sup>) into high-value chemical feedstocks and energy resources. Because nature mostly uses metal ions to activate these relatively inert molecules and modulate their reactivity, much inspiration for the field has come from bioinorganic chemistry. This talk will focus on some of the recent highlights from our group on homogenously catalyzed bioinspired activation of small molecules, as well as stoichiometric reactions that further our understanding towards such ends. It will cover many aspects of small molecule activation including: organometallic chemistry, spectroscopy, synthesis, and detailed mechanistic studies involving trapping of reactive intermediates. The demonstrated examples will help to emphasize the continuous effort of our group in uncovering the structure-reactivity relationships of biomimetic model complexes, which may allow vital insights into the prerequisites necessary for the design of efficient catalysts for the selective functionalization of unactivated C–H bonds, O<sub>2</sub>/H<sub>2</sub>O/H<sub>2</sub>O<sub>2</sub> activations, or H<sup>+</sup> reductions by using cheap and readily available first-row transition metals under ambient conditions.</span></p>\n<p class=\"MsoNormal\" style=\"margin-top: 6pt; text-align: justify;\"> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1065, 'NULL', '2019-07-25 03:40:46', '2030-12-01 18:30:00'),
(601, 'August 13, 2019 at 2.30 pm in AG-80', 'Title :\nEvaluation of Photocatalytic Activity Over g-C3N4 Coated DFNS and the Role of Interface', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Evaluation of Photocatalytic Activity Over g-C<sub>3</sub>N<sub>4</sub> Coated DFNS and the Role of Interface</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 925, 'NULL', '2019-08-07 23:23:29', '2030-12-01 18:30:00'),
(602, 'August 19, 2019 at 4.00 pm in AG-69', 'Title :\nProtein degradation by a double-ring AAA+ protease: in singulo mechanisms of unfolding and t', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Protein degradation by a double-ring AAA+ protease: in singulo mechanisms of unfolding and translocation</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\"> </span></p>\n<p style=\"text-align: center;\"><span style=\"font-size: 12.16px;\"><img src=\"images/image-hemachandra.png\" border=\"0\" alt=\"\" /></span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">ATP powered molecular motors play a crucial role in maintaining protein quality control in a cell and AAA+ proteases maintain protein homeostasis by degrading damaged and unneeded proteins. Single-molecule manipulation tools complement the biochemical experiments and provide deeper insights into the mechanisms of these molecular motors and their interaction with protein substrates. In this talk, I will discuss my recent work on mechanistic investigations of a double-ring AAA+ protease, E.coli ClpAP using single-molecule optical tweezers and determine the role of individual ATPase rings in protein unfolding and translocation. Our single-molecule studies provide new insight into the functional importance of the D1 ring of ClpA and the role of coordination between the two AAA+ rings. Also, the differences in translocation from N- and -C termini indicate that the enzyme can recognize subtle differences in direction of the polypeptide track. In addition, I will elucidate the paramount role of local stability of a substrate in protein degradation and provide clues as to how the placement of degradation signals on a substrate may evolve to minimize the energetic cost of degradation.</span></p>\n<p style=\"text-align: justify;\"><span style=\"text-decoration: underline;\">References</span>:</p>\n<p style=\"text-align: justify;\">Hema Chandra Kotamarthi, Robert Sauer, Tania Baker. “The non-dominant AAA+ ring in the ClpAP protease functions as an anti-stalling motor to accelerate protein unfolding and translocation” (Pre-peer reviewed version at bioarXiv: https://doi.org/10.1101/585554)</p>\n<p style=\"text-align: justify;\">Adrian Olivares*, Hema Chandra Kotamarthi*, Benjamin Stein, Robert Sauer, Tania Baker, “Effect of directional pulling on mechanical protein degradation by ATP-dependent proteolytic machines”, Proceedings of National Academy of Sciences, USA, 2017, Vol 114, E6306-E6313. * Equal Contribution.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 812, 'NULL', '2019-08-13 05:37:40', '2030-12-01 18:30:00'),
(603, 'August 20, 2019 at 2.30 pm in AG-69', 'Title :\nPicturing the future of healthcare through molecular imaging \nAbstract :\nIn vivo molecular ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Picturing the future of healthcare through molecular imaging </span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In vivo molecular imaging has the unique advantage of noninvasively assessing cancer metabolism or providing functional real-time information relative to obtaining ex vivo pathological information from tissue biopsies. Two important molecular imaging modalities are Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET). </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">The first part of the presentation will focus on my research in the development of multiple diamagnetic MRI contrast agents and MRI methods that exploit Chemical Exchange Saturation Transfer (CEST) for the detection of enzyme activity (an important cancer biomarker) within in vivo tumor models of ovarian, colon and pancreatic cancers. This description will also demonstrate CEST MRI methods that have been used to correlate enzyme activity with tumor aggressiveness; to support planning for surgical resection of solid tumors; and to evaluate the early response to enzyme inhibitor treatments.  In conclusion, the first part of the talk represents a new paradigm for molecular imaging that can be translated to the radiology clinic to improve early diagnoses of cancer. </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">The second part of the presentation will focus on my contribution to the field of molecular imaging of several infectious diseases such as HIV/SIV, cerebral malaria (CM), Ebola virus disease, and Marburg hemorrhagic fever, using both MRI and PET imaging modalities. The overarching goal of these studies was to develop neuroimaging biomarkers that are useful for detecting CNS involvement prior to display of clinical symptoms. These studies with a transgenic rat model and SIV rhesus macaque models have identified dopaminergic and serotonergic neurotransmitter biomarkers and have evaluated the role of neuroinflammation in an SIV-model of encephalitis. In a related study with a CM mouse model, we used MRI to evaluate the neuropathology of the disease.  We demonstrated, for the first-time, that reversal of clinical symptoms such as edema can occur with a glutamine antagonist, JHU-083, thus suggesting a possible drug candidate for CM therapy. These studies hope to convey to the audience the growing importance of molecular imaging in unraveling early details of the disease pathology, and to recognize potential opportunities for treatment for these diseases. </span></p>\n<p style=\"text-align: justify;\"> </p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">The remaining talk will focus on harnessing molecular imaging techniques such as MRI for evaluating other biomarkers of the tumor microenvironment such as extracellular tumor pH, as well as new imaging modalities such as Photoacoustic tomography for improvement in cancer surgery. </span></p>\n<p style=\"text-align: justify;\"> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 780, 'NULL', '2019-08-18 23:43:05', '2030-12-01 18:30:00'),
(604, 'August 21, 2019 at 2.30 pm in AG-69', 'Title :\nPicturing the future of healthcare through molecular imaging \nAbstract :\nIn vivo molecula', '<p><strong><span style=\"text-decoration-line: underline;\">Title</span> :</strong></p>\n<h3><span style=\"font-size: 12.16px;\">Picturing the future of healthcare through molecular imaging </span></h3>\n<p><strong><span style=\"text-decoration-line: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">In vivo molecular imaging has the unique advantage of noninvasively assessing cancer metabolism or providing functional real-time information relative to obtaining ex vivo pathological information from tissue biopsies. Two important molecular imaging modalities are Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET). </p>\n<p style=\"text-align: justify;\">The first part of the presentation will focus on my research in the development of multiple diamagnetic MRI contrast agents and MRI methods that exploit Chemical Exchange Saturation Transfer (CEST) for the detection of enzyme activity (an important cancer biomarker) within in vivo tumor models of ovarian, colon and pancreatic cancers. This description will also demonstrate CEST MRI methods that have been used to correlate enzyme activity with tumor aggressiveness; to support planning for surgical resection of solid tumors; and to evaluate the early response to enzyme inhibitor treatments.  In conclusion, the first part of the talk represents a new paradigm for molecular imaging that can be translated to the radiology clinic to improve early diagnoses of cancer. </p>\n<p style=\"text-align: justify;\">The second part of the presentation will focus on my contribution to the field of molecular imaging of several infectious diseases such as HIV/SIV, cerebral malaria (CM), Ebola virus disease, and Marburg hemorrhagic fever, using both MRI and PET imaging modalities. The overarching goal of these studies was to develop neuroimaging biomarkers that are useful for detecting CNS involvement prior to display of clinical symptoms. These studies with a transgenic rat model and SIV rhesus macaque models have identified dopaminergic and serotonergic neurotransmitter biomarkers and have evaluated the role of neuroinflammation in an SIV-model of encephalitis. In a related study with a CM mouse model, we used MRI to evaluate the neuropathology of the disease.  We demonstrated, for the first-time, that reversal of clinical symptoms such as edema can occur with a glutamine antagonist, JHU-083, thus suggesting a possible drug candidate for CM therapy. These studies hope to convey to the audience the growing importance of molecular imaging in unraveling early details of the disease pathology, and to recognize potential opportunities for treatment for these diseases. </p>\n<p style=\"text-align: justify;\"> </p>\n<p style=\"text-align: justify;\">The remaining talk will focus on harnessing molecular imaging techniques such as MRI for evaluating other biomarkers of the tumor microenvironment such as extracellular tumor pH, as well as new imaging modalities such as Photoacoustic tomography for improvement in cancer surgery. </p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 832, 'NULL', '2019-08-18 23:43:51', '2030-12-01 18:30:00'),
