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(641, 'February 20, 2020 at 2.30 pm in AG-80', 'Title :\nDesign Strategies Towards Stabilization of Organic Radical Ions and their Electroactive Part', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Design Strategies Towards Stabilization of Organic Radical Ions and their Electroactive Partners</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"font-family: Symbol; mso-ascii-font-family: \'Times New Roman\'; mso-fareast-font-family: Meiryo; mso-hansi-font-family: \'Times New Roman\'; mso-char-type: symbol; mso-symbol-font-family: Symbol;\" lang=\"EN-US\"><span style=\"mso-char-type: symbol; mso-symbol-font-family: Symbol;\">p</span></span><span style=\"mso-fareast-font-family: Meiryo;\" lang=\"EN-US\">-conjugated molecules are intriguing building blocks to realize diverse range of closed and open-shell molecular materials.<sup>1</sup> The major challenge facing their applications is the intrinsic reactivity of highly electron-deficient and electron-rich molecules in the neutral and radical ion forms. In this context, the naphthalenediimide (NDI) and the perylenediimide (PDI) </span><span style=\"font-family: Symbol; mso-ascii-font-family: \'Times New Roman\'; mso-fareast-font-family: Meiryo; mso-hansi-font-family: \'Times New Roman\'; mso-char-type: symbol; mso-symbol-font-family: Symbol;\" lang=\"EN-US\"><span style=\"mso-char-type: symbol; mso-symbol-font-family: Symbol;\">p</span></span><span style=\"mso-fareast-font-family: Meiryo;\" lang=\"EN-US\">-scaffolds provide an intriguing platform to design new electro-active molecules.<sup>2</sup></span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"text-indent: 36pt;\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"text-indent: 36pt;\">In this talk, we would discuss how the arylenediimide scaffolds integrated with specific design elements</span><sup style=\"text-indent: 36pt;\">3a</sup><span style=\"text-indent: 36pt;\"> can be utilized to synthesize and isolate new ambient stable radical ions. We have recently extended our efforts in synthetic spin chemistry towards the development of eco-friendly synthetic protocols towards radical ions.</span><sup style=\"text-indent: 36pt;\">3b</sup><span style=\"text-indent: 36pt;\"> Along with this, we recently isolated new </span><em style=\"text-indent: 36pt;\">planar</em><span style=\"text-indent: 36pt;\"> as well as </span><em style=\"text-indent: 36pt;\">twisted</em><span style=\"text-indent: 36pt;\"> ambient stable radical anions as well as the strongest electron acceptors with calculated LUMO of -5.2 eV.</span><sup style=\"text-indent: 36pt;\">4a,b </sup><span style=\"text-indent: 36pt;\">Considering the other end of the electrochemical window, we have been able to isolate highly electron-rich, di-reduced NDI systems, which have an unusual doubly zwitterionic molecular structure and redox switchable aromatic-antiaromatic sites.</span><sup style=\"text-indent: 36pt;\">5</sup><span style=\"text-indent: 36pt;\"> In short, we would discuss the possibilities to expand the electrochemical window of the arylenediimides maintaining their ambient stability. We believe their excited states would be of interest for photocatalysis and other relevant opto-electronic applications.</span></p>\n<p class=\"MsoNormalCxSpLast\" style=\"margin-right: -3.1pt; mso-add-space: auto; text-align: justify; text-indent: 36.0pt;\"><span style=\"mso-fareast-font-family: Meiryo;\" lang=\"EN-US\"> </span></p>\n<h1 style=\"text-align: justify; tab-stops: 36.0pt 72.0pt 108.0pt 144.0pt;\"><!--[if gte vml 1]><v:shapetype\n id=\"_x0000_t5\" coordsize=\"21600,21600\" o:spt=\"5\" adj=\"10800\" path=\"m@0,l,21600r21600,xe\">\n <v:stroke joinstyle=\"miter\"/>\n <v:formulas>\n  <v:f eqn=\"val #0\"/>\n  <v:f eqn=\"prod #0 1 2\"/>\n  <v:f eqn=\"sum @1 10800 0\"/>\n </v:formulas>\n <v:path gradientshapeok=\"t\" o:connecttype=\"custom\" o:connectlocs=\"@0,0;@1,10800;0,21600;10800,21600;21600,21600;@2,10800\"\n  textboxrect=\"0,10800,10800,18000;5400,10800,16200,18000;10800,10800,21600,18000;0,7200,7200,21600;7200,7200,14400,21600;14400,7200,21600,21600\"/>\n <v:handles>\n  <v:h position=\"#0,topLeft\" xrange=\"0,21600\"/>\n </v:handles>\n</v:shapetype><v:shape id=\"AutoShape_x0020_23\" o:spid=\"_x0000_s1027\" type=\"#_x0000_t5\"\n style=\'position:absolute;left:0;text-align:left;margin-left:436pt;\n margin-top:9.1pt;width:5.95pt;height:5.95pt;flip:y;z-index:251661312;\n visibility:visible\' o:gfxdata=\"UEsDBBQABgAIAAAAIQC2gziS/gAAAOEBAAATAAAAW0NvbnRlbnRfVHlwZXNdLnhtbJSRQU7DMBBF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\ncy9kb3ducmV2LnhtbFBLBQYAAAAABAAEAPMAAAABBgAAAAA=\n\" stroked=\"f\">\n <o:lock v:ext=\"edit\" aspectratio=\"t\"/>\n</v:shape><![endif]--><!--[if !vml]--><span style=\"mso-ignore: vglayout; 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position: absolute; z-index: 251660288; left: 0px; margin-left: 559px; margin-top: 11px; width: 9px; height: 9px;\"><img src=\"file:///C:/Users/DCS/AppData/Local/Temp/msohtmlclip1/01/clip_image001.gif\" border=\"0\" width=\"9\" height=\"9\" /></span><!--[endif]--><strong style=\"mso-bidi-font-weight: normal;\"><span style=\"font-family: \'Times New Roman\',\'serif\';\" lang=\"EN-US\">References</span></strong></h1>\n<p class=\"E4References\" style=\"margin-left: 18.0pt; text-indent: -18.0pt; line-height: normal; mso-list: l0 level1 lfo1; tab-stops: 12.0pt;\"><!--[if !supportLists]--><span style=\"font-size: 10.0pt; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN;\" lang=\"EN-US\"><span style=\"mso-list: Ignore;\">1.<span style=\"font: 7.0pt \'Times New Roman\';\">   </span></span></span><!--[endif]--><span style=\"font-size: 10.0pt;\" lang=\"EN-GB\">Morita, </span><span style=\"font-size: 10.0pt; mso-ansi-language: EN-US;\" lang=\"EN-US\">Y.; </span><span style=\"font-size: 10.0pt;\" lang=\"EN-GB\">Suzuki,</span><span style=\"font-size: 10.0pt; mso-ansi-language: EN-US;\" lang=\"EN-US\"> S.;</span><span style=\"font-size: 10.0pt;\" lang=\"EN-GB\"> Sato,</span><span style=\"font-size: 10.0pt; mso-ansi-language: EN-US;\" lang=\"EN-US\"> K.;</span><span style=\"font-size: 10.0pt;\" lang=\"EN-GB\"> Takui,</span><span style=\"font-size: 10.0pt; mso-ansi-language: EN-US;\" lang=\"EN-US\"> T.</span><em style=\"mso-bidi-font-style: normal;\"><span style=\"font-size: 10.0pt;\" lang=\"EN-GB\">Nature Chem</span></em><span style=\"font-size: 10.0pt;\" lang=\"EN-GB\">. <strong style=\"mso-bidi-font-weight: normal;\">2011</strong>, <em style=\"mso-bidi-font-style: normal;\">3</em>, 197</span><span style=\"font-size: 10.0pt; mso-fareast-font-family: Calibri; color: #232021; mso-ansi-language: EN-IN; mso-fareast-language: EN-US; mso-bidi-font-weight: bold;\">.</span></p>\n<p class=\"E4References\" style=\"margin-left: 18.0pt; text-indent: -18.0pt; line-height: normal; mso-list: l0 level1 lfo1; tab-stops: 12.0pt;\"><!--[if !supportLists]--><span class=\"listitem-data4\"><span style=\"font-size: 10.0pt; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN;\" lang=\"EN-US\"><span style=\"mso-list: Ignore;\">2.<span style=\"font: 7.0pt \'Times New Roman\';\">   </span></span></span></span><!--[endif]--><em><span style=\"font-size: 10.0pt; mso-fareast-font-family: Calibri; color: #232021; mso-ansi-language: EN-IN; mso-fareast-language: EN-US; mso-bidi-font-weight: bold;\">A review on electron-poor arylenediimides</span></em><span style=\"font-size: 10.0pt; mso-fareast-font-family: Calibri; color: #232021; mso-ansi-language: EN-IN; mso-fareast-language: EN-US; mso-bidi-font-weight: bold;\">: Kumar, S.; Shukla, J.; Kumar, Y.; Mukhopadhyay, P. </span><strong><em><span style=\"font-size: 10.0pt; mso-ansi-language: EN; font-weight: normal; mso-bidi-font-weight: bold;\" lang=\"EN\">Org. Chem. Front.</span></em></strong><span class=\"listitem-data4\"><span style=\"font-size: 10.0pt; mso-ansi-language: EN;\" lang=\"EN\">, <strong style=\"mso-bidi-font-weight: normal;\">2018</strong>, <em style=\"mso-bidi-font-style: normal;\">5</em>, 2254.</span></span></p>\n<p class=\"E4References\" style=\"margin-left: 18.0pt; text-indent: -18.0pt; line-height: normal; mso-list: l0 level1 lfo1; tab-stops: 12.0pt;\"><!--[if !supportLists]--><span style=\"font-size: 10.0pt; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN;\" lang=\"EN-US\"><span style=\"mso-list: Ignore;\">3.<span style=\"font: 7.0pt \'Times New Roman\';\">   </span></span></span><!--[endif]--><span style=\"font-size: 10.0pt; mso-fareast-font-family: Calibri; color: #232021; mso-ansi-language: EN-IN; mso-fareast-language: EN-US; mso-bidi-font-weight: bold;\">a) Kumar, S.; Ajayakumar, M. R.; Hundal, G.; Mukhopadhyay, P. <em style=\"mso-bidi-font-style: normal;\">J. Am. Chem. Soc</em>. <strong>2014</strong>, <em style=\"mso-bidi-font-style: normal;\">136</em>, 12004; b) Kumar, S.; Mukhopadhyay, P. <em style=\"mso-bidi-font-style: normal;\">Green</em>. <em style=\"mso-bidi-font-style: normal;\">Chem</em>. <strong>2018</strong>, <em style=\"mso-bidi-font-style: normal;\">20</em>, 4620.</span></p>\n<p class=\"E4References\" style=\"margin-left: 18.0pt; text-indent: -18.0pt; line-height: normal; mso-list: l0 level1 lfo1; tab-stops: 12.0pt;\"><!--[if !supportLists]--><span style=\"font-size: 10.0pt; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN;\" lang=\"EN-US\"><span style=\"mso-list: Ignore;\">4.<span style=\"font: 7.0pt \'Times New Roman\';\">   </span></span></span><!--[endif]--><span style=\"font-size: 10.0pt; mso-fareast-font-family: Calibri; color: #232021; mso-ansi-language: EN-IN; mso-fareast-language: EN-US; mso-bidi-font-weight: bold;\">a) Kumar, Y.; Kumar, S.; Mandal, K.; Mukhopadhyay, P<em style=\"mso-bidi-font-style: normal;\">. Angew. Chem. Int. Ed</em>. <strong>2018</strong>, <em style=\"mso-bidi-font-style: normal;\">57</em>, 16318; b) </span><span style=\"font-size: 10.0pt; color: black;\" lang=\"EN-GB\">Kumar, </span><span style=\"font-size: 10.0pt; color: black; mso-ansi-language: EN-US;\" lang=\"EN-US\">Y.; </span><span style=\"font-size: 10.0pt; color: black;\" lang=\"EN-GB\">Kumar,</span><span style=\"font-size: 10.0pt; color: black; mso-ansi-language: EN-US;\" lang=\"EN-US\"> S.;</span><span style=\"font-size: 10.0pt; color: black;\" lang=\"EN-GB\">Bansal, D.</span><span style=\"font-size: 10.0pt; color: black; mso-ansi-language: EN-US;\" lang=\"EN-US\">;</span><span style=\"font-size: 10.0pt; color: black;\" lang=\"EN-GB\"> Mukhopadhyay, P. <em style=\"mso-bidi-font-style: normal;\">Org. Lett.</em> </span><strong style=\"mso-bidi-font-weight: normal;\"><span style=\"font-size: 10.0pt; color: black; mso-ansi-language: EN-US;\" lang=\"EN-US\">2019</span></strong><span style=\"font-size: 10.0pt; color: black; mso-ansi-language: EN-US;\" lang=\"EN-US\">,</span><em style=\"mso-bidi-font-style: normal;\"><span style=\"font-size: 10.0pt; color: black;\" lang=\"EN-GB\">21</span></em><span style=\"font-size: 10.0pt; color: black; mso-ansi-language: EN-US;\" lang=\"EN-US\">,</span><span style=\"font-size: 10.0pt; color: black;\" lang=\"EN-GB\">2185.</span></p>\n<p class=\"E4References\" style=\"margin-left: 18.0pt; text-indent: -18.0pt; line-height: normal; mso-list: l0 level1 lfo1; tab-stops: 12.0pt;\"><!--[if !supportLists]--><span style=\"font-size: 10.0pt; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN;\" lang=\"EN-US\"><span style=\"mso-list: Ignore;\">5.<span style=\"font: 7.0pt \'Times New Roman\';\">   </span></span></span><!--[endif]--><span style=\"font-size: 10.0pt; mso-fareast-font-family: Calibri; color: #232021; mso-ansi-language: EN-IN; mso-fareast-language: EN-US; mso-bidi-font-weight: bold;\">Kumar, S.; Shukla, J.; Kumar, Y.; <span style=\"mso-spacerun: yes;\"> </span>Mandal, K.; Prakash, R.; Ram, P.; Mukhopadhyay, P<em style=\"mso-bidi-font-style: normal;\">.</em> <em>Chem. Sci</em>. </span><strong style=\"mso-bidi-font-weight: normal;\"><span style=\"font-size: 10.0pt; mso-fareast-font-family: Calibri; color: #232021; mso-ansi-language: EN-IN; mso-fareast-language: EN-US;\">2019</span></strong><span style=\"font-size: 10.0pt; mso-fareast-font-family: Calibri; color: #232021; mso-ansi-language: EN-IN; mso-fareast-language: EN-US; mso-bidi-font-weight: bold;\">, <em>10</em>, 6482.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 715, 'NULL', '2020-02-12 02:50:09', '2030-12-01 18:30:00'),
(642, 'February 17, 2020 at 4.00 pm in AG-69', 'Title :\nTime-Domain Raman Spectroscopy and Its Application to Ultrafast Photochemical/Photobiologic', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Time-Domain Raman Spectroscopy and Its Application to </span>Ultrafast Photochemical/Photobiological Reactions</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">Since its discovery 90 years ago, Raman spectroscopy has been developing continuously, and it is now one of the most important spectroscopies which is extensively utilized in various fields of science and technology. In traditional Raman spectroscopy, the energetically-shifted inelastic light scattering (Raman scattering) is measured, and the energy shift from the excitation light provides information about the vibrational energy of the molecules. On the other hand, using an ultrashort optical pulse that has a duration shorter than the vibrational period of molecules, we can carry out time-domain Raman spectroscopy in which we induce coherent nuclear motion of the molecule with the impulsive stimulated Raman process and observe Raman-active vibrations directly in the time domain. In principle, the information obtainable with time-domain Raman spectroscopy is equivalent to that obtained by ordinary frequency-domain Raman spectroscopy. However, because time-domain Raman spectroscopy is performed with only femtosecond pulses, we can trace the temporal change of the molecular vibrations with a femtosecond accuracy by combining it with a femtosecond pump pulse that starts chemical reactions [1-3]. In this lecture, I talk about the recent progress of our research about femtosecond time-domain Raman spectroscopy. A newly developed apparatus using 7-fs optical pulses allowed us to investigate the ultrafast dynamics of complex molecular systems such as the chromophore isomerization in photoreceptor proteins and the chemical bond formation process in molecular assemblies [4, 5, 6]. We also showed the possibility of multi-dimensional time-domain Raman spectroscopy that reveals the anharmonicity of reactive excited-state potential energy surfaces of complex molecules [7].</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"text-decoration: underline;\"><span lang=\"EN-US\">References</span></span><span lang=\"EN-US\">:</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\" style=\"margin-left: 18.0pt; text-align: justify; text-indent: -18.0pt; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span lang=\"EN-US\">1.<span style=\"font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: \'Times New Roman\';\">       </span></span><!--[endif]--><span lang=\"EN-US\">S. Fujiyoshi, S. Takeuchi and T. Tahara, J. Phys. Chem. A, 107, 494 (2003).</span></p>\n<p class=\"MsoNormal\" style=\"margin-left: 18.0pt; text-align: justify; text-indent: -18.0pt; mso-list: l0 level1 lfo1;\"><span style=\"text-indent: -18pt;\" lang=\"EN-US\">2.<span style=\"font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: \'Times New Roman\';\">       </span></span><span style=\"text-indent: -18pt;\" lang=\"EN-US\">G. Cerullo, L. Lüer, C. Manzoni, S. De Silvestri, O. Shoshana and S. Ruhman, J. Phys. Chem. A, 107, 8339 (2003).</span></p>\n<p class=\"MsoNormal\" style=\"margin-left: 18.0pt; text-align: justify; text-indent: -18.0pt; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span lang=\"EN-US\">3.<span style=\"font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: \'Times New Roman\';\">       </span></span><!--[endif]--><span lang=\"EN-US\">S. Takeuchi, S. Ruhman, T. Tsuneda, M. Chiba, T. Taketsugu and T. Tahara, Science 322, 1073 (2008).</span></p>\n<p class=\"MsoNormal\" style=\"margin-left: 18.0pt; text-align: justify; text-indent: -18.0pt; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span lang=\"EN-US\">4.<span style=\"font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: \'Times New Roman\';\">       </span></span><!--[endif]--><span lang=\"EN-US\">T. Fujisawa, H. Kuramochi, H. Hosoi, S. Takeuchi and T. Tahara, J. Am. Chem. Soc. 138, 3942 (2016).</span></p>\n<p class=\"MsoNormal\" style=\"margin-left: 18.0pt; text-align: justify; text-indent: -18.0pt; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span lang=\"EN-US\">5.<span style=\"font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: \'Times New Roman\';\">       </span></span><!--[endif]--><span lang=\"EN-US\">H. Kuramochi, S. Takeuchi, K. Yonezawa, H. Kamikubo, M. Kataoka and T. Tahara, Nat. Chem. 9, 660 (2017). </span></p>\n<p class=\"MsoNormal\" style=\"margin-left: 18.0pt; text-align: justify; text-indent: -18.0pt; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span lang=\"EN-US\">6.<span style=\"font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: \'Times New Roman\';\">       </span></span><!--[endif]--><span lang=\"EN-US\">H. Kuramochi, S. Takeuchi, M. Iwamura, K. Nozaki, T. Tahara, J. Am. Chem. Soc. in press (2019).</span></p>\n<p><span style=\"font-size: 10.0pt; font-family: \'Times New Roman\',\'serif\'; mso-fareast-font-family: Meiryo; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\" lang=\"EN-US\">7.     H. Kuramochi, S. Takeuchi and T. Tahara, Sci. Adv. 5, eaau4490 (2019).</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 803, 'NULL', '2020-02-13 23:41:26', '2030-12-01 18:30:00'),
(643, 'February 25, 2020 at 11.30 am in AG-80', 'Title :\nManipulating Light with Molecular Excitons\nAbstract :\nThere are many applications that deman', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Manipulating Light with Molecular Excitons</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span lang=\"EN-US\">There are many applications that demand that the properties of light be controlled by molecular excitons. This includes upconversion applications, where shorter wavelengths are generated from longer wavelengths, and multiple exciton generation and photon multiplication, where a high energy photon is split into smaller energy packets.</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\">Over the past decade, we have applied triplet-triplet annihilation upconversion to photovoltaics. Recently, we achieved photochemical upconversion from beyond the silicon bandgap for the first time.</p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"font-family: \'Times New Roman\', serif; font-size: 10pt;\">Singlet fission is a process where a photon-generated singlet state splits into two spin-correlated triplets. In solar cells it is hoped that this will give rise to two excitons per absorbed photon above a certain energy, increasing the efficiency limit to nearly 46%. Here I will discuss the role of the excimer state in singlet fission.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 591, 'NULL', '2020-02-20 02:19:03', '2030-12-01 18:30:00'),
(644, 'March 2, 2020 at 4.00 pm in AG-69', 'Title :\nProbing the conformational differences of membrane attached proteins at a single molecule l', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Probing the conformational differences of membrane attached proteins </span>at a single molecule level</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 687, 'NULL', '2020-02-25 00:34:42', '2030-12-01 18:30:00'),
(645, 'March 6, 2020 at 2.30 pm in AG-66', 'Title :\nThe nature of scientific publishing\nAbstract :\nThe scientific publishing process can often s', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">The nature of scientific publishing</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">The scientific publishing process can often seem like a black box, filled with mystery and misapprehension. In this talk, Bryden Le Bailly, a Senior Editor at Nature, will discuss the publishing process at Nature journals, how best to navigate its pitfalls, and share the answers to some of the most frequently held misconceptions.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 638, 'NULL', '2020-03-02 00:01:52', '2030-12-01 18:30:00'),
(646, 'November 9, 2020 at 4.30 pm (via Zoom)', 'Title :\nFrom Designing Enzyme Mimetics to Probing Protein Citrullination\nAbstract :\nIn this seminar,', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">From Designing Enzyme Mimetics to Probing Protein Citrullination</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">In this seminar, I’ll discuss my doctoral research on the biomimetic dehalogenation of thyroid hormones, their metabolites and halogenated nucleosides as well as my postdoctoral research on the development of small molecule inhibitors and chemical probes of protein arginine deiminases (PADs) that catalyze protein citrullination.</span></p>\n<p><span style=\"font-size: 12.16px;\">Thyroid gland produces thyroxine (T4) as a prohormone and regioselective deiodination by a group of mammalian selenoenzymes, iodothyronine deiodinase type 1 (DIO1), type 2 (DIO2) and type 3 (DIO3) play important roles in the activation and inactivation of T4. We developed nahthyl-based organo-sulphur and/or selenium compounds as functional mimics of DIO3, and showed that deiodination of thyroid hormones and various metabolites by these compounds relies on the synergistic actions of halogen and chalcogen bonding interactions. These nahthyl-based organochalcogen compounds were also used to dehalogenate the halogenated nucleosides that can be incorporated into DNA during DNA replication and cause potential DNA damages in the presence of UV irradiation. Additionally, we discovered that commercial T4, a generic drug prescribed for hypothyroidism, exists in at least two different stable crystalline modifications with different three-dimensional structure, conformation, physical properties and solubility.</span></p>\n<p><span style=\"font-size: 12.16px;\">Citrullination is a post-translational modification of arginine, catalyzed by a group of hydrolases called protein arginine deiminases (PADs – PAD1, 2, 3 and 4). Despite various physiological roles, protein hypercitrullination is associated with various diseases including rheumatoid arthritis (RA), lupus, ulcerative colitis (UC), multiple sclerosis (MS) and certain cancers. These strong disease links have established PADs as potential therapeutic targets and several PAD inhibitors are known in the literature. To reduce the off-target toxicity, we developed an azobenzene-substituted PAD2 inhibitor that undergoes trans-cis photoisomerism and can be activated at the target cell/tissue with light. Notably, the cis-isomer of this inhibitor is 10-fold more active than its trans-isomer. Furthermore, using a fluoroacetamidine warhead and iodo-substitutions in the molecular scaffold, we developed the first potent PAD1 inhibitor with 74-fold selectivity over other PADs. Detailed studies indicate that the potency and isozyme-selectivity of this inhibitor is due to the formation of a halogen bond between the inhibitor and PAD1 active site. This inhibitor exhibited excellent efficacy for the inhibition of histone H3 citrullination in HEK293TPAD1 cells and mouse zygotes. Based on this molecular scaffold, we also developed a PAD1-selective activity-based probe with remarkable cellular efficacy and proteome selectivity.</span></p>\n<p><span style=\"font-size: 12.16px;\">References:</span></p>\n<p><span style=\"font-size: 12.16px;\">1. S. Mondal, K. Raja, U. Schweizer, G. Mugesh, Angew. Chem. Int. Ed. 2016, 55, 7606.</span></p>\n<p><span style=\"font-size: 12.16px;\">2. S. Mondal, D. Manna, G. Mugesh, Angew. Chem. Int. Ed. 2015, 54, 9298.</span></p>\n<p><span style=\"font-size: 12.16px;\">3. S. Mondal, G. Mugesh, Angew. Chem. Int. Ed. 2015, 54, 10833.</span></p>\n<p><span style=\"font-size: 12.16px;\">4. S. Mondal, G. Mugesh, Chem. Eur. J. 2014, 20, 11120.</span></p>\n<p><span style=\"font-size: 12.16px;\">5. S. Mondal, G. Mugesh, Chem. Eur. J., 2019, 25, 1773.</span></p>\n<p><span style=\"font-size: 12.16px;\">5. S. Mondal, P. R. Thompson, Acc. Chem. Res. 2019, 52, 818.</span></p>\n<p><span style=\"font-size: 12.16px;\">6. S. Mondal, X. Gong, X. Zhang, A. J. Salinger, L. Zheng, S. Sen, E. Weerapana, X. Zhang,</span></p>\n<p><span style=\"font-size: 12.16px;\">P. R. Thompson, Angew. Chem. Int. Ed. 2019, 58, 12476.</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">7. S. Mondal, S. S. Parelkar, M. Nagar, P. R. Thompson, ACS Chem. Biol. 2018, 13, 1057.</span></p>\n<p><span style=\"text-decoration: underline;\"><strong><span style=\"font-size: 12.16px;\">ZOOM DETAILS:</span></strong></span></p>\n<p><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">Join Zoom Meeting</span><br style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\" /><a href=\"https://zoom.us/j/4906223773?pwd=RHgzbzdMYjh4MDQvd2JKaWM1YmRmZz09\" target=\"_blank\" rel=\"noreferrer\" style=\"color: #0186ba; font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">https://zoom.us/j/4906223773?pwd=RHgzbzdMYjh4MDQvd2JKaWM1YmRmZz09</a><br style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\" /><br style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\" /><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">Meeting ID: 490 622 3773</span><br style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\" /><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">Passcode: 04072020</span><br style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\" /><br style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\" /><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">Join by SIP</span><br style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\" /><a href=\"mailto:4906223773@zoomcrc.com\" rel=\"noreferrer\" style=\"color: #0186ba; font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">4906223773@zoomcrc.com</a></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 399, 'NULL', '2020-11-05 01:08:11', '2020-11-09 05:17:34'),
(647, 'November 10, 2020 at 4.30 pm (via Zoom)', 'Title :\nChemical Biology of Protein Citrullination\nAbstract :\nIn this seminar, I’ll discuss my pos', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Chemical Biology of Protein Citrullination</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">In this seminar, I’ll discuss my postdoctoral research on protein citrullination, a post-translational modification associated with multiple autoimmune disorders, and my research proposals.</span></p>\n<p><span style=\"font-size: 12.16px;\">Protein citrullination by protein arginine deiminases (PADs – PAD1, 2, 3 and 4) plays pivotal roles in several physiological processes, such as epigenetic regulation of gene expression, neutrophil extracellular trap (NET) formation and DNA-damage induced apoptosis. However, aberrant protein citrullination by PADs is associated with multiple autoimmune disorders, including rheumatoid arthritis (RA), multiple sclerosis (MS), ulcerative colitis (UC) and lupus, neurodegenerative diseases and certain forms of cancer. For example, a citrulline-specific probe, Biotin-PG and chemoproteomics platform enabled us to identify various classes of novel citrullinated proteins, including serine protease inhibitors (SERPINs), serine proteases, transport proteins and complement system components along with known citrullinated proteins (e.g., vimentin, enolase, keratin and fibrin) in the serum, synovial fluid and synovial tissue of RA patients. Although the list of citrullinated proteins is ever expanding, the effect of citrullination on the structure and activity of a given protein remains poorly understood mainly due to the lack of a method for site-specific incorporation of citrulline into proteins. We developed a novel technology that enables the site-specific incorporation of citrulline (Cit) into proteins in mammalian cells. This approach exploits an engineered E. coli-derived leucyl tRNA synthetase-tRNA pair that incorporates a photocaged-citrulline (SM60) into proteins in response to a nonsense codon. Subsequently, SM60 is readily converted to Cit with light in vitro and in living cells. To demonstrate the utility of the method, we biochemically characterized the effect of incorporating Cit at two known autocitrullination sites in Protein Arginine Deiminase 4 (PAD4, R372 and R374) and showed that the R372Cit and R374Cit mutants are 181- and 9-fold less active than the wild-type enzyme.</span></p>\n<p><span style=\"font-size: 12.16px;\">Additionally, I’ll discuss my future plans for research on the covalent modification and degradation of proteins, and photochemical control of the bioactivity of small molecules.</span></p>\n<p><span style=\"font-size: 12.16px;\">References:</span></p>\n<p><span style=\"font-size: 12.16px;\">1. S. Mondal, P. R. Thompson, Acc. Chem. Res. 2019, 52, 818.</span></p>\n<p><span style=\"font-size: 12.16px;\">2. S. Mondal, S. Wang, Y. Zheng, S. Sen, A. Chatterjee, P. R. Thompson, Nat. Commun.</span></p>\n<p><span style=\"font-size: 12.16px;\">2020, Manuscript Accepted.</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">(Preprint: bioRxiv, https://doi.org/10.1101/2020.06.06.137885)</span></p>\n<p><span style=\"text-decoration: underline;\"><strong><span style=\"font-size: 12.16px;\">ZOOM DETAILS:</span></strong></span></p>\n<p><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">Join Zoom Meeting</span><br style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\" /><a href=\"https://zoom.us/j/4906223773?pwd=RHgzbzdMYjh4MDQvd2JKaWM1YmRmZz09\" target=\"_blank\" rel=\"noreferrer\" style=\"color: #0186ba; font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">https://zoom.us/j/4906223773?pwd=RHgzbzdMYjh4MDQvd2JKaWM1YmRmZz09</a><br style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\" /><br style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\" /><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">Meeting ID: 490 622 3773</span><br style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\" /><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">Passcode: 04072020</span><br style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\" /><br style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\" /><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">Join by SIP</span><br style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\" /><a href=\"mailto:4906223773@zoomcrc.com\" rel=\"noreferrer\" style=\"color: #0186ba; font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">4906223773@zoomcrc.com</a></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 392, 'NULL', '2020-11-05 01:17:35', '2020-11-09 05:17:44'),
(648, 'November 16, 2020 at 4.00 pm (Via Zoom)', 'Title :\nActivity and crowding, two major players in single probe dynamics\nAbstract: \n \nA biologica', '<h3>Title</h3>\n<h3><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">Activity and crowding, two major players in single probe dynamics</span></h3>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"><strong><span style=\"text-decoration: underline;\">Abstract</span>: </strong></div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"> </div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">A biological cell is probably the best example of a medium in the mesoscopic length scale that is truly out of equilibrium. This non-equilibrium arises due the processes occurring inside that do not follow detailed balance and are commonly fuelled by the energy released due to some chemical reaction, such as ATP hydrolysis. In other words, the constituents of biological cells are \"active\"[1]. Apart from its constituents being active, the cell is highly packed or crowded. Therefore, dynamics of a biomolecule inside a cell is an example of the dynamics of an active probe in a crowded environment. Motivated by these, physical scientists have come up with biomimetic environments, where the true biomolecules are replaced by probes, such as active or self-propelled colloids or single polymer chains, fuelled by some chemical reaction or by some other means [2, 3]. One interesting aspect of the dynamics of these probes is their persistent motion [4] like bacteria. Another direction in which experimentalists have recently ventured into, is the dynamics of a passive probe in an active medium such as bacteria bath [3, 5]. One motivation is to build highly efficient micron sized heat engines in a non-equilibrium active bath.</div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"> </div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">These processes occurring inside a cell or in a biomimetic environment cannot be modelled in the framework of equilibrium statistical mechanics. In this talk I plan to discuss our recent attempts to model the dynamics of a probe (passive or active) in a crowded medium (passive) using non equilibrium statistical mechanics and computer simulations. The probe is either a single self-propelled colloid [6, 7, 8] or a single polymer chain [9, 10] and the medium is either viscoelastic or non-viscoelastic. Our analytically solvable models and computer simulations reveal interesting aspects of the probe dynamics, sometimes counter intuitive. Most importantly, our theoretical predictions are either predicted by experiments in the recent past [2, 4, 5] or later confirmed by new experiments [3].  </div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"> </div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"> </div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">[1] F. S. Gresotto, F. Mura, J. Galdrow and C. P. Broedersz Rep. Progr. Phys. 81, 066601 (2018).</div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">[2] J. R. Gomez-Solano, A. Blokhuis and C. Bechinger Phys. Rev. Lett. 116, 138301(2016).</div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">[3] M. S. Aporvari, M. Utkur, E. U. Saritas, G. Volpe and J. Stenhammar, Soft Matter 16, 5609 (2020).</div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">[4] <span style=\"font-size: 9pt;\">X.-L. Wu and A. Libchaber </span><span style=\"font-size: 9pt;\">Phys. Rev. Lett.</span><span style=\"font-size: 9pt;\">, </span><span style=\"font-size: 9pt;\">84</span><span style=\"font-size: 9pt;\">, 3017 (2000).</span></div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">[5] S. Krishnamurthy, S. Ghosh, D. Chatterji, R. Ganapathy and A. K. Sood  Nat. Phys. 12, 1134 (2016). </div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">[6] L. Theeyancheri, S. Chaki, N. Samanta, R. Goswami, R. Chelakkot and R. Chakrabarti Soft Matter 16, 8482 (2020).</div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">[7] S. Chaki and R. Chakrabarti Soft Matter 16, 7103 (2020).</div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">[8] M.Kaiser, P. A. Sanchez, N. Samanta, R. Chakrabarti and S. S. Kantorovich J. Phys. Chem. B 124, 8188 (2020).</div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">[9] N. Samanta and R. Chakrabarti J. Phys. A: Math. Theor. 49, 195601 (2016). </div>\n<div style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">[10] S. Chaki and R. Chakrabarti J. Chem. Phys. 150, 094902 (2019). </div>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 414, 'NULL', '2020-11-09 05:17:14', '2030-12-01 18:30:00'),
(649, 'November 23, 2020 at 4.00 pm (via Zoom)', 'Title :\nWatt Webb: Shining Light on Biology', '<h3>Title</h3>\n<h3><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">Watt Webb: Shining Light on Biology</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 310, 'NULL', '2020-11-18 05:06:03', '2030-12-01 18:30:00'),
(650, 'December 14, 2020 at 5.30 pm (via zoom)', 'Title :\nStructure of Hemagglutinin Fusion Peptide and Correlation of the Structure with Fusion Catal', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Structure of Hemagglutinin Fusion Peptide and Correlation of the Structure with Fusion Catalysis</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">Enveloped viruses, like influenza virus are coated with a lipid membrane, and fusion peptides present in the lipid envelope are responsible for the fusion between the viral and the host cell membrane on infection. The fusion peptide is highly conserved such that modest mutation can arrest membrane fusion. Despite the fusion peptide’s critical role in fusion, there is no clear consensus in the literature of the structure and function of the influenza fusion peptide. Research over the last 25 years on the influenza fusion peptide showed very different structures; 20-residue influenza fusion peptide adopts open boomerang structure while the 23-residue adopts a tightly packed closed helical hairpin structure in detergents.1,2 Based on the different interhelical geometries different membrane-binding mechanisms were proposed. The different functional models were based on different structures in detergents, but influenza fusion peptide induces fusion of membranes and not detergents, so the membrane structures are more relevant for function. We recently showed that both the 20- and 23-residue influenza fusion peptide adopts similar structures in membrane.3 In this talk, we will discuss about the determination of the structure of influenza fusion peptide in membranes. Later, how the structural features were correlated to the function of the influenza fusion peptide will be discussed.</span></p>\n<p><span style=\"font-size: 12.16px;\">References:</span></p>\n<p><span style=\"font-size: 12.16px;\">1. Han, X.; Bushweller, J. H.; Cafiso, D. S.; Tamm, L. K. Nat. Struct Biol. 2001, 8, 715</span></p>\n<p><span style=\"font-size: 12.16px;\">2. Lorieau, J. L.; Louis, J. M.; Bax, A. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 11341</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">3. Ghosh, U.; Xie, L.; Jia, L.; Liang, S.; Weliky, D.P. J Am. Chem. Soc. 2015, 137, 7548</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 363, 'NULL', '2020-12-01 00:06:54', '2030-12-01 18:30:00'),
