<h3>Title</h3>
<h3>Organocatalysis: Engineering Catalytic Methods of Covalent Intermediates and Ion Pairs towards Synthetic Applications</h3>
<p><strong><span style="text-decoration: underline;">Abstract</span> :</strong></p>
<p style="text-align: justify;">Catalysis is a powerful tool that enables efficient processes that give precise control over molecular architecture. Catalytically controlled generation of reactive intermediates via new generic modes inspired organic chemists to design a variety of new asymmetric transformations. In this context, there has been a significant expansion of the reactions that catalyzed by organic molecules. The advent of organocatalysis (catalysis using small organic molecules) has introduced several new activation modes, mainly falling under two categories: covalent bonding (eg. NHC-catalysis, amine catalysis etc.) and non-covalent interactions such as ion pairing. This presentation will detail examples from each of these categories. First, the development and applications of NHC catalyzed homoenolate annulation in the stereoselective construction of γ- and δ-lactones and cyclopentenes will be discussed. Second, the design and synthesis of new chiral Brønsted acid catalysts for asymmetric acetalization leading to cyclic acetals and its drug derivatives will be covered.</p>
<p><br />Selected References</p>
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