(605, 'August 26, 2019 at 4.00 pm in AG-69', 'Title :\nSeries “Quantum” Resistors: Design of “molecule like” spin-filtering using superlatt', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Series “Quantum” Resistors: Design of “molecule like” spin-filtering using superlattices</span></h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In the 1980s, the era of mesoscopic transport while clearing many mists about the microscopic nature of electrical resistance, simultaneously unveiled new and counter-intuitive aspects about it. An example being that of double barrier tunneling and its hallmark consequence - two “quantum” resistors in series may give rise to an equivalent resistance that is smaller than that of each component! This aspect has been extensively studied in the context of microelectronic applications of resonant tunneling diodes (RTD). In this talk, while keeping the motif of “multiple quantum resistors”, we draw attention to some next generation applications in the realm of spintronics and energy conversion-an area commonly referred to as spin-caloritronics.</span></p>\n<p style=\"text-align: justify;\">Starting from the basic tenets of quantum transport in the double barrier context, we present novel double barrier applications in spintronics based on the physics of resonant spin filtering [1-3]. We demonstrate an ultraenhancement in the tunnel magneto resistance (TMR), well in excess of 2000%, as a result of highly sensitive and tunable spin filtering physics. With myriad applications possible by utilizing such a tunable spin filtering scheme [1- 3], we present device designs catered toward emerging logic, memory and sensing functionalities that include (i) ultra-high sensitivity magneto resistance H-field sensors (ii) Improved spin transfer torque switching resulting from the non-trivial spin current profiles, and (iii) high-power output microwave generators and oscillators based on resonant spin-transfer torque dynamics.</p>\n<p style=\"text-align: justify;\">We then extend our analysis on how electronic analogs of optical phenomena such as anti-reflection coatings and Fabry-Perot resonances may be used to engineer double barrier tunneling for spintronic and thermoelectric power co-generation [4-6]. These ideas, we believe would be useful in the next generation of spintronic logic-memories that combine in-chip heat to spin current co-harvesting.</p>\n<p><span style=\"font-size: 12.16px;\"> </span><span style=\"text-decoration: underline;\">References</span> :</p>\n<p><span style=\"font-size: 12.16px;\">[1] N. Chatterji, A. A. Tulapurkar and B. Muralidharan, Appl. Phys. Lett., 105, 232410,(2014).</span></p>\n<p><span style=\"font-size: 12.16px;\">[2] A. Sharma, A. A. Tulapurkar and B. Muralidharan, IEEE Trans. Elec. Dev., (2016).</span></p>\n<p><span style=\"font-size: 12.16px;\">[3] A. Sharma, A. A. Tulapurkar and B. Muralidharan, Phys. Rev. Applied, 8, 064014, (2017).</span></p>\n<p><span style=\"font-size: 12.16px;\">[4] A. Agarwal and B. Muralidharan, Appl. Phys. Lett., 105,013104, (2014).</span></p>\n<p><span style=\"font-size: 12.16px;\">[5] A. Sharma, A. A. Tulapurkar and B. Muralidharan, Appl. Phys. Lett., 112, 192404, (2018).</span></p>\n<p><span style=\"font-size: 12.16px;\">[6] S. Mukherjee, P. Priyadarshi and B. Muralidharan, IEEE Trans. Elec. Dev., (2018).</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 791, 'NULL', '2019-08-19 00:26:37', '2030-12-01 18:30:00'),
(606, 'August 29, 2019 at 2.30 pm in AG-80', 'Title :\nEngineering Artificial Metalloenzyme for Enantioselective Catalysis\nAbstract :\nArtificial me', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Engineering Artificial Metalloenzyme for Enantioselective Catalysis</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Artificial metalloenzymes (ArMs) offer new opportunities to improve catalytic selectivity and efficiency. They are a class of catalysts that result from incorporation of an organometallic catalyst precursor within a host protein. This combination exploits the reactivity of the transition metal catalysts while taking advantage of the selectivity and adaptability of proteins. Our research has demonstrated formation of ArMs through strain promoted azide-alkyne cycloaddition. It is a ‘click’ bioconjugation approach, where a covalent link is formed between metal complex and protein through cycloaddition of a strained alkyne linker and genetically encoded p-azidophenyl alanine on the protein scaffold. Several scaffold proteins and cofactor components were explored to demonstrate versatility of this method. Extensive biophysical characterization of these Arms was also done by mass spectrophotometry, fluorescence spectroscopy and X-ray crystallography. Scaffold proteins were engineered to get accelerated bioconjugation of metal cofactors without perturbing the structural conformation around the catalytic site. Enantioselective carbene insertion into Si-H bond and olefin has been observed using dirhodium based ArMs. Further improvement in selectivity was explored via structure based single point mutagenesis and directed protein evolution approach.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 858, 'NULL', '2019-08-20 03:50:00', '2030-12-01 18:30:00');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(607, 'September 11, 2019 at 11.30 am in AG-80', 'Title :\nBispidine coordination chemistry – ligands for medicinal chemistry, bioinorganic modeling ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Bispidine coordination chemistry – ligands for medicinal chemistry, bioinorganic modeling and oxidation catalysis</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">All important properties of coordination compounds – hermodynamics (complex stabilities, metal ion selectivities, redox potentials), kinetics (reaction rates, selectivities and pathways) as well as electronics (spectroscopy and magnetism) – depend on their structure. The structure of metal complexes is the result of metal ion and ligand preferences, and it is shown that ligand preferences prevail, especially with ligands as rigid as the bispidines. The unique geometries of bispidine transition metal and lanthanide complexes will be described and the resulting properties will be discussed. Specific examples and applications that will be presented include the Cu</span><sup style=\"color: #222222; font-family: verdana, arial, serif; text-align: justify;\">II/I</sup><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\"> couple with applications ranging from oxygen activation, azidirination and positron emission tomography (PET) and high-valent nonheme iron model chemistry (oxidation catalysis).</span><br style=\"font-size: 13px; color: #444444; font-family: verdana, arial, serif; text-align: justify;\" /><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\"> </span><br style=\"font-size: 13px; color: #444444; font-family: verdana, arial, serif; text-align: justify;\" /><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">References</span><br style=\"font-size: 13px; color: #444444; font-family: verdana, arial, serif; text-align: justify;\" /><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">P. Comba, M. Kerscher, W. Schiek </span><em style=\"font-size: 13px; color: #444444; font-family: verdana, arial, serif; text-align: justify;\">Progr. Inorg. Chem., 2007, 55, 613.</em><br style=\"font-size: 13px; color: #444444; font-family: verdana, arial, serif; text-align: justify;\" /><span style=\"color: #222222; font-family: verdana, arial, serif; font-size: 13px; text-align: justify;\">P. Comba, M. Kerscher, K. Rück, M. Starke</span><em style=\"font-size: 13px; color: #444444; font-family: verdana, arial, serif; text-align: justify;\"> Dalton Perspective 2018, 47, 9202</em></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 866, 'NULL', '2019-09-08 22:43:57', '2030-12-01 18:30:00'),
(608, 'September 13, 2019 at 11.30 am in AG-80', 'Title :\nTargeted Prodrugs to Manipulate Copper Biology of Prostate Cancer\nAbstract :\nCancer cells ha', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Targeted Prodrugs to Manipulate Copper Biology of Prostate Cancer</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; mso-layout-grid-align: none; text-autospace: none;\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">Cancer cells have considerably different metallome than normal cells. Especially prostate cancer has been shown to overexpress several important copper trafficking proteins and recruit high levels of copper, making it more sensitive towards drugs like disulfiram.<sup>1</sup> Disulfiram acts by altering the copper biology of prostate cancer. Though disulfiram is a promising anticancer agent, the off-target activities lead to adverse side effects.<sup>2</sup> Disulfiram’s off-target effects can be mitigated in the cancer setting by chemical modification of the active pharmacophore, dithiocarbamate, in ways that target it preferentially to prostate cancer cells.<sup>3</sup> In this seminar, I will present the design, development, and activity of dithiocarbamate prodrug, a Cu prochelator, that is activated in the prostate cancer microenvironment specifically. </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; mso-layout-grid-align: none; text-autospace: none;\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; mso-layout-grid-align: none; text-autospace: none;\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">References :</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; mso-layout-grid-align: none; text-autospace: none;\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\"> </span></p>\n<p class=\"MsoNormal\" style=\"margin-left: 19.5pt; text-align: justify; text-indent: -19.5pt; mso-list: l0 level1 lfo1; mso-layout-grid-align: none; text-autospace: none;\"><!--[if !supportLists]--><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\"><span style=\"mso-list: Ignore;\">(1)<span style=\"font: 7.0pt \'Times New Roman\';\">      </span></span></span><!--[endif]--><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">Safi, R.; Nelson, E. R.; Chitneni, S. K.; Franz, K. J.; George, D. J.; Zalutsky, M. R.; McDonnell, D. P. Copper signaling axis as a target for prostate cancer therapeutics.<em>Cancer Res </em><strong>2014</strong>, <em>74</em>, 5819. </span></p>\n<p class=\"MsoNormal\" style=\"margin-left: 19.5pt; text-align: justify; text-indent: -19.5pt; mso-list: l0 level1 lfo1; mso-layout-grid-align: none; text-autospace: none;\"><!--[if !supportLists]--><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\"><span style=\"mso-list: Ignore;\">(2)<span style=\"font: 7.0pt \'Times New Roman\';\">      </span></span></span><!--[endif]--><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">Schweizer, M. T.; Lin, J.; Blackford, A.; Bardia, A.; King, S.; Armstrong, A. J.; Rudek, M. A.; Yegnasubramanian, S.; Carducci, M. A. Pharmacodynamic study of disulfiram in men with non-metastatic recurrent prostate cancer.<em>Prostate Cancer Prostatic Dis </em><strong>2013</strong>, <em>16</em>, 357. </span></p>\n<p class=\"MsoNoSpacing\" style=\"margin-left: 19.5pt; text-align: justify; text-indent: -19.5pt; line-height: 115%; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span style=\"font-size: 10.0pt; line-height: 115%; mso-bidi-font-family: Calibri; color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\"><span style=\"mso-list: Ignore;\">(3)<span style=\"font: 7.0pt \'Times New Roman\';\">      </span></span></span><!--[endif]--><span style=\"font-size: 10.0pt; line-height: 115%; font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: \'Times New Roman\'; color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">Bakthavatsalam, S.; Sleeper, M. L.; Dharani, A.; George, D. J.; Zhang, T.; Franz, K. J. Leveraging γ-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells.<em>Angew. Chem. Int. Ed. </em><strong>2018</strong>, <em>57</em>, 12780.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 872, 'NULL', '2019-09-08 23:37:26', '2030-12-01 18:30:00'),