(651, 'December 15, 2020 at 5.30 pm (via zoom)', 'Title :\nMolecular structure of a prevalent amyloid-β fibril polymorph from Alzheimer\'s disease brai', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Molecular structure of a prevalent amyloid-β fibril polymorph from Alzheimer\'s disease brain tissue</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">Amyloid fibril formation by various polypeptides is a biophysically interesting and biomedically important phenomenon, any understanding of which depends on molecular structural information. The aggregation of amyloid-β (Aβ) peptide in the brain as amyloid fibrils is a pathological hallmark of Alzheimer’s disease. Structural studies of these aggregates are important in understanding their formation, spreading, and for development of therapeutic and diagnostic approaches. In this talk, I will describe the structural studies of Aβ-fibrils from the postmortem brain of an individual with Alzheimer’s disease. Here we have integrated both solid-state NMR and cryo-EM to solve the structure of the most common polymorph of Aβ-fibrils that develop in the brain of Alzheimer’s disease patients. Here we present the cryo-EM map of Aβ-fibril at 2.7 Å resolution. The information from both solid-state NMR and cryo-EM are combined in a single structure calculation to obtain the structure of brain-derived Aβ-fibrils. In the case of Aβ fibrils, we have found a surprising two-fold symmetric polymorph with a mass-per-length value of 27 kDa/nm (indicating three Aβ molecules per β-sheet repeat spacing). The integration of cryo-EM and solid-state NMR pave the way for structural studies of complex systems.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 428, 'NULL', '2020-12-01 00:11:30', '2030-12-01 18:30:00');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(652, 'December 21, 2020 at 4.30 pm (Via Zoom)', 'Title :\nDevelopment of New Methods for Selective and Efficient Chemical Synthesis\nAbstract :\nIn spi', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Development of New Methods for Selective and Efficient </span>Chemical Synthesis</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p><span style=\"font-size: 12.16px;\">In spite of the changing face of chemistry, the impact of chemical synthesis - the ability to </span>make organic molecules in a controlled manner - has not diminished. Nevertheless, the increasingly complex synthetic problems being posed by nature, medicine and organic materials demand new concepts and strategies to meet these challenges. This seminar will describe new methods for selective and efficient chemical synthesis that I have developed in three different research areas: photocatalysis, hypervalent iodine chemistry, and organoboron chemistry. The generation of aryl radicals from aryl diazonium salts needs, in traditional methods, a catalytic or stoichiometric amount of a redox-active transition metal salt. Visible light can provide the required redox energy and has been considered as an ideal reagent for organic synthesis. In the first part, I will discuss the photoredox catalyzed Meerwein arylation. 1 Alkynes are ubiquitous in both naturally occurring and synthetic organic compounds. One of the most often used methods for the synthesis of alkynes consists in the addition of acetylene anions to electrophilic positions of molecules. In contrast, the reversed polarity approach, the addition of alkynes onto nucleophiles, has been less investigated, limiting the structural diversity and potential applications of this important class of compounds. In the second part, I will present electrophilic alkynylation methods using hypervalent iodine reagents.2 In the last part of the seminar, I will discuss my current research on 1,2-metalate rearrangements of boron derivatives to access substituted cyclobutane derivatives.3 This method allows for a rapid and stereoselective synthesis of Grandisol.</p>\n<p><span style=\"font-size: 12.16px;\">1 a) Hari, D. P.; Schroll, P.; König, B. J. Am. Chem. Soc. 2012, 134, 2958. b) Hari, D. P.; König, B. Angew. Chem, Int.</span></p>\n<p><span style=\"font-size: 12.16px;\">Ed. 2013, 52, 4734. c) Hari, D. P.; Hering, T.; König, B. Angew. Chem. Int. Ed. 2014, 53, 725.</span></p>\n<p><span style=\"font-size: 12.16px;\">2 a) Hari, D. P.; Waser, J. J. Am. Chem. Soc. 2016, 138, 2190. b) Hari, D. P.; Waser, J. J. Am. Chem. Soc. 2017, 139,</span></p>\n<p><span style=\"font-size: 12.16px;\">8420. c) Hari, D. P.; Caramenti, P.; Waser, J. Acc. Chem. Res. 2018, 51, 3212. d) Hari, D. P.; Pisella, D.; Wodrich,</span></p>\n<p><span style=\"font-size: 12.16px;\">M. D.; Tsymbal, A. V.; and Waser. J. Angew. Chem. Int. Ed. 2020, 10.1002/anie.202012299.</span></p>\n<p><span style=\"font-size: 12.16px;\">3 Hari, D. P.; Abell, J. C.; Fasano, V.; Aggarwal, V. K. J. Am. Chem. Soc. 2020, 142, 5515. b) Hari, D. P.;</span></p>\n<p><span style=\"font-size: 12.16px;\">Madhavachary, R.; Fasano, V.; Haire. J.; Aggarwal, V. K. J. Am. Chem. Soc.2020, submitted.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 427, 'NULL', '2020-12-07 05:30:59', '2030-12-01 18:30:00'),
(653, 'December 22, 2020 at 4.30 pm (Via Zoom)', 'Title :\nNew Reaction Development\nAbstract :\nThe synthesis of organic molecules has transformed our s', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">New Reaction Development</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">The synthesis of organic molecules has transformed our society, providing medicines, biological probes, crop protectants, food preservatives and components of organic materials. As we advance further into the 21st century, synthetic chemistry will continue to play an important role and will continue to deliver major societal benefits. However, despite significant progress, the problems and difficulties associated with chemical synthesis continue to limit the rate of growth and development of these disciplines. To meet the emerging challenges across new disciplinary boundaries in a rapidly changing scientific landscape we require more rapid and robust techniques for organic synthesis. I plan to address these issues in my research proposal by developing innovative reactions and strategies that enable us to access versatile reactive intermediates for the mild and sustainable synthesis of medicinally relevant compounds. To achieve these ambitious goals, I have divided the research program into three key objectives. 1) Synthesis and applications of α-diazo boronic esters, 2) Ring strain enabled reaction discovery, and 3) Deconstructive functionalizations for drug discovery.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 416, 'NULL', '2020-12-07 05:32:41', '2030-12-01 18:30:00'),
(654, 'January 11, 2021 at 4.00 pm (Via Zoom)', 'Title :\nSwitching DNA Junction Binding ability of metallosupramolecular Nano-cylinder Helicates by ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Switching DNA Junction Binding ability of metallosupramolecular </span>Nano-cylinder Helicates by rotaxination</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p><span style=\"font-size: 12.16px;\">In this talk I will be discussing a new class of rotaxane that is created by our research group at </span>the University of Birmingham, UK. this is the first report of this kind of rotaxane. The principle involves inserting a three-dimensional, cylindrical, nanosized, self-assembled supramolecular helicate into a large cucurbit[10]uril macrocycle as the axle.<sup>1</sup> The resulting pseudo-rotaxane is readily converted into a proper interlocked rotaxane by adding branch points to the helicate strands that form the surface of the cylinder (like branches and roots on a tree trunk). The supramolecular cylinder that forms the axle is itself a member of a unique and remarkable class of helicate metallo-drugs that bind Y-shaped DNA junction structures and induce cell death.<sup>2</sup> While pseudo-rotaxanation i.e., the capped cylinder without CB10 does not modify the DNAbinding properties, proper, mechanically interlocked rotaxanation transforms the DNA-binding and biological activity of the cylinder. The interesting observation is the ability of the cylinder to de-thread from the rotaxane (and thus to bind DNA junction structures) is controlled by the extent of branching: fully-branched cylinders are locked inside the cucurbit[10]uril macrocycle, while cylinders with incomplete branch points can de-thread from the rotaxane in response to competitor and being available for binding to the Y shaped junction binding. The number of branch points can thus afford kinetic control over the drug de-threading and release.</p>\n<p><img src=\"images/Garai.png\" border=\"0\" alt=\"\" width=\"629\" height=\"471\" /></p>\n<p><span style=\"font-size: 12.16px;\">References:-</span></p>\n<p><span style=\"font-size: 12.16px;\">1. Catherine A. J. Hooper, Lucia Cardo, James S. Craig, Lazaros Melidis, Aditya Garai, </span>Ross Egan, Viktoriia Sadovnikova, Florian Burkert, Louise Male, Nikolas J. Hodges, Douglas F. Browning, Roselyne Rosas, Fengbo Liu, Fillipe V. Rocha, Mauro A. Lima, David Bardelang, Simin Liu and Michael J. Hannon \" Rotaxanating metallosupramolecular Nano-cylinder Helicates to Switch DNA Junction Binding \" J. Am. Chem. Soc. 2020, 142, 20651-20660.</p>\n<p><span style=\"font-size: 12.16px;\">2. Lucia Cardo, Michael J. Hannon “Non-covalent metallo-drugs: using shape to target </span>DNA and RNA junctions and other nucleic acid structures” 5 Feb 2018, Metallo-drugs: Development and Action of Anticancer Agents. Walter de Gruyter GmbH &amp; Co. KG, p. 303-324 22 p.(Metal Ions in Life Sciences; vol. 18).</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 475, 'NULL', '2021-01-04 01:18:49', '2030-12-01 18:30:00'),
(655, 'January 15, 2021 at 2.30 pm (via Zoom)', 'Title :\nEarth Abundant Metal Functionalized Graphene Based Hybrid Electrocatalyst for CO2 Reduction\n', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Earth Abundant Metal Functionalized Graphene Based Hybrid Electrocatalyst for CO<sub>2</sub> Reduction</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; text-justify: inter-ideograph;\"><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">Rapidly increasing CO<sub>2</sub> in the atmosphere is becoming the big challenge of scientific community globally because of serious environmental and societal issues. The major contributor for CO<sub>2</sub> is mostly from combustion of fossil fuel during industrialization. On the other end there is an increase in demand of energy because of globalization responsible for increase in level in atmosphere. It motivates to search for the ways to reduction of CO<sub>2</sub> to other chemical intermediates and/or back to fuel. Among the existing conversion ways electrocatalytic approach by selecting appropriate cathode electrode nanomaterial is one of the most promising and cost effective approach to convert CO<sub>2</sub> to variety of hydrocarbons. [1]</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; text-justify: inter-ideograph;\"><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">Further nanomaterials for electro catalysis are superior because of its compare to bulk large surface area, hence less utilization, spatial confinement, and many more. Another issue of it requires wide electrochemical window which controls the use of aqueous electrolytes. Depending up on electron transfer in electrochemistry of CO<sub>2</sub> there are different types of product formed such as Hydrocarbons, alcohols, Formic acid etc. [2] In addition to this other structural issues of CO<sub>2</sub> includes solubility, and comfortably of other reduced intermediates results into hamper its conversion. To overcome this barrier, we herewith used as-synthesized Graphene oxide decorated metal oxide hybrid electrocatalytic system for the reduction of CO<sub>2</sub> considering their synergetic effect to useful product formic acid. [3] Moreover, as a one of the active component g-carbon nitrite (g-C<sub>3</sub>N<sub>4</sub>) is having highly polymeric class and consists of carbon and nitrogen with different types of allotropes with sheet-like structure, synthesized by simple way from commercially accessible and low-cost materials. Again, N-doping materials are having more active sites and a large number of defects because of Sp<sup>3</sup> carbon atoms, which possess additional surface energy with enhanced electron enrichment for electrochemical activation of CO<sub>2 </sub>molecules. In the line of this we have synthesized non Nobel metal/metal oxide nanoparticles and decorated on graphene and g-carbon nitrite based hybrid electrocatalyst for electrochemical hydrogenation of CO<sub>2</sub> to formate/formic acid. [4]</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; text-justify: inter-ideograph;\"><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">Furthermore reduction of formic acid to give methanol and finally methane as product which has widely used in petroleum industry as part of this formic acid important intermediate for came back again to fuel from CO<sub>2</sub>. Formic acid has natural antibacterial properties because of that used as antibacterial in food products as a preservative or on crops as a pesticide, production of leather, dyeing and finishing textiles, coagulant in many rubber manufacturing processes, it also helps to</span><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">fermentation at a lower temperature,</span><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">one of the basic raw materials of organic chemical and it has insect protective mechanisms. [5]</span></p>\n<p class=\"MsoNormal\"><strong style=\"mso-bidi-font-weight: normal;\"><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">References </span></strong></p>\n<p class=\"MsoListParagraphCxSpFirst\" style=\"margin-top: 0cm; margin-right: 0cm; margin-bottom: 12.0pt; margin-left: 18.0pt; mso-add-space: auto; text-indent: -18.0pt; line-height: 150%; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span style=\"mso-bidi-font-size: 12.0pt; line-height: 150%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\"><span style=\"mso-list: Ignore;\">1.<span style=\"font: 7.0pt \'Times New Roman\';\">      </span></span></span><!--[endif]--><span style=\"mso-bidi-font-size: 12.0pt; line-height: 150%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">J. Qiao, Y. Liu, F. Hong, J. Zhang, A review of catalysts for the electroreduction of carbon dioxide to produce low-carbon fuels,Chem. Soc. Rev. 43 (2014) 631-675.</span></p>\n<p class=\"MsoListParagraphCxSpMiddle\" style=\"margin-top: 0cm; margin-right: 0cm; margin-bottom: 12.0pt; margin-left: 18.0pt; mso-add-space: auto; text-indent: -18.0pt; line-height: 150%; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span style=\"mso-bidi-font-size: 12.0pt; line-height: 150%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\"><span style=\"mso-list: Ignore;\">2.<span style=\"font: 7.0pt \'Times New Roman\';\">      </span></span></span><!--[endif]--><span style=\"mso-bidi-font-size: 12.0pt; line-height: 150%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">B. Khezri, A. C. Fisher, M. Pumera, CO<sub>2</sub> reduction: the quest for electrocatalytic materials, J. Mater. Chem. A. 5 (2017) 8230-8246.</span></p>\n<p class=\"MsoListParagraphCxSpMiddle\" style=\"margin-top: 0cm; margin-right: 0cm; margin-bottom: 12.0pt; margin-left: 18.0pt; mso-add-space: auto; text-indent: -18.0pt; line-height: 150%; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span style=\"mso-bidi-font-size: 12.0pt; line-height: 150%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\"><span style=\"mso-list: Ignore;\">3.<span style=\"font: 7.0pt \'Times New Roman\';\">      </span></span></span><!--[endif]--><span style=\"mso-bidi-font-size: 12.0pt; line-height: 150%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">W. Zhang, Y. Hu, L. Ma, G. Zhu, Y. Wang, X. Xue, R. Chen, S. Yang, Z. Jin,<span style=\"mso-bidi-font-weight: bold;\"> Progress and Perspective of Electrocatalytic CO<sub>2</sub> Reduction for Renewable Carbonaceous Fuels and Chemicals, </span><span style=\"mso-spacerun: yes;\"> </span>Adv. Sci. 5 (2018) 1-25.</span></p>\n<p class=\"MsoListParagraphCxSpMiddle\" style=\"margin-top: 0cm; margin-right: 0cm; margin-bottom: 12.0pt; margin-left: 18.0pt; mso-add-space: auto; text-indent: -18.0pt; line-height: 150%; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span style=\"mso-bidi-font-size: 12.0pt; line-height: 150%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\"><span style=\"mso-list: Ignore;\">4.<span style=\"font: 7.0pt \'Times New Roman\';\">      </span></span></span><!--[endif]--><span style=\"mso-bidi-font-size: 12.0pt; line-height: 150%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">Q. Han, N. Chen, <span style=\"mso-spacerun: yes;\"> </span>J. Zhanga, L. Qu, Graphene/graphitic carbon nitride hybrids for catalysis, </span></p>\n<p class=\"MsoListParagraphCxSpMiddle\" style=\"margin-top: 0cm; margin-right: 0cm; margin-bottom: 12.0pt; margin-left: 18.0pt; mso-add-space: auto; line-height: 150%;\"><span style=\"mso-bidi-font-size: 12.0pt; line-height: 150%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">Mater. Horiz., 4 (2017) 832-850.</span></p>\n<p class=\"MsoListParagraphCxSpLast\" style=\"margin-top: 0cm; margin-right: 0cm; margin-bottom: 12.0pt; margin-left: 18.0pt; mso-add-space: auto; text-indent: -18.0pt; line-height: 150%; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span style=\"mso-bidi-font-size: 12.0pt; line-height: 150%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\"><span style=\"mso-list: Ignore;\">5.<span style=\"font: 7.0pt \'Times New Roman\';\">      </span></span></span><!--[endif]--><span style=\"mso-bidi-font-size: 12.0pt; line-height: 150%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">D. Du, R. Lan, J. Humphreys, Progress in inorganic cathode catalysts for electrochemical conversion of carbon dioxide into formate or formic acid, J. Appl. Electrochem. 47 (2017) 661-678.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 238, 'NULL', '2021-01-12 23:39:25', '2030-12-01 18:30:00'),
(656, 'January 18, 2021 at 4.00 pm (via Zoom)', 'Title :\nSynthesis and Applications of Carbon Nano-onins and Carbon dots\nAbstract :\nThe progress of n', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Synthesis and Applications of Carbon Nano-onins and Carbon dots</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">The progress of nanotechnology, especially nano-materials based on carbon, has revamped the existing science and technology world. The carbon family has produced tremendous interest due to their varied potential applications since the discovery of fullerenes,1 followed by carbon nanotubes (CNTs),2 carbon nano-onions (CNOs),3 graphene,4 and, most recently, carbon dots.5 The synthesis and applications of fluorescent carbon nano-onions, carbon dots6 in the field of sensors and agriculture will be discussed in this talk. Carbon nano-onions were used as a growth promotor for gram plants.7 Entire life cycle stages of gram plants will be discussed. For the application of sensors, fluorescent carbon dots have been used. These carbon dots selectively detect trinitrophenol.8</span></p>\n<p><span style=\"font-size: 12.16px;\">References:</span></p>\n<p><span style=\"font-size: 12.16px;\">1. Kroto, H. W.; Heath, J. R.; O’Brien, S. C.; Curl, R. F.; Smalley, R. E., C60: Buckminsterfullerene. Nature 1985, 318, (6042), 162-163.</span></p>\n<p><span style=\"font-size: 12.16px;\">2. Iijima, S., Helical microtubules of graphitic carbon. Nature 1991, 354, (6348), 56-58.</span></p>\n<p><span style=\"font-size: 12.16px;\">3. Ugarte, D., Curling and closure of graphitic networks under electron-beam irradiation. Nature 1992, 359, (6397), 707-709.</span></p>\n<p><span style=\"font-size: 12.16px;\">4. Novoselov, K. S.; Geim, A. K.; Morozov, S. V.; Jiang, D.; Zhang, Y.; Dubonos, S. V.; Grigorieva, I. V.; Firsov, A. A., Electric Field Effect in Atomically Thin Carbon Films. Science 2004, 306, (5696), 666.</span></p>\n<p><span style=\"font-size: 12.16px;\">5. Sun, Y.-P.; Zhou, B.; Lin, Y.; Wang, W.; Fernando, K. A. S.; Pathak, P.; Meziani, M. J.; Harruff, B. A.; Wang, X.; Wang, H.; Luo, P. G.; Yang, H.; Kose, M. E.; Chen, B.; Veca, L. M.; Xie, S.-Y., Quantum-Sized Carbon Dots for Bright and Colorful Photoluminescence. J. Am. Chem. Soc. 2006, 128, (24), 7756-7757.</span></p>\n<p><span style=\"font-size: 12.16px;\">6. Babar, D. G.; Sonkar, S. K.; Tripathi, K. M.; Sarkar, S., P2O5 Assisted Green Synthesis of Multicolor Fluorescent Water Soluble Carbon Dots. Journal of Nanoscience and Nanotechnology 2014, 14, (3), 2334-2342.</span></p>\n<p><span style=\"font-size: 12.16px;\">7. Sonkar, S. K.; Roy, M.; Babar, D. G.; Sarkar, S., Water soluble carbon nano-onions from wood wool as growth promoters for gram plants. Nanoscale 2012, 4, (24), 7670-7675.</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">8. Babar, D. G.; Garje, S. S., Nitrogen and Phosphorus Co-Doped Carbon Dots for Selective Detection of Nitro Explosives. ACS Omega 2020, 5, (6), 2710-2717.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 286, 'NULL', '2021-01-12 23:42:01', '2030-12-01 18:30:00'),
(657, 'January 25, 2021 at 4.00 pm (via Zoom)', 'Title :\nStudies on Interaction of Peptides and Polymers with Phospholipid Bilayer\nAbstract :\nIn this', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Studies on Interaction of Peptides and Polymers with Phospholipid Bilayer</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">In this seminar, I’ll discuss my doctoral research on interaction of peptides and polymers with liposomes for drug delivery applications. Our work has technological potential in the area of drug delivery. But it can also serve as a model system for understanding how the membrane properties change due to interaction with drug delivery cargoes, drug molecules, peptides, and polymers.</span></p>\n<p><span style=\"font-size: 12.16px;\">Low endosomal escape efficiency of liposome following internalization into the endosomal compartment is one of the significant limitations to conventional liposomal drug delivery systems [1]. The encapsulated drug in the liposome must reach into the cell cytoplasm through two membranes, one of the liposomes itself and other of the endosome, while avoiding degradation in the lysosomal environment. A possible solution for achieving endosomal escape and intracellular drug delivery is provided by pH sensitive cell-penetrating peptides. We have utilized a single giant unilamellar vesicle assay to study the kinetics of pH sensitive cell-penetrating peptide induced pore formation in vesicles. Moreover, kinetics of peptide induced leakage at single vesicle level, mechanism of pore formation in phospholipid bilayer, estimation of the rate constant of pore formation, and rate of increase in pore density as a function of peptide concentration addressed in our studies will also be discussed.</span></p>\n<p><span style=\"font-size: 12.16px;\">Rapid clearance of liposomes from the circulatory system is another major limitation associated with liposomes. Chitosan, a cationic linear polysaccharide has been widely used in polymer based liposomal drug delivery system because of its biodegradability, biocompatibility, non-toxicity, and mucoadhesive properties. In this study, chitosan-bearing giant unilamellar vesicles were prepared using inverse phase precursor method. We measured mechanical properties such as bending and area compressibility moduli and lysis tension using micropipette aspiration assay [2]. Our findings demonstrate that incorporation of chitosan in phospholipid bilayers modulates the mechanical and transport properties of liposomes, which may affect their in vivo circulation time and drug release rate. Collectively, a deep understanding of the interaction of polymers and cell-penetrating peptides with phospholipid bilayer may help in designing an efficient liposomal drug delivery platform.</span></p>\n<p><span style=\"font-size: 12.16px;\">[1] T.M. Allen, P.R. Cullis, Liposomal drug delivery systems: From concept to clinical applications, Adv. Drug Deliv. Rev. 65 (2013) 36–48. doi:10.1016/j.addr.2012.09.037.</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">[2] H.P. James, S. Jadhav, Mechanical and transport properties of chitosan-zwitterionic phospholipid vesicles, Colloids Surfaces B Biointerfaces. 188 (2020) 110782.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 253, 'NULL', '2021-01-12 23:47:33', '2030-12-01 18:30:00'),
(658, 'January 21, 2021 at 2.30 pm (via Zoom)', 'Title :\nForce Response and Unfolding Pathways of Ubiquitin using Steered Molecular Dynamics Simulati', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Force Response and Unfolding Pathways of Ubiquitin using Steered Molecular Dynamics Simulations</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 290, 'NULL', '2021-01-13 00:48:50', '2030-12-01 18:30:00'),
(659, 'January 28, 2021 at 2.30 pm (via Zoom)', 'Title :\nTa doped compact TiO2  for improved performance in perovskite solar cells\nAbstract :\nPerovs', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Ta doped compact TiO<sub>2</sub>  for improved performance in perovskite solar cells</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">Perovskite solar cells (PSCs) are currently the most exciting solar photovoltaic technologies for future deployment. A conventional PSC device structure typically employs a titanium dioxide (TiO<sub>2</sub>) electron transport layer. However, the low electrical conductivity of TiO<sub>2</sub> is an obstacle to PSC efficiency enhancement. In this work, we report on the conductivity enhancement of TiO<sub>2</sub> by tantalum (Ta) doping and its effect on improving the device performance. Photovoltaic measurements show that Ta doping of compact TiO<sub>2</sub> results in an improvement in the fill factor (FF) of the devices due to a decrease in the series resistance (Rs), attributed to improved charge transport and an increase in the shunt resistance (Rsh), due to reduced leakage paths.  Further it was found  that the Fermi level of TiO<sub>2</sub> shifts downward upon Ta doping providing driving force for the electron transfer from the perovskite LUMO to the TiO<sub>2</sub> conduction band resulting in higher current density. PSC devices with Ta doping of 3.0% led to a 40% improvement in the overall efficiency as compared to un-doped TiO<sub>2</sub> with the best device showing a power conversion efficiency of ca. 9.94%</span></p>', 'draft', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 23, 'NULL', '2021-01-22 05:57:32', '2030-12-01 18:30:00'),
(660, 'January 28, 2021 at 10.00 am (via Zoom)', 'Title :\nUnderstanding the activation and regulation of the mitogen-activated protein kinase p38 usin', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Understanding the activation and regulation of the mitogen-activated protein kinase p38 using solution NMR spectroscopy</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\">Enzymes, including kinases, require conformational and dynamic changes to perform their biological function. Conformational changes associated with the function are well-documented using X-ray crystallography and NMR spectroscopy. However, dynamic changes associated with allostery and catalysis are getting established. NMR spectroscopy is the method of choice for these studies as it reports directly on protein dynamics/motions across different time scales (ps to s; most of the catalytic activity occurs at this timescale).</p>\n<p style=\"text-align: justify;\"> </p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Mitogen-activated protein kinases (MAPKs), including p38, belong to the family of ser/thr protein kinases that are essential for cell differentiation and autophagy. p38 becomes activated by phosphorylation of two residues (TxY) in its activation loop. Substrate binding occurs at a recognition sequence, commonly referred to as the D-motif or the Kinase Interaction Motif (KIM). Despite extensive efforts, the molecular mechanism of activation, including how p38 dynamics are correlated with activity and regulation, remains unclear. Here, the results of auto-correlated 15N fast (ns-ps) and intermediate timescale (s-ms) dynamics measurements to understand the activation and regulation of p38 will be presented. NMR relaxation measurements were performed on the different states along the activation pathway of p38, which includes phosphorylation, substrate, and ATP binding. Unexpectedly, our data showed that phosphorylation of p38 is important, but substrate binding is indeed key for the synchronization of the dynamics across the molecule to activate p38. And, it is this synchronization that allows for enhanced ATP recruitment and thus, the full activity of p38. Besides, the regulation of MAPKs is achieved via a plethora of regulatory proteins, including activating MAPKKs and an abundance of deactivating phosphatases. Although all regulatory proteins that include MAPK phosphatases, use identical interaction sites on MAPKs, they use distinct kinase interaction motif (KIM) sequences that are present in linear, peptide-like, or well-folded protein domains. To understand how the MAPK phosphatases, interact with substrates and elucidate the structural basis for the specificity of these regulatory proteins, we studied the interaction of the MAPK binding domain of a dual-specificity phosphatase (DUSP16) with p38, using integrated structural biology approaches the results of which, will also be presented.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 312, 'NULL', '2021-01-24 23:56:32', '2030-12-01 18:30:00'),
(661, 'February 1, 2021 at 4.00 pm (via Zoom)', 'Title :\nEmotional Intelligence at the Workplace\nAbstract :\nEmotional intelligence, sometimes referre', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Emotional Intelligence at the Workplace</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Emotional intelligence, sometimes referred to as EQ (\"emotional quotient\"), refers to a person\'s ability to recognize, understand, manage, and reason with emotions. It is a critical ability when it comes to interpersonal communication—and a hot topic not only in psychology, but in the business world. The term was coined by psychologists in the 1990s.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Interest in emotion psychology and the concept of emotional intelligence really caught fire with the 1995 publication of Daniel Goleman\'s book \"Emotional Intelligence: Why It Can Matter More Than IQ.\" In the book, Goleman argued that emotional intelligence was critical for predicting success in life. Emotional competencies, he argued, also played a particularly important role in the workplace. Researchers have suggested that emotional intelligence influences how well employees interact with their colleagues, and EQ is also thought to play a role in how workers manage stress and conflict. It also affects overall performance on the job. Other studies have linked emotional intelligence with job satisfaction. Studies have shown that employees with higher scores on measures of EQ also tend to be rated higher on measures of interpersonal functioning, leadership abilities, and stress management.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In the talk, the concept of EI will be introduced followed by a deliberation on how each one of us can improve this skill with training and practice, because if you want to succeed in the workplace and move up the career ladder, emotional intelligence is critical to your success.</span></p>\n<p style=\"text-align: justify;\"><em><span style=\"font-size: 12.16px;\">I attended a workshop “Emotional Intelligence at the Workplace for Scientists/Technologies” organized by Centre for Organization Development, Hyderabad  (Feb. 17-21, 2020), sponsored by Dept. of Science &amp; Technology, Govt. of India, and the concepts of EI which I learnt in this are worth sharing with all colleagues.</span></em></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 311, 'NULL', '2021-01-25 00:05:12', '2030-12-01 18:30:00'),
(662, 'February 4, 2021 at 3.00 pm (via Zoom)', 'Title :\nUnderstanding Protein-Protein Interaction in CDK1/Cyclin B and SARS-COV-2-RBD/ACE2 protein ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Understanding Protein-Protein Interaction in </span>CDK1/Cyclin B and SARS-COV-2-RBD/ACE2 protein complex</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In many diseases, protein-protein interactions (PPIs) in the functional protein complexes are found to </span>be dysregulated, so understanding PPI and their regulation will help in designing the drug molecules to tackle these PPIs and hence disease. Here we have studied the PPI in two protein complexes, CDK1/cyclin B and SARS-COV-2-SPIKE/ACE2.</p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">The protein-protein binding in CDK1-cyclin B which is an essential cell cycle regulator 1 is known to </span>be a default process. Our molecular dynamics (MD) simulation result suggest that PPI between them is not a default process rather regulated by acetylation and ATP binding in CDK1. Based on this evidence, we propose the formation of the CDK1-cyclin B complex, first through deacetylation of CDK1 and then Cyclin B binding in presence of ATP.</p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">The receptor-binding domain (RBD) in SPIKE protein from the SARS-COV-2 virus interacts with </span>human cell receptor protein ACE2 and this interaction acts as an entry point for the virus into the human cell 2. The interaction of ACE2 with RBD is mainly dominated by a helix called SBP1 3 which opens a route for disrupting PPI between SPIKE and ACE2 through designing an inhibitor based on SBP1 peptide. However, it has been reported that removing the SBP1 helix from ACE2 disrupts the helicity of SBP1. So, to tackle this, we have applied a lactam group based linker on SBP1 and studied the linker position-dependent stability of SBP1. We found that stapling at specific positions in the SBP1 peptide drastically improved its helicity.</p>\n<p><span style=\"font-size: 12.16px;\">References:</span></p>\n<p><span style=\"font-size: 12.16px;\">1-N. R. Brown, S. Korolchuk, M. P. Martin, W. A. Stanley, R. Moukhametzianov, M. E. Noble, and J. </span>A. Endicott, “CDK1 structures reveal conserved and unique features of the essential cell cycle CDK ”, Nature Communications, vol. 6, pp. 1–12, 2015.</p>\n<p><span style=\"font-size: 12.16px;\">2-Renhong Yan, Yuanyuan Zhang, Yaning Li, Lu Xia, Yingying Guo, Qiang Zhou, “Structural basis for </span>the recognition of SARS-CoV-2 by full-length human ACE2 ”, Science, vol. 367, pp. 1444-1448, 2020.</p>\n<p><span style=\"font-size: 12.16px;\">3-G. Zhang, S. Pomplun, A. R. Loftis, A. Loas, B. L. Pentelute “The first-in-class peptide binder to the </span>SARS-CoV-2 spike protein’’ bioRxiv 2020.03.19.999318</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 257, 'NULL', '2021-01-29 02:39:57', '2021-02-03 00:25:30'),
(663, 'February 9, 2021 at 2.30 pm (Via Zoom)', 'Title :\nStrain and support effects for enhanced electrocatalytic performance\nAbstract :\nThe renewab', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Strain and support effects for enhanced electrocatalytic </span>performance</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>The renewable energy resources have got a huge attention in lieu of fossil fuel-based energy resources due to the rise in environmental pollution along with a concomitant increase in global energy demand. The most challenging issue lies on the intermittent nature of these renewable resources. One of the important alternatives of these is use of fuel cells which uses chemical energy of a fuel and cleanly produces electricity without combustion. Electrocatalysis, used as the electrode material, accelerates the rate of an electrochemical reaction under a given electrical potential. The main aim in the development of an electrocatalyst is that the material designed should have better catalytic activities at a fairly cheaper cost. In a bi/multi-metallic system, with distinct lattice constants, a synergistic interaction modifies the electronic features such as position of d-band center and shift in core level with respect to the Fermi level and tunes the catalytic properties to be better than that of the individual metal analogues. The geometric (strain) and support effects in nanomaterials were studied for hydrogen evolution reaction (HER) and carbon dioxide (CO<sub>2</sub>) reduction. In this seminar, I will present the following research investigations:</p>\n<p> The effect of surface strain in the carbon supported Pt<sub>3</sub>Co dealloyed catalyst towards HER has been studied. Dealloying process was adopted to generate the geometric strain in Pt<sub>3</sub>Co/C alloy by preferential dissolution of non-noble metal (Co) from the alloy and the improved activity in Pt<sub>3</sub>Co/C dealloy was due to the compressive strain generated in it.</p>\n<p> The electrochemical reduction of carbon dioxide to recycle CO<sub>2</sub> into CO (an important raw material of syn gas for the synthesis of industrially valuable products via Fischer–Tropsch process) was studied. Au NPs supported on RGO have been studied for CO<sub>2</sub> reduction. The presence of defect sites on RGO in RGOAu, the influence of reducing agent (NaBH<sub>4</sub>) and the optimum concentration of Au on RGO support were studied for carbon dioxide reduction.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 273, 'NULL', '2021-02-03 06:18:58', '2030-12-01 18:30:00'),
(664, 'February 15, 2021 at 4.00 pm (via Zoom)', 'Title :\nImproving Device Performance of PbS Quantum Dot Solar Cells Using Inorganic Hole Transport L', '<h3>Title</h3>\n<h3><span style=\"font-family: arial, sans-serif; font-size: 11px; text-align: justify;\">Improving Device Performance of PbS Quantum Dot Solar Cells Using Inorganic Hole Transport Layers</span></h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-family: arial, sans-serif; font-size: 11px; text-align: justify; line-height: 12.65px;\">Colloidal quantum dots (CQDs) are nanometer-scale semiconductor crystals. These \"quantum dot\" materials exhibiting three dimensional (3-D) confinement, are highly desired for their size-tunable optical properties synthesis routes utilizing organo-metallic precursors enable the production of nanocrystalline particles with nearly monodisperse size dispersions. I </span><span style=\"font-family: arial, sans-serif; font-size: 11px; text-align: justify; line-height: 12.65px; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-origin: initial; background-clip: initial;\">improved the efficiency of the colloidal PbS quantum dot solar cell efficiency by varying the device structure with the help of an inorganic hole transport materials like 2D-MoS<sub>2</sub> nanosheets and by changing the chemical nature of the QD surface by ultraviolet ozone treatment (UVO). UVO treatment for few seconds lowers the Fermi energy level and increases p-doping through control oxidation of the PbS QD surface. I developed a two-stage solution-phase ligand exchange process by substitution of the organic counter cation with the inorganic metal cation is achieving superior stability and performance of the CsI and NaI treated PbS quantum dot solar cells.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 253, 'NULL', '2021-02-07 22:44:56', '2030-12-01 18:30:00'),
