<h3>Title</h3>
<p><strong><span style="color: #0000ff;">Molecules of Life</span></strong></p>
<p><strong><span style="text-decoration: underline;">Abtract</span> :</strong></p>
<p style="text-align: justify;">On the first day of the seminar, I will discuss (a) tale of a molecular timekeeper and continue with (b) evolution biology in a single-molecular regime. Proteins switching their structures can act as molecular timekeepers and regulate biochemically relevant reactions. Prolyl isomerization is one of such regulatory mechanisms, which play a crucial role in ion channel gating, cell signaling, and phage virus infection. I will present fascinating evidence showing how a single proline in an isolated protein domain (filamin) controls its folding kinetics and function.</p>
<p style="text-align: justify;">In the second section, I shall talk about the reverse-chaperon effect of cationic amino acid on a ribozymal RNA. In the light of current models for an early nucleic acid-based universe, the potential influence of simple amino acids on RNA tertiary folding into biochemically competent structures is speculated to be of significant evolutionary importance. In this work, the (un)folding kinetics of a ubiquitous RNA motif is investigated in single molecule regime in presence of natural amino acids with protonated side chain residues.</p>