(609, 'September 19, 2019 at 4.00 pm in AG-80', 'Title :\nCu2ZnSnS4: A potential photovoltaic material for low-cost thin film solar cell\nAbstract :\nSh', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Cu<sub>2</sub>ZnSnS<sub>4</sub>: A potential photovoltaic material for low-cost thin film solar cell</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\">Shifting to renewable energy is the solution for meeting the ever-increasing energy demand as well as preventing the deterioration of the environment due to the use of fossil fuel-based energy sources. The Sun from which abundant energy is received on the Earth is probably the most promising renewable energy source. A solar photovoltaic (PV) device converts the solar radiation directly into electricity. Such as device is comprised of a photo-absorber material that absorbs incident photons and uses their energy for raising the chemical potential of electrons within the material. Other materials interfaced with this photo-absorber help collect these excited electrons at one end of the PV device and thereby help generate a potential difference.</span></p>\n<p style=\"text-align: justify;\"><span style=\"text-align: justify; text-indent: 36pt; font-size: 10pt; line-height: 115%; font-family: \'Times New Roman\', serif;\" lang=\"EN-US\">Silicon has been the semiconductor of choice for the role of photo-absorber in a PV device, however, due to lower absorption coefficient (α =10<sup>3</sup> cm<sup>−1</sup>; λ &lt; 825 nm) and brittleness, several other materials and related PV technologies have been developed. Among these, the technologies based on CdTe and Cu(In,Ga)Se<sub>2</sub> (CIGSe) semiconductors have been commercially successful with a photoconversion efficiency  of more than 20 %. However, the concerns associated with toxic element Cd and less abundant elements In and Ga have propelled the investigation for alternative semiconductors. A quaternary compound Cu<sub>2</sub>ZnSnS<sub>4</sub> (CZTS) is a promising candidate owing to the facts that all the elements used in it are non-toxic and have relatively abundant availability; moreover, it has a high absorption coefficient (α =10<sup>4</sup> cm<sup>−1</sup>; λ &lt; 825 nm) and close to an optimum band gap (</span><span style=\"text-align: justify; text-indent: 36pt; font-size: 10pt; line-height: 115%; position: relative; top: 4.5pt;\" lang=\"EN-US\"><img src=\"file:///C:/Users/DCS/AppData/Local/Temp/msohtmlclip1/01/clip_image002.gif\" border=\"0\" width=\"16\" height=\"19\" /></span><span style=\"text-align: justify; text-indent: 36pt; font-size: 10pt; line-height: 115%; font-family: \'Times New Roman\', serif;\" lang=\"EN-US\"> = 1.5 eV).</span></p>\n<p style=\"text-align: justify;\"><span style=\"text-align: justify; text-indent: 36pt; font-size: 10pt; line-height: 115%; font-family: \'Times New Roman\', serif;\" lang=\"EN-US\">In the present talk, the challenges associated with the synthesis of CZTS thin films via solution chemistry will be discussed and ways to eliminate/control them have been suggested. First, in order to obtain a film with a desired surface morphology, a combined use of the chloride and acetate salts of copper in the precursor solution has been found to be helpful. Further to this, a capping layer of ZnS was necessary on top of the precursor film in order to obtain a CZTS thin film with controlled surface morphology. The CZTS film prepared by this strategy had a stoichiometric composition, the grain size of the order of ~ 200 nm, </span><span style=\"text-align: justify; text-indent: 36pt; font-size: 10pt; line-height: 115%; position: relative; top: 4.5pt;\" lang=\"EN-US\"><img src=\"file:///C:/Users/DCS/AppData/Local/Temp/msohtmlclip1/01/clip_image002.gif\" border=\"0\" width=\"16\" height=\"19\" /></span><span style=\"text-align: justify; text-indent: 36pt; font-size: 10pt; line-height: 115%; font-family: \'Times New Roman\', serif;\" lang=\"EN-US\"> = 1.5 eV, and a high hole-carrier density ~ 10<sup>19</sup> cm<sup>−3</sup>.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\">Further, the tuning of electrical and optical properties of the CZTS via incorporation of silver (Ag) at copper sub-lattice sites in CZTS will be discussed. Thin films of the resulting pentanary alloys (Ag</span><sub style=\"font-family: \'Times New Roman\', serif; text-align: justify; text-indent: 36pt;\">1-<em>x</em></sub><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\">Cu</span><em style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\"><sub>x</sub></em><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\">)</span><sub style=\"font-family: \'Times New Roman\', serif; text-align: justify; text-indent: 36pt;\">2</sub><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\">ZnSnS</span><sub style=\"font-family: \'Times New Roman\', serif; text-align: justify; text-indent: 36pt;\">4</sub><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\"> (0 ≤ </span><em style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\">x</em><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\"> ≤ 1) show a remarkable change in their microstructure and electronic properties with increasing Ag content. Going from Cu</span><sub style=\"font-family: \'Times New Roman\', serif; text-align: justify; text-indent: 36pt;\">2</sub><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\">ZnSnS</span><sub style=\"font-family: \'Times New Roman\', serif; text-align: justify; text-indent: 36pt;\">4</sub><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\"> (</span><em style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\">x</em><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\"> = 0) to Ag</span><sub style=\"font-family: \'Times New Roman\', serif; text-align: justify; text-indent: 36pt;\">2</sub><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\">ZnSnS</span><sub style=\"font-family: \'Times New Roman\', serif; text-align: justify; text-indent: 36pt;\">4</sub><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\"> (</span><em style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\">x</em><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\"> = 1), the grain size increased from 0.2 to 2 μm which has been correlated to the formation of intermediate phase with relatively lower melting point.</span><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt; text-align: justify; text-indent: 36pt;\"> </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 10.0pt; font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\" lang=\"EN-US\">Finally, optimized (Ag<sub>1-<em>x</em></sub>Cu<em><sub>x</sub></em>)<sub>2</sub>ZnSnS­<sub>4</sub> thin films were incorporated in a PV device that resulted in a short circuit current density <em>J</em><sub>sc </sub></span><span style=\"font-size: 10.0pt; font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\" lang=\"EN-US\">of 9.47 mA/cm<sup>2</sup>, open circuit voltage (<em>V<sub>oc</sub></em>) of 600 mV, and a fill factor of 34 % leading to <em>ƞ </em>of 1.92 %. </span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 971, 'NULL', '2019-09-11 03:41:04', '2030-12-01 18:30:00'),
(610, 'September 16, 2019 at 4.00 pm in AG-69', 'Title :\nDressed Coupled Cluster Theory For Non-Covalent Interactions\nAbstract :\nNon-covalent forces ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Dressed Coupled Cluster Theory For Non-Covalent Interactions</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 10.0pt; font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\" lang=\"EN-US\">Non-covalent forces are ubiquitous in nature. The existing ab-initio theories often require large basis set and high computational scaling to account for the same in a qualitatively correct manner. This often restricts the applicability of these methods to small sized systems. In order to circumvent this problem, I shall propose a dual exponential Ansatz based recursive similarity transformed Coupled Cluster methodology, which accurately captures non-covalent interactions in an affordable manner. The superior accuracy of the proposed method is ensured by the inclusion of high rank correlation effects and a balanced treatment of screened Coulomb interactions. Our method strikes the right balance between computational cost and accuracy, and thus promises to be a black-box electronic structure tool in near future. We shall demonstrate the efficacy of the formulation with a number of numerical examples on difficult systems with arbitrarily complex electronic configurations. Further, I shall show a road-map within the framework of our theory to handle strongly correlated molecular systems.</span></p>', 'draft', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 21, 'NULL', '2019-09-11 22:42:33', '2030-12-01 18:30:00'),
(611, 'October 14, 2019 at 4.00 pm in AG-69', 'Title :\nThe Electron Attachment Induced Radiation Damage to Genetic Materials : The Role of Water\nAb', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">The Electron Attachment Induced Radiation Damage to Genetic Materials : The Role of Water</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">Radiation damage to genetic material is one of the active fields of chemical research with implications in both the cause and cure of cancer.  The origin of the damage for a long time is attributed to ionization and excitation process created by the high energy radiation.  But recent experiments have highlighted the critical role played by the low-energy secondary electron in the radiation damage process[1]. Water has been shown to accelerate the process of radiation damage[2]. We have proposed a mechanism for the water-mediated attachment of electron to nucleobases. The initial electron attached state is localized on the water, and the water bound states act as a doorway for the electron attachment to nucleobases. Subsequently, the electron is transferred  to the nucleobase due to the mixing of the electronic and the nuclear degrees of  freedom in the solvated nucleobase. Our theoretical simulations show that the presence of bulk water increases the rate of the electron transfer, which takes place in the ultrafast time scale. The local structure of water around the nucleobase anion plays a crucial role in the electron attachment process. The computed adiabatic electron affinity of nucleobases and rate of electron transfer from water to the nucleobases shows good agreement with the experimental results validating our proposed mechanism[3].</span></p>\n<p><span style=\"font-size: 12.16px;\"> </span></p>\n<p><span style=\"font-size: 12.16px;\"><img src=\"images/Fig 1.jpg\" border=\"0\" alt=\"\" width=\"325\" height=\"214\" />         <img src=\"images/Fig 2.jpg\" border=\"0\" alt=\"\" width=\"388\" height=\"291\" /></span></p>\n<p><span style=\"font-size: 12.16px;\">References:</span></p>\n<p><span style=\"font-size: 12.16px;\">[1]B. Boudaïffa, P. Cloutier, D. Hunting, M. A. Huels, L. Sanche, Science (80. )., 2000, DOI:10.1126/science.287.5458.1658.</span></p>\n<p><span style=\"font-size: 12.16px;\">[2]J. Ma, F. Wang, S. A. Denisov, A. Adhikary, M. Mostafavi, Sci. Adv., 2017, DOI:10.1126/sciadv.1701669.</span></p>\n<p><span style=\"font-size: 12.16px;\"> [3]      M. Mukherjee, D. Tripathi, A.K. Dutta, 2019 (to be communicated )</span></p>\n<p><span style=\"font-size: 12.16px;\"> </span></p>\n<p> </p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 1055, 'NULL', '2019-10-11 00:32:53', '2030-12-01 18:30:00'),
(612, 'November 18, 2019 at 4.00 pm in AG-69', 'Title :\nLeadership and Organization Development\nAbstract :\nThe training on \"Leadership and Organizat', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Leadership and Organization Development</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">The training on \"Leadership and Organization Development\" was about the development of the mindset for women Scientists/Technologists. It is necessary to learn various leadership skills for enhancement of organization development. The perspective was to nurture and grow Scientists/Technologists\' skills to further increase the growth of their organizations. Working well with others would enhance the team productivity and create a positive environment in organizations. Scientists as Leaders in any organization are required to build teams, envisage change and create vision, mentor followers, and nurture a culture of excellence.  Hence, this programme on \"Leadership and Organization Development\" (under the \"DISHA Programme for women in Science\") is designed to impart necessary skills for Scientists/Technologists to assume leadership role in efficient way.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 767, 'NULL', '2019-11-13 23:45:54', '2030-12-01 18:30:00'),