(665, 'February 22, 2021 at 4.30 pm (via Zoom)', 'Title :\nFrom Molecular to Supported Single Atom Catalysts: Catalysis in Homogeneous and Heterogeneou', '<p>Title :</p>\n<p><span style=\"font-size: 12.16px;\">From Molecular to Supported Single Atom Catalysts: Catalysis in Homogeneous and Heterogeneous Phase</span></p>\n<p><span style=\"font-size: 12.16px;\">Abstract :</span></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: 115%;\"><span style=\"mso-bidi-font-size: 12.0pt; line-height: 115%; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: Calibri; background: white; mso-ansi-language: EN-US;\" lang=\"EN-US\">Polyoxometalates (POMs) are best known for their acidic properties, ability towards electron transfer (ET), proton transfer (PT), proton coupled electron transfer (PCET) and electron transfer-oxygen transfer (ET-OT) reactions.<sup>[1]</sup> These abilities strictly depend on addenda atoms incorporated to the POM. For example, phosphovanadomolybdic acid, H<sub>5</sub>PV<sub>2</sub>Mo<sub>10</sub>O<sub>40</sub> can act as ET-OT agent for the oxidation of anthracene to anthraquinone whereas H<sub>5</sub>PMo<sub>12</sub>O<sub>40</sub> can act as only ET agent. Moreover, reaction medium plays a decisive role in the rate of the reaction. Using a mixture of water and sulfuric acid as solvent, we were able to protonate H<sub>5</sub>PV<sub>2</sub>Mo<sub>12</sub>O<sub>40</sub>, which facilitates the ET-OT reactions for the activation of C-H bond of toluene and benzene.<sup>[2],[3]</sup> Electron paramagnetic resonance (EPR) spectroscopy was used to detect the presence of organic radical in the X-band.<sup>[4]</sup> <span style=\"mso-spacerun: yes;\"> </span></span></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: 115%;\"><img src=\"images/BBS1a.jpg\" border=\"0\" alt=\"\" width=\"775\" height=\"149\" /></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: 115%;\"><span style=\"line-height: 115%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;\" lang=\"EN-US\">In a different study, cavity of polyoxometalate wheel such as Mo<sub>132</sub> was used as a nano-reactor which allows selective organic molecules to assemble inside the POM and further halogen migration reaction and Friedel-Craft arylation reaction was observed due to intrinsic acidity generated inside the cavity. Two-dimensional NMR, such as rotating frame overhause effect spectroscopy (ROESY) and heteronuclear overhause effect spectroscopy (HOESY) were used to understand the interactions between the organic molecules and the POMs.<sup>[5]</sup> </span></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: 115%;\"> </p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: 115%;\"><span style=\"line-height: 115%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;\" lang=\"EN-US\">All these results lead to remarkably interesting questions such as (a) can we mimic these reactions in heterogeneous phase? (b) can we anchor single atoms over support and understand the behavior of molecular catalysts? (c) can we tune the surrounding environment of the metal via different metal-support interaction? Synchrotron based X-ray absorption spectroscopy will be used as one of the major characterization tools in order to derive coordination number, oxidation state and symmetry of the supported single atom.</span></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: 115%;\"><span style=\"line-height: 115%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;\" lang=\"EN-US\"><img src=\"images/BBS2a.jpg\" border=\"0\" alt=\"\" width=\"855\" height=\"210\" /></span></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: 115%;\"> </p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span style=\"font-size: 11.0pt; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: Calibri;\" lang=\"DE\">References:</span></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: normal;\"><span style=\"font-size: 11.0pt; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: Calibri;\" lang=\"DE\">[1] A. M. Khenkin, L. Weiner, Y. Wang and R. Neumann; J. Am. </span><span style=\"font-size: 11.0pt; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: Calibri; mso-ansi-language: EN-US;\" lang=\"EN-US\">Chem. Soc. 2001, 123, 35, 8531–8542</span></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: normal;\"><span style=\"font-size: 11.0pt; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: Calibri; mso-ansi-language: EN-US;\" lang=\"EN-US\">[2]</span><span style=\"font-size: 11.0pt; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: Calibri; mso-ansi-language: EN-US;\" lang=\"EN-US\">B. B. Sarma, R. Neumann; Nature Communications, 5, 4621, 2014</span></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: normal;\"><span style=\"font-size: 11.0pt; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: Calibri;\" lang=\"DE\">[3]</span><span style=\"font-size: 11.0pt; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: Calibri;\" lang=\"DE\">B. B. Sarma, I. Efremenko, R. Neumann; J. Am. Chem. Soc., 2015, 137, 18, 5916–5922</span></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: normal;\"><span style=\"font-size: 11.0pt; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: Calibri;\" lang=\"DE\">[4] B. B. Sarma, R. Carmieli, A. Collauto, I. Efremenko, J. M. L. Martin, R. Neumann; ACS Catalysis, 2016, 6, 6403-6407</span></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: normal;\"><span style=\"font-size: 11.0pt; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: Calibri;\" lang=\"DE\">[5] B. B. Sarma, L. Avram-Biton and R. Neumann; Chem. Eur. J., 2016, 22, 43, 15231 – 15236.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 234, 'NULL', '2021-02-07 23:04:31', '2030-12-01 18:30:00');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(666, 'February 23, 2021 at 4.30 pm (via Zoom)', 'Title :\nDynamic Behavior of Atomically Dispersed Catalysts: Tracking the Active Site with In-situ/Op', '<p>Title :</p>\n<p><span style=\"font-size: 12.16px;\">Dynamic Behavior of Atomically Dispersed Catalysts: Tracking the Active Site with In-situ/Operando Spectroscopy</span></p>\n<p><span style=\"font-size: 12.16px;\">Abstract :</span></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: 120%;\"><span style=\"mso-bidi-font-size: 12.0pt; line-height: 120%; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: \'Times New Roman\'; mso-ansi-language: EN-US;\" lang=\"EN-US\">A thrilling ongoing interest in heterogeneous catalysis is to understand the dynamic behavior of atomically dispersed metals, which is also often referred to as single-atom catalysts (SACs).</span><!--[if supportFields]><span\nlang=EN-US style=\'mso-bidi-font-size:12.0pt;line-height:120%;mso-fareast-font-family:\n\"Times New Roman\";mso-bidi-font-family:\"Times New Roman\";mso-ansi-language:\nEN-US\'><span style=\'mso-element:field-begin\'></span> ADDIN EN.CITE <span\nstyle=\'mso-element:field-begin\'></span><span\nstyle=\'mso-spacerun:yes\'> </span>ADDIN EN.CITE.DATA <![if gte mso 9]><xml>\n <w:data>[encoded data, 4236 characters]</w:data>\n</xml><![endif]><span style=\'mso-element:field-end\'></span><span\nstyle=\'mso-element:field-separator\'></span></span><![endif]--><span style=\"mso-bidi-font-size: 12.0pt; line-height: 120%; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: \'Times New Roman\'; mso-ansi-language: EN-US;\" lang=\"EN-US\"><sup><span style=\"mso-no-proof: yes;\">[1]</span></sup><!--[if gte mso 9]><xml>\n <w:data>[encoded data, 4236 characters]</w:data>\n</xml><![endif]--></span><!--[if supportFields]><span lang=EN-US\nstyle=\'mso-bidi-font-size:12.0pt;line-height:120%;mso-fareast-font-family:\"Times New Roman\";\nmso-bidi-font-family:\"Times New Roman\";mso-ansi-language:EN-US\'><span\nstyle=\'mso-element:field-end\'></span></span><![endif]--><span style=\"mso-bidi-font-size: 12.0pt; line-height: 120%; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: \'Times New Roman\'; mso-ansi-language: EN-US;\" lang=\"EN-US\"> Single atom can be anchored over various supports such as metal-oxide, 2D carbon like materials, 3D materials such as zeolite, metal-organic framework and in the host matrix of other atom (known as single atom alloy). When stabilized over these materials, single atom exhibits different degree of coordination, charge on the metal and confinement within the support.<sup>[2],[3]</sup> These parameters strongly determine the driving force with regard to catalyst stability, performance towards catalytic reactions and most of the time governs the selectivity of the products. Hence, it strongly encourages me to understand in-depth how atoms breathe when incorporated in a host matrix under the operating conditions. Various spectroscopic tools such as X-Ray absorption spectroscopy (XAS), Fourier Transform-Infra Red (FT-IR) spectroscopy, Raman spectroscopy and few others will be used to determine the active species generated during the reactions. XAS is an emerging tool in the area of atomically dispersed catalysts, which has been used to derive information regarding coordination number, oxidation state and geometry around the metal atom upto 5-6 </span><span style=\"mso-bidi-font-size: 12.0pt; line-height: 120%; font-family: \'Sylfaen\',serif; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: \'Times New Roman\'; mso-ansi-language: EN-US;\" lang=\"EN-US\">Å</span><span style=\"mso-bidi-font-size: 12.0pt; line-height: 120%; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: \'Times New Roman\'; mso-ansi-language: EN-US;\" lang=\"EN-US\">.<span style=\"mso-spacerun: yes;\">  </span>Diffuse Reflectance Infrared Fourier Transform (DRIFT) spectroscopy will be used to identify the metal-adsorbate species generated during the reaction.<span style=\"mso-spacerun: yes;\">  </span>A comparative study between supported atom, atom plus cluster and over cluster under operando conditions will answer the key questions raised within the proposed research.</span></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: 120%;\"><span style=\"mso-bidi-font-size: 12.0pt; line-height: 120%; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: \'Times New Roman\'; mso-ansi-language: EN-US;\" lang=\"EN-US\"><img src=\"images/BBS3a.jpg\" border=\"0\" alt=\"\" width=\"856\" height=\"418\" /></span></p>\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; text-align: justify; line-height: 115%;\"><span style=\"font-size: 11.0pt; line-height: 115%; mso-fareast-font-family: \'Times New Roman\'; mso-bidi-font-family: \'Times New Roman\'; mso-ansi-language: EN-US;\" lang=\"EN-US\">References:</span></p>\n<p class=\"EndNoteBibliography\" style=\"margin-top: 0cm; margin-right: 0cm; margin-bottom: .0001pt; margin-left: 18.0pt; text-align: justify; text-indent: -18.0pt;\"><!--[if supportFields]><span lang=EN-US style=\'font-size:11.0pt\'><span\nstyle=\'mso-element:field-begin\'></span><span\nstyle=\'mso-spacerun:yes\'> </span>ADDIN EN.REFLIST <span style=\'mso-element:\nfield-separator\'></span></span><![endif]--><span style=\"font-size: 11.0pt;\" lang=\"EN-US\">[1]  (a) A. Wang, J. Li, T. Zhang, Nat. Rev. Chem<em>., </em>2018, <em>2</em>, 65-81; (b) X.-F. Yang, A. Wang, B. Qiao, J. Li, J. Liu, T. Zhang, Acc. Chem. Res<em>., </em>2013, 46, 1740-1748</span></p>\n<p class=\"EndNoteBibliography\" style=\"margin-top: 0cm; margin-right: 0cm; margin-bottom: .0001pt; margin-left: 18.0pt; text-align: justify; text-indent: -18.0pt;\"><span style=\"font-size: 11.0pt;\" lang=\"EN-US\">[2]  B. B. Sarma, J. Kim, J. Amsler, G. Agostini, C. Weidenthaler, N. Pfänder, R. Arenal, P. Concepción, P. Plessow, F. Studt, G. Prieto, Angew. Chem. Int. Ed.<em>, </em>2020, 59, 5806-5815</span></p>\n<p><span style=\"font-size: 11.0pt; line-height: 107%; font-family: \'Calibri\',sans-serif; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: \'Times New Roman\'; mso-bidi-theme-font: minor-bidi; mso-ansi-language: DE; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\" lang=\"DE\">[3]          B. B. Sarma, P. N. Plessow, G. Agostini, P. Concepción, N. Pfänder, L. Kang, F. R. Wang, F. Studt, G. Prieto, J. Am. Chem. Soc.<em>, </em>2020, 142, 14890-14902</span><!--[if supportFields]><span lang=DE style=\'font-size:11.0pt;\nline-height:107%;font-family:\"Calibri\",sans-serif;mso-ascii-theme-font:minor-latin;\nmso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;mso-hansi-theme-font:\nminor-latin;mso-bidi-font-family:\"Times New Roman\";mso-bidi-theme-font:minor-bidi;\nmso-ansi-language:DE;mso-fareast-language:EN-US;mso-bidi-language:AR-SA\'><span\nstyle=\'mso-element:field-end\'></span></span><![endif]--></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 297, 'NULL', '2021-02-07 23:07:32', '2030-12-01 18:30:00'),
(667, 'February 18, 2021 at 4.00 pm (Via Zoom)', 'Title :\nChemical Tools for Tracking Phospholipid Dynamics', '<h3>Title</h3>\n<h3><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">Chemical Tools for Tracking Phospholipid Dynamics</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 241, 'NULL', '2021-02-15 00:31:09', '2021-02-15 00:31:12'),
(668, 'March 11, 2021 at 2.30 pm (Via Zoom)', 'Title :\nDeveloping a General Platform for Long Wavelength and Water Soluble BODIPY Photocages with ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Developing a General Platform for Long Wavelength and Water Soluble BODIPY </span>Photocages with Tunable Cell Permeability for Controlled Delivery of Biologically Relevant Molecules.</h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">Photocages are light-sensitive protecting groups that functionally encapsulate molecule of interest (MOI) in an inactive form. Irradiation with light releases the trapped molecule, permitting targeted perturbation of a biological process. Photocages enable to control the spatial distribution and temporal release of MOI using light as an external, a non-invasive trigger. However, most caging groups available that operate by one-photon are excited with UV light. This results in potential tissue damage, limits tissue penetration and restricts the wavelength-window available for activation of multiple cues.</span></p>\n<p><span style=\"text-align: justify;\">Recently, Weinstain et al. </span><sup style=\"text-align: justify;\">1</sup><span style=\"text-align: justify;\"> and others</span><sup style=\"text-align: justify;\">2</sup><span style=\"text-align: justify;\">, introduced a novel photocage, excitable in the visible light range, based on the boron-dipyrromethene (BODIPY) core. In order for BODIPY cages to become more practical and functional for biological applications, three main issues were need to be addressed: (i) improving the photoreaction efficiency (ii) introducing cell organelle specificity and (iii) fine-tuning the structure’s photophysical properties and water solubility as well as controlling cell membrane permeability</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">During this presentation, I will showcase our efforts and outcome to address above drawbacks. This work combines new synthetic routes to develop highly functionalized BODIPY photocages.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">To improve photoreaction efficiency we have investigated a systematic structure activity relationship study on 32 mesomethyl BODIPY photocages and assessed their photophysical and photochemical properties. On the other hand, although photocaging facilitates non-invasive and precise spatio-temporal control over the release of biologically relevant MOI using light, subcellular organelles are dispersed in cells in a manner that renders selective light-irradiation of a complete organelle impractical. Organelle-specific photocages could provide a powerful method for releasing bioactive molecules in subcellular locations. We have developed a general platform for introducing cell organelle targeting groups on 2, 6 methyl groups of BODIPY photocages. To test general applicability, we have developed a general post-synthetic method for the chemical functionalization and the synthesis of endoplasmic reticulum (ER)-, lysosome-, and mitochondria-targeted derivatives. We also demonstrated that 2,4-dinitrophenol, a mitochondrial uncoupler, and puromycin, a protein biosynthesis inhibitor, can be selectively photoreleased in mitochondria and ER, respectively, in live cells by using visible light. We have also extended the application of this methodology to develop water-soluble BODIPY photocages with tunable cellular permeability.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">References:</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">1) N. Rubinstein, P. Liu, E. W. Miller, R. Weinstain, Chem. Commun. 2015, 51, 6369–6372.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">2) P. P. Goswami, A. Syed, C. L. Beck, T. R. Albright, K. M. Mahoney, R. Unash, E. A. Smith, A. H. Winter, J. Am. Chem. Soc. 2015, 137, 3783– 3786.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 256, 'NULL', '2021-02-18 04:11:25', '2021-02-18 04:16:53'),
(669, 'March 12, 2021 at 2.30 pm (Via Zoom)', 'Title :\nDesign and Synthesis of Fluorescent Probes for Selective Detection of Thiols\nAbstract :\nCyst', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Design and Synthesis of Fluorescent Probes for Selective Detection of Thiols</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) are three major low molecular weight biothiols that perform and regulate crucial physiological processes including proteins folding, biological redox homeostasis, intracellular signal transduction and gene regulation. Alterations in plasma and intracellular thiols levels have been linked to various diseases including Alzheimer’s disease, cardiovascular diseases, cancer and skin lesions. Therefore, selective and quantitative detection of thiols may help in early diagnosis of such diseases, in understanding the roles of biothiols in their onset which may help in preventing onset of the same.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Design principle and outcome: Most biological thiols are not inherently fluorescent and therefore cannot be directly visualized via fluorescence spectroscopy. Hence, in my PhD, I devoted my efforts to development and application of selective fluorescent probes that enables indirect visualization and quantification of specific biothiols in a complex biological environment.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In the design a fluorophore is attached to suitable moiety (quencher) which selectively reacts with biothiols . This state is termed as “Fluorescence-Off” state of the probe. Reaction with thiol results in the strong fluorescence of the resultant species. One strategy of sensing involves thiol mediated cleavage of the quencher releasing free fluorophore. Alternately, chemical reaction of thiol with quencher leads to destruction of its quenching ability. In both processes formation of strong fluorescent product leads to “Fluorescence-On” state of the probe.</span></p>\n<p style=\"text-align: justify;\">For developing fluorescent probes having better photophysical properties such as excitation and emission in visible region, good water solubility and improved cell permeability various fluorophores like NBD chloride, Iminocoumarin, Naphthaleimide, Chromenoquinolines, BODIPY and Fluorescein are used. Cell permeability, selectivity and sensitivity of these probes was demonstrated via cell imaging studies.</p>\n<p style=\"text-align: justify;\"> </p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In the second part of this talk, I will discuss about my future research plans.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 266, 'NULL', '2021-02-18 04:22:13', '2030-12-01 18:30:00'),
(670, 'March 15, 2021 at 4.30 pm (via Zoom)', 'Title :\nInterface-selective Nonlinear Spectroscopy at Aqueous Interface\nAbstract :\nAqueous interface', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Interface-selective Nonlinear Spectroscopy at Aqueous Interface</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"line-height: 115%; text-align: justify;\"><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; color: black; mso-themecolor: text1; mso-no-proof: yes;\" lang=\"EN-US\">Aqueous interfaces are ubiquitous and play vital roles in a variety of processes relevant to heterogeneous catalysis, electrochemistry, atmospheric, environmental chemistry, and biological self-assembly. </span><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-bidi-theme-font: minor-bidi; color: black; mso-themecolor: text1;\" lang=\"EN-US\">Nevertheless, molecular-level understanding of aqueous interfaces is very limited compared to that of the corresponding bulk media. A huge challenge in investigating the aqueous interface is to selectively observe few molecular layer thick interface in the presence of surrounding more plentiful bulk. Due to lack of interface-selectivity, most of the spectroscopic techniques are inadequate for probing aqueous interfaces. Moreover, unlike a solid, water has substantial vapor pressure, which makes it difficult to probe the water surface by conventional spectroscopy such as X-ray photoelectron spectroscopy (XPS). Thus, it is essential to utilize </span><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; color: black; mso-themecolor: text1;\" lang=\"EN-US\">spectroscopic techniques that can selectively detect interfacial molecules and directly reveal the structure and properties of the interface at the molecular level. </span></p>\n<p class=\"MsoNormal\" style=\"text-indent: 36pt; line-height: 115%; text-align: justify;\"><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; color: black; mso-themecolor: text1;\" lang=\"EN-US\">In this seminar, I will introduce interface-selective nonlinear spectroscopy technique called heterodyne-detected vibrational sum frequency generation (HD-VSFG)</span><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-bidi-theme-font: minor-bidi; color: black; mso-themecolor: text1;\" lang=\"EN-US\">, which I have been actively developing during my PhD and postdoctoral research. </span><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; color: black; mso-themecolor: text1;\" lang=\"EN-US\">HD-VSFG can selectively probe the </span><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-bidi-theme-font: minor-bidi; color: black; mso-themecolor: text1;\" lang=\"EN-US\">aqueous interfaces via the vibration of the interfacial molecules<sup>1</sup>. In fact, HD-VSFG </span><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; color: black; mso-themecolor: text1;\" lang=\"EN-US\">provides the accurate vibrational spectra of interfacial molecules that are comparable to the IR/Raman spectra for the bulk. Moreover, the sign of HD-VSFG spectrum (i.e., positive or negative amplitude of the signal) reveals the absolute orientation of interfacial molecules. As typical examples, </span><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-bidi-theme-font: minor-bidi; color: black; mso-themecolor: text1;\" lang=\"EN-US\">I will discuss the application of HD-VSFG that addresses the hydrogen bonding and orientation of water molecules at the air/water interface<sup>2</sup>, properties of osmolyte and denaturant at water surface<sup>3</sup>. Furthermore, I will discuss my recent HD-VSFG study that resolved the controversy on the origin of SFG signal for the bend vibration of interfacial water<sup>4</sup>. The presented results highlight the importance of interface-selective molecular information obtainable with HD-VSFG and its potential application to explore interfacial phenomena in more complex chemical and biological systems.</span></p>\n<p class=\"MsoNormal\" style=\"text-indent: 36pt; line-height: 115%;\"><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-bidi-theme-font: minor-bidi; color: black; mso-themecolor: text1;\" lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\" style=\"line-height: 115%;\"><span style=\"font-size: 10.5pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-bidi-theme-font: minor-bidi; color: black; mso-themecolor: text1;\" lang=\"EN-US\">1 S. Nihonyanagi, J. A. Mondal, S. Yamaguchi, and T. Tahara, Annu. Rev. Phys. Chem. 64, 579 (2013).</span></p>\n<p class=\"MsoNormal\" style=\"line-height: 115%;\"><span style=\"font-size: 10.5pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-bidi-theme-font: minor-bidi; color: black; mso-themecolor: text1;\" lang=\"EN-US\">2 M. Ahmed, Y. Nojima, S. Nihonyanagi, S. Yamaguchi, and T. Tahara, ‎J. Chem. Phys. 152, 237101 (2020).</span></p>\n<p class=\"MsoNormal\" style=\"line-height: 115%;\"><span style=\"font-size: 10.5pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-bidi-theme-font: minor-bidi; color: black; mso-themecolor: text1;\" lang=\"EN-US\">3 M. Ahmed, V. Namboodiri, P. Mathi, A. K. Singh, and J. A. Mondal, ‎J. Phys. Chem. C 120, 10252 (2016).</span></p>\n<p><span style=\"font-size: 10.5pt; line-height: 107%; font-family: \'Times New Roman\',serif; mso-fareast-font-family: \'MS Mincho\'; mso-fareast-theme-font: minor-fareast; mso-bidi-theme-font: minor-bidi; color: black; mso-themecolor: text1; mso-ansi-language: EN-US; mso-fareast-language: JA; mso-bidi-language: AR-SA;\" lang=\"EN-US\">4 M. Ahmed, S. Nihonyanagi, A. Kundu, S. Yamaguchi, and T. Tahara, ‎J. Phys. Chem. Lett. 11, 9123 (2020).</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 275, 'NULL', '2021-02-22 00:29:56', '2030-12-01 18:30:00'),
(671, 'March 16, 2021 at 4.30 pm (Via Zoom)', 'Title :\nInterface-selective Time-resolved Nonlinear Spectroscopy at Aqueous Interface\nAbstract :\nAqu', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Interface-selective Time-resolved Nonlinear Spectroscopy at Aqueous Interface</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Aqueous interfaces play key roles in a wide variety of fields including atmospheric and environmental chemistry, “on-water” catalysis, electrochemical reactions and biochemical processes. These interfacial reactions are governed by elementary processes involving transfer of energy and electron, making and breaking of bonds as well as conformational transformations which occur on the ultrafast time scale. Although there are spectroscopic techniques that can track down the dynamics of these elementary processes in the bulk, it is extremely challenging to measure these dynamical processes at the interface because its typical thickness is only a few nanometer.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In this seminar, I will talk about interface-selective time-resolved- (TR-) and two-dimensional (2D-) heterodyne-detected vibrational sum frequency generation (HD-VSFG) techniques, which have been pioneered by our group<sup>1</sup> for observing the ultrafast dynamics at aqueous interfaces. During my postdoctoral research in Tahara group for the last five years, I have been actively involved in the development of two-dimensional (2D) HD-VSFG setup. I will discuss application of this novel technique to unravel the hitherto unknown dynamics of water at the biological lipid-water<sup>2</sup> and charged hydrophobe-water interfaces<sup>3</sup> as well as the vibrational relaxation of topmost water (free OH) at the air-water interface<sup>4</sup>. </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">At the end, I will discuss my future research plans to address important issues relevant to chemical and biological phenomena at interfaces.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\"> </span></p>\n<p><span style=\"font-size: 12.16px;\">1 S. Nihonyanagi, S. Yamaguchi, and T. Tahara, Chem.Rev. 117, 10665 (2017).</span></p>\n<p><span style=\"font-size: 12.16px;\">2 K. Inoue, M. Ahmed, S. Nihonyanagi, and T. Tahara, ‎J. Chem. Phys. 150, 054705 (2019).</span></p>\n<p><span style=\"font-size: 12.16px;\">3 M. Ahmed, K. Inoue, S. Nihonyanagi, and T. Tahara, Angew. Chem. Int. Ed. 59, 9498 (2020).</span></p>\n<p><span style=\"font-size: 12.16px;\">4 K. Inoue, M. Ahmed, S. Nihonyanagi, and T. Tahara, Nat. Commun 11, 5344 (2020).</span></p>\n<p><span style=\"font-size: 12.16px;\"> </span></p>\n<p> </p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 275, 'NULL', '2021-02-22 00:34:31', '2030-12-01 18:30:00'),
(672, 'February 25, 2021 at 4.00 pm (Via Zoom)', 'Title :\nChemical Substitution Based Designs for Bis-terpyridine Molecular Breadboard Circuits: Knobs', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Chemical Substitution Based Designs for Bis-terpyridine Molecular Breadboard Circuits: Knobs to Tune Quantum Interference Effects</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 209, 'NULL', '2021-02-22 04:24:30', '2030-12-01 18:30:00'),
(673, 'March 22, 2021 at 4.30 pm (Via Zoom)', 'Title :\nInfluence of Lattice Ordering on the Catalytic Activity of Bimetallic Nanoparticles: Structu', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Influence of Lattice Ordering on the Catalytic Activity of Bimetallic Nanoparticles: Structure Matters!</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">With rising fossil fuel prices and worsening air quality, scientific research for alternative and sustainable energy conversion techniques has become an imminent necessity. Among these techniques, fuel cells that convert chemical energy into electricity have emerged as one of the most prominent options owing to high energy efficiency, low emissions and noise levels, as well as modular structure.<sup>1</sup> Electrochemical oxidation of fuels such as methanol, ethanol, formic acid, etc. (referred to as small organic molecules or SOMs) needs a stable and highly active catalyst to lower the activation energy that is measured as “overpotential”. Precious metal based bimetallic or multi-metallic nanoparticles are one of the most effective class of catalysts in this respect. However, they suffer from a severe drawback known as “catalyst poisoning” caused by the strong metal-ligand binding with various reaction intermediates.<sup>2</sup> Use of various catalyst support may alleviate this problem to a great extent, but homogeneous distribution of an active catalyst on a support may prove to be a challenging task at larger scale.<sup>3</sup></span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In this seminar, I will talk about unsupported intermetallic nanoparticles that have high intrinsic catalytic activity owing to their ordered crystal structure. I will discuss the role of uniform surrounding of the active sites by catalytically “inactive” atoms in two different systems – Ag3In and Pd2Ge nanoparticles used respectively for reduction of an organic molecule and electrochemical oxidation of ethanol.<sup>4,5</sup> I will also stress on the importance of lattice defects within the ordered crystal structure of the nanoparticles toward its catalytic activity. </span></p>\n<p><span style=\"font-size: 12.16px;\"> </span></p>\n<p><span style=\"font-size: 12.16px;\">References</span></p>\n<p><span style=\"font-size: 12.16px;\"> </span></p>\n<p><span style=\"font-size: 12.16px;\">1. Staffell, I., Scamman, D.; Velazquez, A. A.; Balcombe, P.; Dodds, P. E.; Ekins, P.; Shah, N.; Ward, K. R. Energy Environ. Sci. 2019, 12, 463-491</span></p>\n<p>2. Zhou, M.; Li, C.; Fang, F. Chem. Rev. 2021 121 (2), 736-795</p>\n<p>3. Ramani, S.; Sarkar, S.; Vemuri, V.; Peter S. C. J. Mater. Chem. A 2017,5, 11572-11576</p>\n<p>4. Sarkar, S.; Balisetty, L.; Shanbogh, P. P.; Peter, S. C. J. catal. 2014, 318, 143-150</p>\n<p>5. Sarkar, S.; Jana, R.; Suchitra; Waghmare, U. V.; Kuppan, B.; Sampath, S.; Peter. S. C. Chem. Mater. 2015, 27 (21), 7459-7467</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 255, 'NULL', '2021-03-14 23:15:29', '2030-12-01 18:30:00'),
(674, 'March 23, 2021 at 4.30 pm (Via Zoom)', 'Title :\nChemical Control of Defects for Optimizing Thermoelectric Performance of Lead Telluride\nAbst', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Chemical Control of Defects for Optimizing Thermoelectric Performance of Lead Telluride</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">A surprisingly large portion of energy is lost as waste heat every year due to inefficient utilization.<sup>1</sup> Thermoelectric (TE) materials may increase the overall efficiency of our energy utilization by directly converting waste heat to electricity.<sup>2</sup> It is essential to have high efficiency in both p and n type semiconducting materials to achieve a high performance in thermoelectric generators. However, the efficiency of a TE material depends on the dimensionless figure of merit that involves a complex relation between the electronic and thermal properties as stated by the Wiedemann-Franz law.<sup>2</sup> This presents a serious roadblock in the optimization of thermoelectric performance of any material.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In this seminar, I will present effective strategies to circumvent this problem in lead telluride (PbTe) which is a benchmark thermoelectric material via chemical control of point defects in the matrix. I will discuss the mechanisms to decouple the electronic and thermal properties of this system. I will further elaborate how these defects affect the electronic band structure of p and n type PbTe leading to modulation of the carrier concentration over a broad temperature range to facilitate high thermoelectric performance.<sup>3,4</sup> </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In the later part of the seminar, I will discuss my future research plans related to thermal energy harvesting using environment friendly materials and the study of their structure-property correlations. </span></p>\n<p><span style=\"font-size: 12.16px;\">References</span></p>\n<p><span style=\"font-size: 12.16px;\">1. Rattner, A. S.; Garimella S. Energy 2011, 36(10), 6172–6183</span></p>\n<p>2. He, J.; Tritt, T. M. Science 2017, 357 (6358), eaak9997</p>\n<p>3. Sarkar, S.; Zhang, X.; Hao, S.; Hua, X.; Bailey, T. P.; Uher, C.; Wolverton, C.; Dravid, V.; Kanatzidis, M. G. ACS Energy Lett. 2018, 3 (10), 2593–2601 </p>\n<p>4. Sarkar, S.; Hua, X.; Hao, S.; Zhang, X.; Bailey, T. P.; Slade, T. J.; Yasaei, P.; Korkotz, R.; Tan, G.; Uher, C.; Wolverton, C.; Dravid, V. P.; Kanatzidis, M. G. Chem. Mater. 2021, 33, 5, 1842–1851</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 290, 'NULL', '2021-03-14 23:18:15', '2030-12-01 18:30:00'),
(675, 'March 19, 2021 at 2.30 pm (Via Zoom)', 'Title :\nInvestigating Protein-Protein and Protein-Lipid Interaction\nAbstract :\nProtein-protein and p', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Investigating Protein-Protein and Protein-Lipid Interaction</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Protein-protein and protein-membrane interaction play a major role in various cellular functions. I have probed three such interactions. First, based on protein-protein interactions between SARS-COV-2 and human ACE2, we have designed a detection method that does not require RNA extraction or amplification. We achieve this by measuring FRET (Förster resonance energy transfer), occurring between two appropriately labeled peptides (1,2) bound to the same spike protein. Our initial results show that we do have a weak FRET signal when two peptides bind to the Receptor Binding Domain.  </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Another example of protein-protein interaction is amyloid aggregation. It has been a challenge to determine the structure of transient aggregation intermediates. We plan to use optical pH recycling using a photoacid to hold the system indefinitely in the transient state. I will describe our preliminary characterization of the reversibility of a photoacid molecule synthesized by us and its effect on the aggregation kinetics of the amyloid-beta peptide.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Protein lipid interaction plays a major role in the toxicity of amyloid. However, the location and arrangement of amyloid oligomers in the membrane is unknown. We probe this by following the distance-dependent modulation of triplet state relaxation dynamics of fluorescent probes (placed on the peptide) by lipids labeled with radical at different sites. Our results show that amyloid-beta inserts in lipid vesicles at a specific location that is consistent with it forming a specific structure in the membrane. I will show the results of our computational investigation of the stability of antiparallel beta-hairpin conformation, which we have earlier shown to be the relevant structure for small oligomers (3,4), in the solution phase as well as in the lipid membrane. </span></p>\n<p><span style=\"font-size: 12.16px;\">References.</span></p>\n<p><span style=\"font-size: 12.16px;\">1)Cao et. al., Science, 2020, 370, 426-431</span></p>\n<p><span style=\"font-size: 12.16px;\">2)Pomplun et. al., ACS Cent. Sci., 2021, 7, 156−163</span></p>\n<p><span style=\"font-size: 12.16px;\">3)Chandra et. al., Biophysics J, 2017, 113, 805-816</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">4)Chandra et. al., Chem. Commun., 2018, 113, 7750-7753</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 329, 'NULL', '2021-03-16 22:16:38', '2030-12-01 18:30:00'),
(676, 'March 25, 2021 at 10.00 am (Via Zoom)', 'Title :\nNon-Macrocyclic Chelators for Metal-based Radiopharmaceuticals\nAbstract :\nRadiopharmaceutica', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Non-Macrocyclic Chelators for Metal-based Radiopharmaceuticals</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\">Radiopharmaceuticals are a class of drug that relies on the physical decay of a radionuclide to elicit a diagnostic or therapeutic purpose. While organically derived radiotracers, which employ non-metal radionuclides (e.g., <sup>18</sup>F, <sup>11</sup>C, <sup>123</sup>I), have received considerable attention in the field of nuclear medicine, metal-based radiopharmaceuticals are undoubtedly more versatile and hold great promise for the future. The availability of diverse medicinally useful radiometals with varying physical (half-life, specific activity, emission type) and chemical (hardness, oxidation state, acidity) properties has stimulated research interest in harnessing the potential of radiometals for diagnostic imaging as well as use of the emitted particles “millions of tiny bullets of energy” (α- particles, β - particles and Auger electrons) for therapy to kill welltargeted cancerous cells. Contemporary inorganic radiopharmaceuticals often follow a fourcomponent design and are comprised of a radiometal, bifunctional chelator, linker and targeting vector. This talk will focus on the role of coordination chemistry in the development of chelators for their application in nuclear medicine. The synthesis and detailed studies of three new chelators for hexa- and octa-coordinated (radio)metal ions (e.g., Sc<sup>3+</sup>, Ga<sup>3+</sup>, In<sup>3+</sup>, Lu<sup>3+</sup>) will be discussed</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 219, 'NULL', '2021-03-23 23:52:51', '2030-12-01 18:30:00'),
(677, 'April 9, 2021 at 6.00 pm (Via Zoom)', 'Title :\nMechanistic investigations of high-valent metal intermediates of biomimetic non-heme model s', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Mechanistic investigations of high-valent metal intermediates of biomimetic non-heme model systems</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Metalloenzymes are known to play pivotal role in catalysing a plethora of biological and biochemical reactions. These transformations are directed by a variety of high-valent reactive intermediates that undergo crucial redox reactions by atom-transfer or electron-transfer or radical reaction pathways. These high-valent reactive intermediates of non-heme model systems are known to be influenced by factors like coordination motifs and topology, ligand architecture, pH, spin states of metal ions, solvation and temperature.<sup>1</sup> The factors that govern the reactivity profiles are often associated with the mechanistic pathways followed. Hence, it is important to dig deep into the mechanistic details of the reactions performed by these model systems.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Non-heme iron-oxo intermediates have been identified as potential reactive intermediates in a variety of electrophilic reactions. It can catalyse C-H activation reactions and can also undergo heteroatom oxidation. Subtle modifications in a ligand skeleton can be seen to hugely accelerate reaction rates catalysed by non-heme iron-oxo complexes.<sup>2</sup> Also, with the help of a series of structurally tweaked ligand frameworks, the governing factors that orchestrate the eccentric reactivity trends of iron-oxo moieties have been brought to the forefront.<sup>3</sup> With the help of a couple of isomeric bispidine Mn(III)-peroxo complexes, a new mechanism for aldehyde deformylation reaction has been established. Keto-enol tautomerism in the reaction mechanism can be seen to trigger an electrophilic pathway instead of the commonly portrayed nucleophilic mechanism.<sup>4</sup> Another intended engineering in the bispidine framework resulted in stabilizing a metastable non-heme iron(III)-alkylperoxo complex. These complexes are generally non-reactive. Surprisingly, however, versatile reactivity towards both electrophiles and nucleophiles have been observed for the same.</span></p>\n<p><span style=\"font-size: 12.16px;\">References:</span></p>\n<p><span style=\"font-size: 12.16px;\">1. Mukherjee, G.; Sastri, C. V. Isr. J. Chem. 2020, 60, 1032-1048.</span></p>\n<p><span style=\"font-size: 12.16px;\">2. Mukherjee, G.; Lee, C. W. Z.; Nag, S. S.; Alili, A.; Cantú Reinhard, F. G.; Kumar, D.; Sastri, C. V.; de Visser, S. P. Dalton. Trans. 2018, 47, 14945-14957.</span></p>\n<p><span style=\"font-size: 12.16px;\">3. Mukherjee, G.; Alili, A.; Barman, P.; Kumar, D.; Sastri, C. V.; de Visser, S. P., Chem. Eur. J. 2019, 25, 5086-5098.</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">4. Cantu Reinhard, F. G.; Barman, P.; Mukherjee, G.; Kumar, J.; Kumar D.; Kumar D.; Sastri, C. V.; de Visser, S. P. J. Am. Chem. Soc. 2017, 139, 18328-18338.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 244, 'NULL', '2021-03-24 00:56:38', '2030-12-01 18:30:00');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(678, 'April 5, 2021 at 4.30 pm (Via Zoom)', 'Title :\nSolar energy conversion to storage: my journey\nAbstract :\nFor long sustainable human civiliz', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Solar energy conversion to storage: my journey</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">For long sustainable human civilization we have to reduce our ecological footprint and that can only be done by minimizing the impact on the environment without compromising the current process of modernization. Out of several challenges to mankind, source of energy is the major one. In current time we are very much dependent on our fuel bank i.e. fossil fuels. The stored fossil fuels will not run for ever, sooner or later we will run out of this. The other aspect is that burning fossil fuels generate CO<sub>2</sub> which is the one of the main culprits for global warming and related environmental disbalance. So there is a basic need to search for alternative renewable energy sources. One good way is to utilize the solar energy that can be done either conversion of solar energy into electrical energy or storing as fuels. </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">So here in this seminar I will discuss my contribution towards these goals. A part of my PhD thesis deals with solar energy conversion and to do that I designed several series of organic dyes for dye sensitized solar cells (DSSC). DSSC is a nice technique for converting solar energy into electrical energy but <sub>˜</sub> 20% of total consumption of energy is consumed as electrical energy and rest as fuels. Alternative and effective way to contribute towards the renewable energy research area is to think about storing solar energy as fuel. To fulfil that goal we can mimic natural photosynthesis. So I will discuss some of my works during postdoctoral study which were focused in the area of solar light utilization to do some chemical reactions such as water and CO<sub>2</sub> reduction and alcohol oxidation by either heterogeneous photocatalysis or photo-electrocatalysis through photo-electrochemical cells (PEC).</span></p>\n<p><span style=\"font-size: 12.16px;\"> </span></p>\n<p><span style=\"font-size: 12.16px;\">Reference</span></p>\n<p><span style=\"font-size: 12.16px;\">1) M. Grätzel et al. , Nature, 2001, 414, 338.</span></p>\n<p><span style=\"font-size: 12.16px;\">2) A. Fujishima et al., Nature, 1972, 238, 37.</span></p>\n<p><span style=\"font-size: 12.16px;\">3) P. B. Pati et al., Tetrahedron, 2013, 69, 2167. </span></p>\n<p><span style=\"font-size: 12.16px;\">4) P. B. Pati et al., Energy Environ. Sci., 2017, 10, 1372.</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">5) P. B. Pati et al., Nat. Commun., 2020, 11, 3499.</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 274, 'NULL', '2021-03-24 02:15:28', '2030-12-01 18:30:00'),
(679, 'April 6, 2021 at 4.30 pm (Via Zoom)', 'Title :\nπ-Conjugated functional materials: design, synthesis and potential application\nAbstract :\nE', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">π-Conjugated functional materials: design, synthesis and potential application</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Electronics industries are highly dominated by Si and other inorganic semiconductor. After the discovery of conducting polymers there is enormous hope on carbon-based materials as future electronics. Recent research advancement in this area is highly promising but yet to go a long way. Organic materials as semiconductor have several advantages, such as easier designing and synthesis, better batch to batch reproducibility, cheap and most important one is flexibility which can fulfil the dream of future flexi-electronics. Relatively lower performance and stability than that of inorganic semiconductors are the major issues to be fixed. So designing of new efficient materials is on high demand.</span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">So here in this seminar, I will discuss my contribution towards designing and synthesizing new -conjugated functional materials for potential application in organic electronics. The packing pattern in solid state is very vital which controls the performance of the resulting device, so during my PhD I worked with -conjugated oligomers to understand their intra and inter-molecular non-bonding interaction which control the packing pattern in solid state. Also π-conjugated polymers were developed from these oligomers and their electrochromic behaviours were studied. Graphene has evolved an important class of carbon-based materials as future electronics but zero band-gap and difficult synthetic accessibility is the major problem. Whereas nano-graphene, a smaller unit of graphene is an important alternative class of materials, I will discuss design and synthesis of new nano-graphene moiety. </span></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">In the second half of my seminar I will discuss my future research proposal. Designing of new carbon-rich materials is my primary goal as an independent researcher. To execute the synthesis of these designed materials we will follow some established synthetic strategy or will introduce modified synthetic pathways. Of course the materialistic properties of those new materials will be explored through fabricating devices such as organic field effect transistors (OFETs), organic light emitting diodes (OLEDs) and organic spintronics. Also these materials will be explored in the area of artificial photosynthesis for solar light storage. </span></p>\n<p><span style=\"font-size: 12.16px;\">Reference</span></p>\n<p><span style=\"font-size: 12.16px;\">1) H. Shirakawa, et al. J. Chem. Soc., Chem. Commun., 1977, 578.</span></p>\n<p><span style=\"font-size: 12.16px;\">2) a) M. Stępień et al. Chem. Rev., 2017, 117, 3479; b) J. Wu et al. Chem. Rev., 2007, 107, 718.</span></p>\n<p><span style=\"font-size: 12.16px;\">3) P. B. Pati et al., Angew. Chem. Int. Ed., 2020, 59, 14891. </span></p>\n<p><span style=\"font-size: 12.16px;\">4) P. B. Pati et al., ACS Appl. Mater. Interfaces, 2013, 5, 12460. </span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">5) P. B. Pati et al., Cryst. Growth Des., 2014, 14, 1695. </span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 254, 'NULL', '2021-03-24 02:18:25', '2030-12-01 18:30:00'),
(680, 'March 30, 2021 at 2.30 pm (Via Zoom)', 'Title :\nMolecular dynamics simulation studies of Antigen-Antibody interactions\nAbstract :\nAntigen-An', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Molecular dynamics simulation studies of Antigen-Antibody interactions</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Antigen-Antibody interactions are an important area of research in biophysical chemistry and structural biology. The availability of an increasing amount of structural data of antigens and antibodies allows a better understanding of their interactions and dynamics. The binding of an antibody to the antigen involves a combination of weak non-covalent interactions. This binding may cause significant conformation changes in both antibody and antigen and these changes may involve both structural and dynamical changes. In our study, we have identified the key residues involved in hydrogen-bonding interactions and salt-bridges in Ag-Ab complex by taking an example of HIV-1 protease and F11.2.32 mAb raised against the protease. We also examined the role of CDR flexibility in binding different conformations of the same epitope sequence in peptide and protein antigens. Our results provide the basis for understanding the cross-reactivity observed between the antibody with protease and the epitope peptide from it. We also studied the role played by dynamics in the function of the protease and how control of flexibility through Ab binding and site specific mutations can inhibit its activity. The study points to a plausible method for allosteric drug control. We believe this work is of value to the existing literature on Antigen-Antibody interactions and novel drug discovery methods that involve the modulation of the dynamics of an enzyme. </span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 217, 'NULL', '2021-03-25 02:33:04', '2030-12-01 18:30:00'),
(681, 'April 19, 2021 at 5.00 pm (Via Zoom)', 'Title :\nUltrastable organic fluorophores for single-molecule research: part I\nAbstract :\nPhotophysic', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Ultrastable organic fluorophores for single-molecule research: part I</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Photophysical performances of organic fluorophores in modern imaging applications, including single-molecule and super-resolution fluorescence microscopy, are compromised by their transient excursions to dark triplet and radical states causing stochastic photo blinking and irreversible photobleaching. To circumvent these problems, we develop and study “self-healing” organic fluorophores, in which the dark triplet states are intramolecularly quenched by triplet state quenchers [1,2]. This intramolecular photostabilization approach dramatically increases fluorophore brightness, signal-to-noise ratio, and photostability, while simultaneously reduces phototoxicity by decreasing the generation of reaction oxygen species. The performance enhancements of the fluorophores enable us to achieve robust, submillisecond recordings of protein dynamics using wide-field illumination and camera-based single-molecule Förster resonance energy transfer (smFRET) techniques reaching the theoretical speed limit of camera-based detections [3]. These findings extend the potential to image single molecules in vitro and in live-cell applications in the absence of solution-based photostabilizers at physiological oxygen concentrations in the kilohertz regime [3,4] and shed important light on the multivariate parameters critical to self-healing organic fluorophore design.</span></p>\n<p>[1] Altman et al., Nat. Methods, 9, 68–71 (2011).</p>\n<p><span style=\"font-size: 12.16px;\">[2] Zheng et al., Chem. Soc. Rev., 43, 1044–1056 (2014).</span></p>\n<p><span style=\"font-size: 12.16px;\">[3] Pati et al., PNAS, 117, 24305–24315 (2020).</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">[4] Asher et al., Nat. Methods, doi:10.1038/s41592-021-01081-y (2021).</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 189, 'NULL', '2021-04-07 22:37:49', '2030-12-01 18:30:00'),
(682, 'April 20, 2021 at 5.00 pm (Via Zoom)', 'Title :\nUltrastable organic fluorophores for single-molecule research: part II\nAbstract :\nSingle-mol', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Ultrastable organic fluorophores for single-molecule research: part II</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Single-molecule Förster resonance energy transfer (smFRET) imaging is an integral tool for examining conformational and compositional processes critical to the functions of biological systems. Robustness of smFRET imaging and reproducibility of smFRET efficiencies are increased through photostabilization of fluorophores, state-of-the-art instrumentation, data analysis, and stringent data correction procedures [1,2]. Here, we report that small molecule photostabilizing agents in imaging buffers are although important for photostabilization of fluorophores, they can be bottlenecks for quantitative smFRET imaging due to their varied photophysical and photochemical impacts on fluorophores. To mitigate these problems, we provide a simple strategy of using ‘self-healing’ organic fluorophores that are intramolecularly photostabilized by cyclooctatetraene (COT) as a triplet state quencher. COT-mediated self-healing mechanism enables robust determination of true smFRET efficiency of organic fluorophores on both nucleic acids and proteins in oxygenated as well as in deoxygenated imaging buffers. These findings conceptually advance our understanding of smFRET and provide strategies for robust, quantitative smFRET imaging [3].</span></p>\n<p>[1] Hellenkamp et al., Nat. Methods, 15, 669–676 (2018).</p>\n<p><span style=\"font-size: 12.16px;\">[2] Lerner et al., eLife, 10:e60416 (2021).</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">[3] Pati et al., manuscript to be submitted.</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 192, 'NULL', '2021-04-07 22:39:24', '2030-12-01 18:30:00'),
(683, 'April 22, 2021 at 4.00 pm (Via Zoom)', 'Title :\nExploring high valent rhenium complexes for antiproliferative activities\nAbstract :\nChemothe', '<p>Title :</p>\n<p><span style=\"font-size: 12.16px;\">Exploring high valent rhenium complexes for antiproliferative activities</span></p>\n<p><span style=\"font-size: 12.16px;\">Abstract :</span></p>\n<p><span style=\"font-size: 12.16px;\">Chemotherapy is the cutting-edge method for treatment of both metastatic and localized cancers. Traditionally, platinum based drugs like cisplatin, oxaliplatin, carboplatin are used to treat a variety of cancer. Despite the clinical success, emergence of resistance and lack of cancer selectivity leading to severe side effects like nephrotoxicity, neurotoxicity, anaemia, etc are the major drawbacks of these class of drugs. Altering the metal centre could alter the accumulation, biomolecular interaction leading to an altered cell death. Hence, we plan to explore the non-platinum-based drug candidates for its anticancer properties. Low valent Re-complexes are routinely used for in vitro and in vivo imaging purposes. In recent decade, despite only a few  low valent Re complexes were reported to show excellent anticancer and antibacterial properties, a Re(V) complex was reported to induce necroptosis mode of cell death. Thus, we are interested in high valent Rhenium complexes, hypothesising that the complex will be activated by reduction only under reducing cellular environment and thereby reducing the side effects.</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">With the aim of finding structurally new class of compounds with superior potency than cisplatin, we have succeeded to synthesise to new class of Re(VII) and Re(V) coordination complexes. Both of these classes were designed to have labile and non-labile similar to cisplatin.</span></p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 173, 'NULL', '2021-04-21 06:21:38', '2030-12-01 18:30:00'),
(684, 'April 26, 2021 at 4.00 pm (Via Zoom)', 'Title :\nBlack Gold Based “Antenna-Reactor” of Nickel: Concept of Forced Plasmon to Activate Non-', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Black Gold Based “Antenna-Reactor” of Nickel: Concept of Forced Plasmon to Activate Non-plasmonic Metal Catalysts</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"font-size: 12.0pt; line-height: 107%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">Localized surface plasmon resonance (LSPR) allows metal nanoparticles (NPs) to harvest light and concentrate it near the nanoparticle surface. Light energy is then utilized in the generation of excited charge carriers as well as heat. Plasmonic catalysts used these energetic charge carriers (and the heat) to drive chemical transformations on their surface and allowed the discovery of novel and selective reaction pathways that were not possible in thermal catalysis<sup>1-3</sup>. However, since the number of metals that show plasmon absorption in the visible range is limited, the reactions that can be catalyzed by these metals are also limited. Using the concept of multicomponent plasmonic catalysis, one can design a hybrid catalyst by combining plasmonic metals with non-plasmonic but active catalytic metals in close proximity to each other, named as “antenna-reactor”<sup>4.</sup><span style=\"mso-tab-count: 1;\">            </span></span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\"><span style=\"font-size: 12.0pt; line-height: 107%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\"><span style=\"mso-spacerun: yes;\">   </span>In this work, we have designed and synthesized dendritic plasmonic colloidosomes (DPCs), known as Black Gold<sup>5</sup> based “Antena Reactor” of Nickel (DPC-Ni).When DPC-Ni was illuminated with visible light, the plasmonic metal antenna of Au undergo LSPR and non-radiative Landau damping induces an optical polarization in non-plasmonic Ni metal (reactor) by creating a flow of plasmon energy from the antenna (Au) to the reactor (Ni). This created plasmon on non-plasmonic Ni metal (forced plasmon), which then undergo decay to generate hot charge carriers (electrons and holes). The forced plasmon made the reactor Ni catalytically active and it was able to catalyze several challenging reactions (H<sub>2</sub> dissociation, propene reduction, and C-Cl bond activation) using visible light at room temperature, which generally need high temperature and pressure. In this talk, I will present the synthesis of DPC-Ni, their characterizations, application in catalysis and preliminary insights into the reaction mechanism and electron dynamics of DPC-Ni catalyst.</span></p>\n<p class=\"MsoNormal\"><span style=\"font-size: 12.0pt; line-height: 107%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\"> </span></p>\n<p class=\"MsoNormal\"><span style=\"font-size: 12.0pt; line-height: 107%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">References:</span></p>\n<p class=\"MsoNormal\"><span style=\"font-size: 12.0pt; line-height: 107%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">1. Aslam, U.; Rao, V. G.; Chavez, S.; Linic, S. Catalytic conversion of solar to chemical energy on plasmonic metal nanostructures. Nat. Catal. 2018, 1, 656−665</span></p>\n<p class=\"MsoNormal\"><span style=\"font-size: 12.0pt; line-height: 107%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">2. Gelle, A.; Jin, T.; de la Garza, L.; Price, G. D.; Besteiro, L. V.; Moores, A. Applications of Plasmon-Enhanced Nanocatalysis to Organic Transformations. Chem. Rev. 2020, 120, 986−1041</span></p>\n<p class=\"MsoNormal\"><span style=\"font-size: 12.0pt; line-height: 107%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">3.<span style=\"mso-spacerun: yes;\">  </span>Zhan, C.; Chen, J. X.; Yi, J.; Li, F. J.; Wu, D. Y.; Tian, Z. Q. From Plasmon-Enhanced Molecular Spectroscopy to Plasmon Mediated Chemical Reactions. Nat. Rev. Chem. 2018, 2, 216−230.</span></p>\n<p class=\"MsoNormal\"><span style=\"font-size: 12.0pt; line-height: 107%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">4. Halas, J. N. et al. Heterometallic Antenna−Reactor Complexes for Photocatalysis. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 8916–8920.</span></p>\n<p class=\"MsoNormal\"><span style=\"font-size: 12.0pt; line-height: 107%; font-family: \'Times New Roman\',serif;\" lang=\"EN-US\">5. Polshettiwar etl al. Plasmonic Colloidosomes of Black Gold for Solar Energy Harvesting and Hotspots Directed Catalysis for CO2 to Fuel Conversion. Chemical Science, 2019, 10, 6594-6603.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 148, 'NULL', '2021-04-22 22:45:50', '2030-12-01 18:30:00'),
(685, 'April 29, 2021 at 5.00 pm (Via Zoom)', 'Title :\nEffect of circular permutation on a metalloprotein azurin', '<h3>Title</h3>\n<h3><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">Effect of circular </span><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">permutation on a metalloprotein azurin</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 136, 'NULL', '2021-04-28 00:31:17', '2030-12-01 18:30:00'),
(686, 'May 3, 2021 at 4.00 pm (Via Zoom)', 'Title :\nFluorescent Chemo-sensors for Biomolecules and Ions', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Fluorescent Chemo-sensors for Biomolecules and Ions</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 144, 'NULL', '2021-04-29 02:42:01', '2030-12-01 18:30:00'),
(687, 'May 6, 2021 at 4.00 pm (Via Zoom)', 'Title :\nTT Pair in Singlet Fission\nAbstract :\nSinglet fission1-2 (SF) is a process in which a molecu', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">TT Pair in Singlet Fission</span></h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; text-indent: 36.0pt; line-height: 115%;\"><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-ansi-language: EN-GB;\" lang=\"EN-GB\">Singlet fission<sup>1-2</sup> (SF) is a process in which a molecular chromophore in its singlet excited state shares its excitation energy with an unexcited neighbour leading to formation of two triplet excitons through a spin-allowed process. Due to the high singlet-to-triplet conversion quantum efficiencies up to 200%, SF chromophores have potential application in boosting solar cell efficiencies<sup>3</sup>. However molecular triplet excitons produced through SF usually have shorter triplet lifetimes due to exciton-exciton recombination and relaxation pathways, thereby resulting in complex device architectures for SF-boosted solar cells. In order to elucidate the fundamental mechanism of SF and the triplet-triplet recombination pathways it is highly important to understand the intrinsic nature of the intermediate correlated T-T pair states. Here, using femtosecond transient absorption and femtosecond stimulated Raman spectroscopy, we demonstrate optical as well as vibrational signature of TT pair state in SF across different kinds of SF chromophores namely carotenoids and diketopyrrolopyrrole derivatives. These spectroscopic signatures will help us to understand the origin of the TT pair and fate of it in SF, importance of the morphology of the aggregates to get distinct signatures of the TT pair compared to the free triplets and enhancement of the free triplet lifetime.<sup>4</sup> A complete fundamental understanding of the T-T pair state will enable us to draw the proper structure-function relationship to get the next generation SF chromophores for the application in solar cell devises.</span></p>\n<p class=\"MsoNormal\" style=\"text-align: justify; line-height: 115%;\"><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-ansi-language: EN-GB;\" lang=\"EN-GB\"> </span></p>\n<p class=\"MsoListParagraphCxSpFirst\" style=\"text-align: justify; text-indent: -18.0pt; line-height: 115%; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-GB;\" lang=\"EN-GB\"><span style=\"mso-list: Ignore;\">1)<span style=\"font: 7.0pt \'Times New Roman\';\">     </span></span></span><!--[endif]--><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-ansi-language: EN-GB;\" lang=\"EN-GB\">Smith, M. B.; Michl, J., Singlet fission. <em style=\"mso-bidi-font-style: normal;\">Chemical reviews</em> <strong style=\"mso-bidi-font-weight: normal;\">2010</strong>, 110, 6891-6936.</span></p>\n<p class=\"MsoListParagraphCxSpMiddle\" style=\"text-align: justify; text-indent: -18.0pt; line-height: 115%; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-GB;\" lang=\"EN-GB\"><span style=\"mso-list: Ignore;\">2)<span style=\"font: 7.0pt \'Times New Roman\';\">     </span></span></span><!--[endif]--><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-ansi-language: EN-GB;\" lang=\"EN-GB\">Smith, M. B.; Michl, J., Recent advances in singlet fission. <em style=\"mso-bidi-font-style: normal;\">Annual review of physical chemistry</em> <strong style=\"mso-bidi-font-weight: normal;\">2013</strong>, 64, 361-386.</span></p>\n<p class=\"MsoListParagraphCxSpMiddle\" style=\"text-align: justify; text-indent: -18.0pt; line-height: 115%; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-GB;\" lang=\"EN-GB\"><span style=\"mso-list: Ignore;\">3)<span style=\"font: 7.0pt \'Times New Roman\';\">     </span></span></span><!--[endif]--><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-ansi-language: EN-GB;\" lang=\"EN-GB\">Rao, A.; Friend, R. H., Harnessing singlet exciton fission to break the Shockley-Queisser limit. <em style=\"mso-bidi-font-style: normal;\">Nature reviews materials</em> <strong style=\"mso-bidi-font-weight: normal;\">2017</strong>, 2, 1-12.</span></p>\n<p class=\"MsoListParagraphCxSpLast\" style=\"text-align: justify; text-indent: -18.0pt; line-height: 115%; mso-list: l0 level1 lfo1;\"><!--[if !supportLists]--><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-fareast-font-family: \'Times New Roman\'; mso-ansi-language: EN-GB;\" lang=\"EN-GB\"><span style=\"mso-list: Ignore;\">4)<span style=\"font: 7.0pt \'Times New Roman\';\">     </span></span></span><!--[endif]--><span style=\"font-size: 12.0pt; line-height: 115%; font-family: \'Times New Roman\',serif; mso-ansi-language: EN-GB;\" lang=\"EN-GB\">Kundu, A.; Dasgupta, J., Photogeneration of Long-Lived Triplet States through Singlet Fission in Lycopene H-Aggregates. <em style=\"mso-bidi-font-style: normal;\">J. Phys. Chem. Lett</em>. <strong style=\"mso-bidi-font-weight: normal;\">2021</strong>, 12, 5, 1468–1474</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 195, 'NULL', '2021-05-04 05:46:20', '2030-12-01 18:30:00'),
(688, 'May 20, 2021 at 4.00  pm (Via Zoom)', 'Title :\nAssessing GKS - RPA approach for predicting Core Electron Binding Energies (CEBEs)', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Assessing GKS - RPA approach for predicting Core </span>Electron Binding Energies (CEBEs)</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 185, 'NULL', '2021-05-16 23:31:50', '2030-12-01 18:30:00'),
(689, 'May 27, 2021 at 5.00 pm (Via Zoom)', 'Title :\nPhotogeneration of Carbene and its Reactivity inside Supramolecular Cavity', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Photogeneration of Carbene and its Reactivity inside Supramolecular Cavity</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 148, 'NULL', '2021-05-23 22:53:32', '2021-05-23 23:07:42'),
(690, 'June 1, 2021 at 2.30 pm (Via Zoom)', 'Title :\nEvaluating the Role of an Electrolyte in Photocatalytic  Water Splitting\n ', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Evaluating the Role of an Electrolyte in Photocatalytic </span> Water Splitting</h3>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 133, 'NULL', '2021-05-24 04:47:17', '2030-12-01 18:30:00'),
(691, 'May 31, 2021 at 4.00 pm (Via Zoom)', 'Title :\nAssessment of response theory based methods for open shell systems', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Assessment of response theory based methods for open shell systems</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 126, 'NULL', '2021-05-26 00:33:35', '2030-12-01 18:30:00'),
(692, 'June 7, 2021 at 4.00 pm (Via Zoom)', 'Title :\nOptical Properties and Applications of Novel Stimuli-Responsive Organic Smart Materials\nAbst', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Optical Properties and Applications of Novel Stimuli-Responsive Organic Smart Materials</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">Prediction of multi-stimuli responsive behaviour in newly developed luminogen is an appealing yet challenging puzzle, since no concrete design strategy has been developed so far. In this talk, I will discuss about our unique strategy to establish structure-property relationship for designing of multi-stimuli responsive mechanoluminiscent material. First time we have reported that synergistic effect between twisting, conformational flexibility of donor moieties along with numerous non-covalent interactions endow the multi-stimuli responsive behaviours<sup>1</sup>.</span></p>\n<p><span style=\"font-size: 12.16px;\">In the second part of my talk, I will be talking about a unique strategy to sensitize centrosymmetrically packed organic luminogens,<sup>2</sup> which generally do not respond to external stimuli owing to their zero gross dipole moment and degenerate electronic energy states in solid-state packing.</span></p>\n<p><span style=\"font-size: 12.16px;\">In the last part of my talk, I will be talking about the next generation fluorophores exhibiting “all in one” type applications potentiality. Our work provides the important concept of “all in one” type luminogens possessing the following features comprising optical, biological and materials applications: 1) single source white light emission, 3) stimuli-responsive mechanoluminiscent feature, 2) selective mitochondria tracking.<sup>3</sup></span></p>\n<p><span style=\"font-size: 12.16px;\">1. Bibhisan Roy, M. Chenna Reddy, Partha Hazra. Chemical Science, 2018, 9, 3592-3606.</span></p>\n<p><span style=\"font-size: 12.16px;\">2. Bibhisan Roy, M. Chenna Reddy, Soumendra Nath Panja, Partha Hazra. J. Phys. Chem. C, 2019, 123, 3848-3854.</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">3. Bibhisan Roy, M. Chenna Reddy, Gregor P. Jose, Felix C. Niemeyer, Jens Voskuhl, and Partha Hazra. J. Phys. Chem. Lett. 2021, 12, 1162-1168.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 130, 'NULL', '2021-05-26 00:40:23', '2021-06-01 03:16:20'),
(693, 'June 3, 2021 at 4.00 pm (Via Zoom)', 'Title :\nTowards Understanding the Photodynamics of Tris(pentafluronyl)Borane-doped P3HT', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Towards Understanding the Photodynamics of Tris(pentafluronyl)Borane-doped P3HT</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 114, 'NULL', '2021-05-31 22:25:57', '2030-12-01 18:30:00'),
(694, 'June 17, 2021 at 4.00 pm (Via Zoom)', 'Title :\nModulating Mechanical Properties of β-Rich Proteins', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Modulating Mechanical Properties of β-Rich Proteins</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 149, 'NULL', '2021-06-01 03:19:23', '2030-12-01 18:30:00'),
(695, 'June 10, 2021 at 4.00 pm (Via Zoom)', 'Title :\nOvercoming resistance in cancer cells – Exploring new metal compounds for broader spectrum', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Overcoming resistance in cancer cells – Exploring new metal compounds for broader spectrum of anticancer activity</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 130, 'NULL', '2021-06-07 02:19:54', '2030-12-01 18:30:00'),
(696, 'June 14, 2021 at 4.00 pm (Via Zoom)', 'Title :\nTransient Raman Spectroscopy for Probing Charge Transfer States\nAbstract :\nCharge transfer (', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Transient Raman Spectroscopy for Probing Charge Transfer States</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">Charge transfer (CT) states form the basis for multitude of chemical reactions, and has become relevant due to its ubiquity in all light energy conversion paradigms.[1] In order to discover new materials with optimized charge transfer rates at molecular interfaces for energy conversion technologies, it is imperative to diagnose the structure-function corrleations “in operando”. Tracking the non-equilibrium nuclear dynamics leading up to the charge transfer states and probing the subsequent separation of charges requires time-resolved spectroscopy with structural sensitivity. In this talk, I will discuss the utility of transient Raman spectroscopy as a tool to structurally probe the formation of CT states in molecular dyes with large Stokes shift,[2] and uncover the hidden lengthscale of the photochemistry inside the active site of metalloproteins.[3] Both frequency domain and time-domain methods will be elaborated with emphasis on challenges of real-time Raman detection during chemical reactions.</span></p>\n<p><span style=\"font-size: 12.16px;\">References</span></p>\n<p><span style=\"font-size: 12.16px;\">1. Sajjad Dadashi-Silab, Sean Doran and Yusuf Yagci; Chem. Rev. 2016, 116, 17, 10212–10275; Alexey V. Akimov, Amanda J. Neukirch and Oleg V. Prezhdo; Chem. Rev. 2013, 113, 6, 4496–4565.</span></p>\n<p><span style=\"font-size: 12.16px;\">2. Shreetama Karmakar, Abhinandan Ambastha, Ajay Jha, Aditya Dharmadhikari, Jayashree Dharmadhikari, Ravindra Venkatramani, and Jyotishman Dasgupta; J. Phys. Chem. Lett. 2020, 11, 12, 4842–4848.</span></p>\n<p> </p>\n<p><span style=\"font-size: 12.16px;\">3. Soumyajit Mitra, ASR Koti, and Jyotishman Dasgupta; to be submitted.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 92, 'NULL', '2021-06-09 06:47:03', '2030-12-01 18:30:00'),
(697, 'June 21, 2021 at 4.00 pm (Via Zoom)', 'Title :\nConformation of biomolecules in phase-separated systems investigated by a line-confocal Rama', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Conformation of biomolecules in phase-separated systems investigated by a line-confocal Raman microscope</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 86, 'NULL', '2021-06-18 01:46:03', '2030-12-01 18:30:00'),
(698, 'June 23, 2021 at 12.30 pm (Via zoom)', 'Title :\nGuide to ICPMS', '<h3>Title</h3>\n<h3><span style=\"font-family: monospace; font-size: 12px;\">Guide to ICPMS</span></h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 82, 'NULL', '2021-06-22 23:58:34', '2030-12-01 18:30:00'),
(699, 'July 5, 2021 at 4.00 pm (Via Zoom)', 'Title :\nElectron-molecule reactions probed with photons\nAbstract :\nElectron-molecule reactions are u', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Electron-molecule reactions probed with photons</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12.16px;\">Electron-molecule reactions are ubiquitous in nature and technology. However, probing the details of such reactions remains both an experimental and computational challenge. Here, I will show recent developments from our group in experimentally probing these reactions by using light rather than electrons. This offers some key advantages that have enabled us to probe aspects that were previously not accessible through experiment. These include time-resolution and probing the effect of solvation. Examples of these will be given and some general features that drive electron capture will be discussed.</span></p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 57, 'NULL', '2021-06-30 22:13:47', '2030-12-01 18:30:00'),
(700, 'July 8, 2021 at 4.00 pm (Via Zoom)', 'Title :\nCO2 capture and conversion to fuels using magnesium nanoparticles under ambient conditions\nA', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">CO<sub>2</sub> capture and conversion to fuels using magnesium nanoparticles under ambient conditions</span></h3>\n<p><strong><span style=\"font-size: 12.16px;\">Abstract :</span></strong></p>\n<p><span style=\"font-size: 12.16px;\">Extensive use of fossil fuels is a major cause of anthropogenic CO<sub>2</sub>. Thus, CO<sub>2</sub> capture and conversion are the keys in reducing its increased concentration in the earth\'s atmosphere.<sup>1</sup> Many technologies were deployed to tackle the excess of CO<sub>2</sub> present in the atmosphere.<sup>2,3</sup> But the desired rate of CO<sub>2</sub> conversion has not been yet achieved under ambient conditions. The harsh conditions of temperature and pressure make it less approachable. In this work, we have reported the use of magnesium (Mg) nanoparticles as well as bulk powder to capture and convert CO<sub>2</sub> into valuable products under ambient conditions.<sup>4</sup> It was observed that the Mg nanoparticles can also be deployed for the capture and conversion of CO2 from air. The mechanistic insights for CO<sub>2</sub> conversion into methane, methanol and formic acid was studied by different techniques. This study demonstrates the first step towards sustainable CO<sub>2</sub> utilization to produce fuel and chemicals.    </span></p>\n<p><span style=\"font-size: 12.16px;\"> </span></p>\n<p><span style=\"font-size: 12.16px;\">References:</span></p>\n<ol>\n<li><span style=\"font-size: 12.16px;\">C. Breyer, M. Mahdi Fasihi, C. Bajamundi and F. Creutzig, Direct air capture of CO<sub>2</sub>: a key technology for ambitious climate change mitigation, Joule, 2019, 3, 2053–2065.</span></li>\n<li><span style=\"font-size: 12.16px;\">T. Kong, Y. Jiang and Y. Xiong, Photocatalytic CO<sub>2</sub> conversion: What can we learn from conventional COx hydrogenation?, Chem. Soc. Rev., 2020, 49, 6579–6591.</span></li>\n<li><span style=\"font-size: 12.16px;\">J. Artz, T. E. Müller, K. Thenert, J. Kleinekorte, R. Meys, A. Sternberg, A. Bardow, and W. Leitner, Sustainable Conversion of Carbon Dioxide: An Integrated Review of Catalysis and Life Cycle Assessment, Chem. Rev. 2018, 118, 2, 434–504.</span></li>\n<li><span style=\"font-size: 12.16px;\">S. A. Rawool, R. Belgamwar, R. Jana, A. Maity, A. Bhumla, N. Yigit, A. Datta, G. Rupprechter and V. Polshettiwar, Direct CO<sub>2</sub> capture and conversion to fuels on magnesium nanoparticles under ambient conditions simply using water, Chem. Sci., 2021, 12, 5774-5786.</span></li>\n</ol>\n<p> </p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 87, 'NULL', '2021-07-01 23:12:55', '2021-11-18 05:05:36'),
(701, 'July 12, 2021 at 10.00 am (Via Zoom)', 'Title :\nTheoretical Physics of Disordered Proteins reveal Biological Insights\nAbstract :\n\nProtein se', '<h3>Title</h3>\n<h3><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\">Theoretical Physics of Disordered Proteins reveal Biological Insights</span></h3>\n<p><strong><span style=\"font-family: \'Lucida Grande\', Verdana, Arial, Helvetica, sans-serif; font-size: 11px;\"><span style=\"text-decoration: underline;\">Abstract</span> :</span></strong></p>\n<div>\n<div style=\"padding-top: 0px; border-top: 0px; text-align: justify;\">Protein sequence -- encoding the unique folded structure and consequently function -- plays a profound role in biological information processing. This central notion, however, appears to be at odds with Intrinsically Disordered Proteins (IDP)s that lack unique folded structure. In spite of being disordered and interconverting beween different conformations, IDPs have specific conformational features and critical function. The clues to conformation, function -- and their relation, if any -- must be in the sequence. But how do we decipher this code from the sequence ? Recent advances in heteropolymer theory -- based on a coarse grain Hamiltonian -- unmasked the existence of several elegant mathematical formulae hidden in the sequence that describe IDPs conformational features. We will focus on the set of these formulae/metric that arise specifically from the placement of charges -- and not just their total number -- in the protein sequence. These simple mathematical relations reveal many surprises in IDP conformation and yield biological insights. For example, they show how IDPs can induce collapse and swelling at different length scales. Extending this, we can detect role of phosphorylation at specific hot spots to induce drastic conformation changes, even far from the modification sites, reminiscing `action at a distance\'. These information rich molecular blueprints can even help us identify functionally similar IDPs, not possible by traditional sequence alignment tools used for folded proteins. </div>\n</div>\n<div style=\"text-align: justify;\"> </div>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 26, 'NULL', '2021-07-09 02:08:15', '2021-11-18 05:05:36'),