(613, 'December 12, 2019 at 2.30 pm in AG-80', 'Title :\nUtility of Natural Product Biosynthetic Enzymes for Drug Discovery\nAbstract :\nDr. Singh is ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Utility of Natural Product Biosynthetic Enzymes </span>for Drug Discovery</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Dr. Singh is interested in the structural diversification of natural products to develop drug candidates with biological activity against cancer and infectious diseases. Her research focuses on utility and rationally engineering enzymes to modify substrate acceptability profiles and develop novel drugs with improved activity. Natural products and their derivatives account for about three-quarters of the approved drugs on the market. Using conventional chemical synthesis to structurally diversify complex natural products can be challenging. To overcome this challenge, the Singh Laboratory engineers enzymes for proficiency, promiscuity, or altered substrate specificity, capable of performing regio- and stereo-specific transformations in order to generate a library of new drug-like molecules for screening. Recently, she has developed a platform for drug discovery through engineering the substrate specificity of prenyltransferases, a class of natural product late-stage modification enzymes. In this seminar, she will discuss the development of this prenyltransferase-based chemoenzymatic platform to diversify natural products with a library of novel substrates in order to generate therapeutically relevant molecules with enhanced activity against antimicrobial-resistant bacterial strains. Dr. Singh obtained her PhD from the Tata Institute of Fundamental Research, and subsequently pursued post-doctoral research at the Memorial Sloan Kettering Cancer Center in the United States, and Utrecht University in the Netherlands.</span></p>\n<p style=\"text-align: justify;\"> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 797, 'NULL', '2019-11-13 23:48:06', '2030-12-01 18:30:00'),
(614, 'November 29, 2019 at 2.30 pm in AG-66', 'Title :\nPublishing from an Editor\'s Viewpoint - Insider Tips for Successful Submissions\n \n', '<h3>Title</h3>\n<h3>Publishing from an Editor\'s Viewpoint - Insider Tips for Successful Submissions</h3>\n<p> </p>\n<p><img src=\"images/poster_acd_pp.jpg\" border=\"0\" alt=\"\" width=\"536\" height=\"715\" /></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 855, 'NULL', '2019-11-19 00:46:59', '2019-11-19 00:49:58'),
(615, 'November 25, 2019 at 4.00 pm in AG-69', 'Title :\nDonor-Acceptor materials and their applications in OLEDs and solar cells\nAbstract :\nDonor-ac', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Donor-Acceptor materials and their applications in OLEDs and solar cells</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Donor-acceptor-donor (D-A-D) materials having acridone as acceptor and carbazole as donor were synthesized for opto-electronic applications. Steady state and time dependent emission studied provided insight on their possible thermally activated delayed fluorescence (TADF) behaviour. The singlet-triplet energy gap (∆EST) was found to be as low 0.2eV. These materials were used green TADF emitters in organic light emitting diode (OLED) devices. Furthermore, an exciplex emission at 465 nm was observed in the blends of these D-A-D with polyvinylcarbazole (PVK). OLEDs fabricated with blend showed blue electroluminescence which is matching well with the exciplex photoluminescence. Apart from D-A-D in OLEDs, application of new class of high dipole moment materials in solar cell will also be discussed.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 659, 'NULL', '2019-11-20 04:24:20', '2030-12-01 18:30:00'),
(616, 'November 28, 2019 at 2.30 pm in AG-80', 'Title :\nElectrocatalysis and gas solid catalysis by Pt ions in perovskites: A comparison between sup', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Electrocatalysis and gas solid catalysis by Pt ions in perovskites: A comparison between supported and the doped catalysts</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; text-indent: 36.0pt; line-height: 150%; mso-layout-grid-align: none; text-autospace: none;\"><span style=\"font-size: 12.0pt; line-height: 150%; font-family: \'Times New Roman\',\'serif\';\" lang=\"EN-US\">In this work, La<sub>1-x</sub>Sr<sub>x</sub>CoO<sub>3</sub> perovskite have been used as a host oxide for Pt doping and Pt supported system. The solution combustion and chemical reduction method have been adopted for the catalyst synthesis. Three selected reactions have been investigated in detail during the studies, namely the oxygen evolution reaction (OER), formic acid electro-oxidation and CO oxidation. The catalytic and electro-catalytic differences between the Pt doped and Pt-supported system has been studied. It was found that there are significant differences between the Pt-doped and Pt-supported systems for electro-catalytic and catalytic reactions. Activity of the catalyst depends on the particular reaction selected for comparison.<span style=\"mso-spacerun: yes;\">  </span>We hope that the results presented in this work are a worthwhile contribution to catalysis.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 568, 'NULL', '2019-11-25 00:04:22', '2030-12-01 18:30:00'),
(617, 'November 28, 2019 at 3.00 pm in AG-80', 'Title :\nSignificance of defect engineering and hetero-junction engineering to improve the photoelect', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Significance of defect engineering and hetero-junction engineering to improve the photoelectrochemical properties of ZnO nanorods photoanode</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">The significance of defect engineering in tuning the visible light driven photoelectrochemical properties due to alkali metal (Li, Na, K) doping into ZnO nanorods (NRs) photoanode is investigated. Large concentration of oxygen-vacancies introduced because of alkali doping serve as the light absorbing donor sites and also photoelectron recombination centres resulting enhanced photocurrent and hole separation in the valance band, respectively. The lattice strain developed in the nanorods due to doping contributes in easy electron transportation and mobility. Defect engineering also tunes the electronic structure of the photoanodes boosting charge carrier migration and reduced electron-hole pair recombination resulting enhanced oxygen evolution reaction. On the other hand, the design of multidimensional nano-heterostructures based photoelectrode is demonstrated by coupling the multilayered two-dimensional (2D) structure of MoS<sub>2</sub> and MoO<sub>3</sub> on the well aligned arrays of one-dimensional (1D) ZnO nanorods template expecting the effective synergic effects. The advantages of catalytically active sites of 2D layered structure of transition metal dichalcogenides/oxides is integrated with the distinctive dimensionality dependent phenomena of 1D structure to achieve enormous surface area for light harvesting and photoelectrochemical reaction along with favorable photocarrier dynamics required for water splitting. </span></p>\n<p><span style=\"font-size: 12.16px;\">References:</span></p>\n<p><span style=\"font-size: 12.16px;\">[1]K. Karmakar, A. Sarkar, K. Mandal and G. G.Khan. Investigating the role of oxygen vacancies and lattice strain defects on enhanced photoelectrochemical property of alkali metal (Li, Na and K) doped ZnO nanorods photoanodes.  ChemElectroChem 2018, 5, 1147 –1152. </span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">[2]K. Karmakar, D. Maity, D. Pal, G. G. Khan and K. Mandal. Photo-induced Exciton Dynamics and Broadband Light Harvesting in ZnO Nanorod Templated Multilayered 2D MoS2/MoO3 Photoanodes for Solar Fuel Generation. (Under Review)</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 592, 'NULL', '2019-11-25 00:06:42', '2030-12-01 18:30:00'),
(618, 'January 13, 2020 at 4.00 pm in AG-69', 'Title :\nManeuvering the stability and reactivity of ‘[3]Dendralenes”, an exciting class of oligo', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Maneuvering the stability and reactivity of ‘[3]Dendralenes”, an exciting class of oligo-enes for diversity oriented organic synthesis</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Organic synthesis is mainly concerned with C-C and C-X (X = heteroatom) bond forming reactions. The biggest challenge is to perform them under strict control of regio-, stereo- and enantio-selectivity, and also to achieve diverse structural complexity in fewer steps. Carbon-carbon double bond (olefin) is an important synthon in organic chemistry for further C–C bond formation, diverse functional group generation and for construction of complex organic structures. Olefins also exhibit great structural diversity when several such bonds are put together in a molecule. Depending upon the type of connectivity of the ethylene units, conjugated polyenes can be classified into various classes. A geminal linkage results in a class of cross conjugated polyenes called as \"Dendralenes\". Despite being in existence in Nature and having been synthesized as early as in 1955, they remained \"unmanageable\" until the turn of this century mainly owing to their unpredictable stability and reactivity.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Due to the abundance of fused hetero- and carbocyclic ring systems in numerous bio-active compounds, such motifs have intrigued synthetic organic chemists. Besides, an efficient synthesis of such architecturally complex scaffolds is an uphill task and hence poses a formidable challenge. In this regard, [3]dendralenes are fascinating molecules because they possess huge potential for the quick generation of diverse and complex multicyclic scaffolds when subjected to tandem Diels–Alder (DA) reactions, also known as diene transmissive Diels–Alder (DTDA) sequences. But their synthesis is a tall order.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">The chronicles of our roller-coaster journey and systematic approach beginning from the development of new olefination protocols, synthesis of extremely unstable, non-isolable [3]dendralenes through moderately stable examples and finally, highly functionalized stable [3]dendralenes will be presented. The attributes affecting their stability and reactivity have been recognized. Also, how these dendralenes, upon judicious maneuvering, can be engaged in a DTDA sequence, thus harnessing their full potential by construction of a small but diverse library of complex frameworks in a quick and efficient manner, with step and atom economy will be discussed.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\"> </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Selected References</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">1. S. K. Ghosh, R. Singh and S. M. Date, Chem. Commun., 2003, 636.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">2. S. M. Date and S. K. Ghosh, Angew. Chem. Int. Ed., 2007, 46, 386.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">3. R. Singh and S. K. Ghosh, Org. Lett., 2007, 9, 5071.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">4. R. Singh and S. K. Ghosh, Chem. Commun., 2011, 47, 10809.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">5. G. S. Naidu, R. Singh and S. K. Ghosh, RSC Adv., 2016, 6, 37136.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">6. R. Singh, G. S. Naidu and S. K. Ghosh, Proc. Natl. Acad. Sci., India, Sect. A Phys. Sci., 2016, 86, 619.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">7. G. S. Naidu, R. Singh, M. Kumar and S. K. Ghosh, J. Org. Chem., 2017, 82, 3648.</span></p>\n<p style=\"text-align: justify;\"> </p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">8. G. S. Naidu, R. Singh and S. K. Ghosh, Synlett, 2018, 29, 282.</span></p>\n<p style=\"text-align: justify;\"> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 827, 'NULL', '2019-11-25 03:40:29', '2019-12-04 03:28:52'),
(619, 'December 2, 2019 at 4.00 pm in AG-69', 'Title :\nCell Permeable Ratiometric Fluorescent Sensor for Detecting Signal Mediating Phospholipids', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Cell Permeable Ratiometric Fluorescent Sensor for Detecting Signal Mediating Phospholipids</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 714, 'NULL', '2019-11-28 23:25:52', '2030-12-01 18:30:00'),