(702, 'July 19, 2021 at 4.00 pm (Via Zoom)', 'Title :\nInvestigations into Mechanism of Sequence and Conformation Specific Photo-induced DNA Self-', '<h3>Title</h3>\n<h3><span style=\"font-size: 12.16px;\">Investigations into Mechanism of Sequence and Conformation </span>Specific Photo-induced DNA Self-repair</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">The study of UV-induced photo-damage and repair of nucleic acids is fascinating due to its connections to the molecular origins of life. The role of sunlight is particularly interesting as it not only served as a source of energy for forming new molecules but also quite likely broke down what formed, creating a cycle in which only the toughest could survive. Many molecules of life, including the canonical nucleobases, are thought to have emerged from this competition between photo-creation and photo-destruction. Naturally, their photo-stability would make them ideal building blocks for more complex structures. Despite this the nucleobases are not completely immune to chemical and radiation induced damage. In fact, DNA absorbs in the UV region of solar spectrum and undergoes several photophysical and photochemical processes which lead to formation of harmful photoproducts like cyclobutane pyrimidine dimers (CPDs), 6-4 photo lesion etc. Enzymatic machineries have evolved which can selectively repair different types of photodamage.1 However, in the absence of such sophisticated machinery when life initially evolved, it is tempting to speculate that the nucleotide sequences could be capable of self-repair.2 Investigations into such a self-repair mechanism has received a lot of attention due to the interesting photophysics involved and connections to chemical evolution.3-5 Recently, a tetranucleotide sequence (GATT) was reported to have inherent capability to repair a CPD lesion via a sequence specific sequential electron transfer.6 The details of the mechanisms and the sequence specificity has yet to be rationalized. I will present our findings revealing the possibility of photoinduced self-repair in a commonly occurring tetranucleotide sequence, TTAG. By employing a judicious combination of linear response and real time time-dependent density function theory, we obtain a detailed description of the mechanism of repair, the states involved at the various stages, factors influencing the forward and backward electron transfer as well as the driving force for the CPD repair. We find that, in contrast to the GATT sequence, the forward electron transfer process is promoted by a crucial ultrafast excitation energy transfer (EET) across the nucleobases resulting in charge-injection into the CPD dimer. The conditions favouring this EET are absent in the spectra of other conformations of the same sequence, indicating conformation specificity to the mechanism in addition the sequence specificity. Using examples from our research I will also emphasise on the challenges faced by current theoretical approaches to answer questions posed in the field.</p>\n<p style=\"text-align: justify;\">References:</p>\n<p style=\"text-align: justify;\">1. https://www.nobelprize.org/uploads/2018/06/popular-chemistryprize2015.pdf</p>\n<p style=\"text-align: justify;\">2. Beckstead, A. A.; Zhang, Y.; de Vries, M. S.; Kohler, B., Phys. Chem. Chem. Phys., 2016,18, 24228-24238</p>\n<p style=\"text-align: justify;\">3. M. R. Holman , T. Ito and S. E. Rokita , J. Am. Chem. Soc., 2007, 129 , 6-7.</p>\n<p style=\"text-align: justify;\">4. D. J. F. Chinnapen and D. Sen , Proc. Natl. Acad. Sci. U. S. A., 2004, 101 , 65-69.</p>\n<p style=\"text-align: justify;\">5. N. Khiem Van and C. J. Burrows , Acc. Chem. Res., 2012, 45 , 2151-2159.</p>\n<p style=\"text-align: justify;\">6. Bucher, D. B.; Kufner, C. L.; Schlueter, A.; Carell, T.; Zinth, W., J. Am. Chem. Soc. 2015, 138, 186–190. ; Szabla, R.; Kruse, H.; Stadlbauer, P.; Sponer, J.; Sobolewski, A. L. Chem. Sci. 2018, 9, 3131–3140. </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 32, 'NULL', '2021-07-12 22:24:56', '2021-11-18 05:05:36'),
(703, 'TEST', '', '', 'draft', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-08-04 05:06:26', '2021-08-04 05:06:26'),
(704, 'Xerox', 'Click here', '<p><a href=\"images/Xerox-Service-Indent.pdf\">Click here</a></p>', 'draft', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-08-04 05:09:42', '2021-08-04 05:11:33'),
(705, 'Seminar by Dr. Sumit Kumar, Institute of Basic Science CSLM, South Korea on August 30, 2021 at 3.00 pm (via Zoom)', 'Title:\nExosome: A Journey from Garbage Bags to Life-Saving Case\nAbstract:\nBiological membranes provi', '<p><strong><span style=\"text-decoration: underline;\">Title</span>:</strong></p>\n<p><span style=\"color: #0000ff;\"><strong>Exosome: A Journey from Garbage Bags to Life-Saving Case</strong></span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span>:</strong></p>\n<p>Biological membranes provide a fascinating example of a separation system that is multifunctional, tunable, and efficient for biocatalytic transformations such as enzyme cascades that involve complex networks proceeding in spatially confined nonreactors. Synthetic mimics of cellular compartments based on real membrane, lack the feasibility to encapsulate desired number of reactants together and precisely control the mixing of reactants during chemical transformation due to its mechanical and chemical fragility. Inspired by multicompartment structures of cellular architectures, we present a novel strategy to encapsulate of multiple enzymes and other reactants, in naturally secreted nanosized extracellular vesicles (EV) that act as nanoreactors for effective biocatalytic cascades in vitro and inside cells, and displays long time stability to work as an artificial organelles (AO). EV membrane proteins are chemically engineered by functionalizing the catechol moiety on the outer surface to drive the fusion of vesicles. This strategy is based on supramolecular metal complex formation that bridges the membrane proteins to allow controlled fusion for encapsulating multiple reactants and mixing them inside the EV. The integration of the multienzyme system inside AO leads to dramatically enhancements in their activity of the catalytic cascades, respectively, compared with the bulk mixture of the catalysts in solution. Importantly, our AO are functional after assembling a minimal electron transport chain capable of adenosine triphosphate synthesis (ATP), combining <em>Escherichia coli</em> F<sub>1</sub>F<sub>0</sub> ATP-synthase and the primary proton pump bo<sub>3</sub>-oxidase, which demonstrates the feasibility of our method for using this as cellular implants in living organisms. As a programmable tool to work as membrane fusion machinery, catechol-tethers can be further applied to regulate other biological processes where capturing and bridging of two membranes are the prerequisites.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-08-24 23:31:09', '2021-11-18 05:05:36');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(706, 'Seminar by Dr. Sumit Kumar, Institute of Basic Science CSLM, South Korea on August 31, 2021 at 4.00 pm (via Zoom)', 'Title :\nNano-brick: Designing Nanomaterials for Living system\nAbstract :\nNanomaterials have been wid', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\"><strong>Nano-brick: Designing Nanomaterials for Living system</strong></span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Nanomaterials have been widely explored in the biomedical field, and it is crucial to choose the right material and engineer it appropriately to achieve the desired properties. A variety of natural and synthetic polymers have been investigated in the field, and they can be engineered for different formulations. Here, I will mainly present how biomolecules can be used to engineer the different forms for surface texturing, self-assembling nanoparticles, and creating a confined nanoenvironment. To be effective in medicine, I will introduce new methods for creating diversity in nanostructures to enable seamless integration with living tissue, where the understanding of nanoscale is necessary. These advanced nanomaterials could enable an effective, minimally invasive, personalized healthcare system. Thorough understanding of underlying mechanisms, and advancing to a robust biomedical solution for healthcare, cellular energy generation, and nanobio-manufacturing, could be further translated into commercial products and therapies. These sophisticated nanobio-hybrid platforms with advanced synthetic routes have potential applications in early disease detection and targeted therapy. </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-08-24 23:33:33', '2021-11-18 05:05:36'),
(707, 'Seminar by Dr. Ahin Roy, Trinity College Dublin, Ireland on September 6, 2021 at 4.00 pm (via Zoom)', 'Title :\nAtomic and Electronic Structure of Ultrathin Single-crystalline Nanowires from Electron Micr', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Atomic and Electronic Structure of Ultrathin Single-crystalline Nanowires from Electron Microscopy and Simulations</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Being the eye of nanomaterials space with atomic-scale resolution, aberration-corrected (scanning) transmission electron microscopy (AC-(S)TEM) can provide a wealth of structural information in low-dimensional materials. With a judicious choice of system of interest, atomistic simulations can facilitate such microscopy. In this talk, I will discuss a couple of such simulation-aided microscopy experiments for different inorganic nanowires.</p>\n<p><br />The talk will focus on structural aspect of symmetry-broken single-crystalline ultrathin Au nanowires, wherein simulations predict that the {111} atomic planes of Au undergo wrinkling, leading to formation of saddle surfaces. Detailed AC-TEM on such wires confirms this prediction. Crystallographic arguments pinpoint the nature of surface stress to be the driving factor behind such structural transformation. Recent AC-STEM experiments with similar scale Pt nanowires show that with a priori crystallographic information, it is possible to reconstruct a 3-D structure from a single projection image of the material, paving a way for suitable alternative to conventional electron tomography. Lastly, in terms of electronic properties, I will briefly talk about Te nanowires, wherein simple adsorption of NO2 shows a semiconductor to metal transition- predicted in simulations and verified by experiments.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-09-01 22:34:01', '2021-11-18 05:05:36'),
(708, 'Seminar by Dr. Ahin Roy, Trinity College Dublin, Ireland on September 8, 2021 at 2.30 pm (via Zoom)', 'Title :\nStructure-property Correlation in Oxide Materials through Aberration-corrected Electron Micr', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Structure-property Correlation in Oxide Materials through Aberration-corrected Electron Microscopy</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p><br />The unprecedented control of the electron beam in the modern electron microscopes allows diffraction from nanometer regions, and conjunctionally being equipped with spectrometers, they can explore chemical information of the material – establishing much coveted structure-property correlations on-the-go. This can be of great interest to a materials chemist, and I will illustrate a couple of examples in that direction from recent works on oxides.</p>\n<p>Firstly, the talk will focus on WO3, which exists in a plethora of crystallographic phases. With judicious choice of chemistry, hexagonal and orthorhombic phases can be selectively accessed. Detailed conventional TEM coupled with simulations lead to insights on the operative growth mechanism in that process. Moreover, an epitaxial phase transformation, viz. hexagonal to monoclinic has been observed recently, hitherto unknown in literature. This leads to a possibility of phase-selective ion-intercalation in this material, which will be discussed. Such structural changes have pronounced effect on the electrochromic property of the material. In the next part, I will briefly focus on hexagonal perovskite BaMnO3, wherein reduced Mn-states have been observed on the surface and was established as the reason for its catalytic activity.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-09-01 22:36:17', '2021-11-18 05:05:36'),
(709, 'Seminar by Mr. Dinesh Kumar Yadav, Dept. of Chemical Sciences, TIFR, Mumbai on September 16, 2021 at 4.00 pm (via Zoom)', 'Title:\nProtein Electrochemistry: Metal Complexes as a Promoters of the Electron Transfer from a Gold', '<p><span style=\"text-decoration: underline;\"><strong>Title</strong></span>:</p>\n<p><span style=\"color: #0000ff;\">Protein Electrochemistry: Metal Complexes as a Promoters of the Electron Transfer from a Gold Electrode to Cytochrome c </span></p>\n<p><span style=\"text-decoration: underline;\"><strong>Abstract</strong></span>:</p>\n<p style=\"text-align: justify;\">Direct protein electrochemistry is an important method to determine the redox potential and electron transfer kinetics of metalloproteins. The bare metal electrode generally causes irreversible adsorption and denaturation of the protein on the electrode surface. There have been extensive studies on modification of the gold electrode using thiol functionalized promoters. We have investigated the effect of metal ion binding to a thiol-based Schiff base complex immobilized on the gold electrode for the electron transfer to cytochrome c. Selfassembled Monolayer (SAM) contains Schiff-Base ligand formed by cysteine and salicylaldehyde on the gold electrode was shown to promote quasi-reversible electrochemistry of cytochrome c. Various transition metal complexes of the Schiff-base ligand immobilized on the gold electrode were also found to promote electrochemistry of cytochrome c. The redox potential of the protein was determined to be 0.05±0.02 V (vs Ag/AgCl), which agrees with the reported value. In heterogeneous electron transfer rates for were determined by analyses of the cyclic voltammetric data using Laviron’s equation. The heterogenous electron rate constant (ks) calculated by Laviron’s equation suggest that there is small increase in the electron transfer rates when metal ion (Cr, Fe, Mn) is coordinated to the Schiff base on the electrode surface, suggesting that metal ion coordination possibly stabilizes the SAM of the Schiff base and favours electron transfer to cytochrome c.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-09-09 04:03:56', '2021-11-18 05:05:36'),
(710, 'Seminar by Prof. Katarzyna Pernal, Institute of Physics, Lodz University of Technology, Poland, on September 27, 2021 at 4.00 pm (via Zoom)', 'Title :\nDynamic Electron Correlation with Adiabatic Connection Approaches: describing excited states', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Dynamic Electron Correlation with Adiabatic Connection Approaches: describing excited states and molecular interactions</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Correlation energy, despite being a small fraction of the total electronic energy, governs binding of atoms into molecules. Similarly, noncovalent molecular interactions are flawed if the correlation of electrons belonging to interacting subsystems is not accounted for. The two main approaches to electron-correlation involve either perturbation theory or are based on density functionals. They are deficient either in accuracy or computational efficiency and a generally applicable, computationally efficient approach remains a challenge.</p>\n<p style=\"text-align: justify;\">Recently we have proposed a novel approach to describing electron correlation in multireference systems by adopting the adiabatic connection (AC) formalism [1]. The latter naturally links electron correlation with fluctuation of density at different points in space. Consequently, the final expression for the correlation energy employs density linear response. In our formalism, we use extended random phase approximation (ERPA) to describe the latter. The proposed AC-ERPA method yields excellent results for ground and excited states of molecules described with the CASSCF wavefunction [2-4]. In my talk I will present applications of the AC methods, and their extensions to multiconfigurational DFT [5], to challenging multireference systems and noncovalently bounded excited state systems.</p>\n<p> </p>\n<p>References</p>\n<p>1. K. Pernal, Phys. Rev. Lett. 120 (2018), 013001.</p>\n<p>2. E. Pastorczak, K. Pernal, J. Chem. Theory Comput. 14 (2018), 3493.</p>\n<p>3. E. Pastorczak, K. Pernal, J. Phys. Chem. Lett. 9 (2018), 5534.</p>\n<p>4. E. Pastorczak, M. Hapka, L. Veis, and K. Pernal, J. Phys. Chem. Lett. 10 (2019), 4668.</p>\n<p>5. M. Hapka, E. Pastorczak, A. Krzeminska, and K. Pernal, J. Chem. Phys. 152 (2020), 094102</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-09-21 22:38:12', '2021-11-18 05:05:36'),
(711, 'Seminar by Dr. Abhigyan Sengupta, Technical University of Munich, Germany on October 4, 2021 at 4.00 pm via zoom platform', 'Title :\nMolecules of Life\nAbtract :\nOn the first day of the seminar, I will discuss (a) tale of a mo', '<h3>Title</h3>\n<p><strong><span style=\"color: #0000ff;\">Molecules of Life</span></strong></p>\n<p><strong><span style=\"text-decoration: underline;\">Abtract</span> :</strong></p>\n<p style=\"text-align: justify;\">On the first day of the seminar, I will discuss (a) tale of a molecular timekeeper and continue with (b) evolution biology in a single-molecular regime. Proteins switching their structures can act as molecular timekeepers and regulate biochemically relevant reactions. Prolyl isomerization is one of such regulatory mechanisms, which play a crucial role in ion channel gating, cell signaling, and phage virus infection. I will present fascinating evidence showing how a single proline in an isolated protein domain (filamin) controls its folding kinetics and function.</p>\n<p style=\"text-align: justify;\">In the second section, I shall talk about the reverse-chaperon effect of cationic amino acid on a ribozymal RNA. In the light of current models for an early nucleic acid-based universe, the potential influence of simple amino acids on RNA tertiary folding into biochemically competent structures is speculated to be of significant evolutionary importance. In this work, the (un)folding kinetics of a ubiquitous RNA motif is investigated in single molecule regime in presence of natural amino acids with protonated side chain residues.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-09-30 02:49:23', '2021-11-18 05:05:36'),
(712, 'Seminar by Dr. Abhigyan Sengupta, Technical University of Munich, Germany on October 5, 2021 at 4.00 pm via zoom platform', 'Title :\nMolecules of Life\nAbstract :\nOn day 2, I will discuss (a) chiro-selective folding dynamics o', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\"><strong>Molecules of Life</strong></span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">On day 2, I will discuss (a) chiro-selective folding dynamics of a ribozymal RNA and (b) tweaking proteins into bio-machines. The preponderance of specific D- or L-chirality in fats, sugars, amino acids, and nucleic acids is ubiquitous in nature, yet the biological origin of such chiral dominance remains an open question. One plausible proposal for the predominance of L-chirality in amino acids through evolutionary templating of chiral RNA folding via chaperon activity will be the topic of presentation.</p>\n<p style=\"text-align: justify;\">Proteins are unique molecules, which could be tweaked towards developing exciting engineering applications in the emerging field of Bio-nanotechnology by understanding their general design principles and mechanisms of operation. In this section, I will show a transformation of an isolated Ca+2 binding domain to an ion concentration and time pulsing sensor. I shall also discuss how either a repeat protein or a circularly permuted GFP can be used to develop a mechano-fluorescence sensor.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-09-30 02:51:05', '2021-11-18 05:05:36'),
(713, 'Seminar by Dr. Karan Malik, Indian Institute of Technology, Delhi on October 8, 2021 at 2.30 pm via zoom platform', 'Title :\nElectrochemical Reduction of Carbon Dioxide to Syngas\nAbstract :\nOver the past few years, el', '<h3>Title</h3>\n<p><strong><span style=\"color: #0000ff;\">Electrochemical Reduction of Carbon Dioxide to Syngas</span></strong></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Over the past few years, electrochemical reduction of CO<sub>2</sub> (ERC) has attracted a lot of interest among researchers to convert CO<sub>2</sub> into value-added products using renewable energy. Through ERC, CO<sub>2</sub> and water using renewable energy can be co-electrolyzed to produce many chemicals such as CH<sub>4</sub>, C2H<sub>4</sub>, C<sub>2</sub>H<sub>6</sub>, HCOOH, CH<sub>3</sub>OH, and syngas (CO + H<sub>2</sub>), which are important industrial chemicals. However, CO<sub>2</sub> is a very stable molecule, and thus it is very difficult to reduce it. Therefore, the primary focus of research has been developing an electrocatalyst selective to CO<sub>2</sub> reduction. ERC is carried out in the presence of water. Thermodynamically, the reduction potentials of ERC and hydrogen evolution reaction (HER) potential are close to each other. Moreover, HER has fast kinetics as compared to ERC. Thus, the electrical charge spent during ERC is used by the facile HER instead of ERC. Thus suppression of HER poses a huge challenge.</p>\n<p style=\"text-align: justify;\">Depending upon the electrode potential, electrolyte, electrocatalyst, and reaction conditions. Sixteen different products can be formed using Cu as an electrocatalyst. However, it requires high overpotential (~1.0 V), have poor selectivity, and fast deactivation are the biggest challenges. The research work in this thesis is focused on the selective formation of syngas using Zn and Cu based electrocatalysts. The effect of the nature of the electrocatalyst layer on the ERC selectivity has been studied. It was found that the degree of gas entrapped in different types of layers was different, leading to different selectivity. The role of the addition of Cu into the ZnO has also been studied for the synthesis of syngas. On varying the concentration of Cu into the ZnO, it was found that at a certain fraction of Cu into the ZnO, charge transfer resistance towards ERC is reduced, which ultimately reduces the overpotential requirements. The role of pressure in gas phase ERC was also investigated. It was found that a mild increase in pressure leads to a shift in Zn/Cu selectivity towards syngas formation by changing the orientation of the adsorbed CO<sub>2</sub> molecule.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-10-04 22:31:30', '2021-11-18 05:05:36'),
(714, 'Seminar by Dr. Abhishek Mazumder, Kavli Institute for Nanoscience Discovery, The University of Oxford, The UK, on October 25, 2021 at 4.00 pm in AG-66', 'Title :\nHow a gene machine works: solving the puzzle, one molecule at a time\nAbstract :\nIn the first', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">How a gene machine works: solving the puzzle, one molecule at a time</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">In the first step of transcription, a molecular machine called the RNA polymerase (RNAP) locates, binds,and unwinds segments of genomic DNA called promoters and initiates RNA-synthesis. Ensemblebiochemical experiments and high-resolution structures provide a starting point for understanding themechanism of this process. But they only reveal static snapshots of stabilized states and do not offerevidence on the functional nature of the structures, missing intermediates, and kinetics of sub-steps. As aresult, several aspects of the mechanism by which RNAP functions have remained puzzling for decades.Here, I will present an alternative approach of using real-time single-molecule experiments which monitorstructural changes in several mobile domains of RNAP (the clamp, the sigma-finger, and the trigger loop)during an active reaction. I will show how these studies capture signatures of on-pathway states andkinetics of individual sub-steps to help reveal the mechanism of transcription initiation and elongation.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-10-17 22:30:14', '2021-11-18 05:05:36'),
(715, 'Seminar by Dr. Abhishek Mazumder, Kavli Institute for Nanoscience Discovery, The University of Oxford, The UK, on October 26, 2021 at 4.00 pm in AG-66', 'Title :\nFrom trees to forests: studying biochemical machines in the broader context\nAbstract :\nIn th', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">From trees to forests: studying biochemical machines in the broader context</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">In this talk, I will discuss future directions of investigating the heterogeneities and complexities intranscription mechanisms. I will first show how differences in promoter sequence elements lead toalteration of entire mechanistic pathways, highlighting the possibility of massive variations in transcriptionkinetics and gene expression patterns due to subtle changes in an important determinant. Building on thisobservation, I would outline strategies for developing massively parallel single-molecule assays tointerrogate sets of promoters with randomized sequence elements and explore transcription mechanismsacross the promoter space. I would also discuss proposals for monitoring conformational changes in a livebacterium to enable mechanistic studies of biochemical reactions in a physiological setting and underchanging environmental conditions. Finally, I will discuss plans to employ these techniques to study themechanism of coupling between the transcription and translation machinery – a process that underpinsgene regulation in bacteria.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-10-17 22:32:05', '2021-11-18 05:05:36'),
(716, 'Seminar by Dr. Kiran Patil, Nanyang Technological University, Singapore, on November 8, 2021 at 4.00 pm via zoom platform', 'Title :\nPROTACs (Proteolysis Targeting Chimeras) and Oligo-PROTACs: Emerging strategies to confront', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">PROTACs (Proteolysis Targeting Chimeras) and Oligo-PROTACs: Emerging strategies to confront diseases</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>PROTACs are emerging class of drug molecules which have two desperate domains connected by a linker molecule, one binds to protein of interest (POI) whereas another attach to E3-ligase. The formed ternary complex (POI-PROTAC-E3 ligase) then harnesses cell’s ubiquitin proteasomal system (UPS) for degradation of POI via it’s polyubiquitination. Recently, we and others are applied the concept of small molecular-based PROTAC to oligonucleotide-based PROTAC (oligo-PROTAC) to target previously un-targetable but highly desirable protein targets such as transcription factors or for numerous other practical applications in biology.</p>\n<p> <img style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"images/Karan.jpg\" alt=\"\" width=\"709\" height=\"377\" /></p>\n<p> </p>\n<p>I will discuss few of the newly discovered PROTACs, oligo-PROTACs and our findings in G4-PROTAC (G-quadruplex-PROTACs) for their specific aims. Additionally, the proposed novel oligo based PROTAC entities for my planned research work.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-11-09 22:37:48', '2021-11-18 05:05:36'),
(717, 'Seminar by Dr. Nabanita Saikia, Navajo Technical University, Chinle, Arizona, USA,  on November 22, 2021 at 4.00 pm via zoom platform', 'Title :\nConformational Dynamics and Supertertiary Structure of Multi-domain  Scaffold Protein, PSD', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Conformational Dynamics and Supertertiary Structure of Multi-domain  Scaffold Protein, PSD-95</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>PSD-95 (Postsynaptic density protein 95) is a scaffolding protein in the excitatory synapse that connects proteins involved in neurotransmitter release. The interdomain organization within the supertertiary structure of PSD-95 reveals two independent supramodules, PDZ1-PDZ2 tandem and PDZ3-SH3-GuK (PSG) core, which gives rise to its dynamic supertertiary structure. Supertertiary interactions between these domains have been suggested to regulate their binding activity although structural models for the PSG vary widely. Here we characterize the structure and dynamics of the PSG supramodule using a combination of discrete molecular dynamics simulations and single molecule FRET experiments with time resolution spanning picoseconds to seconds. We measured a FRET network of 12 variants in full-length PSD-95, which we used in rigid body modeling to map out the supertertiary landscape. PDZ3 samples two conformational basins, which were confirmed with disulfide mapping. PDZ3 showed a fuzzy electrostatic interaction with the SH3<sub>HOOK</sub> insertion along with a secondary binding site on GuK that allowed for a wide range of conformations including some involving the binding face of PDZ3. Truncation of PSD-95 to the PSG, showed increased dynamics but did not disrupt interdomain interactions. The research findings are proposed to be significant in characterizing the conformational dynamics of PSD-95, understanding its role in the downstream regulation of signal transduction pathways, and identifying the long-term critical effects of posttranslational modifications.</p>\n<p><u>Selected publication:</u></p>\n<p>1. George Hamilton, Nabanita Saikia, Sujit Basak, Franceine S. Welcome, Yan Hao, Fang Wu, Jakub Kubiak, Claus A.M. Seidel, Feng Ding, Hugo Sanabria, Mark E. Bowen. Fuzzy Supertertiary Interactions within PSD-95 Enable</p>\n<p>    Ligand Binding (submitted).</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-11-09 22:46:13', '2021-11-18 05:08:04'),
(718, 'Seminar by Dr. Nabanita Saikia, Navajo Technical University, Chinle, Arizona, USA,  on November 23, 2021 at 4.00 pm via zoom platform', 'Title :\nDirected Self-Assembly of Biological and Bio-Inspired Molecules on Functional Nanomaterials', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Directed Self-Assembly of Biological and Bio-Inspired Molecules on Functional Nanomaterials</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>The self-assembly of bio-inspired molecules into well-defined hierarchical nanostructures has outlined some of the promising applications in molecular and cellular biophysics, including recent advances in the fabrication of biosensors for therapeutics and diagnostics, water purification, and biocatalysts. The molecular recognition and complementary growth patterns rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial’s surface. Due to the growing interest in developing nanoelectronic devices using unusual DNA-assemblies (“nano-oddities”), biological, and bio-inspired molecules, the proposal will advance <em>in silico</em> protocols to engineer hybrid nanostructures. Multiscale modeling methods, computer simulations, and experiments will be employed to systematically investigate the kinetic and thermodynamic effects on the assembly process. The distinctive patterns in assembly would, in turn, serve as fingerprints for biomolecular recognition at the solid/liquid interface.</p>\n<p>In this part of my talk, I will cover, 1) doctoral research contributions on using multi-scale computational techniques for the rational design and application of functionalized nanomaterials in drug delivery, 2) postdoctoral research contributions on the surface mediated hierarchical self-assembly of noncanonical DNA nucleobases and synthetic analogs of DNA at the solid/liquid interface on graphene-based nanomaterials, and 3) proposed research on the directed self-assembly of biological and bio-inspired molecules on 2D transition metal dichalcogenides and other novel hybrid materials. The formation of stable hybrids will open new avenues in research for the design and application of novel DNA based biosensors and biocompatible nanoelectronic devices. By taking cues from the complimentary growth patterns, structural hierarchy, interfacial properties, and tunable functionality, the research proposal will establish design rules to assimilate biomimicry or bio-inspiration using nature’s design principles to model smart bio-inspired nanosystems and interfaces for sustainable energy, health, and environmental applications.</p>\n<p> </p>\n<p><u>Selected publications:</u></p>\n<p><sup>*=Corresponding author</sup></p>\n<ol>\n<li><strong>Nabanita Saikia</strong>,<sup>*</sup> Probing the Adsorption Behavior and Free Energy Landscape of Single–Stranded DNA Oligonucleotides on Single–Layer MoS<sub>2</sub> with Molecular Dynamics. <em>Nanotechnology, </em>2021 (<em>under review</em>).</li>\n<li><strong>2020 HOT PCCP article:</strong> <strong>Nabanita Saikia</strong>,<sup>*</sup> Taha, and Ravindra Pandey,<sup>*</sup> Peptide Nucleic Acid Functionalized Carbon and Boron Nitride Nanotubes: Mapping the Free-energy Landscape to Determine Dynamic Stability in Aqueous Solution. <em>Phys. Chem. Chem. Phys</em>. <strong>2021</strong>, 23, 219.</li>\n<li><strong>Nabanita Saikia</strong>,<sup>*</sup> and Ravindra Pandey,<sup>*</sup> Polarity-Induced Surface Recognition and Self-Assembly of Noncanonical DNA Nucleobases on Hexagonal Boron Nitride. <em> Phys. Chem. C</em> <strong>2018</strong>, <em>122</em>, 3915.</li>\n<li><strong>Nabanita Saikia</strong>,<sup>*</sup> Floyd Johnson, Kevin Waters and Ravindra Pandey,<sup>*</sup> Dynamics of Self-Assembled Cytosine Nucleobases on Graphene. <em>Nanotechnology</em> <strong>2018</strong>, <em>29</em>, 195601.</li>\n</ol>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-11-09 22:48:01', '2021-11-18 05:08:10'),
(719, 'Seminar by Dr. Kalaivanan Nagarajan, University of Strasbourg, France on December 6, 2021 at 4.00 pm in AG-66', 'Title :\nInteraction of Light with Matter: From Real to Virtual Photons\nAbstract :\nLight-matter inter', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Interaction of Light with Matter: From Real to Virtual Photons</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Light-matter interactions are perpetual sources of stimulation in experimental and theoretical sciences. Such interactions can involve real or virtual photons and examples of both cases will be presented. The first part of the talk will focus on the photo-physics of organic molecules. After excitation, among the various intramolecular processes, singlet-triplet intersystem crossing is an important channel both fundamentally and technologically. In organic chromophores, the quantum yield of intersystem crossing is often low due its spin forbidden nature. Strategies to enhance intersystem crossing such as heavy atom effect, molecular twist, and singlet fission in different core-twisted aromatic molecules will be presented and discussed.1-2<br />In the second part, an overview of the light-matter strong coupling will be presented where virtual photons (a.k.a. vacuum field) play a key role. In the strong coupling regime, hybrid light-matter states (polaritonic states), are formed by the interaction of a molecular transition with the electromagnetic field. The formation of such hybrid states results in the modification of various physical and chemical properties of the molecules/materials as it has been demonstrated over the past decade. 3-4</p>\n<p><span style=\"text-decoration: underline;\">References</span>:</p>\n<p>1. Nagarajan, K.; Mallia, A. R.; Reddy, V. S.; Hariharan, M., Access to Triplet Excited State in Core-Twisted Perylenediimide. J. Phys. Chem. C 2016, 120, 8443-8450.<br />2. Nagarajan, K.; Mallia, A. R.; Muraleedharan, K.; Hariharan, M., Enhanced intersystem crossing in core-twisted aromatics. Chem. Sci. 2017, 8, 1776-1782.<br />3. Ebbesen, T. W., Hybrid Light–Matter States in a Molecular and Material Science Perspective. Acc. Chem. Res. 2016, 49, 2403-2412.<br />4. Nagarajan, K.; George, J.; Thomas, A.; Devaux, E.; Chervy, T.; Azzini, S.; Joseph, K.; Jouaiti, A.; Hosseini, M. W.; Kumar, A.; Genet, C.; Bartolo, N.; Ciuti, C.; Ebbesen, T. W., Conductivity and Photoconductivity of a P-Type Organic Semiconductor under Ultrastrong Coupling. ACS Nano 2020, 14, 10219-10225.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-11-09 22:57:32', '2021-11-18 05:08:10'),
(720, 'Seminar by Dr. Kalaivanan Nagarajan, University of Strasbourg, France on December 7, 2021 at 4.00 pm in AG-66', 'Title :\nChemistry under Vibrational Strong Coupling\nAbstract :\nLight-matter strong coupling in gener', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Chemistry under Vibrational Strong Coupling</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Light-matter strong coupling in general, vibrational strong coupling (VSC) in particular, offers exciting possibilities in molecular/material science. Formation of vibro-polaritonic states leads to a large modification in chemical reactivity and other molecular properties under strong coupling conditions.1-2 This emerging field of research is highly multi-disciplinary, and much of its potential has yet to be explored.</p>\n<p>The thrust of my future research will be focused on understanding the fundamental mechanism(s) of VSC and to explore its potential applications in different fields of chemistry. For instance, so far only about a dozen chemical reactions have been studied under VSC and so much remains to be understood to explain how VSC induces such large changes in reactivity. In another direction, the perturbation of solute-solvent interactions under VSC clearly opens a new pathway in the field of chemical equilibria, supramolecular assembly, and crystal engineering that need to be further investigated.3-4 VSC undoubtedly will become a useful tool in chemistry and material science. It will also contribute to the fundamental understanding of the role of vacuum field in common molecular processes.</p>\n<p><span style=\"text-decoration: underline;\">References</span>:</p>\n<p>1. Sau, A.; Nagarajan, K.; Patrahau, B.; Lethuillier-Karl, L.; Vergauwe, R. M. A.; Thomas, A.; Moran, J.; Genet, C.; Ebbesen, T. W., Modifying Woodward–Hoffmann Stereoselectivity Under Vibrational Strong Coupling. Angew. Chem. Int. Ed. 2021, 60, 5712-5717.<br />2. Nagarajan, K.; Thomas, A.; Ebbesen, T. W., Chemistry under Vibrational Strong Coupling. J. Am. Chem. Soc. 2021, 143, 16877-16889.<br />3. Joseph, K.; Kushida, S.; Smarsly, E.; Ihiawakrim, D.; Thomas, A.; Paravicini-Bagliani, G. L.; Nagarajan, K.; Vergauwe, R.; Devaux, E.; Ersen, O.; Bunz, U. H. F.; Ebbesen, T. W., Supramolecular Assembly of Conjugated Polymers under Vibrational Strong Coupling. Angew. Chem. Int. Ed. 2021, 60, 19665-19670.<br />4. Hirai, K.; Ishikawa, H.; Chervy, T.; Hutchison, J. A.A.; Uji-i, H., Selective crystallization via vibrational strong coupling. Chem. Sci. 2021, 12, 11986-11994.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-11-09 23:00:28', '2021-11-18 05:08:10'),
(721, 'Seminar by Dr. Keshab Karmakar, Indian Association for the Cultivation of Science, Kolkata, on November 22, 2021 at 4.00 pm via zoom platform', 'Title :\nZnO Nanorod-Templated Multi-layered Two-Dimensional MoS2/ MoO3 Photoanodes for Solar Fuel Ge', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">ZnO Nanorod-Templated Multi-layered Two-Dimensional MoS<sub>2</sub>/ MoO<sub>3</sub> Photoanodes for Solar Fuel Generation</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Photoelectrochemical (PEC) water splitting is one of the sustainable ways to convert abundant solar energy into solar fuel (hydrogen) with zero carbon dioxide emissions. Herein, multidimensional nano-heterostructures based photoelectrodes are employed for PEC water splitting where the multi-layered two-dimensional (2D) structure of MoS<sub>2</sub> and MoO<sub>3</sub> are coupled separately on the well-aligned arrays of one-dimensional (1D) ZnO nanorods template, with the expected effective synergic effects. The advantages of catalytically active sites of the 2D layered structure of transition-metal dichalcogenides/oxides are combined with the distinctive dimensionality-dependent phenomena of 1D structure for photoelectrochemical water splitting. A low onset potential and boosted broadband light absorption is evinced by the ZnO/MoS<sub>2</sub> and ZnO/MoO<sub>3</sub> photoanodes, with significantly high photocurrent densities of 2.04 and 0.67 mA cm<sup>−2</sup> at 1.23 V versus reversible hydrogen electrode, thereby enhancing the photocurrent up to 334% and 43%, respectively, compared to that of pristine ZnO nanorods. Consequently, photoanodes also exhibit enhanced applied bias photon-to-current conversion efficiency, owing to superior spatial photo-induced exciton separation and transportation triggered by favourable interfacial band alignment at 2D−1D heterointerfaces. Moreover, favourable band alignment promotes hole transportation at the heterostructure/electrolyte interface and boost the surface oxygen evolution reaction, leading to enhanced photoelectrochemical performance.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-11-18 04:59:18', '2021-11-18 05:08:10'),
(722, 'Seminar by Dr. Amartya Bose, Princeton University, USA on November 29, 2021 at 5.30 pm via zoom platform', 'Title :\nExact Quantum Dynamics of Open Systems\nAbstract :\nAn ability to accurately simulate the dyna', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Exact Quantum Dynamics of Open Systems</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">An ability to accurately simulate the dynamics of quantum systems is essential to understanding all of Chemistry and much of Physics.  While quantum mechanics is, in principle, linear in time, simulations scale exponentially with degrees of freedom.  This is a huge problem when it comes to simulating large systems involving quantum transport.  Broadly, computational approaches can be classified as ones based on “augmented” classical trajectories and ones that are based on a “system-solvent decomposition.” In this first presentation, I would discuss the work that I have done on path integral methodologies for simulating system-solvent dynamics.  This technique of decomposing the problem into a system, treated at a more accurate level of theory, and a solvent, that is typically traced over, is particularly effective if the quantum effects are limited to a small subspace of the problem.  While various formalisms exist to simulate a system-solvent problem, they are typically plagued by computational bottlenecks.  Methods of speeding up such simulations<sup>1, 2</sup> would be presented.  Recently, I have developed an exciting simulation framework combining various tensor network approaches with Feynman-Vernon influence functionals<sup>3-5</sup>.  The most exciting method in this family combines ideas from density matrix renormalization group (DMRG) with influence functionals to give rise to a very promising framework that even in its most primitive form is able to solve problems involving dissipative molecular aggregates and spin chains with unprecedented efficiency.  I would discuss these developments, illustrating their wide-ranging applicability through simulations of essentially quantum mechanical, non-adiabatic processes like electron<sup>4</sup> and excitonic energy<sup>6</sup> transfer.  Recent results exploring energy transfer in photosynthetic complexes along with the effect of local vibrations and spatial inhomogeneities will also be shown.</p>\n<p> </p>\n<h1>References</h1>\n<ol>\n<li>Bose, A.; Makri, N., Non-equilibrium reactive flux: A unified framework for slow and fast reaction kinetics. <em>J. Chem. Phys. </em><strong>2017,</strong> <em>147</em> (15), 152723.</li>\n<li>Bose, A.; Makri, N., Quantum‐classical path integral evaluation of reaction rates with a near‐equilibrium flux formulation. <em>Int. J. Quantum Chem. </em><strong>2021,</strong> <em>121</em> (10).</li>\n<li>Bose, A., A Pairwise Connected Tensor Network Representation of Path Integrals. <em>arXiv pre-print server </em><strong>2021</strong>.</li>\n<li>Bose, A.; Walters, P. L., A tensor network representation of path integrals: Implementation and analysis. <em>arXiv pre-print server </em><strong>2021</strong>.</li>\n<li>Bose, A.; Walters, P. L., A Multisite Decomposition of the Tensor Network Path Integrals. <em>arXiv pre-print server </em><strong>2021</strong>.</li>\n<li>Bose, A.; Makri, N., All-Mode Quantum–Classical Path Integral Simulation of Bacteriochlorophyll Dimer Exciton-Vibration Dynamics. <em>J. Phys. Chem. B </em><strong>2020,</strong> <em>124</em> (24), 5028-5038.</li>\n</ol>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-11-23 22:43:36', '2021-11-23 22:43:36'),
(723, 'Seminar by Dr. Amartya Bose, Princeton University, USA on November 30, 2021 at 5.30 pm via zoom platform', 'Title :\nClassical Trajectory Methods for Approximate Quantum Dynamics\nAbstract :\nChemistry is the st', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Classical Trajectory Methods for Approximate Quantum Dynamics</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Chemistry is the study of large systems of molecules.  Accurate simulations of quantum dynamics scale exponentially with the number of degrees of freedom, making them impractical.  Thus, approximations have to be made.  In the previous talk, I discussed my work involving the system-solvent decomposition using real-time path integral.  In this talk, I would like to focus on problems that are not amenable to such decompositions such as calculating the infrared and Raman spectra or bulk transport properties like diffusion coefficient.  Often dynamical quantum interference gets washed away in condensed phases under ambient conditions leading to an effective utilization of semiclassical<sup>1-3</sup> and other classical trajectory-based approximations<sup>4-6</sup>.  The simplest of these approximations incorporates quantum dispersion effects into a phase space distribution called the Wigner distribution<sup>3</sup>, defined as a multidimensional Fourier transform.  Computational simulation of this distribution is complicated by the Monte Carlo “sign problem.”  I have developed various methods to overcome these problems.  First, I will introduce a very simple adiabatic switching method<sup>7, 8</sup> that can approximate the Wigner distribution using classical trajectories.  Then I would describe an exact path integral method<sup>9</sup> that is systematically convergeable and mitigates the sign problem through a physically motivated series expansion.  Other approaches of extracting quantum information from classical trajectories would also be presented<sup>10</sup>.  I will show my current work in comparing various augmented classical trajectory methods in simulating spectra and density of states of bulk water using <em>ab initio</em> deep neural network force fields<sup>11-13</sup>.</p>\n<p>Finally, I will discuss my future research plans utilizing many of the frameworks that I have developed to address open research questions in Chemistry, and also talk about avenues of further improving these methods.</p>\n<h1>References</h1>\n<ol>\n<li>Van Vleck, J. H., The Correspondence Principle in the Statistical Interpretation of Quantum Mechanics. <em>Proc. Natl. Acad. Sci. </em><strong>1928,</strong> <em>14</em> (2), 178-188.</li>\n<li>Herman, M. F.; Kluk, E., A semiclasical justification for the use of non-spreading wavepackets in dynamics calculations. <em>Chem. Phys. </em><strong>1984,</strong> <em>91</em> (1), 27-34.</li>\n<li>Wigner, E., On the Quantum Correction For Thermodynamic Equilibrium. <em>Phys. Rev. </em><strong>1932,</strong> <em>40</em> (5), 749-759.</li>\n<li>Craig, I. R.; Manolopoulos, D. E., Quantum statistics and classical mechanics: Real time correlation functions from ring polymer molecular dynamics. <em>J. Chem. Phys. </em><strong>2004,</strong> <em>121</em> (8), 3368-3373.</li>\n<li>Cao, J.; Voth, G. A., The formulation of quantum statistical mechanics based on the Feynman path centroid density. I. Equilibrium properties. <em>J. Chem. Phys. </em><strong>1994,</strong> <em>100</em> (7), 5093-5105.</li>\n<li>Cao, J.; Voth, G. A., The formulation of quantum statistical mechanics based on the Feynman path centroid density. II. Dynamical properties. <em>J. Chem. Phys. </em><strong>1994,</strong> <em>100</em> (7), 5106-5117.</li>\n<li>Bose, A.; Makri, N., Wigner phase space distribution via classical adiabatic switching. <em>J. Chem. Phys. </em><strong>2015,</strong> <em>143</em> (11), 114114.</li>\n<li>Bose, A.; Makri, N., Wigner Distribution by Adiabatic Switching in Normal Mode or Cartesian Coordinates and Molecular Applications. <em>J. Chem. Theory Comput. </em><strong>2018,</strong> <em>14</em> (11), 5446-5458.</li>\n<li>Bose, A.; Makri, N., Coherent State-Based Path Integral Methodology for Computing the Wigner Phase Space Distribution. <em>J. Phys. Chem. A </em><strong>2019,</strong> <em>123</em> (19), 4284-4294.</li>\n<li>Bose, A.; Makri, N., Quasiclassical Correlation Functions from the Wigner Density Using the Stability Matrix. <em>J. Chem. Inf. Model </em><strong>2019,</strong> <em>59</em> (5), 2165-2174.</li>\n<li>Wang, H.; Zhang, L.;  Han, J.; E, W., DeePMD-kit: A deep learning package for many-body potential energy representation and molecular dynamics. <em>Comput. Phys. Commun. </em><strong>2018,</strong> <em>228</em>, 178-184.</li>\n<li>Zhang, L.; Han, J.;  Wang, H.;  Car, R.; E, W., Deep Potential Molecular Dynamics: A Scalable Model with the Accuracy of Quantum Mechanics. <em>Phys. Rev. Lett. </em><strong>2018,</strong> <em>120</em> (14), 143001.</li>\n<li>Zhang, L.; Chen, M.;  Wu, X.;  Wang, H.;  E, W.; Car, R., Deep neural network for the dielectric response of insulators. <em>Phys. Rev. B </em><strong>2020,</strong> <em>102</em> (4), 041121.</li>\n</ol>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-11-23 22:45:20', '2021-11-23 22:45:20'),
(724, 'Seminar by Dr. Tushar Debnath, Ludwig - Maximilians - University, Munich, Germany on December 20, 2021 at 2.00 in AG-66', 'Title :\nUltrafast Photophysical Dynamics of Energy Harvesting Nanomaterials and Bio-relevant Molecul', '<h3>Title</h3>\n<p><strong><span style=\"color: #0000ff;\">Ultrafast Photophysical Dynamics of Energy Harvesting Nanomaterials and Bio-relevant Molecules</span></strong></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>It has been more than 30 years that the field of nanocrystal (NC) has emerged, driven by the attractive physics due to its strong confinement, along with several prospective applications. To fully realize the potential of the NCs, it is of utmost importance to study the fundamental of the exciton relaxation-recombination dynamics which often falls in the femto (10<sup>-15</sup> s) - to nanosecond (10<sup>-9</sup> s) timescale. Ultrafast optical spectroscopic techniques offer a detailed understanding of exciton relaxation and recombination dynamics.</p>\n<p><br />In this talk, I will focus on the ultrafast excitonic properties of the recently emerged undoped and doped perovskite NCs. Then I will talk about the ultrafast charge transfer dynamics of undoped and doped II-VI quantum dot (QD) materials on the relevance of solar energy harvesting. Finally, I will briefly introduce the elementary processes that accompany the interaction of ionizing radiation with biologically relevant molecules in an aqueous solution. Using femtosecond coherence spectroscopy, I will elucidate the vibrational wave packet dynamics that follow the photodetachment of amino acids in an aqueous solution.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-12-15 05:15:11', '2021-12-15 05:15:11'),
(725, 'Seminar by Dr. Tushar Debnath, Ludwig - Maximilians - University, Munich, Germany on December 21, 2021 at 4.00 in AG-66', 'Title :\nVibrational Wave-packet Dynamics to Unravel the Bio-solid Coupling\nAbstract :\nThe coherent i', '<h3>Title</h3>\n<p><strong><span style=\"color: #0000ff;\">Vibrational Wave-packet Dynamics to Unravel the Bio-solid Coupling</span></strong></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>The coherent interaction between a light photon and a semiconductor provides fundamental insights into solid-state physics. Incorporation of biologically relevant molecules, such as amino acids, as a capping agent in fluorescent semiconductor nanocrystals (NCs), can make them suitable as fluorescent bioimaging probes. Unraveling the strain-induced ultrafast lattice rearrangement dynamics due to coherent phonon formation in bio-functionalized semiconductor NCs can open new insights.</p>\n<p><br />Continuing from the first talk, where mainly I will talk about the excitonic properties of semiconductor nanomaterials, in the second talk I will show the vibrational coherences in bio-functionalized nanomaterials. Before going into my future research plan, I will show some of our very recent work on coherent phonon dynamics in perovskite NCs. Biomolecules with several functional moieties will supposed to influence the coherent phonon dynamics to a larger extend due to enhance bio-solid coupling. With this idea in mind, I will then establish my future research plan on bio-functionalized Cd- and Pb-free non-toxic nanomaterials.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2021-12-15 05:16:52', '2021-12-15 05:16:52');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(726, 'Seminar by Dr. Amrit Venkatesh, Laboratory of Magnetic Resonance, EPFL, Switzerland on January 10, 2022 at 4.00 pm in AG-66', 'Title :\nSensitizing solid-state NMR using fast magic angle spinning and dynamic nuclear polarization', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Sensitizing solid-state NMR using fast magic angle spinning and dynamic nuclear polarization</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>NMR is a powerful atomic-level characterization technique but it suffers from an intrinsically poor sensitivity, limiting its application to common spin-1/2 isotopes such as <sup>1</sup>H, <sup>13</sup>C, <sup>15</sup>N, <sup>29</sup>Si, <sup>31</sup>P etc. Whereas, over 75% of the periodic table consists of unreceptive nuclei that are rarely studied using NMR due to the lack of sensitive approaches. Fast magic angle spinning (MAS) enables the observation of the sensitive <sup>1</sup>H spins in solids by narrowing <sup>1</sup>H NMR lineshapes. This allows the use of <sup>1</sup>H spins as ‘spies’ for indirect detection of other nuclei, much like solution NMR spectroscopy. Here, we will demonstrate how <sup>1</sup>H detection methods in solids allow meaningful chemical information to be extracted from low gyromagnetic ratio nuclei, half-integer quadrupolar nuclei and the spin-1 isotope <sup>14</sup>N.</p>\n<p>The sensitivity of NMR can alternatively be drastically improved using dynamic nuclear polarization (DNP) from nearby electron spins. Gd(III) complexes are attractive exogenous PAs for MAS DNP due to their high chemical stability, but they are infrequently used for DNP due to their limited DNP efficiency. Here, we will establish a model that correlates the DNP enhancements provided by Gd(III) complexes with zero-field splittings. These results will pave the way for the development of efficient Gd(III) polarizing agents.</p>\n<p>Finally, the application of these state-of-the-art solid-state NMR techniques to characterize small molecule pharmaceuticals, organometallic compounds and semi-conducting nanomaterials will be demonstrated.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-01-03 22:17:44', '2022-01-03 22:17:44'),
(727, 'Seminar by Dr. Adusumalli Srinivasa Rao, University of Cambridge, UK on January 17, 2022 at 4.00 pm via Zoom Platform', 'Title :\nChemical technologies for precision labeling of native proteins\nAbstract :\nSingle-site prote', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Chemical technologies for precision labeling of native proteins</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Single-site protein modification impacts diverse aspects of Science at the interface of biology, chemistry, biomaterials, and biologics. The prominent way to access such protein conjugates is through bio-synthetically pre-engineered proteins with un-natural amino acids or fragments. Unfortunately, these methods do not operate with native proteins leaving an enormous technological void. The solution to this challenge would require a chemical transformation that can allow single-site protein labeling, regulation of the site-of-labeling, and operate with multiple proteins. During my talk, I will present the chemical tools for precession engineering of proteins. The challenges related to reaction kinetics, chemoselectivity, and site-selectivity for single-site labeling of proteins will be addressed. These chemical methods can render site-selective N-terminus labeling of proteins and also can distinguish N-terminus residues for site-specific labeling. In particular, I would like to bring your attention to Gly-Tag® and Linchpin Directed Modification (LDM®) technologies that led to residue-specific labeling and site-selective labeling of proteins respectively. The native proteins can now be labeled with absolute precision enabled by a modular chemical platform (LDM®). The functional groups introduced by labeling open the potential for the orthogonal late-stage installation of an affinity tag, NMR tag, and a fluorophore. These chemical technologies are operationally simple, deliver ordered immobilization, and analytically pure probe tagged proteins. The LDM technology enabled the synthesis of homogeneous antibody-drug conjugates that exhibits highly specific antiproliferative activity toward HER-2 positive SKBR-3 breast cancer cells. Besides, I will discuss the first general method for chemoselective functionalization of serine residue which is rarely chosen as a handle for selective derivatization. Finally, I will end my talk with the development of new PSI-reagents that can render selective transformation of serine residue into Dha formation, a post-translational modification.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-01-03 22:22:12', '2022-01-03 22:22:12'),
(728, 'Seminar by Dr. Adusumalli Srinivasa Rao, University of Cambridge, UK on January 18, 2022 at 4.00 pm via Zoom Platform', 'Title :\nChemical tools for selective probing of protein activity and degradation of biomolecules\nAbs', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Chemical tools for selective probing of protein activity and degradation of biomolecules</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Technological advancement often leads to major discoveries in chemical biology research. The functional diversity of biomolecules and their impact on vital biological processes inspire the development of methods for the precision engineering of these molecules. The growing interest in selective labeling and/or degradation of biomolecules has emerged from the necessity to understand and regulate their structure and function. During my talk, I will discuss how chemical tools can enable the selective tuning/degradation of biomolecules for their therapeutic applications. First, I will introduce a new electrophilic warhead to deliver the cysteine conjugates for protein therapeutics. Besides, the development of biorthogonal chemical reactions has been an unprecedented opportunity for the study and manipulation of biological processes within living systems. Precise perturbation of protein activity with high selectivity is crucial to probe and control dynamic protein activity. The development of proximity driven reversible covalent orthogonal strategy will enable the loss and gain of the function of protein with high selectivity to study dynamic cellular processes.</p>\n<p style=\"text-align: justify;\">Methods for target protein degradation have advanced the field of drug discovery. In particular, PROTACs and molecular glues gained much attention during the last decade. However, the PROTACs require strong affinity ligands for both E3 ligase and target protein whereas the discovery of most of the molecular glues was serendipitous. Hence, there is an unmet need to develop new technologies. A novel rational design of reversible covalently binding PROTACs (RECOBIN-PROTACs) will be discussed for target protein degradation. Also, another reversible/irreversible covalent strategy will introduce a new modality on PROTACs to generate a new class of Electrophilic-PROTACs that does not require the need of ligand for protein degradation. This new modality enhances the protein-protein interaction between E3 ligase and protein and it also stabilizes the ternary complex formation which plays a key role in the efficient degradation of the protein. Finally, targeted degradation of RNA species plays a key role in numerous cellular mechanisms. The specific interactions of enzyme with RNA gives an ample opportunity to develop small molecule degraders. So the principles of small molecule degraders that take advantage of specific enzyme-RNA interactions and modified bases on RNA to induce the degradation of specific RNA will be outlined.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-01-03 22:24:42', '2022-01-03 22:24:42'),
(729, 'Seminar by Dr. Aditi Verma, Dept. of Chemical Sciences, TIFR, Mumbai,  on February 7, 2022 at 4.00 pm via zoom platform', 'Title :\nVesicular membrane “reads” the intravesicular serotonin concentration to facilitate exoc', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Vesicular membrane “reads” the intravesicular serotonin concentration to facilitate exocytosis</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Neurotransmission is an essential process through which neurons communicate their signals to target cells. Chemical neurotransmission involves the release of neurotransmitter in multiples of a fixed amount (quantum) of the neurotransmitter, a process termed as quantal release. This fixed amount of neurotransmitter is packaged in membrane bound vesicles that undergo an elaborate and dynamic process, which facilitates the release of the neurotransmitter. At a given time the neuron contains vesicles filled with a varied range of neurotransmitter concentrations owing to the continuous recycling and refilling of these vesicles. However, the mechanism underlying the selection of mature vesicles that have the required neurotransmitter content for exocytosis is not known. The membrane of the vesicles forms a direct interface between the intravesicular neurotransmitter concentration and the external molecular machinery that enables exocytosis. Further, the neurotransmitter, serotonin, is known to alter the properties of the lipid bilayer membrane. We sought to determine if serotonin concentration alters membrane properties of the vesicles, which can subsequently affect their exocytosis. Using label-free multiphoton imaging for serotonin and single-photon spectral imaging for Nile red (used as a probe for measuring membrane order), we demonstrated that vesicular serotonin concentration modulates membrane order, elucidating a novel mechanism for selection of mature vesicles for exocytosis.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-01-31 23:03:12', '2022-03-07 23:49:43'),
(730, 'Annual Works Seminar by Mr. Arpan Dey, Dept. of Chemical Sciences, TIFR, Mumbai on February 10, 2022 at 4.00 pm via Zoom platform', 'Title :\nSystematic investigation of toxicity linked parameters of amyloid oligomers\nAbstract :\nParki', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Systematic investigation of toxicity linked parameters of amyloid oligomers</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Parkinson’s disease, Type II diabetes etc.) suggest that the intermediate soluble oligomers (which form during the process of aggregation) are key players in the disease. Decades of extensive research has failed to provide a clear mechanism of disease progression. Here, we have tried to understand a few toxicity-linked parameters of two amyloid peptides by using two completely different approaches. For amyloid beta (Abeta, responsible for Alzheimer\'s disease), we came across a mysterious interaction in its N-terminus. It was manifested in the form of a short lifetime component of an attached dye (rhodamine-B) in cultured rat neuronal cell line which made it toxic. We found a transient interaction of Abeta with a lipid carrier protein apoE that changes its conformation. We validated this observation in primary rat astrocyte cells and also in patient ipsc derived neural stem cells providing a strong correlation between the short lifetime and Alzheimer’s disease. On the other hand, we tried to understand the molecular arrangements of individual oligomers of amylin (responsible for type II diabetes) in a model lipid bilayer. Using a method Q-SLIP that we recently developed, and by using quencher labelled lipids, we found that the monomeric arrangement in the oligomers are very different from the self-replicative arrangement observed in mature amyloid fibrils. This may explain why they are more toxic than the fibrils.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-02-07 00:18:16', '2022-03-07 23:56:29'),
(731, 'Annual Works Seminar by Mr. Mitradip Das, Dept. of Chemical Sciences, TIFR, Mumbai on February 24, 2022 at 4.00 pm via Zoom platform', 'Title:\r\nTracking Protein Dynamics in Atomistic MD simulations\r\nAbstract:\r\nProteins undergo thermally dr', '<p><strong><u>Title</u> :</strong></p><p><span style=\"color:#0000ff;\">Tracking Protein Dynamics in Atomistic MD simulations</span></p><p><strong><u>Abstract</u> :</strong></p><p>Proteins undergo thermally driven dynamical motions on their potential energy surface (PES) which are crucial for biological function, like DNA replication, catalysis and cell signalling. Molecular dynamics (MD) simulations present a powerful tool to computationally sample the PES of a protein and visualize protein dynamics. However, despite the development of techniques to obtain dynamical information from MD trajectories such as principal component analysis (PCA),[1] time-structured independent component analysis (TICA),[2] and autoencoders,[3] the following questions still remain unaddressed: (1) How deterministic/stochastic is protein dynamics? (2) which set of motions are involved during non-equilibrium transitions between different PES minima, and (3) how does protein dynamics evolve with time as a protein samples the PES? In this work, we developed a PCA based metric to study the time-evolution of protein dynamics in MD trajectories. The new metric when applied together with a previously developed energylandscape sensitive measure,[4] provides us with unprecedented insights on changes in protein dynamics as it samples the PES. We demonstrate attractive features of the metric on model PES sampled using Monte Carlo (MC) simulations, and on MD trajectories of ubiquitin,[4] Aβ42 and HIV protease. [5] We foresee the metrics to be useful to study functional aspects of proteins such as enzyme catalysis and allostery. Our metrics can also be potentially used to accelerate MD simulations.</p><p>References:</p><p>1. David, C. C. &amp; Jacobs, D. J. Methods Mol. Biol. 1084, 193–226 (2014).</p><p>2. Naritomi, Y. &amp; Fuchigami, S. J. Chem. Phys. 134, 065101 (2011).</p><p>3. Wehmeyer, C. &amp; Noé, F. J. Chem. Phys. 148, 241703 (2018).</p><p>4. Paul, S., Ainavarapu, S. R. K. &amp; Venkatramani, R. J. Phys. Chem. B 124, 4247–4262 (2020).</p><p>5. Badaya, A. &amp; Sasidhar, Y. U. Sci. Rep. 10, 1–15 (2020).</p>', 'draft', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-02-16 03:55:22', '2024-11-20 21:49:51'),
(732, 'Seminar by Dr. Debayan Chakraborty, The University of Texas at Austin, USA on February 21, 2022 at 4.00 pm via zoom platform', 'Title :\nTaking bumpy rides on the energy landscape\nAbstract :\nDuring the last few decades, the energ', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Taking bumpy rides on the energy landscape</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>During the last few decades, the energy landscape framework has emerged both as a conceptual and a computational tool to understand the intimate connections between biomolecular structure, dynamics, and function. Nonetheless, determining the global topography of the landscape, using standard computational techniques, such as molecular dynamics simulations, has proved challenging because of the computational cost. For many practical applications, it is often sufficient to consider a coarse-grained description of the landscape, in terms of stationary points (minima and transition states). This coarse-graining eliminates the need for dynamical sampling, and the stationary points can be located using tools of geometry optimization. In my talk, I will highlight how this approach makes it easier to take bumpy rides on energy landscapes, particularly for those systems that exhibit multiple competing structures. </p>\n<p><br />I will discuss some recent applications of the energy landscape framework in the context of RNA folding, as well as the extremely slow conformational switching between DNA helix morphologies.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-02-18 03:24:00', '2022-02-18 03:24:00'),
(733, 'Seminar by Dr. Debayan Chakraborty, The University of Texas at Austin, USA on February 22, 2022 at 4.00 pm via zoom platform', 'Title :\nCoarse-grained simulations of biomolecules: from peptides to large assemblies\nAbstract :\nIn', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Coarse-grained simulations of biomolecules: from peptides to large assemblies</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>In my first talk, I illustrated how coarse-graining the energy landscape to its bare essentials (stationary points) can be an effective means of studying biomolecular folding and dynamics over time-scales that are not accessible by standard simulation techniques. Here, I will illustrate how coarse-graining the degrees of freedom (resulting in a simplified representation of the energy landscape) can also be a viable route towards understanding key biophysical phenomena. In this context, I will illustrate how coarse-grained simulations of peptide monomers could provide a microscopic basis for the apparent anomaly observed in the aggregation rates of Ab40 and Ab42. I will show that despite having identical ensemble-averaged properties, reminiscent of random coils, the monomer conformational ensembles of the two sequences encode cryptic signatures of the aggregation-prone (N*) fibrillike states. The nearly one order of magnitude difference between the aggregation rates of Ab40 and Ab42 can be quantitatively explained in terms of the relative populations of the N* states. Interestingly, the transitions to fibril-like states appear<br />to follow Ostwald’s rule of stages. </p>\n<p>Finally, I will present a roadmap to my future research, which will exploit both flavors of coarse-graining to provide molecular insights into functional, as well as aberrant assembly phenomena in biology. Specifically, I will discuss how I plan to answer some intriguing questions related to the hierarchical organization of the genome, as well as liquid-liquid phase separation, and its potential link to protein aggregation diseases.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-02-18 03:27:00', '2022-02-18 03:27:00'),
(734, 'Annual Works Seminar by Mr. Mitradip Das, Dept. of Chemical Sciences, TIFR, Mumbai on February 24, 2022 at 4.00 pm via Zoom platform', 'Title :\nTracking Protein Dynamics in Atomistic MD simulations\nAbstract :\nProteins undergo thermally ', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Tracking Protein Dynamics in Atomistic MD simulations</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Proteins undergo thermally driven dynamical motions on their potential energy surface (PES) which are crucial for biological function, like DNA replication, catalysis and cell signalling. Molecular dynamics (MD) simulations present a powerful tool to computationally sample the PES of a protein and visualize protein dynamics. However, despite the development of techniques to obtain dynamical information from MD trajectories such as principal component analysis (PCA),<sup>[1]</sup> time-structured independent component analysis (TICA),<sup>[2]</sup> and autoencoders,<sup>[3]</sup> the following questions still remain unaddressed: (1) How deterministic/stochastic is protein dynamics? (2) which set of motions are involved during non-equilibrium transitions between different PES minima, and (3) how does protein dynamics evolve with time as a protein samples the PES? In this work, we developed a PCA based metric to study the time-evolution of protein dynamics in MD trajectories. The new metric when applied together with a previously developed energylandscape sensitive measure,<sup>[4]</sup> provides us with unprecedented insights on changes in protein dynamics as it samples the PES. We demonstrate attractive features of the metric on model PES sampled using Monte Carlo (MC) simulations, and on MD trajectories of ubiquitin,<sup>[4]</sup> Aβ42 and HIV protease.<sup> [5]</sup> We foresee the metrics to be useful to study functional aspects of proteins such as enzyme catalysis and allostery. Our metrics can also be potentially used to accelerate MD simulations.</p>\n<p>References:</p>\n<p>1. David, C. C. &amp; Jacobs, D. J. Methods Mol. Biol. 1084, 193–226 (2014).</p>\n<p>2. Naritomi, Y. &amp; Fuchigami, S. J. Chem. Phys. 134, 065101 (2011).</p>\n<p>3. Wehmeyer, C. &amp; Noé, F. J. Chem. Phys. 148, 241703 (2018).</p>\n<p>4. Paul, S., Ainavarapu, S. R. K. &amp; Venkatramani, R. J. Phys. Chem. B 124, 4247–4262 (2020).</p>\n<p>5. Badaya, A. &amp; Sasidhar, Y. U. Sci. Rep. 10, 1–15 (2020).</p>', 'draft', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-02-18 03:51:19', '2022-02-18 03:51:19'),
(735, 'Annual Works Seminar by Mr. Debojyoti Roy, Dept. of Chemical Sciences, TIFR, Mumbai on February 25, 2022 at 4.30 pm via Zoom platform', 'Title :\nOrganic Photoredox catalysis inside Supramolecular Cavities\nAbstract :\nNatural enzymes carry', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Organic Photoredox catalysis inside Supramolecular Cavities</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Natural enzymes carry out organic transformations efficiently via pre-organizing substrates inside hydrophobic cavities to achieve selectivity and specificity during reaction turnover. Chemists have mimicked the enzymes by creating supramolecular cavities which can serve as active sites for catalysis. Recently it has been demonstrated that organic C-H activation reactions can be carried out inside a metal-based cationic water-soluble nanocage with visible light activation. To completely report a metal-free photoactivation scheme for carrying out catalysis, we planned to synthesize an all-organic cationic nanocage ExBox<sup>4+</sup>. By incarcerating a series of polyaromatic hydrocarbon (PAH) guests inside the ExBox<sup>4+</sup> we were able to generate host-guest CT states that enabled a completely new metal-free C-H activation chemistry in acetonitrile under ambient conditions. The characterization of the host-guest complexes with PAHs of different sizes and their photoexcited dynamics for C-H bond activation using transient absorption spectroscopy will be discussed in the first part of the talk.            </p>\n<p>The second part of my talk will be dedicated to the formation of C-C bonds through sp C-H activation in aqueous confinement.  A Pd-based hybrid metal-organic supramolecular cavity was used in this case to encapsulate the guest phenyl acetylene. Upon visible light photoirradiation we found dimer products which indicated C-C bond formation after proton-coupled electron transfer steps. Characterization of photoproducts via GCMS and the mechanistic insights towards the formation of coupling products will be demonstrated using time-resolved absorption measurements.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-02-21 22:58:59', '2022-02-21 22:58:59'),
(736, 'Seminar by Prof. Henrik Ottosson Department of Chemistry – Ångström Laboratory, Uppsala University, Sweden, on February 28, 2022 at 4.00 pm on Zoom platform', 'Title :\nExcited State Aromaticity and Antiaromaticity: From Scopes to Pitfalls\nAbstract :\nUse of the', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Excited State Aromaticity and Antiaromaticity: From Scopes to Pitfalls</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Use of the excited state aromaticity and antiaromaticity concepts (ESA &amp; ESAA) to rationalize excited state properties and processes has grown rapidly in recent years. <sup>[1-3]</sup> The concepts are often described by Baird\'s 4n and 4n+2 rules for, respectively, aromaticity and antiaromaticity in the lowest ππ* excited states, and they have been utilized to rationalize various photoreactions, <sup>[4-6]</sup> to explore and design photofunctional molecules, <sup>[7-9]</sup> and to interpret fundamental excited state properties.<sup> [10-14]</sup> The concepts can likely find use in a variety of areas, ranging from astrochemistry and organic synthesis to biophysics and photovoltaics. Examples of such applications will be presented. Yet, simultaneously as the concepts are applied within gradually more areas it is important to explore their limitations, complications and pitfalls so as to avoid improper use; an induced diatropic ring current in the T1 state does not always indicate Baird-aromaticity. Indeed, there are molecules which are Hückel-aromatic in their excited states, <sup>[14,15]</sup> and some quinoidal compounds can be simultaneously Hückel- and Baird-aromatic. <sup>[16,17]</sup> Finally, heterocycles as well as macrocycles with tentative ESA character expose a number of complications, both computationally and conceptually. <sup>[18,19]</sup> Thus, at the same time as we explore and expand the scopes of the ESA &amp; ESAA concepts we also need an improved knowledge on their limitations, complications and pitfalls. The talk will address both aspects.</p>\n<p>[1] N. C. Baird, J. Am. Chem. Soc. 1972, 94, 4941 - 4948.</p>\n<p>[2] H. Ottosson, Nat. Chem. 2012, 4, 969 – 971.</p>\n<p>[3] M. Rosenberg, C. Dahlstrand, K. Kilså, H. Ottosson, Chem. Rev. 2014, 114, 5379 - 5425.</p>\n<p>[4] R. Mohamed, et al., J. Am. Chem. Soc. 2015, 137, 15441 - 15450.</p>\n<p>[5] R. Papadakis, et al. Nat. Commun. 2016, 7, 12961.</p>\n<p>[6] T. Slanina, et al., J. Am. Chem. Soc. 2020, 142, 10942 - 10954.</p>\n<p>[7] M. Hada, et al., J. Am. Chem. Soc. 2017, 139, 15792 - 15800.</p>\n<p>[8] O. El Bakouri, J. R. Smith, H. Ottosson, J. Am. Chem. Soc. 2020, 142, 5602 - 5617.</p>\n<p>[9] A. Pati, et al., Proc. Natl. Acad. Sci., 2020, 117, 24305 - 24315.</p>\n<p>[10] H. Ottosson, et al, Chem. Eur. J. 2007, 13, 6998 - 7005.</p>\n<p>[11] M. Rosenberg, H. Ottosson, K. Kilså, Phys. Chem. Chem. Phys, 2011, 13, 12912 - 12919.</p>\n<p>[12] Y. M. Sung, et al., Nat. Chem. 2015, 7, 418 - 422.</p>\n<p>[13] L. Karas, C.-H. Wu, H. Ottosson, J. I.-C. Wu. Chem. Sci. 2020, 11, 10071 - 10077.</p>\n<p>[14] B. Uruganti, J. Wang, B. Durbeej, Org. Lett., 2017, 19, 4818 - 4821.</p>\n<p>[15] W. Zeng, O. El Bakouri, D. Szczpanik, H. Bronstein, H. Ottosson, Chem. Sci., 2021, 12, 6159 - 6171.</p>\n<p>[16] K. Jorner, F. Feixas, R. Ayub, R. Lindh, M. Solà, H. Ottosson, Chem. Eur. J. 2016, 22, 2793 - 2800.</p>\n<p>[17] S. Escayola, et al. Angew. Chem. Int. Ed. 2021, 60, 10255 - 10265.</p>\n<p>[18] Y. Shoji, et al., Angew. Chem. Int. Ed. 2021, 60, 21817 - 21823.</p>\n<p>[19] R. Ayub, O. El Bakouri, J. R. Smith, K. Jorner, H. Ottosson, J. Phys. Chem. A, 2021, 125, 570 - 584.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-02-21 23:06:18', '2022-02-21 23:06:18');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(737, 'Annual Works Seminar by Ms. Debanjana Das, Dept. of Chemical Sciences, TIFR, Mumbai on March 8, 2022 at 4.00 pm via Zoom platform', 'Title :\nFolding and unfolding pathways of azurin(s): Is the metal ion important?\nAbstract :\n', '<h3>Title</h3>\n<p><span style=\"color: #0000ff;\">Folding and unfolding pathways of azurin(s): Is the metal ion important?</span></p>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p><img style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"data:image/png;base64,[encoded data, 16199 characters]\[encoded data, 16188 characters]', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-03-02 22:32:30', '2022-03-02 22:32:30'),