(620, 'January 10, 2019 at 11.30 am in AG-80', 'Title :\nMedium Matters: Dynamics of Molecules in a Confined Space\nAbstract :\nFrom time immemorial it', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Medium Matters: Dynamics of Molecules in a Confined Space</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">From time immemorial it is well known that curtailment of freedom often leads to changes in </span>the behaviour of living beings. Similar restriction of freedom leads to selectivity in the chemical behaviour of molecules embedded in biological systems. Extending these well-known behaviours, supramolecular chemists have established that even small molecules upon confinement in synthetic hosts exhibit behaviour distinctly different from the ones in a bulk isotropic solution.</p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In this lecture the role a “Medium” in bringing about changes in the well-established </span>behaviour of excited molecules would be illustrated with select examples. Results of steady state and ultrafast experiments will be presented that highlight how the confinement alters the excited state dynamics of molecules such as stilbenes, azobenzenes, anthracene, dibenzyl ketones etc. Another reaction to be discussed concerns with electron transfer and spin transfer that play a fundamental role in a number of biological events including photosynthesis. Examples and ultrafast dynamics of electron and spin transfer between a confined and a free molecule would be presented.</p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">The main message of the talk is that molecules like humans behave differently when confined </span>within synthetic cages.</p>\n<p><span style=\"font-size: 12.16px;\">Selected references</span></p>\n<p><span style=\"font-size: 12.16px;\">[1] V. Ramamurthy, S. Jockusch and M. Porel, Langmuir, 2015, 31, 5554-5570</span></p>\n<p><span style=\"font-size: 12.16px;\">[2] V. Ramamurthy, Acc. Chem. Res. 2015, 48, 2904-2917.</span></p>\n<p><span style=\"font-size: 12.16px;\">[3] A. Mohan Raj, M. Porel, P. Mukherjee, X. Ma, R. Choudhury, E. Galoppini, P. Sen and V. </span>Ramamurthy, J. Phys. Chem. C, 2017, 121, 20205−20216.</p>\n<p><span style=\"font-size: 12.16px;\">[4] C-H. Chuang, M. Porel, R. Choudhury, C. Burda and V. Ramamurthy, J. Phys. Chem. B, </span>2018, 122, 328−337.</p>\n<p><span style=\"font-size: 12.16px;\">[5] C. J. Otolski, A. Mohan Raj, V. Ramamurthy and C.G. Elles, J. Phys. Chem. Lett. 2019, 10, </span>121−127</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 703, 'NULL', '2019-12-04 03:37:06', '2019-12-04 05:05:00'),
(621, 'December 19, 2019 at 2.30 pm in AG-80', 'Title :\nCarbenes in a Supersonic Jet Expansion\nAbstract :\nHydrogen Bond (HB) is one of the important', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Carbenes in a Supersonic Jet Expansion</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"font-size: 14.6667px;\">Hydrogen Bond (HB) is one of the important intermolecular forces and is ubiquitous in Chemistry and Biology. Since it has strong directional nature it plays an important role in supramolecular chemistry as well as molecular recognition. These H-bonds play a vital role in determining the structure of proteins and supramolecules and there is evidence of these interactions in literature. </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"font-size: 14.6667px;\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"font-size: 14.6667px;\">Among different reactive intermediates, Carbene being neutral and highly electron-deficient species play a significant role in various organic transformations. Hydrogen bonding that involves carbene as a hydrogen acceptor is very poorly documented in the literature.1</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"font-size: 14.6667px;\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"font-size: 14.6667px;\">For instance, N-heterocyclic carbene carbon (singlet ground state) is highly nucleophilic due to adjacent nitrogen centres. Such electron-rich nucleophilic species can act as powerful Lewis bases. Water, being proton donor, can interact with Lewis bases like nucleophilic carbenes to form the strong hydrogen-bonded complex.</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"font-size: 14.6667px;\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"font-size: 14.6667px;\">References</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"font-size: 14.6667px;\">1.P. Costa, W. Sander, Angew. Chem. Int. Ed. 53 (2014), 5122-5125.</span></p>\n<p style=\"text-align: justify;\"> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 720, 'NULL', '2019-12-16 05:22:31', '2019-12-18 22:06:48'),
(622, 'December 23, 2019 at 2.30 pm in AG-80', 'Title :\nDesign and Development of Optical Probes for Tracking Essential and Toxic Metal Ions', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Design and Development of Optical Probes for Tracking </span>Essential and Toxic Metal Ions</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 740, 'NULL', '2019-12-18 05:26:48', '2030-12-01 18:30:00'),
(623, 'January 2, 2019 at 11.30 am in AG-80', 'Title :\nL-Amino acid Based Polyester Nanocarriers for Drug Delivery and Bio-imaging\nAbstract :\nThe p', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">L-Amino acid Based Polyester Nanocarriers for Drug Delivery and Bio-imaging</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">The past generation therapeutic agents are increasingly failing in combating new-age threats. Therapeutics based on polymers are advantageous as they possess advanced targeting, can target hard to reach agents, and carry multiple cargos of conflicting nature. These can be extremely selective, owing to several phenomena such as Enhanced Permeation (EPR) effect and carrying multiple cargoes in a single particle, which can have synergistic effects, leaving them more potent than any of the medicine alone. </span></p>\n<p>L-Amino acid-based synthetic polypeptides non-peptides are extensively explored for biomedical applications owing to their structural diversity and biocompatibility. My talk is aimed to explore new classes of amphiphilic and biodegradable polyester and their fluorescent nano-assemblies based on natural L-aspartic acid resources for accomplishing anticancer drug delivery and intracellular bioimaging in cancer cells. These polymers were designed with the dual response to acidic conditions and enzyme-rich environment stimuli. Different therapeutically active drugs were loaded into the polymer scaffolds, and their cytotoxicity was studied in the cancer cell lines. </p>\n<p>The uptakes of these drugs were monitored using confocal microscopy. L-amino acid-based amphiphilic luminescent polyester was developed using <span style=\"font-size: 11pt; font-family: \'Times New Roman\', serif;\">π</span>- conjugated oligo-phenylenevinylene (OPV) custom made diols, while Aggregation induced emission (AIE) capable hydroxyl functionalized tetraphenylethyelene (TPE) diol was tailor-made through multi-step reaction and was subjected to melt transesterification with L-aspartic acid monomer to yield new blue-luminescent amphiphilic polyesters. </p>\n<p>Hydroxyl and carboxylic functionalized polyesters were also synthesized. The hydrophilic hydroxyl and carboxylic groups along with the hydrophobic aliphatic backbone made these polymer amphiphilic in nature and enabled these to self-assemble into spherical nanoparticles in water, which exhibited superior encapsulation capabilities to load wide ranges of both water-soluble and water-insoluble anticancer drugs and fluorophores. The amphiphilic polyesters designed and developed based on L-aspartic acid residues presented in the talk are new entries as enzymatic-biodegradable polymers in the literature, and the custom-designed OPV-tagged and TPE-tagged fluorescent polymers are excellent nano-scaffolds for constructing a wide range of FRET probes with drugs and fluorophores which could be employed for early diagnostics of cancer and other bio-imaging applications. Thus, the work opens up a new platform of opportunities in the biomaterials arena based on L-Amino acid polymers.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 612, 'NULL', '2019-12-26 00:42:03', '2030-12-01 18:30:00'),
(624, 'January 20, 2020 at 2.30 pm in AG-80', 'Title :\nPlanarization of Anthracene fused Cyclooctatetraene', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Planarization of Anthracene fused Cyclooctatetraene</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 711, 'NULL', '2020-01-07 22:00:25', '2030-12-01 18:30:00'),
(625, 'January 13, 2020 at 11.30 am in AG-80', 'Title :\nMultiphoton femtosecond laser spectroscopy of anisotropic molecular probes\nAbstract :\nThe ta', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Multiphoton femtosecond laser spectroscopy of anisotropic molecular probes</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">The talk presents a review of theoretical and experimental investigations of polarized fluorescence in anisotropic molecular probes excited via two-color two-photon transitions by femtosecond laser pulses.  </span></p>\n<p>The molecular probes under study were small biomolecules which are of importance for bio-medical applications: indole, tryptophan, and NADH (nicotinamide adenine dinucleotide). The polarized fluorescence was excited in molecular solutions by simultaneous absorption of two laser photons with different and variable wavelengths thus allowing for tuning of the total excitation energy in the range 4,04-7,09 eV. By alternating the polarization of each of the three photons involved in the photoprocess a set of molecular parameters describing the photoprocess dynamics were determined. Analysis of the results obtained was performed on the basis of ab initio computations of excited state molecular structure and transition dipole moments.  </p>\n<p>As pointed out in the talk, the molecular parameter values are very sensitive to the molecular microenvironment thus allowing for investigation of thin details of enegry transfer processes in excited molecules characterized by: anisotropic distribution of molecular axes, lifetimes, rotation correlation times, and the dynamics of nonadiabatic transitions between different potential energy surfaces. As shown, investigation of polarized fluorescence from molecular probes imbedded into biological structures opens a new information channel on protein structure, folding, hydration, and on the mechanizms of redox reactions in living organisms. </p>\n<p>1. P. S. Shternin, K.-H. Gericke, O. S. Vasyutinskii, Molecular Physics, 2010, 108(7), 813.</p>\n<p><span style=\"font-size: 12.16px;\">2. S. Denicke, K.-H. Gericke, A. G. Smolin, P. S. Shternin, O. S. Vasyutinskii, J. Phys. Chem. A  </span>2010, 114, 9681.</p>\n<p><span style=\"font-size: 12.16px;\">3. S. Herbrich, K.-H. Gericke, A. G. Smolin, O. S. Vasyutinskii, J. Phys. Chem. A. 2014, 118, 5248.</span></p>\n<p><span style=\"font-size: 12.16px;\">4. S. Herbrich, T. Al-Hadhuri, K.-H. Gericke, P. S. Shternin, A. G. Smolin, O. S. Vasyutinskii, J. </span>Chem. Phys. 2015, 142, 024310.</p>\n<p><span style=\"font-size: 12.16px;\">5. M. E. Sasin, A. G. Smolin, K.-H. Gericke, E. Tokunaga, O. S. Vasyutinskii, PCCP, 2018, V.20,</span> pp. 19922.