(738, 'Annual Works Seminar by Mr. Manikandan M, Dept. of Chemical Sciences, TIFR, Mumbai on March 14, 2022 at 4.00 pm via Zoom platform', 'Title :\nA Ruthenium (II)-Ferrocene hetero bimetallic anticancer agent circumvents cisplatin resistan', '<h3>Title</h3>\n<h3><span style=\"color: #0000ff;\">A Ruthenium (II)-Ferrocene hetero bimetallic anticancer agent circumvents cisplatin resistance</span></h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Platinum drugs cisplatin, carboplatin and oxaliplatin are the frontline treatment options for a variety of localized as well as metastatic cancers.<sup>1</sup> However, their efficacy is often comprised due to inherent and acquired resistance in cancers. To circumvent this issue, we recently designed dual-targeting platinum-ferrocene (<strong>Pt-Fc</strong>) bimetallic hybrids with potent anticancer activity (manuscript submitted). The <strong>Pt-Fc</strong> derivative has much lower platinum cross-resistance compared to cisplatin, but was unable to circumvent the resistance completely.   Encouraged by the lack of cross-platinum resistance of ruthenium (Ru) compounds,<sup>2</sup> we synthesized a Ru-Fc derivative (<strong>1</strong>) and evaluated its anticancer potential <em>in vitro</em>. Moreover, we performed a structure activity relationship on this class of compound (<strong>1 - 6</strong>) to understand the role of various functionalities. We confirmed by comparing IC<sub>50</sub> values in platinum sensitive and resistance cancer cells that <strong>1</strong> has the ability to circumvent Pt resistance. In depth biological studies were performed to identify intracellular targets and mechanism of action of this promising anticancer drug candidate.  </p>\n<p><strong>Reference</strong></p>\n<ol>\n<li>Kenny, R. G.; Marmion, C. J., Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens? <em> Rev. </em><strong>2019,</strong> <em>119</em> (2), 1058-1137.</li>\n<li>Jyoti Yellol, Sergio A. Perez, ́ Alicia Buceta, Gorakh Yellol, Antonio Donaire, Piotr Szumlas, Patrick J. Bednarski., Gamall Makhloufi, Christoph Janiak, Arturo Espinosa,∥ and JoséRuiz*,† <em>Med.Chem</em>, <strong>2015</strong>, <em>58</em>, 7310-7327</li>\n</ol>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-03-07 23:46:13', '2022-03-07 23:47:34'),
(739, 'Annual Works Seminar by Ms. Simran Arora, Dept. of Chemical Sciences, TIFR, Mumbai on March 17, 2022 at 4.00 pm via Zoom platform', 'Title :\nCrowding-induced effects on the stability of ubiquitin-family proteins\nAbstract :\nThe interi', '<h3>Title</h3>\n<h3>Crowding-induced effects on the stability of ubiquitin-family proteins</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>The interior of the cell is highly complex and crowded with various macromolecules.<sup>1</sup> Such complex environment can alter thermodynamic, structural and functional properties of proteins as compared to dilute buffer conditions. To study the effect of crowding on protein stability <em>in vitro</em>, researchers often use synthetic polymers such as dextran, polyethylene glycol, ficoll, etc. as crowding agents.<sup>2</sup> These cosolutes can influence the stability of the protein by hard-core repulsions (crowding) and soft chemical interactions (sticking).<sup>3</sup> It has been found that cosolute-induced effects on proteins depend upon the size and shape of the cosolute as well as on the nature of the test protein.<sup>4,5</sup> To understand the factors influencing the cosolute-induced effects, we use two well-studied structurally homologous proteins of similar sizes, ubiquitin and N-del SUMO-1 (SUMO-1 protein without its unstructured N-terminal tail). From thermal and chemical denaturation experiments performed on ubiquitin, we observed that PEG-20000 destabilizes the protein. The extent of destabilization depends on size and concentration of the PEG polymer. However, N-del SUMO-1 was found to start aggregating within few minutes on addition of 15% PEG-20000 at pH 7.4. In contrast, another cosolute dextran-20000 is found to increase the stability of ubiquitin. The effect of dextran on SUMO-1 is currently being studied.</p>\n<p> References:</p>\n<ol>\n<li>Zimmerman, S. B., and S. O. Trach<em>. J. Mol. Biol</em>.1999, 222, 599–620.</li>\n<li>Zhou, H. X., G. Rivas, and A. P. Minton. <em> Rev. Biophys</em>. 2008, 37, 375–397.</li>\n<li>Grasso, D. M.; Sciacca, M. F. M.; Milardi, D.; Pappalardo, M.;La Rosa, C. <em> Therm. Anal. Calorim.</em> 2006, 86, 311−314.</li>\n<li>Nilimesh Das and Pratik Sen <em>The Journal of Physical Chemistry B</em>2020, 124, 5858-5871</li>\n<li>Nilimesh Das and Pratik Sen <em> J. Biol. Macromol.</em> 2019, 141, 843-854.</li>\n</ol>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-03-13 22:47:03', '2022-03-13 22:47:03'),
(740, 'Annual Works Seminar by Mr. Ritaj Tyagi, Dept. of Chemical Sciences, TIFR, Mumbai on March 21, 2022 at 4.00 pm via Zoom platform', 'Title :\nQuantifying the impact of halogenation on intermolecular interactions of aromatic systems\nAb', '<h3>Title</h3>\n<h3>Quantifying the impact of halogenation on intermolecular interactions of aromatic systems</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Recently, a new generation of self-assembled structures made up of perhalobenzenes (PHBs), C<sub>6</sub>X<sub>6</sub>, is reported that uses halogen bonding type interactions for self-assembly <sup>[1]</sup>. These molecules have a varied range of applications owing to their good optical and electrical properties because of their high electron affinity and diffuse electronic states <sup>[2,3]</sup>. PHB interactions involve X-X, π-π, and X-π interactions, leading to a complex interplay of intermolecular interactions. Here we quantify the relative binding energies for different conformations of PHBs, as a function of halogenation at the level of RPA-AXK. We observe that going from F to I the interaction energies increase four-fold with the parallel displaced conformation being the most stable one for all cases.  We also established high-level “benchmark” binding energies using the DLPNO-CCSD(T) method where we observe similar trends in the binding energies of dimers. However, we observed large percentage errors in the DLPNO-CCSD(T) binding energies compared to CCSD(T). These findings indicate that more caution is required in choosing so-called “benchmark method” while dealing with non-covalent interactions involving halogen bonding or molecules having large polarizability.</p>\n<p> In addition, I will briefly discuss the work towards extending the applicability of response-function based methods for studying electron attachment energies of large systems. I will discuss the parallarization efforts using the corray feature of FORTRAN programming, and also developing computationally cheap approximations to GKS-spRPA<sup>[3-4]</sup> method.</p>\n<p><strong> </strong><strong>References:</strong></p>\n<p>[1] Teyssandier, J. <em>et. al.</em> <em>ChemistryOpen</em> <strong>2020</strong>, 9, 225–241</p>\n<p>[2] Nyikos, L. <em>et. al.</em> <em>The Journal of Physical Chemistry</em> <strong>1980</strong>, 84, 1154–1155</p>\n<p>[3] Voora, V. K. <em>The Journal of Physical Chemistry Letters</em> <strong>2020</strong>, 12, 433–439</p>\n<p>[4] Voora, V. K. <em>et. al. Physical Review A, </em><strong>2019</strong>, 99(1)</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-03-15 07:14:05', '2022-03-15 07:14:05'),
(741, 'Annual Works Seminar by Mr. Rishi Verma, Dept. of Chemical Sciences, TIFR, Mumbai on March 24, 2022 at 4.00 pm via Zoom platform', 'Title :\nTo be announced', '<h3>Title</h3>\n<h3>To be announced</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-03-15 22:33:24', '2022-03-15 22:33:24'),
(742, 'Seminar by Dr. Amrit Venkatesh, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland, on March 28, 2022 at 4.00 pm via zoom platform', 'Title :\nSensitizing solid-state NMR using fast magic angle spinning and dynamic nuclear polarization', '<h3>Title</h3>\n<h3>Sensitizing solid-state NMR using fast magic angle spinning and dynamic nuclear polarization</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>NMR is a powerful atomic-level characterization technique but it suffers from an intrinsically poor sensitivity, limiting its application to common spin-1/2 isotopes such as <sup>1</sup>H, <sup>13</sup>C, <sup>15</sup>N, <sup>29</sup>Si, <sup>31</sup>P etc. Whereas, over 75% of the periodic table consists of unreceptive nuclei that are rarely studied using NMR due to the lack of sensitive approaches. Fast magic angle spinning (MAS) enables the observation of the sensitive <sup>1</sup>H spins in solids by narrowing <sup>1</sup>H NMR lineshapes. This allows the use of <sup>1</sup>H spins as ‘spies’ for indirect detection of other nuclei, much like solution NMR spectroscopy. Here, we will demonstrate how <sup>1</sup>H detection methods in solids allow meaningful chemical information to be extracted from low gyromagnetic ratio nuclei, half-integer quadrupolar nuclei and the spin-1 isotope <sup>14</sup>N.</p>\n<p>The sensitivity of NMR can alternatively be drastically improved using dynamic nuclear polarization (DNP) from nearby electron spins. Gd(III) complexes are attractive exogenous PAs for MAS DNP due to their high chemical stability, but they are infrequently used for DNP due to their limited DNP efficiency. Here, we will establish a model that correlates the DNP enhancements provided by Gd(III) complexes with zero-field splittings. These results will pave the way for the development of efficient Gd(III) polarizing agents.</p>\n<p>Finally, the application of these state-of-the-art solid-state NMR techniques to characterize small molecule pharmaceuticals, organometallic compounds and semi-conducting nanomaterials will be demonstrated.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-03-15 22:42:57', '2022-03-15 22:42:57'),
(743, 'Seminar by Dr. Ketaki Belsare, University of California, USA on March 29, 2022 at 9.00 am via zoom platform', 'Title :\nSoluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular upt', '<h3>Title</h3>\n<h3>Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Proteins and enzymes are basic biomolecules and are the major structural and functional element of a cell. Mutations in cellular proteins result in changes in their functionality due to either loss of function or toxic gain of function.<br />In the first talk, I will describe a protein- Triggering receptor expressed on myeloid cells 2 (TREM2) which is a single-pass transmembrane receptor of the immunoglobulin superfamily that is secreted in a soluble (sTREM2) form. Mutations in TREM2 have been linked to increased risk of Alzheimer’s disease (AD). A prominent neuropathological component of AD is deposition of the amyloid beta (Aβ) into plaques, particularly Aβ40 and Aβ42. While the membrane-bound form of TREM2 is known to facilitate uptake of Aβ fibrils and the polarization of microglial processes toward amyloid plaques, the role of its soluble ectodomain, particularly in interactions with monomeric or fibrillar Aβ has been less clear. Using biophysical studies and biochemical &amp; cellular assays, we probed the interaction of sTREM2 and Aβ. Kinetic analysis shows that sTREM2 inhibits the secondary nucleation step in the fibrillization of Aβ, while having little effect on the primary nucleation pathway. Furthermore, binding of sTREM2 to fibrils markedly enhanced uptake of fibrils into human microglial and neuroglioma derived cell lines. The disease-associated<br />sTREM2 mutant, R47H, displayed little to no effect on fibril nucleation and binding, but it decreased uptake and functional responses markedly. Finally, I will describe the structure of the WT sTREM2–Aβ fibril complex using integrative molecular modeling based primarily on the cross- linking mass spectrometry data. The model shows that sTREM2 binds fibrils along one face of the structure, leaving a second, mutation-sensitive site free to mediate cellular binding and uptake.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-03-15 22:54:01', '2022-03-15 22:54:01'),
(744, 'Seminar by Dr. Ketaki Belsare, University of California, USA on March 30, 2022 at 9.00 am via zoom platform', 'Title :\nDesign and Engineering of Natural and Artificial Biocatalyst using Directed Evolution and D', '<h3>Title</h3>\n<h3>Design and Engineering of Natural and Artificial Biocatalyst using Directed Evolution and De novo Design Approaches for Sustainable Chemistry</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Proteins are molecular machines whose function depends on their ability to achieve complex folds with precisely defined structural and dynamic properties. AlphaFold, Rosetta, and machine learning approaches have been a breakthrough in the field of protein design and structure determination which can be used to predict quite accurately the secondary structure of most proteins from many different families. However, to achieve an “active” or “attractive” protein/enzyme is still a challenging feat which can be tackled using protein engineering. Continuing from my talk yesterday, I will describe how purposeful introduction of mutation can be beneficial for improving properties of a protein using examples of Cytochrome P450 and an artificial dirhodium cyclopropanase. Furthermore, I will describe “de novo protein design approach”, a rational way of designing proteins from scratch based on principles of protein folding, thermodynamics, and energetics using an exemplar of a four-helix bundle and a heme metal co-factor. Concluding my talk will be a roadmap to future research directions based on a) metalloenzymes for green chemistry and sustainable catalysis and b) study of metalloproteins as sensors in redox cellular pathways, imbalances in which are associated with a variety of diseases (cancer, neurological disorders, tuberculosis) using<br />mutagenic, metal-substitution, and protein engineering approaches.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-03-15 22:56:45', '2022-03-15 22:56:45');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(745, 'Annual Works Seminar by Mr. Anoop Philip, Dept. of Chemical Sciences, TIFR, Mumbai on March 31, 2022 at 4.00 pm via Zoom platform', 'Title :\nRational design of Xenopeptides; steering towards biological activity\nAbstract :\nProtein fol', '<h3>Title</h3>\n<h3>Rational design of Xenopeptides; steering towards biological activity</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Protein folding events are crucial steps that govern protein structure and function and can differ from one another. Some of these events are limited by kinetics and thermodynamics and determine the major hurdles for protein folding<sup>1</sup>. The introduction of a minimal sequence that can replicate the structure of such a key intermediate back into the protein externally during the protein folding event can alter this process. Such constrained peptide sequences, called xeno-peptides can have various biological implications depending upon the protein of interest. In the case of proteins like ubiquitin protein folding becomes faster in the presence of xeno-peptides, called a xeno-nuclei, as previously reported in our lab<sup>2</sup>. We have tried to make better xeno-peptide candidates for ubiquitin in this work and see if it can be observed in biological systems. The concept of xeno-peptides can have other relevant implications like turning these peptides into an antibiotic, inhibiting the function of relevant proteins in biological systems. We have designed xeno-peptides that can act as zippers that can inhibit functional beta-barrel outer membrane proteins in pathogens like gram-negative bacteria. This can open up a new regime of drug candidates having an entirely new modality of antibiotic activity which can help tackle the emerging antibiotic resistance. </p>\n<p>1. Galzitskaya, O. V, Ivankov, D. N. &amp; Finkelstein, A. V. Folding nuclei in proteins. <em>FEBS Lett.</em> <strong>489</strong>, 113–118 (2001).</p>\n<p>2. Das, A. <em>et al.</em> Rational Design of Protein-Specific Folding Modifiers. <em>J. Am. Chem. Soc.</em> <strong>143</strong>, 18766–18776 (2021).</p>\n<p>3. A., F. M. &amp; T., W. C. Antibiotics for Emerging Pathogens. <em>Science (80-. ).</em> <strong>325</strong>, 1089–1093 (2009).</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-03-29 22:37:37', '2022-03-29 23:57:58'),
(746, 'Seminar by Dr. Chayan Dutta, Rice University, USA on April 5, 2022 at 4.00 pm via zoom platform', 'Title :\r\nUnderstanding molecular orientation and transport: from electrochemical interface to porous', '<p><strong><u>Title</u> :</strong></p><h3>Understanding molecular orientation and transport: from electrochemical interface to porous materials</h3><p><strong><u>Abstract</u> :</strong></p><p style=\"text-align:justify;\">Nanoscale physical properties such as molecular orientation and transport play a fundamental role in the material function and understanding the structure-function relationship is crucial in a variety of fields. As an experimental physical chemist, I strive to explore fundamental physical processes utilizing a range of spectroscopic and optical microscopy techniques. In this talk, I will discuss some of my recent studies on water response at electrochemical surfaces using non-linear vibrational sum frequency generation spectroscopy and molecular transport in complex environments using single-particle microscopy methods. We know that water forms an extended hydrogen bond network that is terminated at the interface producing an inherent inhomogeneity. In the first part of my talk, I will discuss how this interfacial water responds asymmetrically to the externally applied potential. In the second part of my talk, I will talk about heterogeneous mass transport processes in porous materials as well as in live-cell environments. I have designed and built a novel three-color widefield fluorescence microscope for tracking dynamics in 3D while imaging structures of cellular organelles at various depths within the cell. I will talk about the working principles of this novel microscope and demonstrate the complex transport of cholera toxin-B (CTxB) around the Golgi apparatus inside live baby hamster kidney (BHK) cells. This study quantifies heterogeneous transport behavior, especially the active transport processes of CTxB when compared to the transport inhibitory drug-treated BHK cells.</p>', 'draft', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-03-29 22:40:18', '2024-11-20 21:56:03'),
(747, 'Seminar by Dr. Chayan Dutta, Rice University, USA on April 6, 2022 at 4.00 pm via zoom platform', 'Title :\r\nHeterogeneous transport dynamics at soft polymer interfaces\r\nAbstract :\r\nMass transport is an', '<p><strong><u>Title</u> :</strong></p><h3>Heterogeneous transport dynamics at soft polymer interfaces</h3><p><strong><u>Abstract</u> :</strong></p><p style=\"text-align:justify;\">Mass transport is an important physical process with crucial implications in several biophysical, materials, and engineering applications. Molecular transport at soft material interfaces determines material functions that range from how nano- and microplastics disrupt biological membranes and how photoacid diffusion in photoresist polymers impacts semiconductor manufacturing. It is crucial to obtain a mechanistic understanding of the structure and dynamics occurring in these materials, but the inherent heterogeneity in material structure and chemistry makes characterization by ensemble measurements difficult. Single-particle techniques analyze one particle at a time providing nanoscale molecular information uncovering crucial materials processes. I aim to study the nanoscale transport of single particles to reveal material heterogeneity and its implications in biological and material sciences using single-particle techniques. I will develop novel optical microscopy and spectroscopy techniques and apply single-molecule methods for biophysical understanding of particle transport at the nanoscale, and solve real-life problems related to materials, environment, and human health. In this talk, I will present two main areas of research in my laboratory focused on understanding heterogeneous transport processes on soft material surfaces. First, I will talk about understanding the transport processes of plastic nanoparticles (PNP or nanoplastic). PNPs have an immense impact on the environment and can pose a significant health risk due to their interactions with biological membranes. Mechanistic understanding of PNP transport dynamics on model biomimetic systems is limited and single-particle methods with high spatio-temporal resolution are required to uncover nanoscale effects. Using novel optical microscopy techniques, single-particle tracking (SPT), and super-localization analysis I aim to understand the basic mechanism of PNP interaction, uptake, and fate on model membranes, vesicles, and live biological systems. The second part of my talk will be focused on understanding nanoscale molecular diffusion of photoacid in resist materials using single-particle methods to understand the limiting factors of resolution enhancement in the Extreme Ultraviolet (EUV) photolithography used in nanomanufacturing.</p>', 'draft', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-03-29 22:41:50', '2024-11-20 21:56:56'),
(748, 'Annual Works Seminar by Dr. Neha Choudhary, Dept. of Chemical Sciences, TIFR Mumbai, on April 4, 2022 at 4.00 pm via Zoom platform', 'Title :\nDesign and Development of Non-macrocyclic Chelators for Mn-based MRI Contrast Agents\nAbstrac', '<h3>Title</h3>\n<h3>Design and Development of Non-macrocyclic Chelators for Mn-based MRI Contrast Agents</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Contrast-enhanced magnetic resonance imaging (MRI) has become an indispensable non-invasive diagnostic tool since the FDA approval of Gd-DTPA in 1988.1 However, lately, physicians have reported nephrogenic systemic fibrosis in patients with poor kidney function and a history of Gd-based contrast agent use for MRI scans.2 This has led to safety concerns that limit the use of Gd-based contrast agents and ultimately have sparked the search for alternative contrast agents. Mn2+ being an essential divalent metal ion makes an attractive alternative to Gd3+ as it offers ideal properties for efficient T1-weighted MR imaging probes such as 5/2 spin quantum number, rapid water-exchange rates, and long electronic relaxation time.3 In addition to that, the positron emitter manganese-52g is of increasing clinical relevance for its use for PET imaging3 as well as for manganese-52g/55 based bimodal PET/MRI agents. To harness the potential of Mn2+ ion for MRI and PET applications, we are working on developing a library of acyclic chelators using fundamental principles of coordination chemistry. Here, I will talk about the design and development of new heptadentate chelators with N5O2 donor set consisting of three pyridine rings and ethanolamine/carboxylate arms. The ligand, H2PyMEA has been characterized by 1H NMR and 13C NMR and its coordination chemistry has been investigated with 3d transition metal ions (Mn2+, Cu2+, Fe2+, and Zn2+) by employing UV-Vis absorbance spectroscopy, 1H NMR, and mass spectroscopy. Ligand synthesis, characterization and preliminary relaxometry studies of the Mn2+-H2PyMEA complex will be discussed along with ongoing synthesis of another ligand, H2PyGly.</p>\n<p><br />References<br />(1) Caravan, P.; J. Ellison, J.; J. McMurry, T.; B. Lauffer, R. Chem. Rev. 1999, 99, 2293–2352. (2) Le Fur, M.; Caravan, P. Metallomics, 2019,11, 240–254.<br />(3) Wahsner, J.; Gale, E. M.; Rodríguez-Rodríguez, A.; Caravan, P. Chem. Rev. 2019, 119, 957–1057.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-03-29 22:55:10', '2022-03-30 05:24:11'),
(749, 'Seminar by Dr. Chayan Dutta, Rice University, USA on April 5, 2022 at 4.00 pm via zoom platform', 'Title :\nUnderstanding molecular orientation and transport: from electrochemical interface to porous ', '<h3>Title</h3>\n<h3>Understanding molecular orientation and transport: from electrochemical interface to porous materials</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Nanoscale physical properties such as molecular orientation and transport play a fundamental role in the material function and understanding the structure-function relationship is crucial in a variety of fields. As an experimental physical chemist, I strive to explore fundamental physical processes utilizing a range of spectroscopic and optical microscopy techniques. In this talk, I will discuss some of my recent studies on water response at electrochemical surfaces using non-linear vibrational sum frequency generation spectroscopy and molecular transport in complex environments using single-particle microscopy methods. We know that water forms an extended hydrogen bond network that is terminated at the interface producing an inherent inhomogeneity. In the first part of my talk, I will discuss how this interfacial water responds asymmetrically to the externally applied potential. In the second part of my talk, I will talk about heterogeneous mass transport processes in porous materials as well as in live-cell environments. I have designed and built a novel three-color widefield fluorescence microscope for tracking dynamics in 3D while imaging structures of cellular organelles at various depths within the cell. I will talk about the working principles of this novel microscope and demonstrate the complex transport of cholera toxin-B (CTxB) around the Golgi apparatus inside live baby hamster kidney (BHK) cells. This study quantifies heterogeneous transport behavior, especially the active transport processes of CTxB when compared to the transport inhibitory drug-treated BHK cells.</p>', 'draft', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-03-29 22:59:02', '2022-03-29 22:59:02'),
(750, 'Seminar by Dr. Chayan Dutta, Rice University, USA on April 6, 2022 at 4.00 pm via zoom platform', 'Title :\nHeterogeneous transport dynamics at soft polymer interfaces\nAbstract :\nMass transport is an', '<h3>Title</h3>\n<h3>Heterogeneous transport dynamics at soft polymer interfaces</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Mass transport is an important physical process with crucial implications in several biophysical, materials, and engineering applications. Molecular transport at soft material interfaces determines material functions that range from how nano- and microplastics disrupt biological membranes and how photoacid diffusion in photoresist polymers impacts semiconductor manufacturing. It is crucial to obtain a mechanistic understanding of the structure and dynamics occurring in these materials, but the inherent heterogeneity in material structure and chemistry makes characterization by ensemble measurements difficult. Single-particle techniques analyze one particle at a time providing nanoscale molecular information uncovering crucial materials processes. I aim to study the nanoscale transport of single particles to reveal material heterogeneity and its implications in biological and material sciences using single-particle techniques. I will develop novel optical microscopy and spectroscopy techniques and apply single-molecule methods for biophysical understanding of particle transport at the nanoscale, and solve real-life problems related to materials, environment, and human health. In this talk, I will present two main areas of research in my laboratory focused on understanding heterogeneous transport processes on soft material surfaces. First, I will talk about understanding the transport processes of plastic nanoparticles (PNP or nanoplastic). PNPs have an immense impact on the environment and can pose a significant health risk due to their interactions with biological membranes. Mechanistic understanding of PNP transport dynamics on model biomimetic systems is limited and single-particle methods with high spatio-temporal resolution are required to uncover nanoscale effects. Using novel optical microscopy techniques, single-particle tracking (SPT), and super-localization analysis I aim to understand the basic mechanism of PNP interaction, uptake, and fate on model membranes, vesicles, and live biological systems. The second part of my talk will be focused on understanding nanoscale molecular diffusion of photoacid in resist materials using single-particle methods to understand the limiting factors of resolution enhancement in the Extreme Ultraviolet (EUV) photolithography used in nanomanufacturing.</p>', 'draft', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-03-29 23:00:27', '2022-03-29 23:00:27'),
(751, 'Annual Works Seminar by Mr. Debsankar Saha Roy, Dept. of Chemical Sciences, TIFR, Mumbai on April 7, 2022 at 4.00 pm in AG-80', 'Title :\nCan a neurotransmitter control its own exocytosis?\nAbstract :\nIt has been observed that vesi', '<h3>Title</h3>\n<h3>Can a neurotransmitter control its own exocytosis?</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">It has been observed that vesicular exocytosis of neurotransmitters results in “quantal release”, i.e., each vesicle releases a similar amount of neurotransmitter. However, vesicular neurotransmitter uptake by the transporters is not an instantaneous process; therefore, there would always be vesicles with different concentrations of neurotransmitters. How does the cell know which vesicle contains an adequate amount of neurotransmitters, and is therefore “mature” enough to be exocytosed? This problem is even more relevant for somatic neurotransmitter vesicles (such as serotonergic ones), where there is a rather large variation of the “age” of vesicles after their formation. We propose that serotonin interacts with the vesicular membranes, resulting in a change in the membrane mechanical properties, which in turn provides a signal for exocytosis. We have recently shown that serotonin incorporation reduces the mechanical stiffness of artificial lipid bilayers (1). Here we show that for serotonergic vesicles in a neuronal cell line, the vesicular membrane becomes less ordered as the vesicular serotonin concentration increases from a few mM to a few hundred mM. Using three-photon microscopy, we quantify vesicular serotonin concentration in a label-free manner.  We simultaneously perform spectral imaging of the dye Nile red to measure vesicular membrane order. We find a negative correlation between the serotonin intensity and membrane order. Fluorescence lifetime imaging of the mechanosensitive dye FliptR corroborate these results, proving that change of membrane order provides a readout of the intra-vesicular serotonin concentration. Additionally, upon depolarization of the cells, we observe preferential exocytosis of vesicles with lower membrane order.  We infer that membrane mechanics provides a functional readout of the lumenal serotonin concentration, enabling the exocytosis process to preferentially release the well-filled vesicles.</p>\n<p>(1) Dey et al., Chem. Eur. J., Volume27 (2021) 7533-7541</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-04-04 05:31:45', '2022-04-04 05:31:45'),
(752, 'Seminar by Dr. Sudeshna Manna, University of Utah, USA on April 11, 2022 at 4.00 pm in AG-69', 'Title :\nNucleic acid engineering as a toolbox for studying nucleic acids conformations and imaging s', '<h3>Title</h3>\n<h3>Nucleic acid engineering as a toolbox for studying nucleic acids conformations and imaging small molecules in cells</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"margin: 0cm; margin-bottom: .0001pt; text-align: justify;\">Nucleic acids’ biological functions largely depend on their structure in the native cellular environment. In addition to the classical double helical structure, nucleic acids adopt various secondary and tertiary structures like hairpin, pseudoknot, bulge, triplex, tetraplex (G-quadruplex and i-motif) etc. to perform their cellular functions. Biophysical techniques like fluorescence, NMR, EPR, X-ray have been used widely to study nucleic acids <em><span style=\"color: #0e101a;\">in vitro</span></em>. However, understanding the structure-function relationship of nucleic acid motifs in the native cellular environment has remained a major challenge due to the paucity of chemical probes that can be used both in vitro and in vivo. Therefore, the development of biophysical tools, which will enable the probing of nucleic acid structure, dynamics and recognition properties in both cell-free and cellular environments, will be highly beneficial. In my talk, I will present the design, synthesis, and utilization of a dual-app responsive nucleoside probe composed of two labels (fluorescence and 19F NMR) to investigate a therapeutically relevant non-canonical DNA structure, e.g., G-quadruplex in live <em><span style=\"color: #0e101a;\">Xenopus laevis</span></em> oocytes and probe metal ion-induced conformational switch in a viral RNA motif. In the 2nd part of my talk, I will be presenting my current research focused on RNA engineering as a synthetic biology tool for molecular imaging in bacteria. I will describe the development of genetically encodable RNA-based fluorescent biosensors for live-cell imaging of a bacterial metabolite. These biosensors are made of a riboswitch domain that changes conformation upon binding to a specific small-molecule ligand and a fluorogenic RNA aptamer. A crucial aspect of the applications of these riboswitch-based sensors is their turn-on kinetics. A comparison of the in vivo turn-on kinetics of different riboswitch-based sensors will also be discussed in my presentation.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-04-04 23:14:29', '2022-04-04 23:14:29'),
(753, 'Seminar by Dr. Sudeshna Manna, University of Utah, USA on April 12, 2022 at 4.00 pm in AG-69', 'Title :\nBreaking riboswitch speed limits by site specific mutation and un-natural base pair incorpor', '<h3>Title</h3>\n<h3>Breaking riboswitch speed limits by site specific mutation and un-natural base pair incorporation</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Riboswitch-based biosensing tools like reporters, aptazymes, and RNA-based fluorescent (RBF) biosensors have wide applications in cell biology, biotechnology and synthetic biology. A crucial aspect of the applications of these biosensing tools is their turn-on kinetics to monitor sensitive and dynamic biological processes. While considerable effort has been made toward developing new biosensing tools for interesting ligands, the optimization of their activation rate is often neglected. A common step involved in the activation of any riboswitch-based tools is the folding of the riboswitches in the presence of a particular analyte. Hence, optimizing the riboswitch’s folding speed will help to improve any riboswitch-based tool’s performance. In this context, by using a riboswitch-based fluorescent biosensor, we have come up with two different approaches to how a riboswitch’s folding rate can be enhanced by base-pair mutagenesis. The study here has shown that a site-specific single base-pair mutation by transposing the bases or swapping the pyrimidine-purine bases, or incorporating an unnatural hydrophobic base pair can significantly ameliorate a riboswitch-based biosensor’s activation rate. The strategies we have developed can be utilized to improve the performance of other riboswitch-based devices.</p>\n<p style=\"text-align: justify;\"> In the last part of my talk, I will present my future research plans, which will exploit organic synthesis, nucleic acid chemistry, and synthetic biology approaches. Specifically, I will discuss how I plan to develop an RNA-based screening platform and design novel RNA targeting ligands in an effort to explore novel antibacterial RNA drug targets. My research plan will also include designing Xeno-nucleic acid enzymes for efficient gene silencing.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-04-04 23:17:00', '2022-04-04 23:17:00'),
(754, 'Annual Works Seminar by Mr. Pulkit Joshi, Dept. of Chemical Sciences, TIFR, Mumbai on April 184, 2022 at 4.00 pm in AG-80', 'Title :\nUsing response theory based methods to understand weak interactions in open-shell systems\nAb', '<h3>Title</h3>\n<h3>Using response theory based methods to understand weak interactions in open-shell systems</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Interaction of radicals (open-shell) with closed-shell systems occurs in various environments of practical interest such as in atmospheric, polymer, or biological chemistry. Unlike closed shell complexes, radical– closed shell complexes may give rise to interactions that can have partial covalent bond character. Here, we take a set of molecules with doublet ground state interacting with polar molecules H<sub>2</sub>O and HF [1]. These molecules span a variety of interactions such as dispersion, hydrogen bonded, as well as having partial covalent character. Wavefunction based methods are limited to small molecules due to high computational scaling (eg., N<sup>7</sup> for CCSD(T)). The performance of DFAs is inconsistent across different approximations and among different set of complexes [1].</p>\n<p>Generalised Kohn Sham random phase approximation (GKS-spRPA) has been reliable for binding energies for noncovalent complexes in S22 data set with a mean absolute error of 0.64 kcal/mol [2] and has N<sup>4</sup> scaling. Now, we test the weak interactions in 8 open shell complexes using GKS-spRPA. For our test set, we report that the mean absolute error in the interaction energies is 1.83 kcal/mol with respect to CCSD(T). Role of second order exchange interactions was tested to estimate self-interaction errors due to unpaired electrons. We use approximate exchange kernel (AXK) which has been shown to outperform adiabatic connection second-order screened exchange (ACSOSEX) [3]. AXK reduces the mean absolute error in the interaction energy to 0.68 kcal/mol. We also report that the semi-local DFAs like PBE, PBE-D3, and TPSS showed mean absolute errors of 3.93 kcal/mol, 4.43 kcal/mol, and 3.15 kcal/mol respectively.</p>\n<p>For certain low-gap systems, convergence of the orbital optimization step of GKS-spRPA was challenging. This required the use of larger number of grid-points making the method costly by a factor, or the use of empirical shift parameters. Thus, we use a perturbative expansion of the RPA energy functional as a function of the orbital rotation parameter and derive a perturbative correction for orbital relaxation effects. The results from this approach will be discussed for the same test set.</p>\n<p><span style=\"text-decoration: underline;\">References </span></p>\n<p>[1] Peter R Tentscher and J Samuel Arey. Binding in radical-solvent binary complexes: Benchmark energies and performance of approximate methods. Journal of Chemical Theory and Computation, 9(3):1568– 1579, 2013.</p>\n<p>[2] Vamsee K Voora, Sree Ganesh Balasubramani, and Filipp Furche. Variational generalized kohn-sham approach combining the random-phase-approximation and green’s-function methods. Physical Review A, 99(1), 2019.</p>\n<p>[3] Jefferson E Bates and Filipp Furche. Communication: Random phase approximation renormalized many-body perturbation theory. The Journal of chemical physics, 139(17):171103, 2013.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-04-17 23:04:03', '2022-04-17 23:04:03'),
(755, 'Ph.D. Synopsis Seminar by Mr. Amitava Chandra, Dept. of Chemical Sciences, TIFR, Mumbai on April 19, 2022 at 4.00 pm in AG-69', 'Title :\nFluorescent Sensors for Sensing and Imaging Anionic Phospholipids', '<h3>Title</h3>\n<h3>Fluorescent Sensors for Sensing and Imaging Anionic Phospholipids</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-04-18 00:08:48', '2022-04-18 00:08:48'),