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 603, 'NULL', '2020-01-09 23:33:49', '2030-12-01 18:30:00');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(626, 'January 30, 2020 at 2.30 pm in AG-80', 'Title :\nDistribution of Isomerized and Racemized Amyloid b Isoforms in the Sporadic Alzheimer’s ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Distribution of Isomerized and Racemized Amyloid </span><span style=\"font-family: Symbol; text-align: justify;\">b</span><span style=\"font-size: 12.16px;\"> Isoforms in the Sporadic Alzheimer’s Disease using Ion-Mobility Mass Spectrometry</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">Extracellular amyloid plaques and intracellular neurofibrillary tangles are the pathological hallmarks of Alzheimer’s Disease (AD). It takes on average 19 years for amyloid </span><span style=\"font-family: Symbol; mso-ascii-font-family: \'Times New Roman\'; mso-hansi-font-family: \'Times New Roman\'; mso-char-type: symbol; mso-symbol-font-family: Symbol;\" lang=\"EN-US\"><span style=\"mso-char-type: symbol; mso-symbol-font-family: Symbol;\">b</span></span><span lang=\"EN-US\"> (A</span><span style=\"font-family: Symbol; mso-ascii-font-family: \'Times New Roman\'; mso-hansi-font-family: \'Times New Roman\'; mso-char-type: symbol; mso-symbol-font-family: Symbol;\" lang=\"EN-US\"><span style=\"mso-char-type: symbol; mso-symbol-font-family: Symbol;\">b</span></span><span lang=\"EN-US\">) peptides to deposit as insoluble plaques from onset to clinical dementia symptoms in AD. Such long-lived proteins and peptides without degradation and clearance can undergo further post-translational modifications (PTM). Several biochemical and analytical approaches have estimated very high degree of isomerization and racemization of Asp and Ser residues in A</span><span style=\"font-family: Symbol; mso-ascii-font-family: \'Times New Roman\'; mso-hansi-font-family: \'Times New Roman\'; mso-char-type: symbol; mso-symbol-font-family: Symbol;\" lang=\"EN-US\"><span style=\"mso-char-type: symbol; mso-symbol-font-family: Symbol;\">b</span></span><span lang=\"EN-US\"> purified from the insoluble plaques, along with sequential loss of the N-terminal amino acids. In this study we have characterized the most common isomerization and racemization of the Asp-1 and Asp-7 residues of the A</span><span style=\"font-family: Symbol; mso-ascii-font-family: \'Times New Roman\'; mso-hansi-font-family: \'Times New Roman\'; mso-char-type: symbol; mso-symbol-font-family: Symbol;\" lang=\"EN-US\"><span style=\"mso-char-type: symbol; mso-symbol-font-family: Symbol;\">b</span></span><span lang=\"EN-US\"> peptides present in AD brain based on both their chromatographic resolution as well as their collisional cross section (CCS) using high resolution ion mobility (IM) Q-TOF mass spectrometer (Agilent 6560). Using stable isotope labeled peptides we have also quantified the amount of these isomers/racemers in the different fractionated biochemical pools of the temporal cortex grey matter of human AD and control brains. Distribution of these isomerized and racemized peptides change from lower levels in the soluble/peripheral memebraneous to higher levels in the insoluble/aggregated debris in AD brain, also indicating loss in the biochemical exchange of the pool of A</span><span style=\"font-family: Symbol; mso-ascii-font-family: \'Times New Roman\'; mso-hansi-font-family: \'Times New Roman\'; mso-char-type: symbol; mso-symbol-font-family: Symbol;\" lang=\"EN-US\"><span style=\"mso-char-type: symbol; mso-symbol-font-family: Symbol;\">b</span></span><span lang=\"EN-US\"> with the progression of the disease. These findings have implications in A</span><span style=\"font-family: Symbol; mso-ascii-font-family: \'Times New Roman\'; mso-hansi-font-family: \'Times New Roman\'; mso-char-type: symbol; mso-symbol-font-family: Symbol;\" lang=\"EN-US\"><span style=\"mso-char-type: symbol; mso-symbol-font-family: Symbol;\">b</span></span><span lang=\"EN-US\"> neurotoxicity, oligomerization, structures of amyloid fibrils present in the AD brain as well establishing CSF/blood-based biomarkers. </span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 777, 'NULL', '2020-01-14 03:44:21', '2030-12-01 18:30:00'),
(627, 'January 27, 2020 at 4.00 pm in AG-69', 'Title :\nRole of Acetylation at Active Site Lysine in Maintaining the Functional State of CDK1-Cycli', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Role of Acetylation at Active Site Lysine in </span>Maintaining the Functional State of CDK1-Cyclin B Complex</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 560, 'NULL', '2020-01-21 04:18:06', '2030-12-01 18:30:00'),
(628, 'January 28, 2020 at 2.30 pm in D-406', 'Title :\nVibrational spectroscopy of biological systems at the micro and nano level - RERS, SERS, TER', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Vibrational spectroscopy of biological systems at the micro and nano level - RERS, SERS, TERS &amp; AFM-IR</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Raman spectroscopy is an excellent tool for interrogating biomolecules or biological systems in natural environments because water is such a weak Raman scatterer. This is particularly the case when there are chromophoric materials such as hemes, chlorophyll, carotenes that are strong scatterers or give rise to resonance Raman. Over a number of years we have applied Raman, Resonance Raman, Surface Enhanced Raman and Tip enhanced Raman spectroscopies to live cells such as erythrocytes in order to understand and develop probes for disease states. A number of these studies will be used to highlight instrumental and sampling techniques and data analysis in Raman spectroscopy of biosystems. Infrared spectroscopy also has a role, especially nano-IR and a study of DNA methylation will be used to show the power of nano-IR</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 587, 'NULL', '2020-01-23 00:51:38', '2030-12-01 18:30:00'),
(629, 'February 7, 2020 at 11.30 am in AG-80', 'Title :\nMolecular Structure and Weak Interactions Explored by Broadband Microwave Spectroscopy\nAbstr', '<p><strong>Title :</strong></p>\n<h3><span style=\"font-size: 12.16px;\">Molecular Structure and Weak Interactions Explored by Broadband Microwave Spectroscopy</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Microwave spectroscopy allows details of structure to be measured for molecules and complexes which are isolated in the gas phase. One aim is to quantify weak interactions with high selectivity such that intrinsic character can be separated from effects of a solvent or matrix. This theme will be illustrated through recent studies of molecules containing imidazole. It will be shown that two isomers of a complex formed between this molecule and water can be isolated and spectroscopically-characterised in the gas phase. A second aim is to explore the gas phase chemistry prompted by laser vaporisation of solids in the presence of a mixture of chemical precursors, a process known to allow the generation of small molecules that can be found in interstellar and circumstellar environments. Laser vaporisation of platinum in the presence of gaseous hydrocarbons allows very efficient generation of PtC<sub>3</sub>, an atypical and exotic platinum carbene which has structural similarities with the oxycarbon species, OC<sub>3</sub>. Experiments are performed using a unique broadband rotational spectrometer that allows the simultaneous observation of many rotational transitions across a broad bandwidth.  </span></p>\n<p style=\"text-align: center;\"><img src=\"images/walkar.jpg\" border=\"0\" alt=\"\" width=\"499\" height=\"221\" /></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 611, 'NULL', '2020-01-23 23:47:04', '2020-01-23 23:49:33'),
(630, 'February 27, 2020 at 2.30 pm in AG-80', 'Title :\nMechanistic studies of membrane remodeling in receptor mediated endocytosis\nAbstract :\nRecep', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Mechanistic studies of membrane remodeling in receptor mediated endocytosis</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Receptor mediated endocytosis requires the generation of membrane curvature. Followed by external stimulation, various G-protein coupled receptors and epidermal growth factor receptors are internalized and recycled by this crucial membrane trafficking pathway. Bin/Amphiphysin/RVS (BAR) superfamily proteins have emerged as key effectors in membrane reshaping during the endocytic events. In addition to a crescent shaped BAR domain, many of these proteins contain a Src homology 3 (SH3) domain. BAR proteins sense and generate membrane curvature with their membrane binding domain whereas the SH3 domain regulates their interaction with other protein binding partners. Receptors containing proline rich domains (PRD) have been found to interact with different classes of SH3 domain containing proteins. While it has been hypothesized that the SH3 domain-PRD interaction plays an important role in BAR protein mediated receptor internalization, the exact mechanism has thus far remained elusive. We mimic SH3 domain-PRD interactions in artificial lipid bilayers and investigate their effects on the characteristic membrane curvature generation properties of BAR proteins. PRDs covalently linked to the lipid bilayer are designed to recruit the BAR proteins. The associated membrane shape changes are monitored by both optical and electron microscopy techniques. I will discuss our insights into BAR protein mediated membrane remodeling in receptor internalization processes in light of our recent biophysical studies. </span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 622, 'NULL', '2020-01-27 00:25:27', '2030-12-01 18:30:00'),
(631, 'February 13, 2020 at 2.30 pm in AG-80', 'Title :\nAllele-Specific Engineering of Methyllysine Writers and Readers for Controlling Chromatin-De', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Allele-Specific Engineering of Methyllysine Writers and Readers for Controlling Chromatin-Dependent Processes</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">One of the key players in regulating the gene pattern is the post-translational modifications (PTMs) of histone proteins. Histone modifications regulate the transcriptional potential of genes by interacting with reader/effector protein domains. Post-translational modifications on methyllysine are ubiquitous in biological systems and critical for mammalian development. Specific perturbation of such interactions has remained a challenging endeavor. We hypothesized that incorporation of an unnatural modification with the aid of an engineered writer domain and its recognition by reader domain would regulate the downstream genes (epigenetic editing) leading to modification of the epigenetic landscape. The engineered orthogonal pairs together with catalytically inactive Cas9 would specifically modulate the expression of a gene of interest, thereby providing control on transcription machinery. We employed the allele-specific strategy towards engineering the epigenetic landscape at protein-protein interface orthogonal to the human proteome. We generated a hole-modified methyltransferase (writer) that would install an aryllysine moiety on histones <em>in-cellulo</em>. We established the orthogonality of the engineered system, overcame the permeability issue of SAM analogues, developed an antibody and established the applicability of the system in cells. Our data confirms successful benzylation of histone proteins in mammalian cells at sites known to be regulated by SUV39h2 (writer protein) <em>in cellulo</em>. Further we engineered a chromodomain (reader) with a pocket to accommodate the bulky modifications. We established the biochemical integrity of the engineered interface, provided structural evidence for domain integrity, demonstrated the generality of the approach, and validated its applicability to identify transcriptional regulators. We have shown that the orthogonal reader domain on binding to the unnatural modification remains functionally intact and to regulate the epigenetic landscape similar engineering can be translated to other reader-histone proteins as well. </span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 592, 'NULL', '2020-01-31 03:47:49', '2030-12-01 18:30:00'),
(632, 'February 11, 2020 at 2.30 pm in AG-80', 'Title :\nDesigning nano-biocatalyst with improved enzymatic activity and stability\nAbstract :\nIn the ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Designing nano-biocatalyst with improved enzymatic activity and stability</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"mso-fareast-language: EN-IN;\" lang=\"EN-US\">In the current scenario, there is a need to develop clean, reliable, biocompatible and benign processes for the industrial manufacturing of chemicals. Notwithstanding all these advantages of enzymes, industrial application of enzymes is often hampered by a lack of long-term operational stability and difficult recovery and re-use of the enzyme. Hence, r</span><span lang=\"EN-US\">e-engineering of enzymes with high activities in the given environments is required for enzymatic catalysis in industrial biocatalytic processes. The redesign of enzyme can be achieved by chemical approaches including immobilization and chemical modification which represents a simple but effective route. In most of the conventional immobilization methods, the activity of enzymes is usually lower than its native counterpart which is mainly due to the hindered substrate accessing and/or unfavourable conformational transition of enzyme within the matrix. Hence, it is necessary to develop new method which can amplify catalytic activity along with the improvement in the enzyme properties. Recently, t</span><span style=\"mso-fareast-language: EN-IN;\" lang=\"EN-US\">he construction of organic–inorganic hybrid material is a rapidly expanding field of material chemistry for its advanced designs with a specific structure and functionality. Organic–inorganic hybrid platform can be prepared simply by using metal ions as the inorganic component and the organic component at room temperature under aqueous conditions. </span><span lang=\"EN-US\">The main advantages of using hybrid organic-inorganic matrix for enzyme immobilization are: (i). Organic-inorganic platform can help to form strong bonding with enzyme which can prevent the leaching of enzyme in reaction mixture. (ii) The presence of metallic counterpart in hybrid material can exhibit the allosteric effect on enzyme which can ultimately enhance the enzyme activity. (iii) Hybrid material can stabilize the conformational structure in various in-hospitalized conditions and chemical environment.</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">To enhance robustness, thermal stability, and extended the shelf-life time for industrial applications, in this research work, an organic-inorganic hybrid platform for enzyme immobilization has been developed <em>via</em> rapid single pot technique using biomineralization methodology. The allosteric effect (due to metal ion) and structural configuration of enzyme not only helped to enhance the enzyme activity but also improved the stability (mechanically robustness and thermally stable) due to protective shield. Further, the immobilized enzyme was characterized by powdered X-ray diffraction (XRD), Fourier transform infrared (FT-IR) and confocal scanning laser microscopy. The size and morphology were analysed by scanning electron microscopy (SEM). Also, the kinetic parameters (V<sub>max</sub> and K<sub>M</sub>) and thermal stability of free and immobilized enzyme were determined in terms of thermal deactivation constant (k<sub>d</sub>), half-life(t<sub>1/2</sub>) and deactivation energy (E<sub>d</sub>). In addition, conformational changes occurring after immobilization were estimated by FT-IR data analysis tools. Lastly, reusability and storage stability of enzymes were studied to check its durability and industrial feasibility. </span><span lang=\"EN-US\">This exploration of immobilization technology is anticipated to inspire further advancement in the novel design and functionality of the support matrix for a wide range of applications.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 630, 'NULL', '2020-01-31 04:00:26', '2030-12-01 18:30:00'),
(633, 'February 3, 2020 at 4.00 pm in AG-69', 'Title :\nFrom atoms and molecules to solids… A glimpse into my research journey so far…\nAbstract ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">From atoms and molecules to solids… A glimpse into my research journey so far…</span></h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">It is a well-known fact that every material in the universe is composed of atoms, which in turn comprise nuclei and electrons. A comprehensive understanding of the interactions among such sub-atomic particles have enabled us to tailor materials for a plethora of applications that heavily govern our day-to-day living. Thanks to advances in computation and theory development, investigating these interactions systematically has been possible. Based on the type of system, different computational methods are used to achieve this. For example, at the atomic scale, quantum chemistry simulations implemented within a localized orbital (or atomic orbital) basis set are performed routinely. On the other hand, for periodic solids, density functional theory (DFT) generally implemented within a plane-wave basis set, is used. Obviously, the list of methods is not restricted to those mentioned above. My talk will attempt to cover my journey so far, where I have been exposed to both perspectives of thinking. I will be providing a glimpse of my current work on time-dependent thermally-assisted-occupation DFT (TDTAO-DFT) which is a low-cost method to study excited states. This method is based on a modified DFT scheme known as TAO-DFT, which explicitly incorporates the non-dynamical correlation effect in ground-state simulations, but retains the low computational complexity of conventional DFT. In line with the title of my presentation, which coincides with the reverse chronology of my research journey, I will present my earlier works on solid state simulations using phosphorene (a quasi–two-dimensional sheet of phosphorus atoms) as an example. Here, I will be demonstrating how the electronic properties are tuned without affecting its excellent transport properties as well mechanical and structural stability.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 529, 'NULL', '2020-02-02 22:17:41', '2030-12-01 18:30:00'),
(634, 'February 6, 2020 at 2.30 pm in AG-80', 'Title :\nDesign and characterization of Ferritin based bio-catalyst', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Design and characterization of Ferritin based bio-catalyst</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 500, 'NULL', '2020-02-03 02:32:09', '2030-12-01 18:30:00'),
(635, 'February 18, 2020 at 2.30 pm in AG-80', 'Title :\nMorphology Optimization and Photophysical Studies of Perovskite Solar Cell\nAbstract :\nThere ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Morphology Optimization and Photophysical Studies of Perovskite Solar Cell</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">There is an urgent need to shift all existing power systems such as household electricty, transportation, etc. on renewable and clean sources of<span style=\"mso-spacerun: yes;\">  </span>energy such as solar and wind energy etc. To harness solar energy lot of new materials have been discovered that caused the generational evolution of solar cells. Recently, organic-inorganic hybrid perovskite solar cells (PSCs), a third generation solar cell, have received significant research interest due to its high efficiency and low cost fabrication. The major research focus of PSCs is on interface modification, compositional engineering and morphology tailoring since these factors plays crucial role in efficiency modulation. We found that perovskite film morphology and photophysics are the crucial factors in fabricating highly efficient and stable solar cells. We optimized the morphology ofCH<sub>3</sub>NH<sub>3</sub>PbI<sub>3<span style=\"mso-spacerun: yes;\">  </span></sub>perovskites film at room temperature using dual solvent elimination method, antisolvent treatment and solvent annealing and found that these methods are very important to grain size engineering. </span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 674, 'NULL', '2020-02-04 23:58:09', '2030-12-01 18:30:00'),
(636, 'February 18, 2020 at 3.00 pm in AG-80', 'Title :\nOptoelectronic Properties of Perovskite Materials for Photovoltaic Application\nAbstract :\nRe', '<h3>Title</h3>\n<h3 style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Optoelectronic Properties of Perovskite Materials for Photovoltaic Application</span></h3>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 10.0pt; font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: \'Times New Roman\'; color: black; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\" lang=\"EN-US\">Recently, significant research interest has been devoted on the fundamental understanding of the underlying mechanism in solar cells and innovation of new photovoltaic materials. Aim of this research work and its impact deals with the structure-property-performance correlation of the alternative materials for photovoltaic application. The multication complex perovskites (ABO<sub>3</sub> and A<sub>2</sub>B\'B\"O<sub>6</sub> type) which exhibit attractive optical properties along with the electrical properties have been explored for the low cost and efficient photovoltaic application. In this respect, lead free double perovskite oxide, La<sub>2</sub>NiMnO<sub>6</sub>, has shown a promising photovoltaic performance under AM1.5G solar spectrum.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 673, 'NULL', '2020-02-05 00:00:34', '2030-12-01 18:30:00'),
(637, 'March 23, 2020 at 4.00 pm in AG-69', 'Title :\nFrom Designing Enzyme Mimetics to Probing Protein Citrullination\nAbstract :\nIn this seminar,', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">From Designing Enzyme Mimetics to Probing Protein Citrullination</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; mso-layout-grid-align: none; text-autospace: none;\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">In this seminar, I’ll discuss my doctoral research on the biomimetic dehalogenation of thyroid hormones (THs), their metabolites and halogenated nucleosides as well as part of my postdoctoral research on the development of small molecule inhibitors and chemical probes of protein arginine deiminases (PADs) that catalyze protein citrullination. </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; mso-layout-grid-align: none; text-autospace: none;\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">     Thyroid gland produces thyroxine (T4) as a prohormone and regioselective deiodinations by a group of mammalian selenoenzymes, iodothyronine deiodinase type 1 (DIO1), type 2 (DIO2) and type 3 (DIO3) play important roles in the activation and inactivation of T4. Naphthyl-based organo- sulphur and/or selenium compounds are developed as functionally mimics of DIO3. The kinetics and regioselectivity of biomimetic deiodinations of THs and their metabolites are explained on the basis of S/Se∙∙∙I halogen bonding and S/Se∙∙∙S/Se chalcogen bonding. These organochalcogen compounds also mediate the dehalogenation of halogenated nucleosides that are incorporated into DNA during DNA replication and cause potential DNA damages in the presence of UV irradiation. In addition to these, I’ll also discuss the polymorphism of commercial thyroxine, a life-saver of millions of people suffering from hypothyroidism, and its implications on the bioavailability of the drug. </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; mso-layout-grid-align: none; text-autospace: none;\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">     Citrullination is a post-translational modification of arginine, catalyzed by a group of hydrolases called protein arginine deiminases (PADs – PAD1, 2, 3 and 4). Despite various physiological roles, protein hypercitrullination is associated with various diseases including rheumatoid arthritis (RA), lupus, ulcerative colitis (UC), multiple sclerosis (MS) and certain cancers. These strong disease links have established PADs as potential therapeutic targets and numerous PAD inhibitors are known in the literature. Using a fluoroacetamidine warhead and iodo-substitutions in the molecular scaffold, we developed the first potent PAD1 inhibitor with 74-fold selectivity over other PADs. Structure-activity relationship studies indicate that the potency and isozyme-selectivity of this inhibitor is due to the formation of a halogen bond between the iodine atoms and PAD1 active site. This inhibitor exhibits excellent efficiency for the inhibition of PAD1 in HEK293TPAD1 cells and mouse zygotes. Based on this molecular scaffold, we also developed a PAD1-selective activity-based probe with remarkable cellular efficacy and proteome selectivity. </span></p>\n<p class=\"MsoNormal\"><strong><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">References: </span></strong></p>\n<p class=\"MsoNormal\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">1. S. Mondal, K. Raja, U. Schweizer, G. Mugesh, <em>Angew. Chem. Int. Ed. </em><strong>2016</strong>, <em>55</em>, 7606. </span></p>\n<p class=\"MsoNormal\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">2. S. Mondal, G. Mugesh, <em>Chem. Eur. J. </em><strong>2014</strong>, <em>20</em>, 11120. </span></p>\n<p class=\"MsoNormal\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">3. S. Mondal, D. Manna, G. Mugesh, <em>Angew. Chem. Int. Ed. </em><strong>2015</strong>, <em>54</em>, 9298. </span></p>\n<p class=\"MsoNormal\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">4. S. Mondal, G. Mugesh, <em>Angew. Chem. Int. Ed. </em><strong>2015</strong>, <em>54</em>, 10833. </span></p>\n<p class=\"MsoNormal\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">5. S. Mondal, G. Mugesh, <em>Chem. Eur. J.</em>, <strong>2019</strong>, <em>25</em>, 1773. </span></p>\n<p class=\"MsoNormal\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">5. S. Mondal, P. R. Thompson, <em>Acc. Chem. Res. </em><strong>2019</strong>, <em>52</em>, 818. </span></p>\n<p class=\"MsoNormal\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">6. S. Mondal, X. Gong, X. Zhang, A. J. Salinger, L. Zheng, S. Sen, E. Weerapana, X. Zhang, </span></p>\n<p><span style=\"font-size: 10.0pt; font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: \'Times New Roman\'; color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN; mso-bidi-language: AR-SA;\">    P. R. Thompson, <em>Angew. Chem. Int. Ed. </em><strong>2019</strong>, <em>58</em>, 12476.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 717, 'NULL', '2020-02-05 03:12:59', '2030-12-01 18:30:00'),