(756, 'Annual Works Seminar by Ms. Payal, Dept. of Chemical Sciences, TIFR, Mumbai on April 21, 2022 at 4.00 pm in AG-66', 'Title :\nElectrochemical CO2 Reduction\nAbstract :\nThere has been a tremendous increase in emission of', '<h3>Title</h3>\n<h3>Electrochemical CO<sub>2</sub> Reduction</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>There has been a tremendous increase in emission of greenhouse gases over the past few years.<sup>1</sup> The major reason for this is the dependence on non-renewable resources for meeting the world’s energy demand. The largest component of the greenhouse gases that is emitted is <sub>.</sub><sup>2</sup> In my presentation, I will discuss about two different approaches that are being evaluated in our lab to mitigate  levels.</p>\n<p>First part of my talk will focus on formation of an electrolyser wherein two different electrochemical half reactions are performed, in unison, using similar reaction conditions (temperature, pH, chemical nature of electrolyte) to allow not only the reduction of  but also allow the production of industrially important chemical: .  Second part of the talk will focus on improving the selectivity of new catalyst by taking inspiration from nature. I will discuss the formation of an interesting new COF and the introduction of functionalities in the catalyst such that it becomes more selective towards  as compared to other gases present in the environment.</p>\n<p><strong> </strong></p>\n<ol>\n<li>Data from United States Environmental Protection Agency (EPA). 2018. Available online: <a href=\"https://www.epa.gov/ghgemissions\">https://www.epa.gov/ghgemissions</a> overview-greenhouse-gases</li>\n</ol>\n<p> </p>\n<ol start=\"2\">\n<li><em>Energy Information Administration, Annual Energy Outlook </em><strong>2013, </strong><a href=\"http://www.eia.gov/forecasts/aeo/er/pdf/appa.pdf\">http://www.eia.gov/forecasts/aeo/er/pdf/appa.pdf </a><em>and </em><a href=\"http://www.eia.gov/forecasts/aeo/er/pdf/tbla17\">http://www.eia.gov/forecasts/aeo/er/pdf/tbla17.</a> pdf</li>\n</ol>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-04-20 05:30:52', '2022-04-20 05:33:18'),
(757, 'Ph.D. Synopsis Seminar by Mr. Mohd. Taher, Dept. of Chemical Sciences, TIFR, Mumbai on April 25, 2022 at 4.00 pm in AG-69', 'Title :\nDesign and development of Artificial Metalloenzymes: A study of Structure-function relations', '<h3>Title</h3>\n<h3>Design and development of Artificial Metalloenzymes: A study of Structure-function relationship</h3>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-04-21 00:46:33', '2022-04-21 00:46:33'),
(758, 'Annual Works Seminar by Mr. Aditya Shrivastava, Dept. of Chemical Sciences, TIFR, Mumbai on April 26, 2022 at 5.30 pm via Zoom platform', 'Title :\nIonic Liquids and Protein Engineering\nAbstract :\n Part – I Thermodynamic and Mechanical St', '<h3>Title</h3>\n<h3>Ionic Liquids and Protein Engineering</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p><br /> <strong>Part – I Thermodynamic and Mechanical Stability of Ubiquitin in Ionic Liquids</strong></p>\n<p>Biocatalysts are a powerful tool leading the discovery of novel, efficient, non-toxic, and low-cost routes to synthesizing organic compounds. The traditional solvent used for bio-catalysis is water. However, the desired products and precursors are mostly non-polar. Using organic solvents to circumvent this problem results in decreased stability and activity of the enzymes. Additionally, these volatile compounds pose health and environmental hazards. Ionic liquids – low melting temperature solvent consisting of asymmetric, bulky ions, proposes a solution to problems with existing methodology. However, the effect of ionic liquids on protein stability and folding remains to be understood. Moreover, to the best of our knowledge, there are no single-molecule force experimental studies investigating the effect of ionic liquids on the folding of proteins. Here, we take ubiquitin, a well-characterized small protein, to investigate the effect of ionic liquids. Single-molecule and bulk experiments with a variety of ionic liquids: [BMIM][Cl], [bmPyr][Cl], [EMIM][Cl], [BMIM][MeSO4], [EMIM][MeSO4], [BMIM][BF4], [EMIM][BF4], suggest that such non-aqueous (chemical) environment leads to a decrease in the stability of ubiquitin. Furthermore, insights from single-molecule pulling studies validate that those ionic liquids reduce the protein flexibility and decrease the unfolding barrier.</p>\n<p><strong> </strong><strong>Part-II Effect of t-SNAREs binding on the mechanics of C2AB domains of Synaptotagmin</strong></p>\n<p><strong> </strong> The fusion of cellular membranes is a vital process in different cells, especially during the exocytosis of neurotransmitters at chemical synapses in the brain. The soluble N-ethyl maleimide sensitive factor attachment protein receptors (SNAREs) syntaxin-1, SNAP-25, and synaptobrevin-2 play a crucial role in catalyzing membrane fusion. Besides SNARE proteins, many proteins regulate this process, including Munc13, Munc18, Complexin, Synaptotagmin-1, etc. Synaptotagmin-1 (Syt1) is associated with vesicle, and it acts as a Ca<sup>2+</sup> sensor. It interacts with the SNARE-Complex and negatively charged anionic phospholipids during the Ca<sup>2+</sup> influx and causes fast synchronous exocytosis of synaptic vesicles. However, the exact molecular mechanism by which Syt1 triggers vesicle fusion remains controversial, and many competing models exist. To understand the role of Syt1 in the final step in fusion pore formation, Syt1 has been studied using Single-Molecule Force Spectroscopy by AFM. It was revealed that one of the domains of Syt1 (C2A) unfolds from N-terminal at a relatively small stretching force and can act as a mechanical switch for binding partners of Syt1. However, the major shortcoming of this previous study was the absence of binding partners of Syt1, i.e., t-SNAREs and anionic phospholipids. We have introduced t-SNAREs embedded in phospholipid bilayer nanodisc to mimic biologically relevant conditions. We have planned to do SMFS of C2AB domains in the presence of its binding partners.</p>\n<p><strong> </strong><strong>Part-III Revisiting the unconventional linkages in SMFS using non-canonical amino acid protein engineering</strong></p>\n<p>Single-molecule force spectroscopy (SMFS) is a versatile tool for studying proteins. It uses force as a more biologically relevant perturbation as compared to the chemical and temperature perturbation. However, a significant shortcoming of most studies of SMFS is the limited direction of stretching, i.e., conventional N-C terminal. These conventional linkages limit the SMFS to explore only the 1-D dimension of a protein\'s multidimensional potential energy surface. To overcome this, many protein engineering strategies have been implemented, from introducing intermolecular disulfide bonds to recently introducing an internal sortase tag. These strategies have limitations and cannot be generalized for any protein. However, with the rise of new methodology in protein engineering, i.e., incorporating non-canonical amino acids, unconventional linkages in SMFS should be revisited. We have devised strategies for any general protein to form unconventional linkages, including N-terminal to an internal site, C-Terminal to an internal site, two internal sites, and parallel linkages.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-04-24 22:56:54', '2022-04-24 23:05:15'),
(759, 'Annual Works Seminar by Ms. Rajasree Kudu, Dept. of Chemical Sciences, TIFR, Mumbai on April 28, 2022 at 4.00 pm in AG-80', 'Title :\nCell-Permeable, Ratiometric, Fluorescent Sensors for Imaging Phosphoinositides\nAbstract :\nPh', '<h3>Title</h3>\n<h3>Cell-Permeable, Ratiometric, Fluorescent Sensors for Imaging Phosphoinositides</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Phosphoinositides, a class of essential phospholipids, are key mediators of cell signalling and regulatory processes. Dynamic changes in concentrations and distributions of phosphoinositides act as initiating flags for cell signalling events.<sup>1</sup> Impaired phosphoinositide metabolism has been linked to multiple disorders including type-2-diabetes, bipolar disorder, cancer. Hence, tracking phosphoinositide dynamics can provide mechanistic insights into fundamental cellular processes, aid in disease diagnosis, and guide therapeutic routes. Fluorescence microscopy can provide with an appropriate imaging set-up to track phosphoinositides in living cells with high spatiotemporal resolution. Since, phosphoinositides are non-fluorescent, fluorescent sensors selective toward phosphoinositide are required. However, tracking phosphoinositides in living cells is extremely challenging. This is because, phosphoinositides are present in significantly lower concentrations (&lt;1-5 mol%) when compared to other cellular phospholipids. Further, reversible phosphorylation on the inositol headgroup of phosphatidylinositol leads to the presence of seven distinct phosphoinositides in the cell-membrane. Each member of the phosphoinositide family plays a distinct role in the cell. Phosphoinositides are also mostly present in the inner-leaflet of the cell membrane. Therefore in order to track the live cell dynamics of a specific phosphoinositide and elucidate its role in cellular processes we require selective, sensitive, reversible, and cell permeable probes.<sup>1</sup> Towards this goal, we have developed a peptide-based reversible detection scheme for selective tracking of phosphoinositides and have applied the strategy for sensing phosphatidylinositol-(4,5)-bisphosphate (PI(4,5)P2)<sup>2</sup> and phosphatidylinositol-(3,4,5)-trisphosphate (PI(3,4,5)P3). We have harnessed insights from MD simulations on phosphoinositide binding peptides with phospholipid bilayers to fine-tune the selectivity and the sensitivity of the sensors. By leveraging the flexibility of our sensing scheme, we have altered binding scaffolds as well as dyes to make a sensor library for different phosphoinositides. We have successfully developed two orthogonally emitting sensors with high selectivity toward PI(4,5)P2 and PI(3,4,5)P3, respectively. Simultaneous imaging of PI(4,5)P2 and PI(3,4,5)P3 can shed light on the cellular processes like cell proliferation and migration under physiological and pathophysiological conditions where these phosphoinositides are key regulators. Both the sensors have been tested for in vitro selectivity against other biologically relevant phospholipids and are cell-permeable. Current studies are focused on tracking the phosphoinositide dynamics in living cells using these novel sensors. I will present the details of work done in last one year and on-going research on the applications of the novel sensors in live cell imaging.</p>\n<p style=\"text-align: justify;\"> [1] R. Kundu, A. Chandra, A. Datta, <em>Isr. J. Chem.,</em> <strong>2021<em>, </em></strong><em>61</em>, 199.</p>\n<p>[2] S. Mondal, A. Rakshit, S. Pal, A. Datta. <em>ACS Chem. Biol.,</em> <strong>2016</strong>, <em>11</em>, 1834–1843.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-04-25 22:15:00', '2022-04-25 22:15:00'),
(760, 'Annual Works Seminar by Mr. Ravinder Kumar, Dept. of Chemical Sciences, TIFR, Mumbai on May 2, 2022 at 4.00 pm in AG-69', 'Title :\nDesign Principles for Molecular Electronic Breadboards\nAbstract :\nThe electronic breadboard ', '<h3>Title</h3>\n<h3>Design Principles for Molecular Electronic Breadboards</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">The electronic breadboard has played a key role in the development of conventional electronics by enabling assembly of multiple circuits and rapid prototyping of circuit designs. Translating this concept to the molecular scale is critical for developing the field of molecular electronics, which aims to develop single molecules as electronic components in new functional devices with capabilities distinct from semiconductor-based electronics, to its potential. In my talk, I shall present computational framework to design molecular breadboards which can be accessed within an experimental break-junction setup. Our framework addresses the challenges of working with molecules such as their conformational flexibility and their accessibility to microscopic metal electrodes. At present, controlling and combining the electronic properties of multiple circuits within a single-molecule junction remains a challenge. In my talk, I shall discuss strategies to overcome this challenge wherein we examine conductance of three bisterpyridine based molecular breadboards to show that the relative conductance of five single terminal circuits embedded within these scaffolds can be controlled using quantum interference phenomena, the molecule-electrode connection, and external electrochemical gate potential.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-04-27 04:57:44', '2022-04-27 04:57:44'),
(761, 'Annual Works Seminar by Ms. Kunika Gupta, Dept. of Chemical Sciences, TIFR, Mumbai on May 5, 2022 at 4.00 pm in AG-80', 'Title :\nDesign and Applications of Binding and Activity-Based Metal Ion Sensors\nAbstract :\nMetal ion', '<h3>Title</h3>\n<h3>Design and Applications of Binding and Activity-Based Metal Ion Sensors</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Metal ions play important roles in biological systems ranging from catalysis to providing structural stability to proteins to regulating electron transfer pathways. Any internal or external factor causing imbalance in metal homoeostasis leads to several disorders. Therefore, it is important to track the localisation and distribution of the metal ions. Among various metal ions, Mn is an essential metal ion, mostly present in +2 oxidation state, which performs vital biological functions. Mn imbalance leads to its accumulation in brain causing manganism, a disease with symptoms similar to Parkinson’s disease. Hence, tracking and imaging Mn ions within living systems can provide insights into Mn regulation. In this context, fluorescent sensors that can detect metal ions would be key chemical tools to image the metal ions including Mn within living cells. Two mechanisms can be utilised to design the fluorescent sensors for metal ions, activity-based sensing (ABS) and binding based sensing (BBS). ABS provides a dual check for the selectivity of metal ions over BBS as it triggers a metal specific transformation upon binding to the metal ion of interest. This allows to overcome the challenges posed by the paramagnetic metal ions and the ones lying low in the Irving Williams Series, specifically Mn. Apart from being essential nutrients, metal ions have also gained important status in the field of metallodrugs. Recently, Mn centred drugs are in use as antioxidants and MRI contrast agents. However, the cellular environment can destabilize the metallodrugs, resulting in reduced efficacy of drugs and cellular toxicity. So, it is also necessary to determine the intracellular stability of the metallodrugs. Here, we aim to develop a library of fluorescent sensors for Mn ions and utilizing a non-invasive fluorescence imaging-based strategy for tracking manganese (Mn) ions and Mn centred metallodrugs in live cells. In the talk, I will discuss: 1. Design and synthesis of a novel activity  based sensor for Mn<sup>2+</sup> ions, the molecule has been characterised and tested for its response towards Mn ions, 2. Synthesis of a known Mn<sup>2+</sup> sensor from our group (M1) to determine the stability constant of the Mn antioxidants, 3. Plan to utilise M1 to detect the accumulation of Mn<sup>2+</sup> in higher organisms, 4. Attempted synthesis of a next generation water soluble sensor for Mn<sup>2+ </sup>ions utilizing a ‘click’ chemistry based modular synthetic scheme.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-05-02 03:56:37', '2022-05-02 03:56:37'),
(762, 'Annual Works Seminar by Mr. Saideep Singh, Dept. of Chemical Sciences, TIFR, Mumbai on May 9, 2022 at 4.00 pm in AG-69', 'Title :\nPlasmonic Metal Nitrides for Transforming CO2 to CO using Solar Energy\nAbstract :\nMetal nitr', '<h3>Title</h3>\n<h3>Plasmonic Metal Nitrides for Transforming CO<sub>2</sub> to CO using Solar Energy</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Metal nitrides are evolving as promising photocatalysts owing to their exquisite plasmonic features. Recently, Molybdenum nitrides (MoN) nanosheets show plasmonic behavior that allowed the material as a light harvester. We are searching for various stable, and good lightharvesting metal nitrides, that are highly active and selective for CO<sub>2</sub> hydrogenation reactions.</p>\n<p>In this work, we have designed and synthesized nanosheets of Nickel Nitride (Ni<sub>3</sub>N) using the solvothermal process. Material characterizations were carried out using various techniques such as SEM, TEM, HRTEM, XRD, XPS, UV-DRS, N<sub>2</sub> sorption etc. It has a broad optical spectrum and absorbs well in the visible region. EELS spectroscopy indicated the plasmonic character of the material. Ni<sub>3</sub>N was then studied for CO<sub>2</sub> hydrogenation to CO using hydrogen under light. The photocatalytic CO production rate was (713 ± 40 mmol g<sup>-1</sup> h <sup>-1</sup> ) with 100 % CO selectivity. Notably, the reaction was carried out in a flow reactor at low temperature (50-110 °C) and atmospheric pressure without external heating. Linear dependence of CO production rate on light intensity indicated the non-thermal hot-electron mediated CO<sub>2</sub> reduction. Fe<sup>3+</sup> to Fe<sup>2+</sup> one-electron reduction reaction also indicated electron transfer mechanism. Operando diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) showed that CO<sub>2</sub> hydrogenation took place by direct dissociation path via linearly bonded Ni-CO intermediates.</p>\n<p>References:</p>\n<p>1. Bailera, M.; Lisbona, P.; Romeo, L. M.; Espatolero, S. Renew. Sustain. Energy Rev, 2017, 69, 292–312.</p>\n<p>2. Jia, J.; Qian, C.; Dong, Y.; Li, Y. F.; Wang, H.; Ghoussoub, M.; Butler, K. T.; Walsh, A.; Ozin, G. A. Chem. Soc. Rev. 2017, 46, 4631–4644</p>\n<p>3. H.S. Gujral et al. Sci. Technol. Adv. Mater., 2022, 23, 77</p>\n<p>4. Guan, H., Yi, W., Li, T. et al. Nat Commun, 2020, 11, 3889</p>\n<p>5. D. Fomra, M. Mamun, K. Ding, V. Avrutin, Ü. Özgür, N. Kinsey, Opt. Express, 2021, 29, 19586-19592</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-05-04 04:21:56', '2022-05-04 04:21:56'),
(763, 'Annual Works Seminar by Mr. Kishan Kumar Yadav, Dept. of Chemical Sciences, TIFR, Mumbai on May 12, 2022 at 4.00 pm in AG-66', 'Title :\nPhotoredox C-C Coupling Reactions inside Supramolecular Cavities\nAbstract :\nEnzymes act as n', '<h3>Title</h3>\n<h3>Photoredox C-C Coupling Reactions inside Supramolecular Cavities</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Enzymes act as nano-vessels which can selectively catalyze chemical reactions by confinement and controlled activation of substrates.<sup>[1]</sup> Chemists have designed supramolecular cavities to mimic enzymes and demonstrated selective product formation.<sup> [2] </sup>Recently it was shown that the photoactivation of weakly polarized sp<sup>3</sup> C-H bonds in water can be selectively done using water-soluble octahedral Pd<sub>6</sub>L<sub>4</sub><sup>12+</sup> nano-cage.<sup> [3]</sup> However, these cages sometime suffer from low catalytic turnover due to product trapping inside the nano-cages.<sup> [4]</sup> In order to solve this issue we have tried photocatalysis via charge transfer mediated pathways inside a square pyramidal Pd<sub>6</sub>L<sub>4</sub><sup>12+</sup> nano-bowl<sup> [5]</sup> which is formed by self-assembly of [Pd(en)(ONO<sub>2</sub>)<sub>2</sub>] complex with triazine based ligands as the cavity walls.  In this seminar, I will discuss our ongoing efforts to optimize and characterize the photocatalytic inter- and intra-molecular C-C coupling reactions between carbon centres having either sp or sp<sup>3</sup> hybridization leading to selective C-C bond formation in water using steady-state and transient absorption spectroscopy. Subsequently, I will show that how the tuning of shape of confinement from octahedral to square pyramidal is leading to different selectivity and faster kinetics.</p>\n<p>   References</p>\n<ol>\n<li>Rittle J., et. al, <em>Science</em> <strong>2010</strong>, <em>330</em>, 933–937</li>\n<li>Zhang, Q., et. al, <em> Chem. </em><strong>2015</strong>, 7, 197–202</li>\n<li>Das A., et. al, <em> Adv.</em> <strong>2019</strong>, <em>5</em>, eaav4806</li>\n<li>Yoshizawa M., et. al, <em>Science</em> <strong>2006</strong>, <em>312</em>, 251-254.</li>\n<li>Fujita M., et. al, <em> Chem. Int. Ed.</em> <strong>1998</strong>, <em>37</em>, No. 15</li>\n</ol>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-05-10 03:45:40', '2022-05-10 03:45:40'),
(764, 'Annual Works Seminar by Mr. Rohit, Dept. of Chemical Sciences, TIFR, Mumbai on May 17, 2022 at 4.00 pm in AG-69', 'Title :\nHarvesting and storing solar energy\nAbstract :\nSolar energy is the cleanest renewable source', '<h3>Title</h3>\n<h3>Harvesting and storing solar energy</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Solar energy is the cleanest renewable source of energy. Currently, coupling of photovoltaic (PV) devices with batteries and/or supercapacitors harvest and store this energy. However, coupling these devices usually involves multiple interfaces through which the generated excited carriers have to traverse. To mitigate the problem of efficiency losses through multiple interfaces, an approach of capturing and storing solar energy simultaneously in a single material (<em>bi</em>-functional material) has been put forward very recently in the literature. The talk will present the understanding we build through an electrochemical approach on how a single material is capable of harvesting and storing solar energy simultaneously. The talk will also exploit the variety of parameters that include tuning of structural and external parameters, leading to increasing the charge storage amount and prolonging its duration.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-05-16 23:04:26', '2022-05-18 05:13:00');
INSERT INTO `posts` (`id`, `name`, `description`, `content`, `status`, `author_id`, `author_type`, `is_featured`, `image`, `pdf_file`, `views`, `format_type`, `created_at`, `updated_at`) VALUES
(765, 'Annual Works Seminar by Mr. Shreyas Vaidya, Dept. of Chemical Sciences, TIFR, Mumbai on May 19, 2022 at 4.00 pm in AG-80', 'Title :\nTowards Bleomycin-Platinum Glycoconjugates for Targeted Chemotherapy: An Odyssey in Carbohyd', '<h3>Title</h3>\n<h3>Towards Bleomycin-Platinum Glycoconjugates for Targeted Chemotherapy: An Odyssey in Carbohydrate Chemistry</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Cancer is the second leading cause of fatalities worldwide. The serendipitous discovery of anticancer activity of Cisplatin in 1965 by Prof. Rosenberg ushered in a new era of cancer chemotherapy. It is the preferred choice of treatment against a large variety of cancers. Despite its clinical success, cisplatin treatment has some drawbacks. Adverse side effects like nephrotoxicity, ototoxicity, anaemia are commonly observed in patients undergoing chemotherapy.</p>\n<p>In this context, the selective accumulation of the cytotoxic drug at the tumor site is highly desirable to achieve improved efficacy and minimal side-effects. Glucose metabolism is typically upregulated in cancer cells as compared to the normal cells (Warburg Effect). An overexpression of Glucose Transporter (GLUT) family of proteins is observed in the cancer cells. GLUTs have emerged as an attractive target for a large number of targeted anticancer strategies.  Recently, the disaccharide moiety of anticancer drug Bleomycin A<sub>5 </sub>has been reported to exhibit preferential uptake in cancer cells <sup>[1,2]</sup>. However, there is contradiction in the chemical literature about the minimal epitope of this disaccharide which is necessary and sufficient for imparting the observed selectivity <sup>[3]</sup>. We have therefore decided to investigate this problem by carrying out a structure-activity relationship study on the bleomycin disaccharide. In this talk I will discuss about the synthetic problems faced during the journey from the starting molecules to the target sugar-platinum conjugates.</p>\n<p> </p>\n<p>References:</p>\n<ol>\n<li>Zhiqiang Yu.; Ryan M. Schmaltz.; Trevor C. Bozeman.; Rakesh Paul.; Michael J. Rishel.; Krystal S. Tsosie.; Sidney M. Hecht. <em> Am. Chem. Soc</em>. <strong>2013</strong>, 135, 2883−2886</li>\n<li>Benjamin R. Schroeder.; M. Imran Ghare.; Chandrabali Bhattacharya.; Rakesh Paul.; Zhiqiang Yu.; Paul A. Zaleski.; Trevor C. Bozeman.; Michael J. Rishel.; Sidney M. Hecht. <em> Am. Chem. Soc</em>. <strong>2014</strong>, 136, 13641−13656</li>\n<li>Zhou Cui.; Ye Wenchong.; Wang Xiaoyang <em>European Journal of Medicinal Chemistry</em>. <strong>2021</strong>, 226, 112866.</li>\n</ol>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-05-18 05:11:52', '2022-05-18 05:11:52'),
(766, 'Annual Works Seminar by Dr. Abhisek Ghosal, Dept. of Chemical Sciences, TIFR Mumbai, on May 23, 2022 at 4.00 pm in AG-69', 'Title :\nModelling optical properties of f-centre defects: A generalised KS semicanonical projected R', '<h3>Title</h3>\n<h3>Modelling optical properties of f-centre defects: A generalised KS semicanonical projected RPA perspective</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p style=\"text-align: justify;\">Defects can dominate the electronic and optical properties in materials, thus play a vital role in the performance of many technological applications. Among various defects, our primary focus is on f-centre defects which can act as a strong local-reduction site in the chemical processes. The experimental measurement of such defects are usually hampered by their low concentration. Therefore, theoretical studies of defect sites are of major importance for a deeper understanding of how defects might work. Theoretical studies based on periodic supercell model can be a method of choice, but encounters higher defect concentration. It is also computationally demanding using quantum chemistry (QC) methods. On the other hand, embedded cluster model is capable of describing isolated point defects along with the highlevel QC methods. In this direction, we present periodic electrostatic embedding cluster model (PEECM) in which the quantum mechanical part is treated with the recently developed generalised Kohn-Sham semicanonical projected RPA (GKS-spRPA) theory. A detailed systematic assessment of properties towards the bulk limit is presented here on a representative f-center LiF. In all instances, these results are excellent agreement with the available theoretical and experimental results. At the end, I will discuss about the importance of surface defects as well as major challenges to model such defect within the PEECM-GKS-spRPA framework.</p>\n<p style=\"text-align: justify;\">In the second part of my presentation, I will discuss about metastable systems which are observed in radioactive decays, dissociative electron attachment, stark ionisation, even in biomolecules like DNA base pairs, etc. These states are characterised by complex energy, the real part of which is the resonance energy and the imaginary part is associated with its lifetime. The GKS-spRPA can be a method of choice for such problems, but it requires the analytical continuation of real energy to complex domain. Here, a non-Hermitian analogue of adiabatic connection is derived. Further, it has been shown that it is same as the Hermitian approach as long as the non-Hermitian part is symmetric and local. Finally, the ongoing work and future direction is discussed.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-05-18 22:46:58', '2022-05-18 22:46:58'),
(767, 'Annual Works Seminar by Mr. Bibek Samal, Dept. of Chemical Sciences, TIFR Mumbai, on May 26, 2022 at 4.00 pm in AG-80', 'Title :\nA paremeter-free approach for core-level spectroscopy without core-hole reference states\nAbs', '<h3>Title</h3>\n<h3>A paremeter-free approach for core-level spectroscopy without core-hole reference states</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Element-specific inner shell spectroscopy provides valuable information about the local chemical environment of atoms in molecules. Advanced light sources have made it possible to probe the inner shells of heavier elements leading to an increasing number of experiments. A balanced description of orbital-correlation and -relaxation effects, and relativistic corrections is needed for such theoretical studies. The importance of relativistic effects becomes prominent for elements heavier than Ne. Here, we combine GKS-spRPA with scalar relativistic (sr) X2C to study the X-ray photoelectron spectroscopy (XPS) of molecules of third period elements. This method produces MAEs of less than an eV for the core 1s and 2s level of third-period elements. We also developed a method for simulating X-ray emission spectroscopy (XES) where the emission energies are estimated as a difference between the valence and core ionization eigenvalues, computed using the sr-GKS-spRPA. The sr-GKS-spRPA one-particle eigenvalues provide accurate valence and core ionization energies using which accurate XE energies can be estimated without any need for core-hole reference states (unlike ∆SCF methods), empirical shifting parameters, or tuning of density functionals. The sr GKS-spRPA XE energies are within 0.2 eV of experimental values for a set of 27 emission energies of molecules containing second-period and third-period elements. The analytically continued (AC) GKS-spRPA approach, with a O(N<sup>4</sup> ) computational cost, enables efficient computation of medium-sized molecules. GKS-spRPA method can be used straightforwardly for simulating the XES spectra of symmetric molecules like C<sub>6</sub>H<sub>6</sub> and C<sub>60</sub> with several core-hole states.</p>\n<p> </p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-05-23 05:15:59', '2022-05-23 22:12:55'),
(768, 'Annual Works Seminar by Mr. Dipin Tomar, Dept. of Chemical Sciences, TIFR Mumbai, on May 30, 2022 at 4.00 pm Via Zoom Platform', 'Title :\nCharge Transfer mediated Metal-free Photoredox Catalysis\nAbstract :\nCharge transfer complexe', '<h3>Title</h3>\n<h3>Charge Transfer mediated Metal-free Photoredox Catalysis</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Charge transfer complexes are a viable route to generate radical intermediates in the excited state through an electron transfer. These Charged intermediates can either be extracted to do photocatalysis<sup>1,2</sup> or can be channelized to generate a voltage in a photovoltaic device. In catalysis, the main hurdle is to avoid the rapid back electron transfer that hampers the reactivity of Intermediates. Our lab has already established a catalytic scheme for generating reactive free radicals using a Pd<sub>6</sub>L<sub>4</sub><sup>+12</sup> octahedral supramolecule, allowing for desired product conversions<sup>3</sup>. Though highly selective, such a catalyst involves rare metals and is much less stable with different substrates. With such a background in my talk, I will discuss the synthesis of a metal-free, much simpler, catalytically robust, and highly applicable acceptor molecule based on Triazinium salts. Subsequently, the reactivity of substrates will be discussed with a deeper insight into the reaction mechanism and product selectivities.</p>\n<p>References:</p>\n<ol>\n<li>Zhang J., Luo J.,<em> ACS Catal.</em><strong>2016</strong>, 6, 2, 873–877.</li>\n<li>Stepehenson R. J., Beatty J. W., Mori M., Monos T. M., McClain E. J.,<em> ACS Catal.,</em><strong>2020</strong>, 10, 21, 12636–12641.</li>\n<li>Das A., Dasgupta J., <em> Adv., </em><strong>2019, 5</strong>, eaav4806.</li>\n</ol>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-05-26 01:47:34', '2022-05-29 22:16:13'),
(769, 'Seminar by Dr. Gourab Pattnaik, Sambalpur University, on May 27, 2022 at 3.00 pm via Zoom Platform', 'Title :\nInteraction of Peptides with Membranes: Implications in Membrane Fusion\nAbstract :\nMembra', '<h3>Title</h3>\n<h3>Interaction of Peptides with Membranes: Implications in Membrane Fusion</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Membrane fusion is an important step for the entry of the enveloped viruses into the host cells. The fusion process is catalyzed by fusion proteins present in the viral envelope. The class I virus contains a 20–25 amino acid sequence at its N-terminal of the fusion domain, which is instrumental in the fusion and is called a “fusion peptide”. However, severe acute respiratory syndrome (SARS) coronaviruses contain more than one fusion peptide sequence. We have observed that the internal fusion peptide 1 (IFP1) of SARS-CoV-2 is far more fusogenic than its N-terminal counterpart (FP) to induce hemifusion formation in a cholesterol-dependent manner. We have further developed peptide-based fusion inhibitors and tested their inhibitory efficacies. We found that in addition to the altered peptide organization and dynamics in cholesterol-containing membranes, the intrinsic negative curvature of cholesterol might be surpassing the inhibitory effect of an inhibitor peptide, TG-23. We have further demonstrated that peptide-induced water penetration into the hydrophobic region is directly correlated with its fusogenicity, and the membrane composition is adding complexity in the journey of developing peptide-based membrane fusion inhibitors.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-05-25 04:10:00', '2022-05-26 04:33:34'),
(770, 'Annual Works Seminar by Mr. Atish Bhattacharyya, Dept. of Chemical Sciences, TIFR Mumbai, on June 2, 2022 at 4.00 pm in AG-80', 'Title :\nRegioselective, stereoselective cyclopropanation of structurally diverse alkenes\nAbstract :\n', '<h3>Title</h3>\n<h3>Regioselective, stereoselective cyclopropanation of structurally diverse alkenes</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Cytochrome P450known for C-H activation to C-OH. According to previous literature, Ir is the best in place of the Fe in cytochrome p450 for cyclopropanation. At first, I have taken out the heme group using Teale’s method and reconstituted Ir(por) in apo CYP175A1. We have seen 100% removal of the heme group and 50% reconstituted Ir(por)CYP175A1 concentration of ~2uM (according to ICPMS data). Then, we carried out cyclopropanation of (R)-(+)-limonene, using ethyl diazo acetate (EDA) (slow addition) at 40<sup>o</sup>C in an N2 atmosphere. We have seen the formation of a product RT 5.08 with Ir(por)CYP175A1 which is very similar to Ir(por) control.</p>\n<p>Then, we shifted to surfactants like CTAB and DTAB micelles formation are conformed by DLS. Then we have carried out Limonene, Ir(por), and EDA reactions in a confined space of micelles. CTAB shows promising results in GC-FID with two new peaks at RT 4.83 and RT 4.89. Our GC-MS was down, hence, reverse phase HPLC coupled with UV-Vis (wavelength taken 210 nm, 225 nm, 240 nm, 250 nm) was carried out, and additional peaks were observed at A (RT 4.15), B (RT 4.35), C (RT 4.55), and D (RT 5.15) in the case of DTAB and CTAB. The area under the curve of the peaks observed that all peaks are reproducible and increase with time (24hrs to 36hr to 48hrs). We have analyzed these peaks using ESI-MS. ESI-MS of peak A observed a mass of 309.20 which corresponds to the dicyclopropanated derivative of Limonene and peak D observed a mass of 223.17 corresponding to the monocyclopropanated derivative of Limonene. ESI-MS peaks of C and D are mixed compounds. More product yields have been observed in shorter times (24 and 36hrs) may be due to the higher solubility of limonene in the hydrophobic core of CTAB. A high product yield in a longer period (48hr) in the case of DTAB may be due to more solubilized EDA.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-06-01 00:03:33', '2022-06-01 00:04:47'),
(771, 'Annual Works Seminar by Dr. Shubhankar Gadre, Dept. of Chemical Sciences, TIFR Mumbai, on June 6, 2022 at 4.00 pm in AG-69', 'Title :\nAddressing resistance and selectivity issues of metal-based chemotherapeutics through drug d', '<h3>Title</h3>\n<h3>Addressing resistance and selectivity issues of metal-based chemotherapeutics through drug design</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Cancer is the second leading cause of death in the world. It originates from uncontrolled cell growth in abnormal tissues either as a result of DNA mutations or because of inherited faulty genes. Current major clinical treatments for cancer include surgery, chemotherapy, radiation therapy, and in special cases endocrine therapy and immunotherapy. Among these, chemotherapy remains the most widely used treatment modality and particularly, platinum-based drugs remain the most successful clinically used therapeutic drugs<a href=\"#_ftn1\" name=\"_ftnref1\">[1]</a>. Three platinum-containing drugs are approved worldwide for treating cancer in humans, i.e. cisplatin, carboplatin, and oxaliplatin. Though platinum compounds  are very successful in the clinic<a href=\"#_ftn2\" name=\"_ftnref2\">[2]</a> and widely used against various cancers, they suffer from two major drawbacks: 1) severe side effects and 2) emergence of resistance by the cancer cells.<a href=\"#_ftn3\" name=\"_ftnref3\">[3]</a> Since their discovery, tremendous efforts towards optimization of the drug response have gone into making these platinum drugs safer for patients, in particular, reducing the unpredictable side effects like severe neuro- and nephron-toxicity.<a href=\"#_ftn4\" name=\"_ftnref4\">[4]</a> A second major, ongoing, initiative is to overcome tumor resistance to antiproliferative activity of platinum. These two issues are a major hurdle in the discovery of new and improved chemotherapeutics. In the last 10-15 years, the scientific community has been looking at alternate pharmacophores - ruthenium, iridium, and bimetallic compounds including platinum that can address these issues. They exert different modes of action and result in improved selectivity towards cancer cells as well as overcome the platinum resistance. Nevertheless, the improved results are primarily restricted to <em>in vitro</em> assays and further evidence for their activity (<em>in vivo</em>) is still missing. During the last one year, we have worked on the synthesis of a wide range of organometallic compounds belonging to broadly 4 categories based on structural features of the compounds (Figure 1). We have showed through elaborate <em>in vitro</em> experiments that they exert either better or extremely high anticancer efficacy when compared with clinical platinum drugs and use a different mechanism of action for the same. Simultaneously, they are able to address issues of selectivity and resistance. Finally, we have proved their ability to suppress tumor growth <em>in vivo</em> xenograft model experiments with mice, showcasing their high potential to be developed as next generation anticancer drugs.</p>\n<p><img style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"data:image/png;base64,[encoded data, 16260 characters]\[encoded data, 13453 characters]', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-06-02 05:08:56', '2022-06-02 05:09:50'),
(772, 'Annual Works Seminar by Mr. Sushanta Chhatar, Dept. of Chemical Sciences, TIFR Mumbai, on June 9, 2022 at 4.00 pm in AG-80', 'Title :\nIn-depth mode of action of novel chemotherapeutic drugs candidate\nAbstract :\nPlatinum drugs ', '<h3>Title</h3>\n<h3>In-depth mode of action of novel chemotherapeutic drugs candidate</h3>\n<p><strong><span style=\"text-decoration: underline;\">Abstract</span> :</strong></p>\n<p>Platinum drugs have shown excellent efficacy against various types of cancers. However, their clinical efficacy is being challenged because of multifactorial chemoresistance, nephrotoxicity, neurotoxicity etc. To circumvent this issue associated with current platinum therapy, we have designed several novel anticancer drugs. After screening, we obtained several lead molecules which showed excellent stability in biological buffer. These lead compounds showed excellent antiproliferative activities in cancer cells. I performed in depth studies on the mechanism of action of these compounds. This will be discussed during the seminar.</p>', 'published', 1, 'Botble\\Author\\Models\\Author', 0, NULL, NULL, 0, 'NULL', '2022-06-06 05:04:43', '2022-06-06 05:04:43');