(638, 'March 24, 2020 at 2.30 pm in AG-69', 'Title :\nChemical Biology of Protein Citrullination\nAbstract :\nIn this seminar, I’ll discuss my pos', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Chemical Biology of Protein Citrullination</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; mso-layout-grid-align: none; text-autospace: none;\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">In this seminar, I’ll discuss my postdoctoral research on protein citrullination, a post-translational modification associated with multiple autoimmune disorders, and my research proposals. </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; mso-layout-grid-align: none; text-autospace: none;\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">     Protein citrullination by protein arginine deiminases (PADs – PAD1, 2, 3 and 4) plays pivotal roles in several physiological processes, such as epigenetic regulation of gene expression, neutrophil extracellular trap (NET) formation and DNA-damage induced apoptosis. However, strong links between aberrant protein citrullination and multiple autoimmune disorders as well as certain forms of cancer have established PADs as potential therapeutic targets. As PADs are cysteine hydrolases and contain a cysteine residue in the active site, cysteine-targeted haloacetamidine warheads installed on suitable small molecule scaffolds are generally used to irreversibly inhibit PADs. Since photoactivation of small molecule drugs at the target tissue can significantly reduce their off-target toxicity, we incorporated an azobenzene photoswitch that undergoes <em>trans</em>-<em>cis </em>isomerization in the presence of light in a known PAD inhibitor scaffold, BB-Cl-amidine. This led to the development of a PAD2 inhibitor that exhibits 10-fold higher potency upon irradiation with 350 nm light. This inhibitor can be activated in HEK293TPAD2 cells with light for the inhibition of histone H3 citrullination. </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; mso-layout-grid-align: none; text-autospace: none;\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">     Citrullination has remarkable effects on the structure and activity of proteins. For example, citrullination of serine protease inhibitors (SERPINs) and nicotinamide N-methyl transferase (NNMT) dramatically abolishes their activity. Interestingly, autocitrullination of PAD4 is proposed to regulate its enzymatic activity. Although numerous proteins are known to be citrullinated at various positions, the downstream implications of citrullination at each of these positions in a given protein remain elusive. To aid this, we developed, for the first time, a photocaged-citrulline for site-specific incorporation into proteins and subsequent conversion into citrulline (Cit) with light. Using amber codon suppression technique and an engineered leucyl-tRNA synthetase (LeuRS)/tRNALeu pair, we incorporated citrulline into enhanced green fluorescent protein (GFP) at 39 position and into PAD4 at two known autocitrullination sites, 372 and 374. Using various enzyme kinetic assays, we have shown that the R372Cit and R374Cit mutants of PAD4 are 292- and 10-fold, respectively, less active than the wild-type enzyme, indicating that citrullination has remarkable effect on the activity of PAD4. </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; mso-layout-grid-align: none; text-autospace: none;\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">     In addition to the aforementioned topics, I’ll also discuss my future plans for research on the covalent modification of proteins and photochemical control of the bioactivity of small molecules. </span></p>\n<p class=\"MsoNormal\"><strong><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">References: </span></strong></p>\n<p class=\"MsoNormal\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">1. S. Mondal, P. R. Thompson, <em>Acc. Chem. Res. </em><strong>2019</strong>, <em>52</em>, 818. </span></p>\n<p class=\"MsoNormal\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">2. S. Mondal, S. S. Parelkar, M. Nagar, P. R. Thompson, <em>ACS Chem. Biol. </em><strong>2018</strong>, <em>13</em>, 1057. </span></p>\n<p class=\"MsoNormal\"><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">3. S. Sen, S. Mondal, L. Zheng, A. Salinger, W. Fast, E. Weerapana, P. R. Thompson <em>ACS </em></span><em><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">Chem. Biol., </span></em><strong><span style=\"color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN;\">2019</span></strong><span style=\"color: black;\">, <em>14</em>, 613-618.</span></p>\n<p><span style=\"font-size: 10.0pt; font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: \'Times New Roman\'; color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN; mso-bidi-language: AR-SA;\">4. S. Mondal,† S. Wang,† Y. Zheng, A. Chatterjee, P. R. Thompson, Unpublished results</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 735, 'NULL', '2020-02-05 03:15:13', '2030-12-01 18:30:00'),
(639, 'February 10, 2020 at 4.00 pm in AG-69', 'Title :\nDouble Similarity Transformed Coupled Cluster Theory: Non-Covalent Interactions and Excited ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Double Similarity Transformed Coupled Cluster Theory: Non-Covalent Interactions and Excited State Energetics</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 10pt; font-family: \'Times New Roman\', serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;\" lang=\"EN-US\">The existing <em>ab-initio</em> theories often require high computational scaling</span> to account for the ground and excited state energetics in a quantitatively correct manner. In this talk, I shall propose an inexpensive dual exponential Ansatz based recursive similarity transformed Coupled Cluster methodology, which accurately captures dynamical correlation of weakly correlated molecular systems in an affordable manner. The superior accuracy of the proposed method in describing non-covalent interactions is ensured by the inclusion of high rank correlation effects and a balanced treatment of screened Coulomb interactions. Further, starting with a correlated description of the ground state, I shall propose a Linear Response formulation to describe electronically excited states of isolated gas phase molecules. I will demonstrate how our method strikes the right balance between computational cost and accuracy. The efficacy of the formulation will be demonstrated with a number of numerical examples.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 550, 'NULL', '2020-02-05 03:49:10', '2030-12-01 18:30:00'),
(640, 'March 3, 2020 at 2.30 pm in AG-80', 'Title :\nThe Low-Temperature Molecular Precursor Approach to Energy Storage Materials\nAbstract :\nThe', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">The Low-Temperature Molecular Precursor Approach </span>to Energy Storage Materials</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 10.0pt; font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: \'Times New Roman\'; color: black; mso-ansi-language: EN-IN; mso-fareast-language: EN-IN; mso-bidi-language: AR-SA;\">The low-temperature synthesis of inorganic materials and their interfaces at the atomic and molecular level provides numerous opportunities for the design and improvement of inorganic materials in heterogeneous catalysis for sustainable chemical energy conversion or other energy-saving areas. The transformation of molecules to materials is an emergence phenomenon, that is, the process creates novel complex properties of the resulting material entities which are absent in the starting material. Using suitable molecular single-source precursors for functional inorganic nanomaterial synthesis allows for reliable control over uniform particle size distribution, stoichiometry which can help to reach desired chemical and physical properties. In my talk I would like to outline main advantages and challenges of the molecular precursor approach in light of selected recent developments of molecule-to-nanomaterials synthesis for renewable energy applications, relevant for the oxygen evolution reaction (OER), hydrogen evolution reaction (HER) and overall water-splitting. Electrochemical water-splitting into hydrogen (H<sub>2</sub>) and oxygen (O<sub>2</sub>) is widely regarded as a promising approach to producing environmentally-friendly fuel for future energy supply. In the recent years, inexpensive, earth-abundant and environmentally benign transition metal oxides, hydroxides and other functional materials in conjunction with semiconducting co-catalyst that can independently catalyze OER and HER have been established. Still the major challenge is to provide reliable catalyst systems for HER, OER and overall water-splitting which are highly efficient, robust and long-term stable (at least for several months without loosing activity). The advantage of using the low-temperature molecular precursor approach to derive at unique core-shell structures , e.g. leading to the most efficient HER electrocatalysts reported to date, will also be discussed.</span></p>\n<p style=\"text-align: justify;\"><!--[if gte vml 1]><v:shapetype id=\"_x0000_t75\"\n coordsize=\"21600,21600\" o:spt=\"75\" o:preferrelative=\"t\" path=\"m@4@5l@4@11@9@11@9@5xe\"\n filled=\"f\" stroked=\"f\">\n <v:stroke joinstyle=\"miter\"/>\n <v:formulas>\n  <v:f eqn=\"if lineDrawn pixelLineWidth 0\"/>\n  <v:f eqn=\"sum @0 1 0\"/>\n  <v:f eqn=\"sum 0 0 @1\"/>\n  <v:f eqn=\"prod @2 1 2\"/>\n  <v:f eqn=\"prod @3 21600 pixelWidth\"/>\n  <v:f eqn=\"prod @3 21600 pixelHeight\"/>\n  <v:f eqn=\"sum @0 0 1\"/>\n  <v:f eqn=\"prod @6 1 2\"/>\n  <v:f eqn=\"prod @7 21600 pixelWidth\"/>\n  <v:f eqn=\"sum @8 21600 0\"/>\n  <v:f eqn=\"prod @7 21600 pixelHeight\"/>\n  <v:f eqn=\"sum @10 21600 0\"/>\n </v:formulas>\n <v:path o:extrusionok=\"f\" gradientshapeok=\"t\" o:connecttype=\"rect\"/>\n <o:lock v:ext=\"edit\" aspectratio=\"t\"/>\n</v:shapetype><v:shape id=\"_x0000_s1027\" type=\"#_x0000_t75\" style=\'position:absolute;\n margin-left:71.4pt;margin-top:430.5pt;width:299pt;height:215.95pt;z-index:251658240;\n mso-position-horizontal-relative:text;mso-position-vertical-relative:text;\n mso-width-relative:page;mso-height-relative:page\'>\n <v:imagedata src=\"file:///C:\\Users\\DCS\\AppData\\Local\\Temp\\msohtmlclip1\\01\\clip_image001.emz\"\n  o:title=\"\"/>\n <w:wrap type=\"square\"/>\n</v:shape><![endif]--><!--[if !vml]--><br /><!--[endif]--></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 742, 'NULL', '2020-02-12 00:22:24', '2030-12-01 18:30:00');
